GREMLIN Database
DUF1786 - Putative pyruvate format-lyase activating enzyme (DUF1786)
PFAM: PF08735 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 252 (251)
Sequences: 1688 (1193)
Seq/√Len: 75.3
META: 0.921

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_K223_D5.5221.00
209_R219_E4.7441.00
35_E38_R4.3641.00
10_V20_V4.1421.00
218_E222_D3.6141.00
122_I133_A3.2141.00
19_P43_E3.1511.00
197_L224_G3.0991.00
84_V132_V3.0571.00
97_Q217_H3.0371.00
22_A42_I2.7311.00
82_V132_V2.6771.00
102_Y125_Y2.5251.00
191_F206_L2.4871.00
155_A169_V2.4761.00
179_A207_L2.4721.00
216_T219_E2.4361.00
104_R108_R2.4081.00
93_V101_D2.4051.00
30_F40_M2.3121.00
33_D92_G2.2971.00
84_V129_L2.2351.00
11_R15_R2.2031.00
67_R71_A2.1951.00
205_D209_R2.1891.00
31_N36_R2.1171.00
13_H18_L2.1071.00
98_F125_Y2.0741.00
10_V30_F2.0651.00
168_L207_L2.0561.00
6_S29_T2.0261.00
200_P204_E2.0231.00
7_T30_F2.0081.00
83_A147_T1.9781.00
25_E28_R1.9151.00
61_D64_A1.9031.00
68_A72_F1.8691.00
23_T26_A1.8471.00
161_V244_A1.8351.00
117_A143_L1.8301.00
112_R115_A1.7241.00
179_A191_F1.7211.00
208_R212_D1.7181.00
64_A68_A1.6841.00
21_Y52_A1.6701.00
90_A93_V1.6691.00
229_A232_D1.6311.00
228_A231_L1.6231.00
6_S55_I1.5140.99
168_L211_A1.5140.99
202_K205_D1.4920.99
166_G183_G1.4780.99
209_R214_T1.4600.99
60_F136_A1.4320.99
164_R242_F1.4270.99
64_A72_F1.4150.99
12_D15_R1.4030.99
58_R135_S1.3930.99
32_D127_T1.3910.99
82_V142_L1.3840.98
102_Y126_M1.3790.98
28_R95_D1.3750.98
160_R163_A1.3590.98
6_S57_L1.3550.98
210_L214_T1.3530.98
147_T171_N1.3480.98
118_Y126_M1.3440.98
28_R89_F1.3330.98
24_P46_S1.3300.98
14_L42_I1.3220.98
25_E134_D1.3070.98
137_P142_L1.3060.98
38_R43_E1.2960.98
169_V182_L1.2930.98
228_A234_P1.2750.97
148_G178_L1.2730.97
10_V22_A1.2710.97
129_L144_V1.2640.97
21_Y43_E1.2560.97
32_D59_D1.2020.96
94_S221_F1.1980.96
199_T202_K1.1970.96
181_L189_G1.1940.96
206_L210_L1.1690.96
217_H221_F1.1480.95
36_R39_A1.1390.95
170_V207_L1.1330.95
110_G115_A1.1270.95
202_K206_L1.1230.95
118_Y123_P1.1110.94
206_L223_D1.1040.94
231_L234_P1.0900.94
1_M59_D1.0880.94
191_F215_L1.0590.93
84_V147_T1.0590.93
33_D36_R1.0560.93
59_D148_G1.0530.93
152_V180_F1.0470.92
124_P130_R1.0450.92
148_G151_A1.0350.92
206_L220_V1.0340.92
177_T198_L1.0340.92
1_M4_G1.0330.92
68_A71_A1.0300.92
66_R70_A1.0280.92
103_L106_R1.0230.91
31_N95_D1.0140.91
73_G80_V1.0050.91
38_R44_I1.0050.91
33_D91_P1.0040.91
129_L132_V0.9980.90
125_Y129_L0.9890.90
5_P8_W0.9830.90
102_Y175_F0.9800.90
37_V40_M0.9800.90
105_E125_Y0.9800.90
34_L44_I0.9750.89
234_P239_G0.9710.89
127_T131_A0.9670.89
58_R61_D0.9530.88
215_L220_V0.9520.88
230_Y234_P0.9480.88
65_L76_L0.9420.88
85_Q175_F0.9370.87
103_L116_F0.9350.87
