BCS1_N - PFAM28P - GREMLIN Contacts

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BCS1_N - BCS1 N terminal

PFAM:	PF08740	Sequences: LGALLALLRRVPQRLWSWLRRQFTVTVEIPSDDEAYDWVLEWLSEQPFLKRSRRLSVDTTLRSGSKKTRFALVPAPGTHWFWYKGRLFWVTREREESSSKSTDGRTGRPWETLTLTTLGRSRAILKELLEEARELALKRQEGKTVIYTADSYGGEWRRVGSRPKRPLDSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	170 (165)
Sequences:	1724 (1320)
Seq/√Len:	102.8
META:	0.517

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
82_W	87_L	5.696	1.00
84_K	127_E	5.035	1.00
122_R	126_K	3.651	1.00
123_A	127_E	3.549	1.00
83_Y	131_E	3.465	1.00
88_F	115_L	3.224	1.00
92_R	111_E	3.116	1.00
33_D	59_T	2.741	1.00
29_I	39_V	2.628	1.00
39_V	128_L	2.527	1.00
84_K	131_E	2.515	1.00
27_V	55_L	2.484	1.00
45_E	135_L	2.461	1.00
128_L	132_A	2.432	1.00
35_A	57_V	2.285	1.00
83_Y	124_I	2.245	1.00
81_F	88_F	2.218	1.00
87_L	118_L	2.146	1.00
88_F	124_I	2.116	1.00
75_A	79_H	2.075	1.00
117_T	125_L	2.036	1.00
35_A	38_W	2.022	1.00
42_W	46_Q	1.816	1.00
130_E	134_E	1.799	1.00
12_P	15_L	1.795	1.00
86_R	124_I	1.740	1.00
20_R	24_T	1.736	1.00
130_E	133_R	1.682	1.00
70_F	129_L	1.680	1.00
80_W	89_W	1.670	1.00
27_V	125_L	1.631	1.00
8_L	12_P	1.624	1.00
72_L	75_A	1.554	1.00
42_W	131_E	1.549	1.00
38_W	132_A	1.533	1.00
81_F	90_V	1.510	1.00
88_F	128_L	1.497	1.00
6_A	9_R	1.493	1.00
9_R	12_P	1.482	1.00
64_G	68_T	1.454	1.00
24_T	116_T	1.430	1.00
22_Q	120_R	1.420	1.00
20_R	116_T	1.408	1.00
25_V	117_T	1.394	1.00
145_V	158_R	1.394	1.00
38_W	169_S	1.369	1.00
86_R	119_G	1.301	0.99
26_T	114_T	1.299	0.99
80_W	87_L	1.298	0.99
72_L	126_K	1.278	0.99
76_P	94_R	1.277	0.99
19_L	23_F	1.250	0.99
48_F	81_F	1.197	0.99
123_A	126_K	1.189	0.99
88_F	117_T	1.186	0.99
94_R	109_P	1.179	0.98
6_A	12_P	1.177	0.98
19_L	37_D	1.153	0.98
165_R	170_V	1.131	0.98
24_T	119_G	1.096	0.98
148_T	159_V	1.094	0.98
47_P	81_F	1.059	0.97
35_A	132_A	1.057	0.97
38_W	74_P	1.047	0.97
86_R	121_S	1.039	0.97
78_T	91_T	1.036	0.97
42_W	128_L	1.032	0.96
52_S	73_V	1.025	0.96
16_W	20_R	1.020	0.96
47_P	89_W	1.006	0.96
6_A	10_R	0.997	0.96
17_S	127_E	0.993	0.96
10_R	14_R	0.993	0.96
2_G	169_S	0.979	0.95
46_Q	135_L	0.967	0.95
11_V	14_R	0.957	0.95
12_P	16_W	0.954	0.95
83_Y	88_F	0.943	0.94
138_K	141_E	0.936	0.94
35_A	136_A	0.933	0.94
57_V	169_S	0.930	0.94
14_R	21_R	0.921	0.93
148_T	157_R	0.919	0.93
165_R	169_S	0.902	0.93
11_V	15_L	0.892	0.92
94_R	111_E	0.892	0.92
25_V	122_R	0.890	0.92
78_T	82_W	0.884	0.92
4_L	8_L	0.871	0.91
38_W	57_V	0.869	0.91
121_S	124_I	0.863	0.91
2_G	5_L	0.861	0.91
46_Q	81_F	0.860	0.91
9_R	13_Q	0.843	0.90
42_W	47_P	0.836	0.90
43_L	90_V	0.828	0.89
99_S	105_R	0.825	0.89
17_S	123_A	0.823	0.89
42_W	84_K	0.819	0.89
144_T	161_S	0.811	0.88
28_E	115_L	0.809	0.88
68_T	166_P	0.808	0.88
14_R	18_W	0.794	0.87
139_R	164_K	0.788	0.87
55_L	124_I	0.787	0.87
144_T	162_R	0.783	0.86
30_P	108_R	0.776	0.86
28_E	56_S	0.775	0.86
77_G	120_R	0.774	0.86
55_L	77_G	0.773	0.86
39_V	92_R	0.772	0.86
35_A	81_F	0.768	0.85
113_L	161_S	0.764	0.85
30_P	56_S	0.761	0.85
13_Q	23_F	0.758	0.85
63_S	84_K	0.758	0.85
43_L	70_F	0.755	0.84
42_W	132_A	0.754	0.84
84_K	124_I	0.751	0.84
2_G	6_A	0.735	0.83
166_P	169_S	0.731	0.82
158_R	161_S	0.729	0.82
33_D	44_S	0.728	0.82
57_V	72_L	0.727	0.82
139_R	153_G	0.721	0.82
