GREMLIN Database
RES - RES domain
PFAM: PF08808 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (141)
Sequences: 25338 (19355)
Seq/√Len: 1629.9
META: 0.87

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_S112_D4.6221.00
123_R134_T3.0001.00
19_E22_R2.8451.00
33_R115_R2.7771.00
35_V137_A2.5901.00
26_G29_N2.4361.00
123_R136_L2.2721.00
124_Y137_A2.0791.00
114_L119_S2.0001.00
40_E136_L1.8941.00
39_A44_T1.8671.00
40_E123_R1.8461.00
22_R34_G1.8211.00
33_R112_D1.7331.00
42_L73_L1.7191.00
112_D116_A1.7001.00
93_L96_G1.6971.00
41_S129_V1.6901.00
30_S33_R1.6841.00
122_L137_A1.5921.00
97_W100_P1.5921.00
81_A85_D1.5871.00
121_G136_L1.5731.00
49_V71_L1.5451.00
30_S108_Q1.5141.00
39_A135_N1.5031.00
89_P92_L1.5021.00
124_Y135_N1.4791.00
19_E23_P1.4751.00
83_L86_L1.4311.00
104_Y107_T1.4241.00
30_S109_A1.4191.00
92_L96_G1.3871.00
84_V119_S1.3841.00
113_A117_A1.3791.00
41_S44_T1.3771.00
40_E133_E1.3751.00
89_P94_P1.3741.00
90_A96_G1.3691.00
40_E134_T1.3411.00
54_G57_L1.3301.00
99_D102_P1.3151.00
91_A94_P1.3131.00
90_A94_P1.3071.00
60_T64_P1.3051.00
34_G142_A1.2781.00
15_P18_G1.2771.00
44_T133_E1.2621.00
92_L95_L1.2441.00
51_V128_R1.2431.00
82_R120_D1.2371.00
109_A113_A1.2281.00
39_A45_A1.2061.00
145_D148_R1.1901.00
14_A17_S1.1871.00
59_A62_E1.1751.00
131_P134_T1.1711.00
82_R85_D1.1651.00
110_L114_L1.1621.00
33_R116_A1.1611.00
8_P72_R1.1571.00
41_S133_E1.1361.00
29_N35_V1.1331.00
6_R10_Y1.1151.00
14_A18_G1.1071.00
40_E44_T1.0951.00
90_A93_L1.0771.00
111_G139_F1.0741.00
55_R58_A1.0691.00
35_V115_R1.0601.00
12_A15_P1.0471.00
25_G29_N1.0351.00
32_G112_D1.0211.00
53_R56_F1.0171.00
143_H146_A1.0091.00
114_L122_L1.0001.00
61_A64_P1.0001.00
43_A129_V0.9991.00
68_P71_L0.9991.00
25_G31_P0.9951.00
85_D123_R0.9931.00
83_L121_G0.9911.00
21_A25_G0.9871.00
89_P93_L0.9831.00
120_D146_A0.9711.00
146_A149_I0.9641.00
13_A17_S0.9571.00
113_A116_A0.9511.00
67_L70_D0.9241.00
91_A95_L0.9241.00
81_A120_D0.9121.00
60_T63_F0.9091.00
19_E34_G0.9071.00
121_G138_L0.9051.00
13_A16_F0.9031.00
44_T126_S0.8961.00
36_L76_L0.8941.00
70_D73_L0.8911.00
59_A63_F0.8861.00
112_D115_R0.8811.00
106_A109_A0.8811.00
44_T129_V0.8711.00
46_L50_L0.8651.00
28_F124_Y0.8641.00
90_A95_L0.8581.00
80_D83_L0.8561.00
47_A50_L0.8551.00
78_I121_G0.8471.00
104_Y108_Q0.8391.00
53_R57_L0.8391.00
107_T110_L0.8331.00
91_A96_G0.8321.00
58_A61_A0.8281.00
