GREMLIN Database
CNP1 - CNP1-like family
PFAM: PF08750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 136 (132)
Sequences: 2028 (1533)
Seq/√Len: 133.4
META: 0.891

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_I131_I4.5421.00
22_L55_V4.0761.00
57_R63_R3.7611.00
78_K96_S3.6181.00
24_P34_R3.0841.00
21_N40_A3.0151.00
86_D89_T2.5351.00
21_N39_P2.4841.00
33_F56_A2.4701.00
23_I39_P2.1771.00
71_R74_T2.1761.00
45_G49_V2.1571.00
16_Y83_G2.0751.00
36_F57_R2.0491.00
41_S53_T2.0481.00
18_K21_N1.8861.00
79_L82_Y1.8661.00
69_G80_Y1.8561.00
77_Y99_R1.8431.00
54_L109_Y1.8281.00
112_A116_D1.7951.00
77_Y110_H1.7411.00
42_L132_V1.7271.00
54_L66_S1.7241.00
33_F58_S1.7151.00
131_I134_A1.5891.00
71_R76_E1.5771.00
19_D63_R1.5461.00
44_V128_A1.5241.00
35_F56_A1.5171.00
55_V65_V1.4831.00
84_R89_T1.4501.00
113_L118_F1.4231.00
126_R130_E1.3361.00
84_R91_S1.3191.00
66_S79_L1.2891.00
120_P134_A1.2791.00
26_Y29_A1.2401.00
52_Y70_I1.2191.00
125_I130_E1.2161.00
16_Y88_G1.2121.00
76_E97_E1.2121.00
129_A133_R1.2071.00
27_V35_F1.1940.99
9_G46_K1.1700.99
70_I101_I1.1690.99
17_P41_S1.1570.99
128_A132_V1.1560.99
49_V69_G1.1340.99
130_E133_R1.1220.99
44_V50_V1.1030.99
11_V67_Y1.1020.99
127_S130_E1.0830.99
10_E92_P1.0720.99
53_T67_Y1.0620.99
25_F35_F1.0620.99
120_P125_I1.0490.99
56_A109_Y1.0350.99
6_W49_V1.0340.99
93_A96_S1.0080.98
47_D69_G0.9930.98
25_F28_S0.9900.98
9_G12_P0.9880.98
76_E100_P0.9720.98
22_L38_D0.9580.98
125_I134_A0.9540.97
108_R111_A0.9480.97
24_P36_F0.9150.97
128_A131_I0.9080.97
51_R67_Y0.9040.97
13_L53_T0.9020.96
91_S94_R0.8930.96
54_L110_H0.8900.96
129_A132_V0.8790.96
53_T90_W0.8770.96
68_E79_L0.8680.96
31_T35_F0.8570.95
18_K40_A0.8560.95
82_Y91_S0.8460.95
99_R102_E0.8410.95
103_D111_A0.8390.95
47_D78_K0.8340.95
42_L128_A0.8280.94
52_Y118_F0.8230.94
78_K104_R0.8160.94
70_I131_I0.8160.94
28_S112_A0.8050.93
127_S133_R0.8020.93
17_P38_D0.7980.93
78_K105_G0.7940.93
66_S82_Y0.7920.93
7_K10_E0.7850.93
70_I118_F0.7830.92
16_Y65_V0.7820.92
40_A53_T0.7780.92
107_N111_A0.7770.92
53_T65_V0.7760.92
17_P22_L0.7750.92
78_K97_E0.7740.92
52_Y68_E0.7610.91
33_F59_P0.7510.91
124_P127_S0.7470.91
38_D53_T0.7350.90
12_P15_P0.7290.90
35_F111_A0.7280.89
101_I110_H0.7220.89
82_Y93_A0.7210.89
16_Y89_T0.7210.89
120_P131_I0.7190.89
45_G69_G0.7160.89
58_S62_A0.7150.89
17_P83_G0.7140.89
33_F36_F0.7120.88
36_F75_R0.7120.88
23_I135_L0.7110.88
31_T108_R0.7080.88
35_F107_N0.7050.88
25_F113_L0.7030.88
120_P130_E0.6960.87
42_L131_I0.6940.87
49_V80_Y0.6890.87
37_I42_L0.6880.87
45_G51_R0.6880.87
50_V118_F0.6720.85
64_N93_A0.6700.85
77_Y109_Y0.6690.85
28_S90_W0.6690.85
24_P28_S0.6650.85
117_Y134_A0.6620.85
75_R115_R0.6610.84
126_R131_I0.6610.84
52_Y61_G0.6540.84
107_N110_H0.6540.84
83_G88_G0.6490.83
54_L113_L0.6490.83
58_S63_R0.6450.83
11_V78_K0.6380.82
37_I110_H0.6370.82
100_P103_D0.6320.82
6_W12_P0.6310.82
105_G108_R0.6290.81
85_P89_T0.6290.81
116_D121_G0.6270.81
21_N41_S0.6270.81
7_K14_P0.6260.81
130_E134_A0.6250.81
123_A129_A0.6200.81
92_P96_S0.6190.80
95_N99_R0.6180.80
13_L81_A0.6170.80
123_A132_V0.6130.80
98_W119_C0.6110.80
8_E47_D0.6080.79
25_F54_L0.6060.79
77_Y84_R0.6060.79
9_G45_G0.6010.78
35_F90_W0.5940.78
93_A110_H0.5940.78
25_F36_F0.5910.77
47_D80_Y0.5910.77
37_I50_V0.5860.77
4_K7_K0.5840.76
84_R88_G0.5790.76
33_F37_I0.5790.76
127_S135_L0.5750.75
45_G73_A0.5730.75
58_S61_G0.5710.75
25_F31_T0.5670.74
5_P46_K0.5660.74
31_T69_G0.5620.74
26_Y112_A0.5480.72
83_G89_T0.5480.72
13_L92_P0.5470.72
24_P57_R0.5440.71
45_G80_Y0.5430.71
60_S77_Y0.5430.71
24_P27_V0.5420.71
21_N123_A0.5410.71
127_S132_V0.5380.70
117_Y135_L0.5360.70
5_P12_P0.5330.70
26_Y31_T0.5320.70
52_Y110_H0.5300.69
127_S131_I0.5260.69
4_K9_G0.5250.69
66_S109_Y0.5240.68
77_Y104_R0.5230.68
101_I114_A0.5220.68
8_E69_G0.5150.67
33_F60_S0.5130.67
27_V30_A0.5080.66
57_R70_I0.5040.66
12_P26_Y0.5040.66
43_S128_A0.5030.65
27_V76_E0.5020.65
58_S65_V0.5010.65
52_Y77_Y0.5000.65
41_S114_A0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zh5A 1 0.8235 8.7 0.945 Contact Map
4rz7A 2 0.4412 5.6 0.95 Contact Map
3c2eA 5 0.8529 3.6 0.954 Contact Map
1q87A 1 0.4265 3.5 0.955 Contact Map
4arfA 2 0.4338 3.3 0.955 Contact Map
3j20F 1 0.3897 3.1 0.956 Contact Map
4l67B 1 0.1471 3 0.956 Contact Map
3pajA 2 0.8971 2.9 0.956 Contact Map
3fsdA 2 0.3603 2.8 0.957 Contact Map
4pfuA 2 0.6618 2.7 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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