GREMLIN Database
DUF1796 - Putative papain-like cysteine peptidase (DUF1796)
PFAM: PF08795 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 168 (153)
Sequences: 1348 (1234)
Seq/√Len: 99.8
META: 0.815

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_I126_L4.3461.00
106_K110_R3.8051.00
45_D115_L3.7941.00
13_A22_R3.6711.00
22_R25_S3.6401.00
42_L114_F2.9521.00
109_R113_R2.7051.00
48_D51_D2.6541.00
104_K108_D2.5851.00
46_F111_I2.2651.00
30_W106_K2.2481.00
17_K22_R2.1721.00
13_A30_W2.1571.00
126_L161_L2.1111.00
26_Y117_L2.0171.00
103_V107_Y1.9191.00
103_V110_R1.8941.00
48_D54_N1.7481.00
4_I117_L1.7401.00
43_E146_K1.7211.00
111_I114_F1.6831.00
112_E116_E1.6771.00
30_W113_R1.6541.00
31_I49_F1.6271.00
101_P105_E1.6261.00
86_D89_Y1.6201.00
13_A29_D1.6151.00
4_I26_Y1.5831.00
46_F49_F1.5721.00
5_S26_Y1.5681.00
7_G10_C1.5361.00
17_K30_W1.5311.00
22_R110_R1.4771.00
37_G40_D1.4701.00
21_L27_P1.4171.00
140_L144_L1.3921.00
108_D112_E1.3700.99
44_N48_D1.3590.99
28_F31_I1.3540.99
22_R27_P1.3500.99
34_S37_G1.3380.99
111_I115_L1.3320.99
17_K25_S1.3290.99
40_D48_D1.3120.99
27_P110_R1.3010.99
45_D111_I1.2790.99
6_L127_F1.2780.99
15_Q19_L1.2670.99
24_F113_R1.2670.99
105_E108_D1.2500.99
103_V106_K1.2490.99
141_I145_S1.2410.99
139_E143_L1.2290.99
16_L21_L1.2220.99
49_F111_I1.2060.99
37_G41_L1.2030.99
12_P128_I1.1920.98
85_R88_Y1.1840.98
26_Y29_D1.1610.98
46_F114_F1.1470.98
52_P101_P1.1310.98
86_D90_N1.1310.98
9_N12_P1.1260.98
41_L50_L1.0870.97
76_D79_N1.0730.97
9_N13_A1.0630.97
139_E144_L1.0610.97
114_F118_L1.0600.97
116_E120_S1.0570.97
15_Q18_R1.0530.97
106_K113_R1.0240.96
8_S11_L1.0080.96
142_E146_K1.0000.95
93_F97_F0.9860.95
28_F41_L0.9660.94
55_L100_Y0.9560.94
28_F42_L0.9420.94
84_Y87_K0.9360.93
50_L111_I0.9060.92
87_K90_N0.9040.92
93_F96_D0.9010.92
35_L39_I0.8970.92
143_L146_K0.8970.92
22_R30_W0.8910.92
9_N130_T0.8890.92
51_D54_N0.8870.92
27_P49_F0.8790.91
141_I144_L0.8770.91
16_L30_W0.8700.91
30_W107_Y0.8670.91
16_L25_S0.8620.90
140_L148_V0.8570.90
52_P104_K0.8540.90
20_G27_P0.8430.89
14_Y18_R0.8410.89
100_Y103_V0.8400.89
45_D150_K0.8390.89
92_F95_H0.8370.89
77_P80_I0.8350.89
145_S148_V0.8330.89
140_L143_L0.8320.89
76_D80_I0.8290.89
12_P130_T0.8270.88
41_L44_N0.8270.88
80_I84_Y0.8240.88
159_R162_L0.8210.88
11_L130_T0.8130.88
35_L129_R0.8100.87
147_L151_L0.8070.87
94_H97_F0.7980.87
145_S149_K0.7930.86
63_D67_D0.7870.86
105_E109_R0.7860.86
90_N93_F0.7830.86
151_L154_K0.7830.86
86_D95_H0.7810.85
45_D119_K0.7760.85
55_L97_F0.7730.85
82_Y86_D0.7680.84
13_A27_P0.7670.84
131_E136_E0.7650.84