84_V114_L0.8261.00
81_A86_L0.8241.00
126_S135_N0.8041.00
105_A109_A0.7961.00
129_V133_E0.7831.00
71_L75_D0.7731.00
89_P96_G0.7721.00
7_R10_Y0.7711.00
47_A129_V0.7711.00
144_P147_V0.7691.00
79_P82_R0.7601.00
13_A18_G0.7561.00
105_A108_Q0.7551.00
147_V151_I0.7531.00
81_A84_V0.7381.00
78_I81_A0.7341.00
12_A17_S0.7271.00
58_A63_F0.7271.00
42_L132_G0.7261.00
69_R73_L0.7241.00
5_I45_A0.7171.00
46_L51_V0.7141.00
38_A76_L0.7131.00
120_D145_D0.7071.00
29_N37_Y0.7031.00
89_P95_L0.6991.00
67_L71_L0.6971.00
100_P103_D0.6961.00
70_D74_L0.6961.00
103_D107_T0.6941.00
20_G23_P0.6921.00
38_A138_L0.6861.00
43_A133_E0.6801.00
110_L113_A0.6761.00
35_V111_G0.6741.00
77_D150_V0.6731.00
136_L139_F0.6721.00
120_D140_P0.6691.00
6_R15_P0.6631.00
54_G58_A0.6601.00
115_R142_A0.6571.00
143_H147_V0.6541.00
109_A112_D0.6471.00
52_H55_R0.6441.00
78_I83_L0.6431.00
142_A147_V0.6411.00
82_R86_L0.6401.00
106_A110_L0.6391.00
148_R151_I0.6351.00
69_R74_L0.6341.00
98_R102_P0.6341.00
39_A48_E0.6331.00
8_P12_A0.6281.00
6_R9_K0.6251.00
97_W102_P0.6241.00
12_A16_F0.6181.00
76_L149_I0.6171.00
111_G122_L0.6161.00
68_P74_L0.6151.00
6_R74_L0.6141.00
56_F60_T0.6081.00
40_E129_V0.6071.00
140_P145_D0.6071.00
58_A62_E0.6031.00
24_Y31_P0.6031.00
7_R12_A0.6021.00
77_D149_I0.6001.00
12_A18_G0.5991.00
142_A145_D0.5941.00
57_L62_E0.5881.00
104_Y112_D0.5841.00
43_A47_A0.5831.00
3_Y73_L0.5731.00
69_R76_L0.5721.00
25_G108_Q0.5701.00
98_R125_P0.5691.00
3_Y75_D0.5671.00
114_L117_A0.5621.00
5_I49_V0.5611.00
57_L60_T0.5601.00
22_R25_G0.5521.00
69_R72_R0.5511.00
58_A64_P0.5481.00
85_D89_P0.5461.00
96_G106_A0.5431.00
46_L129_V0.5401.00
129_V132_G0.5331.00
137_A140_P0.5331.00
6_R12_A0.5291.00
120_D149_I0.5281.00
115_R140_P0.5271.00
140_P143_H0.5251.00
46_L49_V0.5241.00
3_Y42_L0.5231.00
128_R131_P0.5231.00
59_A64_P0.5211.00
135_N139_F0.5111.00
15_P19_E0.5091.00
47_A128_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g29A 1 0.5155 5.3 0.926 Contact Map
1yz7A 1 0.2795 3 0.934 Contact Map
4nexA 2 0.354 2.5 0.937 Contact Map
1ehwA 4 0.354 2.3 0.938 Contact Map
3ztpA 3 0.3602 1.9 0.941 Contact Map
4nf1A 3 0.354 1.9 0.941 Contact Map
4k30A 2 0.3354 1.7 0.943 Contact Map
4ab7A 3 0.3292 1.7 0.943 Contact Map
1nhkR 3 0.3789 1.7 0.943 Contact Map
1wkjA 4 0.3416 1.6 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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