GREMLIN Database
GYD - GYD domain
PFAM: PF08734 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (89)
Sequences: 32912 (19161)
Seq/√Len: 2031.0
META: 0.982

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_D80_R3.2221.00
46_E77_E3.1061.00
57_D60_T3.0581.00
5_A49_V2.9241.00
35_G55_A2.3411.00
43_T50_V2.2431.00
4_L77_E2.0801.00
10_E13_K2.0781.00
4_L47_Y2.0141.00
27_K31_E1.9251.00
38_E54_E1.8751.00
36_K54_E1.8091.00
24_A27_K1.8021.00
23_R27_K1.8021.00
9_D13_K1.7321.00
3_L53_V1.7131.00
6_S75_R1.6741.00
43_T81_A1.5921.00
6_S47_Y1.5781.00
4_L79_L1.5351.00
2_L50_V1.5261.00
59_E86_E1.5201.00
83_T86_E1.4491.00
14_G17_D1.4171.00
39_A52_I1.3871.00
55_A61_A1.2991.00
35_G64_V1.2521.00
31_E36_K1.2501.00
28_A32_K1.2461.00
59_E89_K1.2211.00
29_A35_G1.1791.00
2_L81_A1.1601.00
41_Y52_I1.1471.00
26_V84_P1.1281.00
42_F87_F1.0881.00
23_R84_P1.0741.00
29_A64_V1.0711.00
17_D21_R1.0601.00
25_A64_V1.0601.00
86_E89_K1.0351.00
1_Y58_D1.0071.00
20_E24_A1.0021.00
24_A28_A0.9981.00
56_P60_T0.9821.00
84_P88_D0.9721.00
55_A64_V0.9691.00
33_L64_V0.9631.00
53_V61_A0.9351.00
22_R26_V0.9291.00
17_D20_E0.9221.00
3_L65_S0.9161.00
82_F90_A0.9141.00
12_I75_R0.9131.00
40_F51_V0.9101.00
16_K70_A0.9051.00
85_E88_D0.9021.00
62_A82_F0.8961.00
42_F84_P0.8931.00
23_R88_D0.8761.00
4_L50_V0.8731.00
7_Y49_V0.8671.00
9_D75_R0.8641.00
10_E14_G0.8641.00
47_Y77_E0.8561.00
6_S77_E0.8461.00
43_T79_L0.8431.00
55_A60_T0.8371.00
62_A66_L0.8291.00
21_R24_A0.8281.00
25_A29_A0.8181.00
44_F82_F0.8001.00
44_F80_R0.7931.00
85_E89_K0.7801.00
45_G48_D0.7801.00
7_Y15_L0.7781.00
47_Y50_V0.7771.00
50_V79_L0.7701.00
23_R26_V0.7661.00
44_F58_D0.7591.00
8_T11_G0.7581.00
40_F49_V0.7511.00
11_G15_L0.7461.00
22_R40_F0.7271.00
44_F62_A0.7261.00
28_A33_L0.7141.00
16_K19_P0.7041.00
80_R86_E0.6971.00
63_A67_A0.6951.00
38_E41_Y0.6891.00
33_L63_A0.6881.00
67_A71_S0.6831.00
18_G21_R0.6691.00
32_K67_A0.6641.00
65_S69_G0.6611.00
6_S76_T0.6611.00
10_E73_N0.6501.00
20_E88_D0.6401.00
5_A74_V0.6381.00
68_L74_V0.6311.00
19_P88_D0.6261.00
61_A78_T0.6231.00
23_R85_E0.6191.00
12_I69_G0.6141.00
21_R26_V0.6031.00
2_L41_Y0.5861.00
46_E79_L0.5851.00
42_F49_V0.5841.00
23_R40_F0.5811.00
2_L43_T0.5711.00
61_A65_S0.5701.00
26_V29_A0.5641.00
67_A70_A0.5631.00
22_R88_D0.5621.00
58_D62_A0.5611.00
27_K32_K0.5581.00
25_A68_L0.5531.00
19_P87_F0.5531.00
19_P22_R0.5451.00
4_L46_E0.5451.00
12_I66_L0.5441.00
65_S78_T0.5411.00
44_F78_T0.5371.00
14_G18_G0.5361.00
63_A90_A0.5321.00
40_F84_P0.5281.00
33_L67_A0.5271.00
16_K21_R0.5261.00
35_G53_V0.5201.00
37_L40_F0.5151.00
3_L76_T0.5141.00
38_E52_I0.5131.00
6_S46_E0.5041.00
71_S74_V0.5001.00
69_G78_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mliA 5 0.978 73.1 0.799 Contact Map
4un1A 1 0.956 70.4 0.803 Contact Map
2jsxA 1 0.9341 65.6 0.81 Contact Map
2cviA 2 0.8571 57.6 0.819 Contact Map
2djwA 6 0.8242 56.7 0.819 Contact Map
2zbcA 6 0.8352 56.2 0.82 Contact Map
4ch7A 1 0.9341 56.1 0.82 Contact Map
3znuA 5 0.9231 53.3 0.823 Contact Map
2w25A 6 0.978 49.1 0.827 Contact Map
4oi3A 2 0.8242 47.7 0.829 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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