GREMLIN Database
U3_assoc_6 - U3 small nucleolar RNA-associated protein 6
PFAM: PF08640 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (78)
Sequences: 658 (487)
Seq/√Len: 55.2
META: 0.365

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_E60_R3.3891.00
12_E19_K3.2421.00
17_F25_I3.1381.00
12_E22_I2.9181.00
32_F49_Y2.8111.00
29_R53_E2.7181.00
36_L49_Y2.5631.00
21_E63_R2.1871.00
59_L63_R2.1471.00
10_D14_K2.0301.00
2_E7_E1.9791.00
17_F60_R1.9281.00
34_Y37_Q1.6740.99
62_K66_R1.5980.98
22_I26_V1.5510.98
51_E55_N1.5410.98
25_I56_L1.5410.98
17_F22_I1.5410.98
9_E12_E1.5210.98
24_A55_N1.3950.96
43_K47_L1.3160.95
35_R64_R1.3130.95
1_L4_M1.2980.94
31_D35_R1.2890.94
72_K75_I1.2850.94
38_R45_D1.2660.93
14_K60_R1.2560.93
20_D23_K1.2530.93
7_E29_R1.2340.92
4_M34_Y1.2310.92
53_E56_L1.1080.88
25_I52_Y1.1070.88
30_R40_G1.0800.86
7_E52_Y1.0780.86
10_D76_S1.0680.86
30_R34_Y1.0570.85
28_K32_F1.0210.83
1_L36_L0.9780.80
42_K45_D0.9670.80
4_M8_L0.9510.78
50_I77_D0.9410.78
7_E53_E0.9330.77
9_E13_R0.8950.74
38_R43_K0.8470.70
73_K76_S0.8450.70
48_R54_M0.8420.69
74_S77_D0.8400.69
39_R63_R0.8300.68
71_K74_S0.8100.66
48_R51_E0.8100.66
49_Y59_L0.8060.66
41_A54_M0.7940.65
55_N68_G0.7940.65
4_M29_R0.7940.65
38_R46_F0.7870.64
5_V9_E0.7710.63
27_K40_G0.7700.62
11_L28_K0.7600.61
4_M23_K0.7420.60
8_L26_V0.7270.58
8_L43_K0.7210.57
8_L53_E0.7200.57
37_Q41_A0.7170.57
75_I78_Y0.7140.57
51_E54_M0.7110.56
24_A62_K0.6960.55
1_L30_R0.6950.55
30_R38_R0.6950.55
7_E49_Y0.6890.54
14_K57_E0.6800.53
59_L66_R0.6800.53
21_E59_L0.6800.53
10_D57_E0.6770.53
6_P23_K0.6670.52
57_E61_K0.6590.51
5_V34_Y0.6510.50
23_K37_Q0.6480.50
49_Y63_R0.6460.49
61_K67_L0.6320.48
27_K31_D0.6200.47
10_D74_S0.6170.46
3_Q20_D0.6150.46
8_L56_L0.6140.46
13_R18_T0.6030.45
41_A46_F0.6020.45
15_G61_K0.5920.44
3_Q34_Y0.5920.44
62_K69_I0.5910.43
21_E33_E0.5900.43
20_D68_G0.5810.42
23_K43_K0.5780.42
41_A64_R0.5760.42
74_S78_Y0.5680.41
9_E54_M0.5670.41
16_L20_D0.5670.41
13_R27_K0.5670.41
2_E64_R0.5620.40
24_A28_K0.5490.39
5_V41_A0.5480.39
9_E41_A0.5460.39
42_K47_L0.5460.39
15_G75_I0.5430.38
28_K31_D0.5410.38
10_D16_L0.5310.37
20_D67_L0.5300.37
13_R23_K0.5300.37
5_V28_K0.5290.37
49_Y56_L0.5270.37
18_T58_K0.5260.37
47_L50_I0.5250.37
65_K71_K0.5170.36
39_R53_E0.5100.35
30_R65_K0.5100.35
28_K45_D0.5020.34
15_G67_L0.5010.34
54_M69_I0.5000.34
73_K77_D0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o51A 3 0.3133 18.8 0.872 Contact Map
3ng0A 5 0.6265 10.9 0.885 Contact Map
1wpbA 6 0.3373 8.6 0.89 Contact Map
1g6uA 3 0.5663 8.4 0.89 Contact Map
3crdA 1 0.8916 6.7 0.895 Contact Map
2p1hA 1 0.7711 6.5 0.895 Contact Map
3hr0A 2 0.494 5.9 0.898 Contact Map
4jupA 2 0.6988 5.7 0.898 Contact Map
2lpeA 1 0.6024 5.6 0.899 Contact Map
2ewvA 3 0.4217 5.5 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0046 seconds.