Nexin_C - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Nexin_C - Sorting nexin C terminal

PFAM:	PF08628	Sequences: WLRRRALAAAKQVLQQLLGGTIERKLRESVKWLTSEESLASYIRLLRDSLWPAEPSPPRTEEEKERTRKEARKLLLTLIPDALVSVVGRANAREGARRVFDMLQNPR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	107 (106)
Sequences:	955 (564)
Seq/√Len:	54.8
META:	0.238

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
60_T	63_E	3.408	1.00
66_R	70_E	3.199	1.00
59_R	67_T	3.027	1.00
59_R	64_K	2.875	1.00
19_G	23_E	2.555	1.00
13_V	17_L	2.202	1.00
11_K	15_Q	2.133	1.00
44_R	47_R	1.932	1.00
32_W	103_L	1.915	1.00
54_E	57_P	1.842	0.99
71_A	100_F	1.821	0.99
61_E	65_E	1.812	0.99
20_G	23_E	1.796	0.99
6_A	13_V	1.741	0.99
53_A	56_S	1.710	0.99
82_A	87_V	1.702	0.99
36_E	40_A	1.695	0.99
33_L	38_S	1.680	0.99
18_L	23_E	1.657	0.99
87_V	92_A	1.656	0.99
38_S	42_Y	1.650	0.99
13_V	86_V	1.589	0.98
6_A	15_Q	1.557	0.98
55_P	99_V	1.544	0.98
46_L	50_L	1.526	0.98
49_S	100_F	1.510	0.98
1_W	14_L	1.479	0.97
97_R	101_D	1.477	0.97
26_L	63_E	1.477	0.97
75_L	89_R	1.470	0.97
14_L	17_L	1.404	0.96
45_L	99_V	1.372	0.96
46_L	57_P	1.333	0.95
63_E	66_R	1.266	0.93
62_E	99_V	1.248	0.93
54_E	58_P	1.246	0.93
48_D	65_E	1.225	0.92
35_S	38_S	1.220	0.92
60_T	66_R	1.210	0.92
70_E	74_L	1.198	0.91
48_D	51_W	1.182	0.91
38_S	84_V	1.175	0.90
7_L	15_Q	1.144	0.89
57_P	63_E	1.132	0.89
99_V	102_M	1.125	0.88
74_L	95_G	1.106	0.87
4_R	12_Q	1.097	0.87
66_R	77_T	1.060	0.85
20_G	36_E	1.036	0.84
80_P	85_S	1.031	0.83
69_K	72_R	1.013	0.82
100_F	104_Q	0.998	0.81
57_P	77_T	0.969	0.79
32_W	68_R	0.967	0.79
58_P	62_E	0.953	0.78
72_R	97_R	0.947	0.78
76_L	84_V	0.940	0.77
6_A	47_R	0.925	0.76
66_R	69_K	0.921	0.76
49_S	53_A	0.912	0.75
15_Q	19_G	0.905	0.75
24_R	42_Y	0.900	0.74
76_L	105_N	0.899	0.74
19_G	67_T	0.893	0.74
51_W	55_P	0.890	0.73
74_L	104_Q	0.888	0.73
5_R	89_R	0.885	0.73
10_A	19_G	0.880	0.72
13_V	87_V	0.872	0.72
58_P	103_L	0.862	0.71
92_A	98_R	0.858	0.71
26_L	57_P	0.845	0.69
45_L	103_L	0.838	0.69
101_D	104_Q	0.832	0.68
3_R	21_T	0.828	0.68
39_L	43_I	0.823	0.67
38_S	41_S	0.821	0.67
80_P	83_L	0.819	0.67
95_G	100_F	0.816	0.67
15_Q	50_L	0.814	0.66
23_E	95_G	0.812	0.66
86_V	102_M	0.792	0.64
29_S	33_L	0.784	0.64
45_L	58_P	0.784	0.64
16_Q	21_T	0.782	0.63
40_A	46_L	0.779	0.63
71_A	74_L	0.776	0.63
35_S	40_A	0.775	0.63
23_E	27_R	0.767	0.62
11_K	16_Q	0.764	0.62
29_S	105_N	0.751	0.60
5_R	16_Q	0.742	0.59
14_L	34_T	0.742	0.59
6_A	14_L	0.740	0.59
16_Q	23_E	0.734	0.58
68_R	72_R	0.729	0.58
84_V	97_R	0.728	0.58
95_G	104_Q	0.721	0.57
92_A	97_R	0.720	0.57
35_S	90_A	0.718	0.57
57_P	60_T	0.713	0.56
72_R	84_V	0.707	0.56
34_T	106_P	0.700	0.55
44_R	48_D	0.698	0.55
14_L	21_T	0.696	0.54
100_F	103_L	0.691	0.54
52_P	55_P	0.688	0.54
30_V	44_R	0.678	0.53
20_G	85_S	0.677	0.52
62_E	73_K	0.675	0.52
33_L	103_L	0.674	0.52
55_P	58_P	0.674	0.52
86_V	94_E	0.673	0.52
68_R	77_T	0.670	0.52
43_I	48_D	0.668	0.51
30_V	71_A	0.668	0.51
57_P	106_P	0.653	0.50
66_R	79_I	0.652	0.50
26_L	41_S	0.649	0.49
6_A	11_K	0.649	0.49
48_D	61_E	0.638	0.48
65_E	69_K	0.635	0.48
22_I	102_M	0.627	0.47
63_E	91_N	0.626	0.47
19_G	24_R	0.623	0.47
26_L	34_T	0.621	0.46
15_Q	21_T	0.620	0.46
10_A	17_L	0.608	0.45
48_D	67_T	0.607	0.45
4_R	68_R	0.604	0.45
65_E	68_R	0.604	0.45
20_G	87_V	0.598	0.44
16_Q	19_G	0.592	0.43
20_G	89_R	0.590	0.43
36_E	86_V	0.587	0.43
33_L	50_L	0.581	0.42
20_G	99_V	0.581	0.42
12_Q	77_T	0.581	0.42
7_L	85_S	0.576	0.42
87_V	94_E	0.570	0.41
92_A	95_G	0.561	0.40
60_T	64_K	0.556	0.40
4_R	16_Q	0.556	0.40
27_R	105_N	0.551	0.39
72_R	100_F	0.550	0.39
66_R	76_L	0.547	0.39
78_L	101_D	0.544	0.38
80_P	97_R	0.541	0.38
12_Q	20_G	0.541	0.38
59_R	81_D	0.529	0.37
74_L	98_R	0.527	0.37
64_K	76_L	0.521	0.36
62_E	69_K	0.517	0.36
5_R	12_Q	0.513	0.35
72_R	76_L	0.510	0.35
13_V	51_W	0.507	0.35
22_I	71_A	0.503	0.34
41_S	77_T	0.501	0.34
43_I	70_E	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j6bA	2	0.5794	14.5	0.894	Contact Map
4ww0A	4	0.3645	10.5	0.901	Contact Map
4npsA	1	0.4019	8	0.906	Contact Map
1jzpA	1	0.1869	6	0.911	Contact Map
3ag7A	1	0.8598	6	0.911	Contact Map
2zu6B	1	0.785	5.8	0.912	Contact Map
2ekgA	2	0.9626	5.5	0.913	Contact Map
2ixnA	1	0.9252	4.9	0.915	Contact Map
3q1xA	3	0.9346	4.3	0.917	Contact Map
2xxaA	1	0.8037	4.2	0.917	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0053 seconds.