GREMLIN Database
GN3L_Grn1 - GNL3L/Grn1 putative GTPase
PFAM: PF08701 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (74)
Sequences: 805 (597)
Seq/√Len: 69.4
META: 0.472

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_E15_R2.6511.00
25_P28_K2.3701.00
13_H17_L2.2321.00
4_Y7_E2.1381.00
61_E65_R2.0721.00
45_E49_K2.0551.00
41_F47_L1.9381.00
68_A72_E1.8981.00
10_V13_H1.8891.00
64_R68_A1.8451.00
39_N44_K1.8121.00
56_E60_E1.8071.00
63_E67_E1.7971.00
20_E23_K1.6460.99
40_L50_E1.6060.99
31_K40_L1.5060.99
54_K57_R1.4610.99
53_E56_E1.4300.98
64_R67_E1.4230.98
10_V14_H1.3890.98
5_K9_K1.3680.98
51_I54_K1.3640.98
47_L50_E1.3550.98
18_R21_A1.3380.98
19_K23_K1.2830.97
71_A74_A1.2630.96
61_E64_R1.2450.96
60_E64_R1.2340.96
20_E24_N1.2330.96
37_I47_L1.2160.96
7_E11_R1.2150.96
2_L6_I1.2000.95
20_E28_K1.1460.94
59_E63_E1.1360.94
68_A71_A1.1060.93
33_K36_G1.0610.91
9_K13_H1.0490.91
11_R18_R1.0480.91
9_K12_E1.0450.91
15_R18_R1.0030.89
1_R4_Y0.9960.88
55_K61_E0.9690.87
67_E71_A0.9580.86
40_L46_E0.9520.86
39_N48_L0.9340.85
66_K69_R0.9100.83
5_K12_E0.8950.82
6_I10_V0.8940.82
56_E59_E0.8850.82
53_E57_R0.8800.81
6_I13_H0.8720.81
67_E70_K0.8700.80
22_K30_K0.8700.80
17_L20_E0.8700.80
70_K73_R0.8650.80
1_R19_K0.8570.79
65_R68_A0.8530.79
52_E56_E0.8460.79
2_L5_K0.8450.79
65_R69_R0.8000.75
32_K40_L0.7960.74
58_K62_K0.7950.74
58_K61_E0.7940.74
68_A73_R0.7830.73
3_R41_F0.7620.71
69_R73_R0.7560.70
59_E71_A0.7530.70
57_R60_E0.7510.70
41_F51_I0.7500.70
3_R7_E0.7190.67
8_K15_R0.7030.65
46_E51_I0.6960.64
69_R72_E0.6950.64
49_K54_K0.6930.64
19_K39_N0.6740.62
39_N59_E0.6670.61
59_E62_K0.6620.60
37_I41_F0.6510.59
3_R37_I0.6420.58
24_N28_K0.6410.58
4_Y13_H0.6400.58
45_E68_A0.6350.57
3_R69_R0.6340.57
65_R72_E0.6210.55
31_K50_E0.6200.55
40_L47_L0.6150.55
4_Y11_R0.6120.54
68_A74_A0.6110.54
46_E49_K0.6070.54
14_H52_E0.6040.53
7_E18_R0.6040.53
8_K32_K0.6000.53
23_K28_K0.5970.52
8_K71_A0.5910.52
55_K59_E0.5860.51
3_R51_I0.5830.51
16_K47_L0.5810.50
18_R52_E0.5730.50
65_R73_R0.5700.49
5_K51_I0.5680.49
22_K70_K0.5640.48
26_K30_K0.5560.47
28_K31_K0.5540.47
21_A24_N0.5430.46
15_R42_P0.5430.46
2_L13_H0.5360.45
48_L51_I0.5310.44
15_R35_P0.5280.44
11_R51_I0.5120.42
22_K25_P0.5040.41
46_E53_E0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i1jA 3 0.3333 9.5 0.878 Contact Map
3j7yq 1 0.9733 4.9 0.893 Contact Map
1v8kA 3 0 2.6 0.907 Contact Map
1ef1C 1 0.3333 2.5 0.908 Contact Map
1utyA 2 0.1867 2.4 0.909 Contact Map
4zrjB 1 0.32 1.9 0.913 Contact Map
3fcnA 2 0.7867 1.9 0.914 Contact Map
4yhuA 1 0 1.4 0.919 Contact Map
3fyfA 2 0.3467 1.2 0.923 Contact Map
4mh6A 1 0.5333 1 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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