GREMLIN Database
DUF1800 - Protein of unknown function (DUF1800)
PFAM: PF08811 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 433 (421)
Sequences: 18593 (14091)
Seq/√Len: 686.7
META: 0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_R244_D4.1081.00
134_L240_E3.7201.00
287_D290_A3.4071.00
28_D293_R3.3371.00
280_V294_A3.0941.00
190_A242_V3.0881.00
137_A166_Y3.0491.00
105_K147_D2.9921.00
17_A29_E2.9771.00
279_A283_D2.8761.00
310_K318_S2.8381.00
21_L29_E2.8311.00
276_R298_S2.7201.00
128_N287_D2.5931.00
253_A282_R2.5221.00
193_A242_V2.5171.00
185_D189_E2.4971.00
284_S287_D2.4971.00
128_N131_D2.4631.00
192_R220_D2.3991.00
123_P135_A2.3801.00
254_R275_D2.3331.00
11_T14_E2.3211.00
184_Q188_K2.2561.00
277_L295_I2.2511.00
275_D279_A2.2441.00
17_A21_L2.2151.00
226_V242_V2.2081.00
192_R222_G2.2061.00
198_T215_N2.1761.00
396_A400_A2.1691.00
124_H135_A2.1461.00
22_G25_A2.1161.00
258_R262_R2.0901.00
271_P275_D2.0771.00
223_E230_T2.0441.00
130_R134_L2.0321.00
89_E122_R2.0281.00
178_V181_G2.0221.00
91_M126_L2.0111.00
383_D399_R2.0041.00
293_R297_L1.9971.00
197_W239_G1.9631.00
257_A277_L1.9541.00
138_K240_E1.9301.00
185_D188_K1.9201.00
31_L289_K1.9121.00
24_E297_L1.9101.00
292_L296_L1.9021.00
14_E17_A1.8941.00
134_L243_L1.8921.00
6_A296_L1.8891.00
189_E192_R1.8851.00
261_A277_L1.8591.00
284_S290_A1.8241.00
229_K232_P1.8241.00
229_K245_I1.8231.00
131_D135_A1.8121.00
120_L139_D1.7691.00
171_M246_L1.7681.00
143_L148_N1.7571.00
134_L244_D1.7331.00
3_L18_V1.7191.00
237_F241_D1.6901.00
176_L252_T1.6841.00
379_D403_A1.6811.00
281_F291_V1.6811.00
260_L291_V1.6811.00
212_F217_R1.6761.00
231_I245_I1.6731.00
288_I292_L1.6651.00
382_V403_A1.6441.00
212_F239_G1.6221.00
225_T230_T1.6211.00
277_L291_V1.6131.00
400_A404_A1.6101.00
12_P16_A1.6071.00
134_L138_K1.5971.00
21_L25_A1.5921.00
386_A394_L1.5831.00
115_A119_D1.5701.00
91_M264_F1.5641.00
85_R88_R1.5581.00
91_M292_L1.5541.00
26_W30_Q1.5511.00
311_S340_Q1.5421.00
248_A285_D1.5411.00
98_H259_K1.5391.00
120_L135_A1.5331.00
394_L398_T1.5301.00
128_N285_D1.5291.00
341_P344_R1.5251.00
102_S344_R1.5051.00
183_T186_D1.5021.00
98_H256_I1.5011.00
133_L170_L1.4981.00
5_R302_W1.4931.00
215_N218_R1.4681.00
148_N151_N1.4611.00
190_A245_I1.4481.00
87_L292_L1.4451.00
93_L97_N1.4441.00
124_H131_D1.4401.00
290_A293_R1.4301.00
27_V297_L1.4291.00
276_R300_E1.4261.00
224_K238_D1.4071.00
190_A226_V1.4071.00
256_I281_F1.4061.00
193_A226_V1.3991.00
227_L245_I1.3941.00
253_A257_A1.3651.00
144_F199_I1.3651.00
200_D213_V1.3651.00
270_P300_E1.3611.00
152_R218_R1.3591.00
144_F149_A1.3571.00
395_S430_E1.3561.00
18_V26_W1.3501.00
280_V284_S1.3341.00
102_S145_Y1.3321.00
