GREMLIN Database
DUF1788 - Domain of unknown function (DUF1788)
PFAM: PF08747 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (122)
Sequences: 4114 (2647)
Seq/√Len: 239.6
META: 0.907

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_N70_A4.0831.00
100_E110_G3.0131.00
102_D107_R2.7001.00
13_E18_L2.6601.00
50_R54_K2.6231.00
1_E66_T2.6171.00
77_S95_L2.3211.00
50_R53_E2.2691.00
10_E14_E2.1461.00
18_L22_L2.1251.00
65_L95_L2.0551.00
52_A87_V2.0271.00
15_R20_K1.9951.00
52_A56_E1.9151.00
6_D10_E1.8731.00
5_Y9_I1.8441.00
68_V95_L1.7691.00
17_L20_K1.7631.00
9_I18_L1.7541.00
10_E50_R1.6401.00
107_R110_G1.5641.00
49_P53_E1.5411.00
102_D105_S1.5151.00
9_I13_E1.5011.00
55_L63_V1.4961.00
10_E13_E1.4831.00
4_L68_V1.4831.00
25_E30_K1.4681.00
64_F96_F1.4321.00
64_F94_V1.4191.00
31_D35_E1.3871.00
34_L38_Q1.3721.00
117_Y121_F1.3661.00
82_N85_Q1.3061.00
19_E23_E1.3041.00
10_E54_K1.3011.00
51_I65_L1.3001.00
107_R113_K1.2411.00
81_L117_Y1.2391.00
24_M28_K1.2311.00
100_E107_R1.2171.00
8_L71_L1.2141.00
56_E59_E1.2051.00
8_L47_L1.1991.00
51_I55_L1.1991.00
7_L10_E1.1861.00
14_E50_R1.1651.00
53_E56_E1.1601.00
12_L37_L1.1151.00
32_A36_A1.1071.00
36_A40_V1.1011.00
54_K57_E1.0941.00
21_I36_A1.0921.00
36_A39_G1.0691.00
28_K39_G1.0641.00
2_I7_L1.0531.00
78_H82_N1.0511.00
20_K23_E1.0461.00
3_N66_T1.0441.00
47_L50_R1.0401.00
28_K36_A1.0211.00
24_M27_E1.0081.00
16_G20_K0.9991.00
30_K33_L0.9901.00
35_E38_Q0.9721.00
16_G19_E0.9701.00
68_V77_S0.9701.00
53_E57_E0.9621.00
12_L15_R0.9591.00
21_I25_E0.9581.00
20_K32_A0.9441.00
20_K28_K0.9341.00
117_Y120_A0.9271.00
7_L50_R0.9271.00
15_R40_V0.9251.00
65_L93_T0.9211.00
113_K116_N0.9181.00
30_K74_F0.9051.00
45_D83_N0.8951.00
63_V88_V0.8901.00
13_E19_E0.8850.99
71_L74_F0.8840.99
49_P52_A0.8840.99
23_E27_E0.8790.99
24_M36_A0.8730.99
103_G109_F0.8720.99
19_E22_L0.8560.99
17_L21_I0.8550.99
80_L114_D0.8370.99
48_A87_V0.8360.99
20_K24_M0.8230.99
88_V93_T0.8210.99
104_Q107_R0.8180.99
47_L51_I0.8180.99
68_V78_H0.8150.99
33_L36_A0.8140.99
111_K115_D0.8070.99
29_G32_A0.7950.99
32_A35_E0.7940.99
17_L40_V0.7830.99
15_R46_K0.7720.99
92_P97_Y0.7530.98
28_K32_A0.7520.98
55_L58_D0.7340.98
62_V96_F0.7270.98
12_L17_L0.7240.98
92_P106_L0.7230.98
112_L115_D0.7200.98
52_A55_L0.7190.98
58_D61_D0.7170.98
39_G43_P0.7160.98
46_K55_L0.7140.98
48_A58_D0.7130.98
102_D114_D0.7130.98
46_K50_R0.7120.98
23_E26_K0.7100.98
112_L116_N0.7030.97
47_L52_A0.6980.97
74_F85_Q0.6950.97
55_L60_R0.6920.97
3_N67_G0.6920.97
79_T86_G0.6880.97
12_L21_I0.6820.97
60_R63_V0.6800.97
39_G42_D0.6750.97
69_G81_L0.6730.97
63_V91_V0.6660.96
68_V108_L0.6640.96
101_Y108_L0.6620.96
109_F112_L0.6620.96
6_D70_A0.6620.96
45_D49_P0.6580.96
18_L21_I0.6500.96
6_D9_I0.6490.96
67_G72_F0.6490.96
105_S114_D0.6470.96
19_E27_E0.6390.95
46_K58_D0.6320.95
24_M40_V0.6260.95
21_I28_K0.6190.95
8_L41_L0.6180.95
116_N119_R0.6140.94
16_G29_G0.6090.94
77_S82_N0.6080.94
17_L24_M0.6070.94
21_I24_M0.6000.94
9_I21_I0.5990.94
47_L84_L0.5980.94
42_D45_D0.5970.94
21_I33_L0.5940.93
49_P87_V0.5940.93
65_L85_Q0.5910.93
12_L97_Y0.5900.93
51_I84_L0.5890.93
11_I40_V0.5820.93
28_K31_D0.5810.93
100_E113_K0.5790.92
63_V67_G0.5740.92
83_N86_G0.5730.92
17_L36_A0.5720.92
26_K29_G0.5710.92
105_S109_F0.5690.92
91_V107_R0.5670.92
79_T83_N0.5630.91
6_D54_K0.5590.91
5_Y70_A0.5590.91
23_E90_D0.5500.90
106_L110_G0.5460.90
48_A52_A0.5300.89
43_P49_P0.5290.89
70_A86_G0.5250.88
55_L88_V0.5240.88
69_G72_F0.5210.88
43_P79_T0.5200.88
49_P122_N0.5190.88
53_E58_D0.5190.88
77_S80_L0.5190.88
52_A88_V0.5150.87
97_Y101_Y0.5140.87
105_S113_K0.5130.87
15_R21_I0.5090.87
32_A39_G0.5040.86
8_L11_I0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hekA 4 0.8455 13.5 0.912 Contact Map
3cmuA 1 0.9512 10.7 0.916 Contact Map
1oaoC 1 0.6341 8.3 0.92 Contact Map
3zh9B 1 0.9431 7.4 0.922 Contact Map
1sazA 3 0.9268 6.1 0.925 Contact Map
1moqA 2 0.9431 5.2 0.928 Contact Map
4s1wA 2 0.8374 5 0.928 Contact Map
3hn7A 1 0.6748 4.9 0.928 Contact Map
1vmkA 3 0.5854 4.4 0.93 Contact Map
2hlsA 5 0.8537 4.3 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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