GREMLIN Database
Fcf2 - Fcf2 pre-rRNA processing
PFAM: PF08698 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 96 (94)
Sequences: 679 (492)
Seq/√Len: 50.8
META: 0.378

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_T74_E3.9741.00
70_L74_E3.7021.00
12_M54_Q2.7471.00
92_Y96_K2.7241.00
21_L55_V2.6191.00
35_D38_R2.3741.00
4_T11_D2.3401.00
31_R40_Y2.1771.00
92_Y95_R2.1751.00
76_K85_A2.1671.00
6_G11_D2.0341.00
6_G52_Y1.8070.99
50_P53_F1.7620.99
60_E69_R1.7530.99
26_Q30_M1.6880.98
15_P53_F1.6050.98
14_A51_K1.5900.98
17_L22_K1.5140.97
14_A52_Y1.4940.97
60_E64_E1.4850.97
17_L21_L1.4560.96
86_D92_Y1.3740.95
3_K52_Y1.3570.94
89_F93_F1.3530.94
65_F68_S1.3270.94
26_Q29_R1.3040.93
60_E75_R1.2980.93
80_V84_L1.2920.93
6_G14_A1.2140.90
60_E63_T1.2130.90
7_K11_D1.2030.90
65_F69_R1.1990.89
77_R81_E1.1640.88
86_D89_F1.1590.88
44_D47_K1.1480.87
69_R75_R1.1380.87
85_A89_F1.1370.87
4_T52_Y1.1050.85
11_D54_Q1.1020.85
36_P40_Y1.0990.85
42_K57_T1.0740.84
33_V93_F1.0640.83
70_L75_R1.0550.82
15_P21_L1.0470.82
30_M80_V1.0290.81
24_D74_E1.0180.80
27_L30_M1.0010.79
41_K57_T0.9970.79
64_E69_R0.9940.78
16_E29_R0.9930.78
4_T14_A0.9860.78
66_Y69_R0.9850.78
63_T78_T0.9790.77
61_G64_E0.9590.76
43_D47_K0.9280.74
72_K76_K0.9260.73
28_L64_E0.9240.73
30_M93_F0.9200.73
3_K16_E0.8890.70
6_G9_W0.8480.67
24_D73_K0.8440.66
30_M33_V0.8300.65
60_E78_T0.8210.64
38_R57_T0.8190.64
21_L24_D0.8110.63
24_D70_L0.7990.62
18_T53_F0.7970.62
3_K8_G0.7960.62
73_K88_E0.7910.61
24_D75_R0.7890.61
67_S75_R0.7860.61
86_D90_R0.7830.60
28_L57_T0.7820.60
24_D41_K0.7730.59
17_L30_M0.7710.59
65_F82_E0.7560.58
47_K53_F0.7500.57
21_L53_F0.7470.57
70_L73_K0.7380.56
31_R82_E0.7330.55
75_R82_E0.7320.55
70_L79_L0.7190.54
80_V88_E0.7190.54
30_M91_K0.7160.54
66_Y73_K0.7140.53
27_L80_V0.7120.53
51_K82_E0.7090.53
53_F83_L0.7070.53
87_E91_K0.7060.53
30_M76_K0.7040.52
16_E30_M0.7020.52
43_D93_F0.6990.52
36_P92_Y0.6970.52
25_L49_L0.6930.51
16_E85_A0.6860.51
18_T22_K0.6820.50
29_R44_D0.6790.50
13_P54_Q0.6780.50
67_S70_L0.6660.48
39_F57_T0.6650.48
2_K29_R0.6590.48
11_D52_Y0.6590.48
64_E67_S0.6580.48
54_Q66_Y0.6460.46
80_V93_F0.6380.46
6_G10_F0.6270.44
33_V38_R0.6200.44
15_P90_R0.6140.43
34_L94_K0.6130.43
49_L53_F0.6090.43
83_L86_D0.6090.43
23_R39_F0.6050.42
61_G72_K0.5900.41
35_D40_Y0.5880.41
34_L89_F0.5870.40
8_G14_A0.5860.40
43_D46_K0.5830.40
78_T81_E0.5820.40
8_G59_V0.5720.39
35_D59_V0.5710.39
7_K74_E0.5640.38
13_P52_Y0.5610.38
25_L72_K0.5540.37
36_P95_R0.5490.37
88_E91_K0.5460.36
16_E23_R0.5410.36
29_R43_D0.5410.36
16_E53_F0.5340.35
23_R59_V0.5280.35
46_K80_V0.5280.35
39_F44_D0.5240.34
30_M34_L0.5220.34
44_D52_Y0.5200.34
22_K49_L0.5190.34
46_K49_L0.5180.34
80_V89_F0.5130.33
74_E77_R0.5100.33
8_G17_L0.5090.33
17_L53_F0.5060.33
12_M52_Y0.5000.32
28_L84_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m4wJ 3 0.1042 7.3 0.923 Contact Map
3e56A 2 0.3125 5.4 0.927 Contact Map
2jz5A 1 0.3958 4.4 0.93 Contact Map
4tp8C 1 0.4688 3.1 0.935 Contact Map
4kiyC 1 0.4688 2.7 0.937 Contact Map
4j2gA 2 0.5417 2.5 0.939 Contact Map
4rd8A 1 0.3438 2.4 0.939 Contact Map
2mobA 1 0.0312 2 0.941 Contact Map
5aj3U 1 0.5208 2 0.941 Contact Map
4rb5C 1 0.4688 2 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0056 seconds.