354_G357_A1.3291.00
399_R403_A1.3281.00
319_A426_L1.3221.00
257_A291_V1.3171.00
398_T430_E1.3061.00
133_L175_T1.3051.00
167_A190_A1.3041.00
257_A278_A1.3031.00
97_N354_G1.2971.00
278_A282_R1.2911.00
138_K236_N1.2861.00
133_L247_A1.2861.00
171_M227_L1.2811.00
101_V141_A1.2811.00
385_L425_L1.2801.00
229_K248_A1.2791.00
352_P357_A1.2791.00
390_L425_L1.2741.00
170_L246_L1.2731.00
280_V283_D1.2641.00
22_G26_W1.2601.00
276_R294_A1.2551.00
386_A399_R1.2551.00
244_D248_A1.2491.00
264_F292_L1.2481.00
228_G231_I1.2471.00
78_L82_Y1.2461.00
100_A145_Y1.2451.00
226_V245_I1.2441.00
280_V290_A1.2441.00
117_Q121_L1.2321.00
23_P302_W1.2261.00
171_M190_A1.2181.00
275_D278_A1.2141.00
99_F133_L1.2141.00
83_S86_Q1.2111.00
257_A281_F1.2081.00
21_L26_W1.1971.00
229_K241_D1.1971.00
117_Q139_D1.1961.00
116_Y139_D1.1851.00
90_R263_R1.1801.00
279_A282_R1.1731.00
2_L6_A1.1691.00
16_A19_A1.1671.00
193_A231_I1.1661.00
98_H129_F1.1611.00
265_V273_L1.1611.00
258_R271_P1.1541.00
289_K293_R1.1521.00
153_K221_P1.1491.00
272_A300_E1.1481.00
212_F215_N1.1441.00
138_K239_G1.1371.00
28_D297_L1.1331.00
91_M125_A1.1301.00
10_A15_I1.1281.00
238_D241_D1.1271.00
189_E224_K1.1261.00
246_L252_T1.1221.00
336_A341_P1.1181.00
277_L294_A1.1151.00
386_A425_L1.1081.00
6_A26_W1.1081.00
121_L136_V1.1071.00
318_S431_F1.1051.00
77_L317_V1.1051.00
130_R247_A1.0961.00
316_V335_L1.0941.00
2_L23_P1.0841.00
258_R274_V1.0751.00
255_F259_K1.0751.00
120_L124_H1.0721.00
402_L421_A1.0681.00
220_D224_K1.0661.00
308_K314_E1.0661.00
254_R278_A1.0631.00
120_L136_V1.0591.00
274_V278_A1.0441.00
120_L123_P1.0371.00
124_H127_G1.0291.00
200_D211_E1.0251.00
92_T125_A1.0241.00
395_S398_T1.0231.00
369_N372_P1.0211.00
180_G251_A1.0211.00
7_G26_W1.0191.00
92_T118_R1.0181.00
131_D134_L1.0171.00
137_A239_G1.0161.00
86_Q321_R1.0141.00
223_E232_P1.0091.00
73_Q341_P1.0061.00
1_H4_R1.0051.00
212_F236_N0.9991.00
315_F371_A0.9981.00
315_F432_Q0.9971.00
197_W212_F0.9951.00
384_A388_L0.9941.00
254_R258_R0.9881.00
129_F256_I0.9761.00
193_A238_D0.9751.00
118_R343_F0.9741.00
213_V217_R0.9741.00
247_A286_G0.9731.00
266_S306_G0.9721.00
27_V31_L0.9711.00
189_E226_V0.9701.00
103_A344_R0.9701.00
291_V295_I0.9641.00
99_F129_F0.9631.00
259_K262_R0.9621.00
138_K197_W0.9611.00
128_N247_A0.9591.00
19_A22_G0.9551.00
212_F218_R0.9551.00
194_F242_V0.9541.00
32_A289_K0.9541.00
101_V117_Q0.9531.00
3_L10_A0.9521.00
403_A407_S0.9521.00
119_D123_P0.9501.00
88_R126_L0.9481.00
81_V317_V0.9461.00
87_L264_F0.9451.00
133_L243_L0.9441.00
137_A194_F0.9421.00
311_S314_E0.9411.00
130_R248_A0.9301.00
223_E233_A0.9291.00
236_N240_E0.9281.00
4_R10_A0.9261.00
349_A352_P0.9251.00