132_A	136_A	0.718	0.81
10_R	13_Q	0.716	0.81
72_L	122_R	0.715	0.81
77_G	119_G	0.715	0.81
123_A	170_V	0.712	0.81
79_H	111_E	0.708	0.80
40_L	43_L	0.705	0.80
40_L	73_V	0.703	0.80
65_S	113_L	0.703	0.80
133_R	137_L	0.702	0.80
44_S	166_P	0.702	0.80
31_S	37_D	0.698	0.79
60_T	69_R	0.696	0.79
86_R	117_T	0.688	0.78
75_A	111_E	0.683	0.78
128_L	161_S	0.672	0.77
76_P	112_T	0.672	0.77
59_T	92_R	0.669	0.76
33_D	125_L	0.667	0.76
108_R	146_I	0.666	0.76
4_L	14_R	0.666	0.76
15_L	19_L	0.665	0.76
81_F	117_T	0.660	0.75
140_Q	158_R	0.660	0.75
29_I	49_L	0.657	0.75
102_T	106_T	0.656	0.75
23_F	86_R	0.655	0.75
29_I	57_V	0.655	0.75
33_D	132_A	0.653	0.75
53_R	119_G	0.652	0.75
45_E	123_A	0.652	0.75
38_W	59_T	0.650	0.74
76_P	79_H	0.649	0.74
35_A	116_T	0.649	0.74
90_V	115_L	0.648	0.74
65_S	168_D	0.648	0.74
55_L	122_R	0.647	0.74
18_W	21_R	0.642	0.73
48_F	90_V	0.640	0.73
117_T	122_R	0.639	0.73
38_W	136_A	0.635	0.73
25_V	170_V	0.633	0.72
16_W	19_L	0.631	0.72
46_Q	72_L	0.629	0.72
164_K	167_L	0.629	0.72
18_W	167_L	0.627	0.72
48_F	52_S	0.627	0.72
38_W	133_R	0.621	0.71
2_G	9_R	0.620	0.71
36_Y	111_E	0.618	0.71
40_L	113_L	0.615	0.70
77_G	111_E	0.615	0.70
17_S	20_R	0.614	0.70
32_D	109_P	0.614	0.70
3_A	7_L	0.611	0.70
29_I	112_T	0.608	0.69
11_V	107_G	0.608	0.69
103_D	106_T	0.607	0.69
4_L	157_R	0.605	0.69
35_A	90_V	0.605	0.69
80_W	162_R	0.604	0.69
37_D	126_K	0.603	0.69
76_P	111_E	0.603	0.69
13_Q	17_S	0.599	0.68
90_V	113_L	0.598	0.68
163_P	166_P	0.597	0.68
110_W	146_I	0.596	0.68
70_F	147_Y	0.596	0.68
78_T	89_W	0.592	0.67
83_Y	128_L	0.589	0.67
39_V	66_K	0.586	0.67
36_Y	135_L	0.585	0.66
69_R	126_K	0.584	0.66
65_S	93_E	0.584	0.66
59_T	70_F	0.584	0.66
17_S	21_R	0.582	0.66
77_G	143_K	0.581	0.66
10_R	17_S	0.579	0.66
26_T	116_T	0.578	0.66
31_S	75_A	0.575	0.65
83_Y	86_R	0.572	0.65
18_W	23_F	0.571	0.65
53_R	71_A	0.570	0.64
45_E	139_R	0.568	0.64
160_G	169_S	0.567	0.64
52_S	55_L	0.567	0.64
7_L	10_R	0.565	0.64
39_V	132_A	0.562	0.63
45_E	50_K	0.554	0.62
22_Q	117_T	0.551	0.62
35_A	169_S	0.550	0.62
9_R	61_L	0.550	0.62
92_R	146_I	0.547	0.61
56_S	60_T	0.547	0.61
16_W	23_F	0.546	0.61
133_R	166_P	0.545	0.61
14_R	113_L	0.545	0.61
39_V	47_P	0.544	0.61
69_R	139_R	0.540	0.60
74_P	125_L	0.540	0.60
42_W	156_W	0.538	0.60
40_L	55_L	0.538	0.60
113_L	138_K	0.536	0.60
140_Q	143_K	0.534	0.59
82_W	86_R	0.533	0.59
6_A	25_V	0.533	0.59
60_T	140_Q	0.530	0.59
8_L	85_G	0.529	0.59
27_V	70_F	0.528	0.59
27_V	105_R	0.528	0.59
143_K	163_P	0.526	0.58
18_W	77_G	0.520	0.57
105_R	110_W	0.520	0.57
81_F	156_W	0.519	0.57
127_E	130_E	0.513	0.56
85_G	152_Y	0.506	0.55
74_P	81_F	0.505	0.55
32_D	111_E	0.505	0.55
93_E	105_R	0.505	0.55
39_V	115_L	0.503	0.55
146_I	162_R	0.501	0.55
144_T	163_P	0.501	0.55
45_E	138_K	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ilcA	1	0.3353	8.5	0.926	Contact Map
2cjrA	2	0.3176	6.8	0.929	Contact Map
3qbrA	1	0.3353	6.1	0.93	Contact Map
4wmuA	1	0.3353	5.3	0.933	Contact Map
4zieA	2	0.3412	4.2	0.936	Contact Map
2ge7A	2	0.3294	4.1	0.936	Contact Map
4cimA	2	0.3353	3.8	0.937	Contact Map
2xa0A	1	0.3529	3.5	0.938	Contact Map
3pk1A	1	0.3412	3.4	0.938	Contact Map
1vmfA	3	0.5765	3.3	0.939	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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