GREMLIN Database
PriCT_2 - Primase C terminal 2 (PriCT-2)
PFAM: PF08707 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (75)
Sequences: 18428 (15508)
Seq/√Len: 1790.7
META: 0.965

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_G40_W4.0501.00
20_L24_M2.8101.00
16_Y58_K2.6821.00
19_W44_S2.0091.00
41_D50_Y1.9571.00
21_R68_I1.9351.00
41_D55_C1.9151.00
40_W55_C1.8331.00
37_L56_E1.7101.00
4_A74_F1.6911.00
17_D21_R1.6371.00
70_I74_F1.5851.00
58_K61_S1.5841.00
23_G62_F1.5721.00
13_A43_W1.5711.00
41_D56_E1.5621.00
51_D54_E1.5181.00
22_V76_L1.5041.00
24_M62_F1.4321.00
25_A68_I1.3561.00
25_A73_L1.3411.00
18_D76_L1.2501.00
15_D18_D1.2331.00
20_L58_K1.2171.00
54_E58_K1.2101.00
36_G39_L1.1851.00
27_H59_W1.1751.00
41_D45_A1.1631.00
26_L40_W1.1601.00
14_D47_S1.1591.00
16_Y20_L1.1561.00
37_L41_D1.1531.00
9_P12_R1.1411.00
21_R76_L1.1201.00
27_H63_K1.0831.00
20_L62_F1.0681.00
37_L55_C1.0641.00
56_E60_D1.0631.00
72_T75_H1.0551.00
26_L39_L1.0391.00
70_I73_L1.0361.00
45_A50_Y0.9901.00
28_N67_G0.9521.00
5_L26_L0.9431.00
3_E7_A0.9411.00
64_P67_G0.9131.00
12_R18_D0.9101.00
10_P46_K0.8951.00
41_D52_E0.8931.00
4_A7_A0.8811.00
24_M68_I0.8781.00
23_G55_C0.8761.00
8_I12_R0.8621.00
57_K61_S0.8621.00
43_W46_K0.8551.00
40_W59_W0.8511.00
68_I72_T0.8411.00
22_V43_W0.8381.00
28_N69_T0.8371.00
72_T76_L0.8371.00
71_G74_F0.8241.00
3_E6_A0.7951.00
58_K62_F0.7911.00
29_E70_I0.7831.00
28_N70_I0.7811.00
29_E32_G0.7641.00
16_Y61_S0.7271.00
50_Y55_C0.7261.00
44_S55_C0.7201.00
10_P13_A0.7191.00
6_A46_K0.7171.00
52_E56_E0.7131.00
11_D47_S0.7121.00
13_A18_D0.7051.00
14_D49_K0.7031.00
7_A77_A0.6911.00
18_D21_R0.6871.00
27_H32_G0.6701.00
6_A42_E0.6671.00
42_E45_A0.6621.00
23_G26_L0.6611.00
38_D42_E0.6551.00
55_C58_K0.6531.00
5_L43_W0.6451.00
27_H62_F0.6431.00
19_W54_E0.6411.00
51_D55_C0.6311.00
14_D18_D0.6291.00
34_G38_D0.6231.00
21_R24_M0.6221.00
17_D20_L0.6191.00
71_G75_H0.6171.00
30_F36_G0.6061.00
43_W73_L0.6001.00
54_E57_K0.5931.00
42_E46_K0.5931.00
47_S50_Y0.5901.00
73_L77_A0.5851.00
11_D14_D0.5831.00
33_S36_G0.5681.00
23_G44_S0.5501.00
13_A47_S0.5451.00
57_K60_D0.5421.00
44_S50_Y0.5281.00
30_F34_G0.5241.00
35_E56_E0.5191.00
11_D18_D0.5191.00
24_M58_K0.5071.00
24_M65_G0.5061.00
8_I22_V0.5021.00
45_A52_E0.5001.00
22_V73_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d2zB 1 0.9351 11.5 0.856 Contact Map
4m59A 2 0.7013 4.3 0.882 Contact Map
4lhfA 1 0.2857 4.2 0.883 Contact Map
4q94A 2 0.3766 3.9 0.885 Contact Map
3avxA 1 0.7013 3.6 0.886 Contact Map
3lvgA 3 0.9481 3.6 0.887 Contact Map
2a9iA 1 0.8701 3.5 0.887 Contact Map
3hlzA 1 0.9481 3.3 0.889 Contact Map
1y6zA 2 0.987 3.3 0.889 Contact Map
3kevA 1 0.3636 3.3 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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