GREMLIN Database
D5_N - D5 N terminal like
PFAM: PF08706 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 150 (147)
Sequences: 18069 (16010)
Seq/√Len: 1320.5
META: 0.93

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_K80_K3.3251.00
72_A76_K3.0701.00
72_A80_K3.0411.00
116_R122_D2.9631.00
106_G115_L2.9591.00
107_T122_D2.7191.00
99_W111_R2.6181.00
104_P131_D2.5741.00
101_L128_T2.4881.00
75_I81_L2.4001.00
143_K147_E2.2611.00
102_N124_I2.1991.00
20_K31_E2.0001.00
72_A81_L1.9931.00
65_W69_S1.9781.00
11_D120_P1.9121.00
27_T127_I1.7871.00
102_N118_H1.7401.00
138_C142_E1.7291.00
144_F148_I1.7081.00
73_S77_A1.6961.00
107_T124_I1.6891.00
25_D28_R1.6661.00
108_L113_G1.6651.00
103_V108_L1.6241.00
71_S74_R1.6211.00
25_D30_E1.6181.00
42_K85_D1.6041.00
18_W22_Y1.5971.00
109_D116_R1.5951.00
105_N131_D1.5841.00
15_V18_W1.5081.00
93_E123_Y1.5021.00
104_P127_I1.4721.00
97_D100_L1.4661.00
109_D112_T1.3941.00
140_R147_E1.3921.00
104_P129_P1.3921.00
5_A87_L1.3811.00
68_K74_R1.3731.00
13_R123_Y1.3711.00
17_E91_P1.3561.00
89_V94_L1.3421.00
100_L124_I1.3221.00
80_K83_R1.3061.00
100_L116_R1.2521.00
72_A77_A1.2491.00
142_E146_D1.2391.00
140_R143_K1.2371.00
36_A40_L1.2341.00
137_D142_E1.2341.00
102_N127_I1.2141.00
27_T118_H1.2131.00
28_R127_I1.1941.00
17_E33_D1.1891.00
103_V130_V1.1801.00
103_V128_T1.1621.00
22_Y31_E1.1351.00
89_V123_Y1.1261.00
95_D125_T1.1211.00
13_R89_V1.1081.00
89_V93_E1.1031.00
141_W144_F1.0941.00
41_A45_A1.0751.00
119_R122_D1.0741.00
140_R144_F1.0641.00
68_K71_S1.0601.00
15_V22_Y1.0561.00
34_T38_R1.0371.00
146_D149_F1.0361.00
7_L47_A1.0301.00
71_S77_A1.0221.00
90_T93_E0.9991.00
48_I51_E0.9941.00
41_A44_V0.9921.00
100_L107_T0.9871.00
35_G38_R0.9851.00
23_V32_D0.9831.00
18_W91_P0.9831.00
18_W31_E0.9831.00
22_Y94_L0.9811.00
74_R77_A0.9801.00
41_A78_M0.9531.00
55_D59_R0.9481.00
4_F82_A0.9481.00
133_D136_A0.9401.00
37_V41_A0.9401.00
60_K64_K0.9301.00
118_H127_I0.9281.00
57_K61_A0.9201.00
36_A39_R0.9151.00
56_E59_R0.8871.00
100_L109_D0.8861.00
64_K67_K0.8851.00
74_R78_M0.8821.00
11_D23_V0.8811.00
81_L85_D0.8701.00
100_L122_D0.8701.00
97_D122_D0.8651.00
79_L83_R0.8491.00
141_W145_L0.8491.00
77_A81_L0.8471.00
39_R42_K0.8461.00
107_T118_H0.8451.00
144_F147_E0.8451.00
138_C141_W0.8411.00
105_N115_L0.8401.00
17_E90_T0.8341.00
4_F12_L0.8301.00
24_W120_P0.8181.00
102_N107_T0.8141.00
27_T104_P0.8111.00
40_L45_A0.8081.00
12_L23_V0.8071.00
105_N132_Y0.8021.00
99_W109_D0.8021.00
