GREMLIN Database
DUF1777 - Protein of unknown function (DUF1777)
PFAM: PF08648 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (167)
Sequences: 596 (547)
Seq/√Len: 42.3
META: 0.141

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_N147_G4.3691.00
123_E126_K3.6271.00
141_V144_N3.3041.00
155_R164_K2.7251.00
46_D49_R2.7231.00
134_D139_K2.6211.00
160_Y163_R2.5251.00
135_T138_G2.4611.00
138_G148_G2.2671.00
19_R22_D2.1981.00
136_T141_V2.1641.00
152_E155_R1.9990.99
140_K157_Y1.9530.99
67_S70_R1.9520.99
152_E156_K1.9150.99
150_R156_K1.8760.99
13_D16_R1.8150.98
147_G153_K1.8150.98
9_D12_R1.7980.98
144_N153_K1.7790.98
149_V154_K1.7660.98
130_F164_K1.7510.98
142_P147_G1.6960.97
152_E157_Y1.6670.97
168_N171_L1.6610.97
167_F171_L1.6390.97
130_F157_Y1.6050.96
12_R15_R1.5960.96
16_R19_R1.5940.96
140_K143_G1.5790.96
56_R62_R1.5780.96
8_R11_R1.5510.95
156_K164_K1.5300.95
11_R14_R1.5270.95
121_E125_M1.5180.95
122_A153_K1.5070.95
130_F153_K1.4790.94
166_G171_L1.4770.94
132_G147_G1.4760.94
145_D152_E1.4110.92
140_K164_K1.3970.92
66_R69_R1.3880.92
154_K157_Y1.3660.91
13_D19_R1.3510.91
64_R67_S1.3210.90
37_R40_D1.3150.89
14_R18_R1.2970.89
166_G169_R1.2920.89
10_R16_R1.2780.88
45_R48_S1.2690.88
75_R78_P1.2540.87
17_D20_D1.2430.87
72_R75_R1.2400.86
77_R80_R1.2350.86
144_N157_Y1.2050.85
150_R164_K1.2020.85
151_K164_K1.1870.84
153_K157_Y1.1850.84
15_R18_R1.1830.84
151_K156_K1.1820.84
13_D18_R1.1820.84
126_K134_D1.1620.83
122_A144_N1.1530.82
146_V152_E1.1450.82
127_M132_G1.1410.81
48_S51_R1.1140.80
125_M141_V1.1110.80
126_K132_G1.1020.79
142_P150_R1.1000.79
140_K153_K1.0910.78
109_E112_E1.0800.78
14_R17_D1.0780.77
138_G155_R1.0740.77
140_K147_G1.0570.76
10_R18_R1.0460.75
27_D30_R1.0410.75
121_E155_R1.0400.75
145_D154_K1.0340.74
163_R171_L1.0320.74
163_R168_N1.0290.74
159_Q162_N1.0200.73
134_D147_G1.0090.73
163_R167_F1.0040.72
48_S53_D1.0020.72
107_E110_E0.9930.71
111_E114_L0.9870.71
151_K154_K0.9830.71
75_R79_R0.9720.70
62_R65_R0.9700.70
105_K110_E0.9700.70
10_R13_D0.9690.70
9_D13_D0.9680.69
110_E113_D0.9630.69
160_Y171_L0.9630.69
151_K157_Y0.9550.68
144_N152_E0.9540.68
61_S71_R0.9540.68
122_A125_M0.9520.68
25_D30_R0.9490.68
43_R46_D0.9480.68
160_Y168_N0.9450.68
160_Y167_F0.9190.65
36_R40_D0.9180.65
150_R154_K0.9180.65
25_D29_D0.9150.65
122_A134_D0.9120.65
82_S85_P0.9100.65
141_V152_E0.9070.64
151_K155_R0.9060.64
120_E143_G0.9000.64
121_E126_K0.8950.63
131_G153_K0.8910.63
12_R19_R0.8860.63
34_R37_R0.8840.62
123_E156_K0.8770.62
19_R23_R0.8760.62
166_G170_P0.8750.62
146_V150_R0.8690.61
167_F170_P0.8670.61
124_M134_D0.8670.61
105_K108_D0.8650.61
50_R135_T0.8620.60
31_D38_R0.8550.60
89_R93_R0.8510.59
122_A131_G0.8490.59
60_R68_R0.8420.59
152_E164_K0.8340.58
6_D9_D0.8320.58
37_R45_R0.8300.57
165_G168_N0.8280.57
120_E127_M0.8220.57
