GREMLIN Database
DUF1799 - Phage related hypothetical protein (DUF1799)
PFAM: PF08809 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (70)
Sequences: 1971 (1734)
Seq/√Len: 207.3
META: 0.868

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_R44_D4.2521.00
22_A68_D3.0631.00
49_P53_R2.9571.00
29_L48_V1.9781.00
20_W24_E1.9091.00
64_E68_D1.9081.00
31_T42_G1.8641.00
75_A78_E1.8441.00
25_L52_L1.7981.00
31_T45_Y1.6661.00
51_V66_F1.6591.00
75_A79_V1.5621.00
15_V20_W1.5211.00
32_Q45_Y1.4761.00
34_R46_A1.4361.00
31_T73_E1.4181.00
45_Y73_E1.3921.00
44_D47_A1.3171.00
72_M75_A1.3101.00
54_L63_P1.3081.00
16_W19_N1.3081.00
52_L62_R1.2761.00
49_P54_L1.2621.00
28_A55_L1.2331.00
33_W43_L1.2231.00
35_V41_T1.2071.00
71_V75_A1.1661.00
19_N68_D1.1611.00
47_A50_A1.1301.00
51_V55_L1.1161.00
36_G40_A1.0881.00
72_M76_A1.0881.00
15_V23_V1.0821.00
35_V40_A1.0791.00
28_A70_Q1.0761.00
50_A54_L1.0291.00
23_V27_L1.0161.00
25_L65_L1.0101.00
23_V72_M0.9691.00
65_L68_D0.9570.99
22_A65_L0.9210.99
28_A67_E0.9160.99
38_G41_T0.9080.99
48_V52_L0.8940.99
37_M40_A0.8890.99
68_D72_M0.8860.99
26_F72_M0.8780.99
53_R62_R0.8570.99
56_G63_P0.8360.99
25_L51_V0.8360.99
45_Y70_Q0.8360.99
21_P61_D0.8320.99
36_G39_G0.8260.99
43_L69_L0.8210.98
23_V26_F0.8100.98
53_R58_P0.8070.98
37_M41_T0.8030.98
50_A53_R0.7960.98
36_G41_T0.7850.98
26_F29_L0.7790.98
45_Y66_F0.7710.98
55_L67_E0.7680.98
59_R62_R0.7460.97
22_A72_M0.7410.97
58_P61_D0.7320.97
52_L57_V0.7290.97
48_V69_L0.7100.96
34_R42_G0.7090.96
26_F76_A0.7050.96
73_E77_L0.7030.96
32_Q70_Q0.6740.95
35_V38_G0.6670.95
29_L51_V0.6640.95
66_F70_Q0.6630.94
46_A50_A0.6620.94
54_L62_R0.6440.94
50_A62_R0.6300.93
56_G59_R0.6270.93
27_L30_Q0.6180.92
22_A25_L0.6170.92
25_L48_V0.6140.92
49_P62_R0.6120.92
46_A49_P0.6090.92
11_E27_L0.6050.91
74_A78_E0.6030.91
52_L59_R0.5970.91
15_V19_N0.5950.91
40_A77_L0.5940.91
23_V71_V0.5920.90
42_G45_Y0.5910.90
24_E27_L0.5900.90
33_W76_A0.5840.90
32_Q47_A0.5770.89
31_T77_L0.5720.89
24_E28_A0.5630.88
25_L55_L0.5590.88
47_A51_V0.5540.87
54_L66_F0.5500.87
29_L49_P0.5460.87
30_Q74_A0.5440.86
68_D71_V0.5120.83
55_L63_P0.5120.83
10_E15_V0.5110.83
13_F23_V0.5080.82
29_L66_F0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uw8A 3 0.8125 8.9 0.899 Contact Map
4dgwA 1 0.325 8.1 0.901 Contact Map
3gw6A 3 0.85 7.7 0.902 Contact Map
4r0vA 1 0.8875 4.4 0.912 Contact Map
3lx4A 1 0.9 4.1 0.914 Contact Map
2k8yA 1 0.85 4.1 0.914 Contact Map
4phzB 3 0.7125 4 0.914 Contact Map
1yewB 3 0.7125 3.8 0.915 Contact Map
4l8kA 3 0.75 3.7 0.915 Contact Map
4l6yA 2 0.4625 3.6 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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