129_F175_T0.9241.00
1_H5_R0.9231.00
273_L298_S0.9211.00
18_V22_G0.9201.00
99_F102_S0.9171.00
170_L190_A0.9141.00
277_L280_V0.9111.00
166_Y194_F0.9081.00
167_A191_A0.9071.00
278_A281_F0.9051.00
81_V320_L0.9031.00
316_V338_L0.8971.00
383_D387_D0.8951.00
247_A252_T0.8951.00
95_W288_I0.8951.00
362_G366_A0.8921.00
398_T402_L0.8921.00
147_D150_Q0.8911.00
69_L103_A0.8901.00
170_L243_L0.8901.00
6_A27_V0.8891.00
100_A345_P0.8881.00
24_E28_D0.8871.00
319_A374_L0.8831.00
261_A300_E0.8821.00
241_D244_D0.8821.00
270_P273_L0.8821.00
345_P349_A0.8771.00
266_S270_P0.8771.00
194_F239_G0.8711.00
267_D308_K0.8691.00
313_V317_V0.8691.00
289_K292_L0.8681.00
354_G358_W0.8671.00
170_L242_V0.8661.00
126_L292_L0.8621.00
136_V166_Y0.8611.00
385_L422_L0.8591.00
118_R122_R0.8581.00
175_T246_L0.8551.00
76_W80_A0.8541.00
237_F240_E0.8521.00
176_L227_L0.8501.00
251_A254_R0.8501.00
231_I241_D0.8481.00
189_E222_G0.8471.00
234_G241_D0.8441.00
137_A243_L0.8421.00
90_R314_E0.8391.00
386_A390_L0.8341.00
261_A265_V0.8341.00
121_L125_A0.8331.00
216_P221_P0.8211.00
77_L335_L0.8181.00
124_H132_L0.8151.00
92_T122_R0.8151.00
267_D355_G0.8131.00
365_L369_N0.8111.00
298_S301_F0.8081.00
273_L277_L0.8081.00
396_A399_R0.8071.00
261_A295_I0.8031.00
383_D386_A0.8031.00
415_A418_A0.8021.00
176_L246_L0.8001.00
138_K212_F0.8001.00
406_L421_A0.7991.00
155_N220_D0.7991.00
117_Q343_F0.7961.00
250_P282_R0.7951.00
401_A404_A0.7941.00
195_T219_H0.7931.00
104_D344_R0.7921.00
92_T121_L0.7911.00
198_T218_R0.7901.00
208_R212_F0.7891.00
333_N336_A0.7891.00
170_L194_F0.7891.00
8_F93_L0.7881.00
214_F235_G0.7881.00
80_A317_V0.7881.00
33_A84_P0.7871.00
359_I364_L0.7861.00
400_A403_A0.7861.00
96_H100_A0.7821.00
192_R224_K0.7801.00
125_A132_L0.7801.00
18_V21_L0.7781.00
69_L73_Q0.7781.00
417_R420_A0.7771.00
232_P241_D0.7751.00
269_P274_V0.7741.00
261_A266_S0.7741.00
17_A20_A0.7731.00
229_K233_A0.7711.00
25_A29_E0.7701.00
113_L141_A0.7691.00
386_A392_G0.7681.00
231_I234_G0.7651.00
414_D417_R0.7641.00
54_R57_A0.7631.00
99_F136_V0.7621.00
345_P350_G0.7591.00
209_G212_F0.7581.00
347_S352_P0.7581.00
149_A199_I0.7581.00
297_L302_W0.7551.00
338_L366_A0.7551.00
390_L394_L0.7551.00
257_A295_I0.7541.00
273_L300_E0.7541.00
254_R271_P0.7521.00
51_P54_R0.7461.00
91_M260_L0.7451.00
240_E244_D0.7451.00
416_A419_A0.7441.00
384_A387_D0.7441.00
143_L149_A0.7431.00
16_A20_A0.7421.00
360_N363_T0.7421.00
164_E191_A0.7411.00
68_L71_E0.7411.00
111_L114_G0.7411.00
1_H301_F0.7401.00
130_R285_D0.7381.00
415_A419_A0.7371.00
93_L313_V0.7351.00
147_D163_N0.7341.00
413_D416_A0.7331.00
281_F286_G0.7331.00
148_N197_W0.7331.00
355_G358_W0.7321.00
241_D245_I0.7311.00
252_T281_F0.7281.00