209_R216_T0.9340.87
11_R31_N0.9330.87
193_H223_D0.9270.87
7_T11_R0.9210.86
210_L228_A0.9180.86
27_A34_L0.9170.86
132_V135_S0.9140.86
148_G171_N0.9120.86
183_G186_R0.9110.86
22_A26_A0.9110.86
158_D161_V0.9080.86
183_G188_E0.9080.86
33_D95_D0.9060.86
48_L52_A0.9030.85
59_D127_T0.9020.85
82_V136_A0.9000.85
190_V210_L0.8890.84
131_A219_E0.8860.84
32_D100_F0.8860.84
32_D96_R0.8850.84
80_V136_A0.8850.84
233_E236_G0.8780.84
90_A95_D0.8770.84
85_Q180_F0.8740.83
101_D104_R0.8650.83
24_P38_R0.8620.83
205_D208_R0.8580.82
81_A117_A0.8570.82
191_F210_L0.8560.82
158_D244_A0.8550.82
23_T81_A0.8550.82
96_R100_F0.8530.82
133_A142_L0.8490.82
14_L207_L0.8410.81
130_R134_D0.8400.81
98_F102_Y0.8400.81
165_E184_G0.8380.81
9_A13_H0.8380.81
197_L206_L0.8280.80
172_V177_T0.8230.80
151_A178_L0.8140.79
6_S22_A0.8130.79
22_A30_F0.8120.79
4_G9_A0.8050.78
96_R221_F0.8050.78
228_A232_D0.8000.78
166_G188_E0.8000.78
116_F167_V0.7980.77
121_P133_A0.7940.77
66_R76_L0.7930.77
16_A220_V0.7840.76
205_D218_E0.7820.76
77_P110_G0.7800.76
30_F42_I0.7790.76
103_L149_P0.7780.76
220_V223_D0.7770.76
66_R71_A0.7730.75
170_V245_V0.7700.75
14_L44_I0.7690.75
132_V144_V0.7670.75
85_Q224_G0.7670.75
234_P237_F0.7590.74
133_A141_P0.7590.74
96_R173_G0.7580.74
34_L37_V0.7570.74
36_R224_G0.7530.73
11_R14_L0.7520.73
231_L235_P0.7520.73
247_G250_R0.7500.73
94_S97_Q0.7500.73
229_A234_P0.7490.73
107_L186_R0.7480.73
66_R78_F0.7470.73
197_L223_D0.7430.72
29_T37_V0.7420.72
29_T136_A0.7410.72
83_A129_L0.7400.72
160_R164_R0.7390.72
129_L136_A0.7390.72
111_G115_A0.7360.72
230_Y233_E0.7320.71
96_R193_H0.7290.71
63_E67_R0.7260.71
195_T198_L0.7250.70
101_D105_E0.7230.70
80_V144_V0.7220.70
12_D67_R0.7200.70
180_F224_G0.7160.69
175_F224_G0.7150.69
94_S116_F0.7140.69
5_P9_A0.7140.69
123_P129_L0.7120.69
107_L229_A0.7110.69
171_N174_N0.7050.68
208_R211_A0.7050.68
59_D74_V0.7030.68
7_T31_N0.7010.68
180_F187_I0.6950.67
102_Y105_E0.6910.67
19_P55_I0.6910.67
135_S142_L0.6910.67
69_L76_L0.6890.67
38_R75_D0.6890.67
102_Y152_V0.6870.66
38_R251_S0.6860.66
104_R217_H0.6850.66
181_L188_E0.6850.66
61_D66_R0.6840.66
36_R40_M0.6820.66
190_V206_L0.6820.66
89_F95_D0.6780.65
129_L147_T0.6780.65
60_F129_L0.6770.65
237_F240_F0.6740.65
217_H224_G0.6730.65
8_W11_R0.6720.65
149_P171_N0.6710.64
60_F80_V0.6710.64
181_L240_F0.6670.64
14_L20_V0.6650.64
60_F82_V0.6630.64
20_V42_I0.6630.64
106_R148_G0.6610.63
68_A73_G0.6580.63
152_V215_L0.6580.63
166_G184_G0.6580.63
7_T29_T0.6560.63
167_V242_F0.6500.62
145_M158_D0.6480.62
181_L211_A0.6480.62
21_Y45_V0.6480.62
136_A151_A0.6460.62
8_W196_G0.6440.61
60_F102_Y0.6430.61
57_L89_F0.6410.61
79_A141_P0.6410.61
106_R116_F0.6390.61
206_L224_G0.6380.61
8_W12_D0.6350.60