49_A52_A0.8001.00
104_P128_T0.7891.00
94_L125_T0.7831.00
33_D90_T0.7801.00
55_D58_K0.7781.00
46_R49_A0.7711.00
35_G39_R0.7571.00
95_D126_K0.7471.00
108_L115_L0.7441.00
40_L44_V0.7421.00
34_T37_V0.7341.00
65_W68_K0.7311.00
24_W28_R0.7311.00
15_V91_P0.7311.00
90_T94_L0.7291.00
47_A51_E0.7221.00
24_W27_T0.7141.00
69_S78_M0.7131.00
101_L110_L0.7071.00
37_V44_V0.6991.00
61_A64_K0.6961.00
56_E60_K0.6931.00
38_R84_S0.6931.00
128_T131_D0.6891.00
36_A41_A0.6891.00
5_A9_G0.6861.00
37_V40_L0.6761.00
38_R76_K0.6751.00
63_L67_K0.6731.00
4_F8_Y0.6701.00
62_L65_W0.6701.00
103_V106_G0.6691.00
109_D114_E0.6681.00
97_D111_R0.6661.00
64_K68_K0.6611.00
19_G83_R0.6591.00
8_Y11_D0.6571.00
11_D40_L0.6541.00
69_S74_R0.6531.00
14_Y83_R0.6471.00
94_L123_Y0.6461.00
38_R42_K0.6461.00
42_K45_A0.6451.00
75_I84_S0.6411.00
5_A85_D0.6391.00
12_L40_L0.6371.00
23_V36_A0.6341.00
53_E58_K0.6341.00
47_A50_E0.6321.00
73_S76_K0.6311.00
21_W82_A0.6291.00
4_F78_M0.6291.00
16_P35_G0.6281.00
16_P88_A0.6281.00
45_A49_A0.6261.00
53_E59_R0.6211.00
102_N126_K0.6171.00
107_T116_R0.6071.00
65_W74_R0.6041.00
44_V47_A0.6001.00
10_D120_P0.5981.00
39_R43_E0.5971.00
81_L84_S0.5941.00
38_R75_I0.5901.00
16_P19_G0.5891.00
115_L132_Y0.5871.00
93_E96_A0.5841.00
145_L149_F0.5821.00
45_A48_I0.5791.00
101_L108_L0.5761.00
77_A80_K0.5651.00
35_G83_R0.5621.00
22_Y125_T0.5621.00
12_L87_L0.5571.00
76_K83_R0.5571.00
57_K60_K0.5571.00
143_K146_D0.5551.00
103_V131_D0.5541.00
15_V89_V0.5501.00
49_A63_L0.5481.00
103_V115_L0.5411.00
39_R86_P0.5391.00
39_R85_D0.5371.00
70_E74_R0.5361.00
53_E57_K0.5361.00
38_R41_A0.5361.00
3_R51_E0.5331.00
66_A70_E0.5301.00
104_P130_V0.5251.00
116_R119_R0.5231.00
97_D124_I0.5221.00
34_T41_A0.5201.00
59_R63_L0.5191.00
67_K70_E0.5161.00
107_T119_R0.5161.00
54_E58_K0.5141.00
60_K63_L0.5121.00
15_V94_L0.5111.00
40_L43_E0.5091.00
13_R87_L0.5081.00
8_Y12_L0.5061.00
75_I78_M0.5061.00
132_Y136_A0.5041.00
75_I79_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wujA 2 0.2133 4.6 0.924 Contact Map
1xatA 3 0.3533 3.9 0.927 Contact Map
4hurA 3 0.3467 3.3 0.93 Contact Map
3n2qA 2 0.4333 3.2 0.93 Contact Map
3ihpA 1 0.3333 2.7 0.933 Contact Map
2fa8A 3 0.22 2.6 0.933 Contact Map
3juiA 1 0.3333 2.5 0.934 Contact Map
3eevA 3 0.3533 2.1 0.936 Contact Map
1paqA 1 0.3267 2 0.937 Contact Map
4ro3A 2 0.3933 1.9 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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