GREMLIN Database
HalX - HalX domain
PFAM: PF08663 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (65)
Sequences: 1496 (1097)
Seq/√Len: 136.1
META: 0.873

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_L44_I3.3471.00
26_K31_L3.2681.00
19_R44_I2.8601.00
16_A44_I2.5441.00
11_E43_R2.4671.00
19_R41_E2.1511.00
19_R37_Y2.1241.00
21_V25_E2.0371.00
16_A20_A1.9001.00
27_S30_E1.7981.00
19_R23_E1.5921.00
8_Q51_L1.5591.00
26_K30_E1.5341.00
31_L37_Y1.5061.00
8_Q50_E1.4901.00
63_D66_A1.4801.00
23_E37_Y1.4681.00
13_F16_A1.4261.00
13_F20_A1.4071.00
12_Y44_I1.4051.00
20_A24_A1.3741.00
12_Y48_R1.3671.00
26_K34_S1.3081.00
17_S21_V1.2831.00
23_E41_E1.2261.00
8_Q54_T1.2231.00
42_E45_E1.1840.99
10_Q14_A1.0890.99
9_L13_F1.0830.99
2_R10_Q1.0110.98
3_S10_Q1.0090.98
2_R16_A0.9920.98
53_E56_D0.9910.98
64_F67_A0.9690.98
37_Y41_E0.9640.98
33_D38_Q0.9460.98
12_Y55_L0.9220.97
30_E34_S0.8910.96
45_E50_E0.8740.96
27_S34_S0.8740.96
5_Y9_L0.8720.96
43_R47_L0.8540.95
60_D63_D0.8380.95
13_F17_S0.8330.95
13_F55_L0.8130.94
16_A19_R0.7990.94
15_L43_R0.7960.93
13_F54_T0.7700.92
12_Y16_A0.7670.92
2_R17_S0.7610.92
23_E31_L0.7520.91
15_L47_L0.7350.90
62_D65_E0.7350.90
34_S38_Q0.7320.90
9_L12_Y0.7120.89
5_Y57_E0.7020.88
28_E32_E0.6960.88
5_Y21_V0.6870.87
38_Q41_E0.6860.87
46_E49_A0.6760.86
21_V44_I0.6560.85
51_L58_L0.6530.84
40_L58_L0.6520.84
10_Q26_K0.6400.83
24_A27_S0.6300.82
40_L53_E0.6280.82
22_L36_E0.6200.81
15_L19_R0.6150.81
9_L53_E0.6120.80
44_I47_L0.6090.80
12_Y17_S0.6080.80
48_R55_L0.6070.80
51_L66_A0.6000.79
53_E57_E0.5960.79
62_D67_A0.5930.78
42_E46_E0.5880.78
14_A52_D0.5790.77
46_E50_E0.5780.76
43_R46_E0.5770.76
16_A48_R0.5740.76
6_D57_E0.5730.76
32_E49_A0.5650.75
7_E59_D0.5620.74
42_E59_D0.5590.74
17_S48_R0.5570.74
55_L66_A0.5550.74
17_S24_A0.5550.74
17_S20_A0.5360.71
33_D39_E0.5310.70
47_L51_L0.5310.70
29_A67_A0.5240.69
58_L65_E0.5200.69
22_L30_E0.5200.69
24_A51_L0.5150.68
39_E46_E0.5110.67
45_E60_D0.5100.67
4_E66_A0.5030.66
3_S28_E0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iffA 2 0.7391 10.6 0.837 Contact Map
2cazB 1 0.971 6.8 0.851 Contact Map
1rq0A 3 0.7826 6.2 0.853 Contact Map
4ohfA 3 0.9565 6.2 0.853 Contact Map
4c91A 2 0.9275 5.2 0.859 Contact Map
1go4E 4 0.6377 4.9 0.859 Contact Map
3ghgA 2 0.8551 4.8 0.86 Contact Map
3tnuB 1 1 4.7 0.861 Contact Map
2p22B 2 0.7391 4.7 0.861 Contact Map
2lw1A 1 0.9565 4.5 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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