173_G193_H0.6340.60
7_T10_V0.6320.60
106_R109_A0.6290.59
24_P159_P0.6250.59
245_V250_R0.6250.59
96_R174_N0.6250.59
120_A133_A0.6240.59
50_A122_I0.6220.59
220_V226_H0.6150.58
63_E163_A0.6150.58
206_L215_L0.6140.58
83_A174_N0.6120.57
155_A246_T0.6110.57
20_V30_F0.6060.57
60_F142_L0.6060.57
105_E130_R0.6020.56
107_L152_V0.6010.56
32_D95_D0.6000.56
119_L133_A0.5950.55
100_F193_H0.5950.55
160_R208_R0.5940.55
24_P47_E0.5940.55
115_A118_Y0.5940.55
23_T47_E0.5940.55
76_L108_R0.5930.55
23_T54_R0.5920.55
145_M150_A0.5920.55
31_N89_F0.5900.55
172_V203_L0.5890.55
13_H16_A0.5890.55
157_L244_A0.5870.54
16_A39_A0.5860.54
168_L181_L0.5860.54
56_E63_E0.5850.54
233_E237_F0.5850.54
44_I231_L0.5810.54
124_P163_A0.5810.54
67_R144_V0.5770.53
72_F117_A0.5750.53
37_V42_I0.5750.53
243_V249_R0.5740.53
169_V244_A0.5740.53
238_G241_E0.5740.53
59_D155_A0.5710.52
164_R167_V0.5660.52
10_V42_I0.5650.52
170_V179_A0.5640.51
95_D147_T0.5640.51
138_R239_G0.5610.51
236_G239_G0.5600.51
18_L22_A0.5600.51
160_R218_E0.5570.51
44_I53_V0.5560.50
55_I75_D0.5550.50
59_D150_A0.5530.50
243_V246_T0.5520.50
231_L239_G0.5510.50
79_A142_L0.5490.50
107_L200_P0.5490.50
1_M5_P0.5480.49
67_R124_P0.5470.49
106_R118_Y0.5470.49
113_L149_P0.5450.49
95_D100_F0.5440.49
166_G181_L0.5430.49
100_F173_G0.5420.49
8_W178_L0.5390.48
85_Q148_G0.5350.48
72_F126_M0.5350.48
14_L53_V0.5340.48
117_A175_F0.5340.48
45_V48_L0.5330.48
166_G241_E0.5330.48
10_V249_R0.5300.47
46_S54_R0.5290.47
106_R220_V0.5280.47
67_R238_G0.5270.47
112_R187_I0.5250.47
170_V198_L0.5230.46
117_A149_P0.5230.46
210_L215_L0.5230.46
75_D78_F0.5220.46
137_P140_P0.5210.46
148_G153_L0.5200.46
64_A155_A0.5200.46
62_L69_L0.5200.46
7_T40_M0.5190.46
55_I155_A0.5180.46
122_I142_L0.5170.46
97_Q187_I0.5170.46
229_A233_E0.5160.45
133_A144_V0.5160.45
32_D174_N0.5150.45
124_P208_R0.5150.45
32_D173_G0.5140.45
72_F153_L0.5140.45
18_L34_L0.5120.45
48_L54_R0.5100.45
127_T155_A0.5100.45
13_H17_G0.5090.45
165_E168_L0.5080.44
118_Y179_A0.5060.44
85_Q181_L0.5050.44
60_F137_P0.5050.44
28_R210_L0.5050.44
73_G97_Q0.5050.44
56_E109_A0.5040.44
97_Q101_D0.5040.44
10_V28_R0.5030.44
9_A16_A0.5010.44
147_T174_N0.5000.43
107_L110_G0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ehuA 2 0.2698 67.8 0.959 Contact Map
3djcA 5 0.3413 67.1 0.959 Contact Map
2h3gX 2 0.3135 64.6 0.96 Contact Map
3nxkA 4 0.2857 42.1 0.965 Contact Map
3bexA 2 0.3373 39.7 0.965 Contact Map
3wisA 4 0.254 38.1 0.966 Contact Map
2fiqA 4 0.8214 34.4 0.966 Contact Map
2ychA 1 0.873 33.3 0.967 Contact Map
3rxyA 4 0.2937 31.2 0.967 Contact Map
3enoA 1 0.2897 29.7 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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