132_G136_T0.8220.57
150_R157_Y0.8190.56
114_L117_D0.8180.56
22_D135_T0.8110.56
19_R24_R0.8100.56
122_A126_K0.8020.55
163_R169_R0.8020.55
134_D153_K0.7990.55
65_R68_R0.7980.54
25_D40_D0.7950.54
165_G171_L0.7810.53
137_K144_N0.7800.53
12_R17_D0.7760.52
59_D62_R0.7710.52
144_N151_K0.7670.52
5_R8_R0.7620.51
12_R16_R0.7590.51
125_M136_T0.7590.51
163_R166_G0.7560.51
158_R161_M0.7560.51
160_Y169_R0.7500.50
160_Y165_G0.7450.49
143_G153_K0.7400.49
137_K143_G0.7390.49
119_D123_E0.7330.48
146_V154_K0.7310.48
138_G153_K0.7300.48
38_R48_S0.7290.48
40_D48_S0.7240.48
83_R87_R0.7230.47
38_R43_R0.7210.47
150_R155_R0.7080.46
122_A130_F0.7070.46
97_K101_D0.7020.45
130_F152_E0.7010.45
11_R17_D0.7010.45
139_K147_G0.7010.45
122_A127_M0.6970.45
165_G169_R0.6920.45
81_R84_S0.6910.44
78_P83_R0.6860.44
59_D66_R0.6840.44
121_E134_D0.6820.44
80_R83_R0.6820.44
96_S99_K0.6780.43
109_E114_L0.6750.43
84_S87_R0.6720.43
130_F140_K0.6710.43
158_R163_R0.6710.43
27_D32_R0.6690.42
87_R90_S0.6580.41
120_E123_E0.6560.41
92_S95_D0.6540.41
123_E127_M0.6490.41
6_D10_R0.6430.40
30_R34_R0.6400.40
32_R44_S0.6390.40
144_N150_R0.6380.40
12_R18_R0.6310.39
160_Y166_G0.6300.39
113_D116_G0.6240.38
140_K144_N0.6230.38
8_R15_R0.6220.38
145_D157_Y0.6220.38
85_P93_R0.6170.38
78_P81_R0.6160.38
89_R92_S0.6140.37
127_M134_D0.6130.37
125_M151_K0.6110.37
131_G147_G0.6090.37
74_S77_R0.6090.37
91_R99_K0.6040.37
134_D152_E0.6030.36
100_K105_K0.5980.36
142_P155_R0.5960.36
143_G155_R0.5950.36
146_V157_Y0.5950.36
81_R85_P0.5930.36
126_K147_G0.5900.35
128_M131_G0.5870.35
23_R30_R0.5870.35
132_G144_N0.5860.35
95_D102_S0.5850.35
145_D148_G0.5840.35
39_R42_S0.5810.35
35_R38_R0.5790.34
43_R71_R0.5780.34
127_M131_G0.5760.34
161_M166_G0.5700.34
159_Q167_F0.5630.33
73_R78_P0.5630.33
126_K153_K0.5620.33
128_M132_G0.5600.33
40_D44_S0.5580.33
140_K155_R0.5500.32
36_R39_R0.5490.32
110_E114_L0.5480.32
116_G122_A0.5480.32
159_Q163_R0.5480.32
15_R20_D0.5410.31
116_G125_M0.5360.31
158_R166_G0.5330.31
122_A164_K0.5290.30
132_G137_K0.5260.30
100_K104_A0.5260.30
153_K164_K0.5250.30
29_D32_R0.5240.30
157_Y164_K0.5220.30
27_D35_R0.5210.30
63_R70_R0.5200.30
63_R67_S0.5170.29
134_D138_G0.5140.29
141_V153_K0.5140.29
150_R153_K0.5090.29
147_G150_R0.5080.29
36_R64_R0.5070.29
22_D27_D0.5050.28
125_M134_D0.5020.28
104_A107_E0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgwS 1 0 51.9 0.918 Contact Map
3sv0A 1 0.3333 8.7 0.944 Contact Map
3vn9A 1 0.345 7.9 0.945 Contact Map
3e3pA 2 0.3158 6.2 0.948 Contact Map
4u6rA 1 0.345 5.8 0.948 Contact Map
2r5tA 2 0.3392 5.8 0.948 Contact Map
4oo6B 1 0.0468 5.6 0.949 Contact Map
2wjvD 1 0.1579 5.3 0.949 Contact Map
3warA 1 0.5088 5 0.95 Contact Map
4x7qB 1 0.2924 4.6 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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