133_N136_E0.7590.84
41_L48_D0.7580.84
86_D93_F0.7520.83
92_F96_D0.7460.83
13_A25_S0.7450.83
24_F118_L0.7440.83
106_K109_R0.7440.83
66_I71_D0.7410.82
61_N64_N0.7410.82
6_L129_R0.7400.82
16_L22_R0.7340.82
26_Y30_W0.7330.82
44_N47_K0.7270.81
124_K159_R0.7230.81
56_E87_K0.7230.81
11_L26_Y0.7150.80
143_L149_K0.7080.79
38_V129_R0.6970.78
15_Q130_T0.6970.78
120_S123_K0.6950.78
17_K113_R0.6950.78
40_D43_E0.6880.77
11_L15_Q0.6880.77
150_K154_K0.6880.77
148_V152_K0.6870.77
91_I95_H0.6810.77
33_S38_V0.6810.77
11_L14_Y0.6770.76
99_N102_E0.6710.76
22_R26_Y0.6700.75
17_K103_V0.6690.75
144_L148_V0.6630.75
36_E143_L0.6630.75
59_G63_D0.6620.75
132_G135_E0.6560.74
32_S35_L0.6540.74
4_I127_F0.6520.73
81_H84_Y0.6490.73
140_L147_L0.6470.73
13_A24_F0.6440.73
81_H86_D0.6440.73
101_P145_S0.6420.72
6_L38_V0.6370.72
3_I16_L0.6320.71
144_L150_K0.6310.71
143_L147_L0.6290.71
146_K150_K0.6280.71
50_L103_V0.6260.70
56_E60_Y0.6260.70
139_E158_F0.6240.70
99_N141_I0.6240.70
110_R114_F0.6240.70
25_S113_R0.6200.70
78_N81_H0.6190.70
50_L54_N0.6130.69
83_L88_Y0.6120.69
138_E142_E0.6110.69
26_Y113_R0.6110.69
22_R38_V0.6090.68
99_N111_I0.6080.68
144_L154_K0.6080.68
58_I61_N0.6040.68
3_I41_L0.6010.67
140_L150_K0.5950.67
49_F107_Y0.5940.66
8_S13_A0.5930.66
140_L152_K0.5930.66
154_K158_F0.5920.66
51_D104_K0.5920.66
100_Y104_K0.5920.66
43_E153_N0.5890.66
13_A17_K0.5840.65
88_Y92_F0.5830.65
32_S38_V0.5820.65
97_F100_Y0.5790.64
63_D66_I0.5780.64
30_W109_R0.5740.64
150_K153_N0.5740.64
100_Y107_Y0.5710.63
27_P114_F0.5670.63
8_S129_R0.5640.62
11_L31_I0.5640.62
27_P111_I0.5610.62
83_L90_N0.5610.62
4_I23_K0.5600.62
59_G64_N0.5580.62
114_F121_S0.5580.62
123_K127_F0.5540.61
80_I83_L0.5540.61
105_E111_I0.5520.61
85_R89_Y0.5520.61
146_K152_K0.5510.61
31_I34_S0.5450.60
41_L49_F0.5440.60
145_S150_K0.5400.59
60_Y63_D0.5400.59
121_S125_I0.5400.59
17_K20_G0.5360.59
94_H107_Y0.5360.59
92_F98_E0.5310.58
13_A16_L0.5280.57
5_S8_S0.5240.57
84_Y92_F0.5240.57
67_D72_N0.5200.56
141_I146_K0.5170.56
39_I146_K0.5140.55
72_N77_P0.5090.55
9_N14_Y0.5080.55
21_L111_I0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g6tA 3 0.8333 56.6 0.888 Contact Map
2j23A 1 0.4226 9.3 0.925 Contact Map
4ekzA 1 0.494 6.4 0.93 Contact Map
4u39J 1 0.1845 5.9 0.931 Contact Map
3h4zA 1 0.3988 5.8 0.931 Contact Map
3dxbA 5 0.3929 5.4 0.932 Contact Map
2r2jA 2 0.3631 5.2 0.933 Contact Map
2qr4A 2 0.2976 5.1 0.933 Contact Map
2f51A 1 0.381 5.1 0.933 Contact Map
4gwrA 1 0.381 5 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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