GREMLIN Database
C8 - C8 domain
PFAM: PF08742 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 71 (70)
Sequences: 4727 (2934)
Seq/√Len: 350.7
META: 0.125

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_C44_C3.9811.00
9_L28_Y3.1741.00
18_C56_C3.0511.00
15_F53_A2.8391.00
19_H52_Y2.5031.00
24_P52_Y2.3801.00
28_Y32_V2.0671.00
67_T70_F1.9681.00
7_I49_L1.8681.00
50_A54_R1.7371.00
19_H24_P1.6871.00
35_L45_L1.6561.00
30_A33_Y1.5651.00
25_E29_E1.5641.00
27_Y55_A1.4901.00
21_V61_V1.3951.00
22_V55_A1.3771.00
55_A58_A1.3191.00
10_S13_G1.2751.00
54_R58_A1.2591.00
50_A66_R1.2351.00
15_F19_H1.1821.00
55_A59_A1.1701.00
11_P16_A1.1271.00
46_C71_C1.1211.00
51_A55_A1.0801.00
22_V59_A1.0771.00
54_R57_A1.0721.00
10_S14_P1.0711.00
5_C31_C1.0571.00
13_G19_H1.0481.00
4_L35_L1.0471.00
49_L63_V1.0451.00
8_L19_H1.0031.00
45_L70_F1.0021.00
37_A47_S0.9951.00
13_G16_A0.9921.00
53_A65_W0.9801.00
52_Y61_V0.9761.00
57_A62_C0.9501.00
21_V59_A0.9361.00
38_C41_G0.8991.00
26_P30_A0.8951.00
22_V61_V0.8941.00
53_A63_V0.8891.00
31_C36_C0.8881.00
30_A34_D0.8841.00
4_L45_L0.8641.00
44_C47_S0.8611.00
51_A54_R0.8601.00
2_E32_V0.8481.00
40_G43_D0.8381.00
42_D68_P0.8371.00
30_A51_A0.8361.00
64_D70_F0.8341.00
9_L24_P0.7931.00
29_E32_V0.7621.00
6_G9_L0.7471.00
35_L47_S0.7461.00
66_R70_F0.7461.00
15_F49_L0.7361.00
31_C34_D0.7331.00
41_G44_C0.7190.99
64_D67_T0.7010.99
47_S57_A0.6940.99
8_L28_Y0.6840.99
37_A51_A0.6700.99
2_E10_S0.6590.99
5_C18_C0.6580.99
53_A57_A0.6400.99
37_A44_C0.6390.99
24_P27_Y0.6330.99
19_H22_V0.6270.98
33_Y37_A0.6260.98
4_L40_G0.6240.98
45_L49_L0.6200.98
22_V43_D0.6190.98
22_V52_Y0.6100.98
44_C48_A0.6090.98
19_H28_Y0.6050.98
37_A41_G0.5990.98
17_A61_V0.5870.98
30_A48_A0.5830.98
26_P41_G0.5800.97
32_V35_L0.5740.97
8_L13_G0.5730.97
50_A69_T0.5700.97
35_L43_D0.5670.97
34_D48_A0.5610.97
2_E64_D0.5590.97
32_V45_L0.5510.97
64_D68_P0.5450.96
10_S19_H0.5420.96
49_L70_F0.5380.96
10_S16_A0.5360.96
39_G47_S0.5350.96
27_Y52_Y0.5310.96
48_A52_Y0.5300.96
28_Y35_L0.5260.96
33_Y45_L0.5180.95
9_L25_E0.5170.95
42_D45_L0.5170.95
3_E21_V0.5100.95
7_I68_P0.5040.94
3_E6_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bq6D 1 0 6 0.868 Contact Map
2lpyA 1 0.4507 2.1 0.895 Contact Map
3c8xA 2 0.3944 1.6 0.902 Contact Map
1baxA 1 0.4648 1.4 0.905 Contact Map
2munA 1 0.6338 1 0.915 Contact Map
4zrlB 1 0.7183 0.9 0.915 Contact Map
4fvmA 1 0.0986 0.9 0.915 Contact Map
3u3lC 1 0.5775 0.9 0.915 Contact Map
3ghmA 1 0.8169 0.9 0.917 Contact Map
2qyuA 1 0.6479 0.9 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0044 seconds.