GREMLIN Database
BCS1_N - BCS1 N terminal
PFAM: PF08740 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 170 (165)
Sequences: 1724 (1320)
Seq/√Len: 102.8
META: 0.517

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_W87_L5.6961.00
84_K127_E5.0351.00
122_R126_K3.6511.00
123_A127_E3.5491.00
83_Y131_E3.4651.00
88_F115_L3.2241.00
92_R111_E3.1161.00
33_D59_T2.7411.00
29_I39_V2.6281.00
39_V128_L2.5271.00
84_K131_E2.5151.00
27_V55_L2.4841.00
45_E135_L2.4611.00
128_L132_A2.4321.00
35_A57_V2.2851.00
83_Y124_I2.2451.00
81_F88_F2.2181.00
87_L118_L2.1461.00
88_F124_I2.1161.00
75_A79_H2.0751.00
117_T125_L2.0361.00
35_A38_W2.0221.00
42_W46_Q1.8161.00
130_E134_E1.7991.00
12_P15_L1.7951.00
86_R124_I1.7401.00
20_R24_T1.7361.00
130_E133_R1.6821.00
70_F129_L1.6801.00
80_W89_W1.6701.00
27_V125_L1.6311.00
8_L12_P1.6241.00
72_L75_A1.5541.00
42_W131_E1.5491.00
38_W132_A1.5331.00
81_F90_V1.5101.00
88_F128_L1.4971.00
6_A9_R1.4931.00
9_R12_P1.4821.00
64_G68_T1.4541.00
24_T116_T1.4301.00
22_Q120_R1.4201.00
20_R116_T1.4081.00
25_V117_T1.3941.00
145_V158_R1.3941.00
38_W169_S1.3691.00
86_R119_G1.3010.99
26_T114_T1.2990.99
80_W87_L1.2980.99
72_L126_K1.2780.99
76_P94_R1.2770.99
19_L23_F1.2500.99
48_F81_F1.1970.99
123_A126_K1.1890.99
88_F117_T1.1860.99
94_R109_P1.1790.98
6_A12_P1.1770.98
19_L37_D1.1530.98
165_R170_V1.1310.98
24_T119_G1.0960.98
148_T159_V1.0940.98
47_P81_F1.0590.97
35_A132_A1.0570.97
38_W74_P1.0470.97
86_R121_S1.0390.97
78_T91_T1.0360.97
42_W128_L1.0320.96
52_S73_V1.0250.96
16_W20_R1.0200.96
47_P89_W1.0060.96
6_A10_R0.9970.96
17_S127_E0.9930.96
10_R14_R0.9930.96
2_G169_S0.9790.95
46_Q135_L0.9670.95
11_V14_R0.9570.95
12_P16_W0.9540.95
83_Y88_F0.9430.94
138_K141_E0.9360.94
35_A136_A0.9330.94
57_V169_S0.9300.94
14_R21_R0.9210.93
148_T157_R0.9190.93
165_R169_S0.9020.93
11_V15_L0.8920.92
94_R111_E0.8920.92
25_V122_R0.8900.92
78_T82_W0.8840.92
4_L8_L0.8710.91
38_W57_V0.8690.91
121_S124_I0.8630.91
2_G5_L0.8610.91
46_Q81_F0.8600.91
9_R13_Q0.8430.90
42_W47_P0.8360.90
43_L90_V0.8280.89
99_S105_R0.8250.89
17_S123_A0.8230.89
42_W84_K0.8190.89
144_T161_S0.8110.88
28_E115_L0.8090.88
68_T166_P0.8080.88
14_R18_W0.7940.87
139_R164_K0.7880.87
55_L124_I0.7870.87
144_T162_R0.7830.86
30_P108_R0.7760.86
28_E56_S0.7750.86
77_G120_R0.7740.86
55_L77_G0.7730.86
39_V92_R0.7720.86
35_A81_F0.7680.85
113_L161_S0.7640.85
30_P56_S0.7610.85
13_Q23_F0.7580.85
63_S84_K0.7580.85
43_L70_F0.7550.84
42_W132_A0.7540.84
84_K124_I0.7510.84
2_G6_A0.7350.83
166_P169_S0.7310.82
158_R161_S0.7290.82
33_D44_S0.7280.82
57_V72_L0.7270.82
139_R153_G0.7210.82
132_A136_A0.7180.81
10_R13_Q0.7160.81
72_L122_R0.7150.81
77_G119_G0.7150.81
123_A170_V0.7120.81
