GREMLIN Database
VirE_N - VirE N-terminal domain
PFAM: PF08800 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 134 (118)
Sequences: 6626 (5072)
Seq/√Len: 466.9
META: 0.952

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A123_L3.6301.00
11_F72_L2.3861.00
119_D122_R2.2651.00
117_C122_R2.0751.00
21_D121_S2.0321.00
20_K23_N2.0201.00
30_L72_L2.0151.00
48_K62_I2.0061.00
59_A72_L1.9711.00
48_K52_K1.9691.00
70_K124_C1.9021.00
30_L58_Y1.9011.00
21_D119_D1.8771.00
64_P70_K1.8711.00
16_S25_I1.8151.00
54_D104_Y1.7901.00
18_K23_N1.7381.00
27_H94_H1.7321.00
57_V105_F1.7081.00
102_E115_K1.7031.00
14_T26_E1.6241.00
32_C70_K1.5951.00
37_H67_N1.5791.00
95_K118_K1.5501.00
57_V71_V1.5241.00
52_K60_A1.4951.00
99_R102_E1.4691.00
43_E46_E1.4451.00
32_C117_C1.4051.00
99_R118_K1.3931.00
47_L50_K1.3851.00
57_V60_A1.3661.00
60_A69_L1.3511.00
35_F71_V1.3471.00
44_L69_L1.3441.00
44_L62_I1.3341.00
13_G24_L1.3271.00
49_E52_K1.3191.00
48_K69_L1.2621.00
6_L64_P1.2601.00
60_A71_V1.2571.00
103_K107_E1.2471.00
59_A132_I1.2031.00
61_F124_C1.1851.00
58_Y74_K1.1841.00
106_E112_E1.1761.00
51_L71_V1.1741.00
35_F113_I1.1611.00
102_E106_E1.1581.00
46_E50_K1.1431.00
33_L71_V1.1391.00
52_K133_Y1.1321.00
38_L47_L1.1281.00
61_F70_K1.1271.00
98_F102_E1.1211.00
54_D109_Y1.1011.00
61_F72_L1.0951.00
78_P81_N1.0901.00
64_P124_C1.0881.00
97_A100_A1.0881.00
35_F111_I1.0861.00
39_D43_E1.0791.00
51_L60_A1.0711.00
12_S27_H1.0681.00
2_L5_K1.0271.00
49_E53_K1.0161.00
95_K99_R1.0111.00
63_S70_K1.0051.00
16_S23_N1.0031.00
48_K60_A0.9831.00
27_H75_I0.9751.00
62_I66_G0.9551.00
4_K125_F0.9471.00
32_C124_C0.9381.00
11_F32_C0.9331.00
9_V126_L0.9171.00
19_R23_N0.9121.00
64_P125_F0.9101.00
47_L111_I0.9051.00
11_F124_C0.9021.00
40_N43_E0.9001.00
57_V73_V0.8651.00
95_K120_V0.8651.00
10_T123_L0.8551.00
39_D42_E0.8541.00
31_I101_L0.8461.00
61_F127_S0.8451.00
14_T25_I0.8411.00
32_C72_L0.8381.00
76_P97_A0.8371.00
45_E48_K0.8281.00
46_E49_E0.8191.00
19_R123_L0.8141.00
39_D67_N0.8071.00
96_E99_R0.8061.00
15_F24_L0.8051.00
33_L113_I0.8041.00
34_D114_D0.8041.00
50_K53_K0.8011.00
54_D105_F0.7991.00
97_A101_L0.7971.00
51_L57_V0.7941.00
75_I97_A0.7931.00
54_D108_L0.7881.00
102_E113_I0.7851.00
101_L105_F0.7841.00
45_E62_I0.7781.00
48_K129_D0.7751.00
27_H77_A0.7751.00
98_F113_I0.7741.00
15_F121_S0.7741.00
12_S94_H0.7651.00
45_E49_E0.7621.00
56_Y73_V0.7511.00
36_D114_D0.7461.00
100_A104_Y0.7371.00
44_L60_A0.7361.00
113_I117_C0.7351.00
102_E112_E0.7251.00
73_V101_L0.7251.00
36_D63_S0.7221.00
19_R24_L0.7061.00
115_K118_K0.6991.00
71_V105_F0.6921.00
31_I75_I0.6891.00
24_L27_H0.6761.00
73_V105_F0.6731.00
30_L74_K0.6711.00
45_E131_D0.6621.00
19_R121_S0.6581.00
26_E77_A0.6551.00
61_F126_L0.6541.00
77_A81_N0.6511.00
94_H98_F0.6491.00
34_D68_G0.6491.00
102_E118_K0.6441.00
100_A105_F0.6381.00
35_F47_L0.6300.99
98_F117_C0.6280.99
116_S122_R0.6230.99
33_L101_L0.6190.99
116_S119_D0.6140.99
112_E115_K0.6090.99
81_N96_E0.6000.99
24_L120_V0.5940.99
105_F109_Y0.5920.99
62_I69_L0.5900.99
36_D68_G0.5800.99
77_A80_E0.5780.99
56_Y104_Y0.5720.99
99_R103_K0.5590.99
44_L48_K0.5580.99
38_L44_L0.5570.99
13_G28_S0.5570.99
98_F101_L0.5510.99
99_R115_K0.5510.99
12_S32_C0.5490.99
106_E113_I0.5470.99
63_S124_C0.5450.99
10_T19_R0.5440.98
75_I78_P0.5410.98
43_E47_L0.5410.98
31_I98_F0.5380.98
61_F71_V0.5380.98
63_S68_G0.5360.98
40_N46_E0.5340.98
21_D120_V0.5270.98
29_G74_K0.5260.98
95_K98_F0.5260.98
27_H120_V0.5240.98
48_K131_D0.5220.98
32_C122_R0.5210.98
35_F106_E0.5150.98
127_S132_I0.5130.98
105_F113_I0.5080.98
78_P97_A0.5040.98
65_S125_F0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h20A 2 0.8134 21 0.908 Contact Map
3m1mA 1 0.8209 10.6 0.92 Contact Map
1zt2A 3 0.8881 7.7 0.924 Contact Map
3cueA 1 0.7537 7.1 0.926 Contact Map
1ro2A 1 0.8209 6.6 0.927 Contact Map
2j3tD 1 0.8433 6.5 0.927 Contact Map
2iruA 1 0.903 6.4 0.927 Contact Map
1v33A 1 0.8582 6.3 0.928 Contact Map
3wtsB 1 0.3358 5.3 0.93 Contact Map
2faoA 1 0.8806 5.1 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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