GREMLIN Database
Nse4_C - Nse4 C-terminal
PFAM: PF08743 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (89)
Sequences: 795 (629)
Seq/√Len: 66.6
META: 0.267

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_N16_Q5.4661.00
71_D74_D4.8601.00
17_T70_L3.7651.00
8_V21_I3.6721.00
8_V24_L3.3531.00
4_L21_I3.2671.00
24_L45_I3.0561.00
7_F45_I2.4511.00
3_N6_E2.1381.00
79_I84_I1.8271.00
4_L68_F1.8261.00
77_E81_A1.8091.00
4_L8_V1.7491.00
14_F25_S1.6800.99
9_I78_L1.6100.99
76_K79_I1.5120.99
84_I89_I1.4390.98
9_I17_T1.4340.98
68_F72_M1.3230.97
85_T89_I1.3200.97
56_A61_V1.3160.97
24_L33_A1.3150.97
17_T20_N1.3030.97
31_G75_W1.2650.96
65_Q72_M1.2450.96
14_F18_V1.2370.96
11_P23_Y1.1810.94
13_S33_A1.1800.94
19_E22_F1.1660.94
46_E70_L1.1630.94
87_P90_P1.1560.94
72_M76_K1.1420.93
17_T74_D1.1380.93
10_N19_E1.1280.93
26_F65_Q1.0730.91
18_V70_L1.0660.91
7_F89_I1.0460.90
19_E23_Y0.9940.87
13_S35_I0.9790.86
12_N15_A0.9740.86
4_L15_A0.9180.83
51_P55_E0.9140.82
27_L31_G0.9100.82
16_Q22_F0.9060.82
28_V65_Q0.9050.82
70_L78_L0.9000.81
11_P79_I0.8680.79
41_G75_W0.8670.79
51_P61_V0.8560.78
51_P56_A0.8530.78
76_K80_E0.8500.77
5_F11_P0.8440.77
50_P90_P0.8300.76
16_Q19_E0.8260.75
11_P82_F0.8080.74
51_P71_D0.8060.74
67_V90_P0.8040.73
25_S35_I0.7730.70
55_E59_G0.7710.70
46_E68_F0.7540.69
47_P50_P0.7470.68
16_Q23_Y0.7460.68
15_A66_A0.7440.67
2_I88_M0.7400.67
29_R65_Q0.7340.66
28_V68_F0.7290.66
39_E56_A0.7250.65
53_A56_A0.7210.65
73_K77_E0.7180.65
36_E62_A0.7170.65
15_A23_Y0.7060.63
21_I62_A0.7030.63
82_F87_P0.7010.63
78_L81_A0.6720.60
20_N26_F0.6710.60
51_P58_S0.6710.60
37_L40_D0.6610.58
75_W78_L0.6570.58
28_V62_A0.6560.58
52_E60_G0.6550.58
4_L23_Y0.6520.57
8_V42_L0.6460.57
22_F26_F0.6380.56
39_E57_A0.6370.56
7_F82_F0.6370.56
67_V81_A0.6300.55
16_Q90_P0.6300.55
23_Y68_F0.6300.55
12_N50_P0.6260.54
28_V48_V0.6250.54
83_E86_E0.6210.54
34_G57_A0.6050.52
37_L78_L0.6010.51
17_T23_Y0.6000.51
60_G64_N0.5930.50
36_E44_V0.5900.50
34_G73_K0.5880.50
22_F29_R0.5860.50
41_G60_G0.5820.49
16_Q25_S0.5810.49
62_A70_L0.5780.49
41_G49_N0.5770.48
31_G47_P0.5760.48
17_T63_R0.5630.47
2_I41_G0.5630.47
70_L74_D0.5580.46
32_R80_E0.5540.46
18_V35_I0.5510.45
12_N62_A0.5480.45
53_A73_K0.5470.45
3_N70_L0.5440.45
3_N44_V0.5430.44
32_R56_A0.5340.43
36_E46_E0.5330.43
53_A57_A0.5280.43
13_S70_L0.5270.43
10_N75_W0.5270.43
44_V81_A0.5260.43
8_V23_Y0.5220.42
48_V51_P0.5210.42
21_I25_S0.5210.42
43_P76_K0.5200.42
57_A68_F0.5190.42
15_A21_I0.5110.41
16_Q28_V0.5100.41
11_P84_I0.5080.40
45_I60_G0.5060.40
47_P54_E0.5060.40
5_F36_E0.5060.40
17_T78_L0.5060.40
48_V52_E0.5040.40
40_D63_R0.5030.40
23_Y65_Q0.5010.40
11_P87_P0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3buaE 1 0.033 11.8 0.908 Contact Map
1ichA 1 0.3516 5.9 0.92 Contact Map
2g8yA 2 0.9121 5.6 0.921 Contact Map
2a8jA 2 0.4725 5 0.923 Contact Map
1zceA 1 0.7363 4.4 0.925 Contact Map
4i99C 1 0.5275 4.1 0.926 Contact Map
3oq9A 3 0.3407 4 0.926 Contact Map
3uw1A 2 0.7473 3.8 0.927 Contact Map
1vbiA 2 0.8791 3.4 0.928 Contact Map
1nxuA 2 0.8132 3.3 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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