74_A78_L0.7181.00
229_K237_F0.7171.00
136_V142_M0.7151.00
214_F217_R0.7141.00
2_L30_Q0.7091.00
313_V335_L0.7071.00
261_A273_L0.7051.00
383_D403_A0.7041.00
37_I40_P0.7001.00
127_G131_D0.7001.00
260_L292_L0.7001.00
80_A313_V0.6991.00
128_N290_A0.6991.00
50_L53_L0.6961.00
7_G86_Q0.6941.00
414_D418_A0.6921.00
404_A407_S0.6901.00
137_A148_N0.6871.00
136_V139_D0.6851.00
148_N194_F0.6841.00
127_G132_L0.6841.00
79_R83_S0.6841.00
97_N100_A0.6821.00
276_R280_V0.6821.00
174_F348_V0.6821.00
33_A36_S0.6801.00
28_D32_A0.6791.00
2_L27_V0.6791.00
64_A67_R0.6771.00
38_P41_A0.6771.00
153_K156_P0.6751.00
371_A375_A0.6741.00
149_A198_T0.6741.00
88_R125_A0.6741.00
48_A51_P0.6741.00
73_Q344_R0.6731.00
257_A280_V0.6721.00
32_A293_R0.6721.00
413_D417_R0.6711.00
94_F259_K0.6701.00
273_L294_A0.6701.00
260_L295_I0.6691.00
379_D383_D0.6651.00
234_G237_F0.6601.00
23_P26_W0.6601.00
88_R92_T0.6591.00
264_F296_L0.6571.00
320_L331_L0.6531.00
405_A424_L0.6481.00
426_L431_F0.6471.00
252_T282_R0.6451.00
254_R282_R0.6451.00
340_Q351_W0.6431.00
125_A288_I0.6421.00
337_R366_A0.6421.00
372_P375_A0.6401.00
316_V370_F0.6391.00
73_Q342_L0.6381.00
402_L405_A0.6361.00
247_A281_F0.6351.00
221_P236_N0.6341.00
402_L425_L0.6341.00
3_L14_E0.6341.00
398_T401_A0.6331.00
72_L118_R0.6321.00
280_V291_V0.6321.00
334_A370_F0.6301.00
132_L288_I0.6291.00
397_A400_A0.6291.00
272_A275_D0.6281.00
171_M187_V0.6261.00
366_A369_N0.6241.00
272_A276_R0.6241.00
319_A370_F0.6221.00
364_L368_L0.6211.00
30_Q33_A0.6201.00
106_V144_F0.6181.00
414_D420_A0.6181.00
73_Q332_A0.6171.00
128_N286_G0.6161.00
44_D48_A0.6151.00
379_D399_R0.6141.00
390_L398_T0.6141.00
7_G10_A0.6141.00
237_F245_I0.6111.00
322_A325_V0.6101.00
4_R391_G0.6091.00
242_V246_L0.6091.00
46_R51_P0.6091.00
52_T56_S0.6091.00
167_A171_M0.6071.00
39_D42_A0.6071.00
14_E18_V0.6071.00
273_L276_R0.6061.00
416_A420_A0.6061.00
229_K234_G0.6061.00
225_T229_K0.6061.00
25_A28_D0.6041.00
126_L289_K0.6041.00
256_I260_L0.6041.00
250_P279_A0.6031.00
53_L56_S0.6031.00
411_A417_R0.6031.00
262_R266_S0.6031.00
193_A239_G0.6031.00
46_R49_A0.6011.00
188_K191_A0.5981.00
227_L231_I0.5981.00
226_V237_F0.5971.00
143_L212_F0.5951.00
327_D330_P0.5931.00
8_F86_Q0.5931.00
422_L425_L0.5931.00
382_V386_A0.5921.00
299_P303_S0.5911.00
228_G234_G0.5911.00
154_P192_R0.5881.00
175_T247_A0.5881.00
314_E317_V0.5881.00
176_L251_A0.5881.00
125_A292_L0.5871.00
389_L426_L0.5871.00
334_A338_L0.5861.00
23_P297_L0.5851.00
394_L399_R0.5851.00
96_H117_Q0.5821.00
176_L180_G0.5821.00
190_A246_L0.5801.00
250_P254_R0.5801.00
19_A23_P0.5791.00
7_G90_R0.5781.00
8_F80_A0.5781.00
100_A117_Q0.5781.00
91_M288_I0.5761.00
334_A337_R0.5761.00