79_H111_E0.7080.80
40_L43_L0.7050.80
40_L73_V0.7030.80
65_S113_L0.7030.80
133_R137_L0.7020.80
44_S166_P0.7020.80
31_S37_D0.6980.79
60_T69_R0.6960.79
86_R117_T0.6880.78
75_A111_E0.6830.78
128_L161_S0.6720.77
76_P112_T0.6720.77
59_T92_R0.6690.76
33_D125_L0.6670.76
108_R146_I0.6660.76
4_L14_R0.6660.76
15_L19_L0.6650.76
81_F117_T0.6600.75
140_Q158_R0.6600.75
29_I49_L0.6570.75
102_T106_T0.6560.75
23_F86_R0.6550.75
29_I57_V0.6550.75
33_D132_A0.6530.75
53_R119_G0.6520.75
45_E123_A0.6520.75
38_W59_T0.6500.74
76_P79_H0.6490.74
35_A116_T0.6490.74
90_V115_L0.6480.74
65_S168_D0.6480.74
55_L122_R0.6470.74
18_W21_R0.6420.73
48_F90_V0.6400.73
117_T122_R0.6390.73
38_W136_A0.6350.73
25_V170_V0.6330.72
16_W19_L0.6310.72
46_Q72_L0.6290.72
164_K167_L0.6290.72
18_W167_L0.6270.72
48_F52_S0.6270.72
38_W133_R0.6210.71
2_G9_R0.6200.71
36_Y111_E0.6180.71
40_L113_L0.6150.70
77_G111_E0.6150.70
17_S20_R0.6140.70
32_D109_P0.6140.70
3_A7_L0.6110.70
29_I112_T0.6080.69
11_V107_G0.6080.69
103_D106_T0.6070.69
4_L157_R0.6050.69
35_A90_V0.6050.69
80_W162_R0.6040.69
37_D126_K0.6030.69
76_P111_E0.6030.69
13_Q17_S0.5990.68
90_V113_L0.5980.68
163_P166_P0.5970.68
110_W146_I0.5960.68
70_F147_Y0.5960.68
78_T89_W0.5920.67
83_Y128_L0.5890.67
39_V66_K0.5860.67
36_Y135_L0.5850.66
69_R126_K0.5840.66
65_S93_E0.5840.66
59_T70_F0.5840.66
17_S21_R0.5820.66
77_G143_K0.5810.66
10_R17_S0.5790.66
26_T116_T0.5780.66
31_S75_A0.5750.65
83_Y86_R0.5720.65
18_W23_F0.5710.65
53_R71_A0.5700.64
45_E139_R0.5680.64
160_G169_S0.5670.64
52_S55_L0.5670.64
7_L10_R0.5650.64
39_V132_A0.5620.63
45_E50_K0.5540.62
22_Q117_T0.5510.62
35_A169_S0.5500.62
9_R61_L0.5500.62
92_R146_I0.5470.61
56_S60_T0.5470.61
16_W23_F0.5460.61
133_R166_P0.5450.61
14_R113_L0.5450.61
39_V47_P0.5440.61
69_R139_R0.5400.60
74_P125_L0.5400.60
42_W156_W0.5380.60
40_L55_L0.5380.60
113_L138_K0.5360.60
140_Q143_K0.5340.59
82_W86_R0.5330.59
6_A25_V0.5330.59
60_T140_Q0.5300.59
8_L85_G0.5290.59
27_V70_F0.5280.59
27_V105_R0.5280.59
143_K163_P0.5260.58
18_W77_G0.5200.57
105_R110_W0.5200.57
81_F156_W0.5190.57
127_E130_E0.5130.56
85_G152_Y0.5060.55
74_P81_F0.5050.55
32_D111_E0.5050.55
93_E105_R0.5050.55
39_V115_L0.5030.55
146_I162_R0.5010.55
144_T163_P0.5010.55
45_E138_K0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilcA 1 0.3353 8.5 0.926 Contact Map
2cjrA 2 0.3176 6.8 0.929 Contact Map
3qbrA 1 0.3353 6.1 0.93 Contact Map
4wmuA 1 0.3353 5.3 0.933 Contact Map
4zieA 2 0.3412 4.2 0.936 Contact Map
2ge7A 2 0.3294 4.1 0.936 Contact Map
4cimA 2 0.3353 3.8 0.937 Contact Map
2xa0A 1 0.3529 3.5 0.938 Contact Map
3pk1A 1 0.3412 3.4 0.938 Contact Map
1vmfA 3 0.5765 3.3 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.