72_L76_W0.5751.00
29_E33_A0.5741.00
140_P212_F0.5721.00
405_A408_A0.5711.00
52_T55_M0.5711.00
7_G14_E0.5711.00
189_E220_D0.5671.00
2_L302_W0.5641.00
328_P332_A0.5641.00
62_R66_R0.5641.00
288_I291_V0.5631.00
167_A187_V0.5621.00
26_W29_E0.5611.00
329_G332_A0.5601.00
211_E217_R0.5591.00
253_A281_F0.5581.00
185_D225_T0.5581.00
15_I19_A0.5581.00
257_A260_L0.5571.00
94_F260_L0.5551.00
51_P55_M0.5541.00
207_R210_G0.5541.00
13_G16_A0.5541.00
206_P209_G0.5531.00
198_T212_F0.5531.00
372_P423_A0.5521.00
48_A54_R0.5521.00
14_E321_R0.5491.00
47_L51_P0.5491.00
358_W367_R0.5481.00
394_L425_L0.5481.00
266_S269_P0.5481.00
273_L295_I0.5481.00
291_V294_A0.5471.00
150_Q198_T0.5471.00
411_A418_A0.5461.00
411_A414_D0.5441.00
97_N263_R0.5441.00
263_R311_S0.5431.00
411_A415_A0.5431.00
67_R71_E0.5431.00
94_F256_I0.5421.00
333_N337_R0.5421.00
322_A326_T0.5421.00
193_A224_K0.5401.00
175_T252_T0.5401.00
251_A255_F0.5381.00
46_R50_L0.5361.00
75_A80_A0.5351.00
360_N371_A0.5351.00
207_R212_F0.5341.00
224_K231_I0.5331.00
328_P331_L0.5321.00
386_A393_P0.5321.00
265_V301_F0.5301.00
179_G184_Q0.5301.00
380_A383_D0.5301.00
412_T415_A0.5291.00
169_E173_L0.5291.00
190_A194_F0.5281.00
385_L421_A0.5271.00
381_L384_A0.5261.00
95_W98_H0.5261.00
165_N169_E0.5261.00
171_M242_V0.5261.00
137_A170_L0.5251.00
148_N166_Y0.5221.00
79_R89_E0.5221.00
121_L124_H0.5221.00
15_I18_V0.5180.99
397_A401_A0.5170.99
227_L234_G0.5170.99
3_L6_A0.5160.99
51_P58_R0.5150.99
235_G241_D0.5140.99
261_A269_P0.5130.99
245_I249_H0.5130.99
45_A49_A0.5120.99
379_D382_V0.5120.99
130_R243_L0.5120.99
142_M166_Y0.5110.99
132_L136_V0.5110.99
76_W96_H0.5110.99
398_T428_S0.5110.99
10_A321_R0.5100.99
189_E225_T0.5090.99
359_I363_T0.5090.99
296_L301_F0.5080.99
40_P43_L0.5080.99
286_G291_V0.5080.99
186_D226_V0.5080.99
18_V23_P0.5080.99
37_I43_L0.5080.99
32_A35_A0.5070.99
89_E92_T0.5070.99
120_L132_L0.5070.99
59_K63_R0.5050.99
387_D399_R0.5050.99
273_L280_V0.5040.99
91_M95_W0.5040.99
113_L116_Y0.5040.99
369_N373_A0.5030.99
407_S410_Q0.5030.99
315_F319_A0.5020.99
310_K431_F0.5020.99
49_A52_T0.5010.99
53_L57_A0.5010.99
153_K220_D0.5010.99
247_A282_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ohwB 1 0.1132 20.6 0.974 Contact Map
1wivA 1 0.1363 13.9 0.976 Contact Map
3ol3A 2 0.2171 9.9 0.978 Contact Map
2wp7A 2 0.1386 8.8 0.978 Contact Map
4j4yA 4 0.351 7.8 0.979 Contact Map
2memA 1 0.2494 6.9 0.979 Contact Map
2jy5A 1 0.1178 5.9 0.98 Contact Map
3nphB 1 0.1132 5.6 0.98 Contact Map
4wv4A 1 0.1432 5.4 0.98 Contact Map
1dm5A 4 0.4042 5.1 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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