GREMLIN Database
Nexin_C - Sorting nexin C terminal
PFAM: PF08628 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (106)
Sequences: 955 (564)
Seq/√Len: 54.8
META: 0.238

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_T63_E3.4081.00
66_R70_E3.1991.00
59_R67_T3.0271.00
59_R64_K2.8751.00
19_G23_E2.5551.00
13_V17_L2.2021.00
11_K15_Q2.1331.00
44_R47_R1.9321.00
32_W103_L1.9151.00
54_E57_P1.8420.99
71_A100_F1.8210.99
61_E65_E1.8120.99
20_G23_E1.7960.99
6_A13_V1.7410.99
53_A56_S1.7100.99
82_A87_V1.7020.99
36_E40_A1.6950.99
33_L38_S1.6800.99
18_L23_E1.6570.99
87_V92_A1.6560.99
38_S42_Y1.6500.99
13_V86_V1.5890.98
6_A15_Q1.5570.98
55_P99_V1.5440.98
46_L50_L1.5260.98
49_S100_F1.5100.98
1_W14_L1.4790.97
97_R101_D1.4770.97
26_L63_E1.4770.97
75_L89_R1.4700.97
14_L17_L1.4040.96
45_L99_V1.3720.96
46_L57_P1.3330.95
63_E66_R1.2660.93
62_E99_V1.2480.93
54_E58_P1.2460.93
48_D65_E1.2250.92
35_S38_S1.2200.92
60_T66_R1.2100.92
70_E74_L1.1980.91
48_D51_W1.1820.91
38_S84_V1.1750.90
7_L15_Q1.1440.89
57_P63_E1.1320.89
99_V102_M1.1250.88
74_L95_G1.1060.87
4_R12_Q1.0970.87
66_R77_T1.0600.85
20_G36_E1.0360.84
80_P85_S1.0310.83
69_K72_R1.0130.82
100_F104_Q0.9980.81
57_P77_T0.9690.79
32_W68_R0.9670.79
58_P62_E0.9530.78
72_R97_R0.9470.78
76_L84_V0.9400.77
6_A47_R0.9250.76
66_R69_K0.9210.76
49_S53_A0.9120.75
15_Q19_G0.9050.75
24_R42_Y0.9000.74
76_L105_N0.8990.74
19_G67_T0.8930.74
51_W55_P0.8900.73
74_L104_Q0.8880.73
5_R89_R0.8850.73
10_A19_G0.8800.72
13_V87_V0.8720.72
58_P103_L0.8620.71
92_A98_R0.8580.71
26_L57_P0.8450.69
45_L103_L0.8380.69
101_D104_Q0.8320.68
3_R21_T0.8280.68
39_L43_I0.8230.67
38_S41_S0.8210.67
80_P83_L0.8190.67
95_G100_F0.8160.67
15_Q50_L0.8140.66
23_E95_G0.8120.66
86_V102_M0.7920.64
29_S33_L0.7840.64
45_L58_P0.7840.64
16_Q21_T0.7820.63
40_A46_L0.7790.63
71_A74_L0.7760.63
35_S40_A0.7750.63
23_E27_R0.7670.62
11_K16_Q0.7640.62
29_S105_N0.7510.60
5_R16_Q0.7420.59
14_L34_T0.7420.59
6_A14_L0.7400.59
16_Q23_E0.7340.58
68_R72_R0.7290.58
84_V97_R0.7280.58
95_G104_Q0.7210.57
92_A97_R0.7200.57
35_S90_A0.7180.57
57_P60_T0.7130.56
72_R84_V0.7070.56
34_T106_P0.7000.55
44_R48_D0.6980.55
14_L21_T0.6960.54
100_F103_L0.6910.54
52_P55_P0.6880.54
30_V44_R0.6780.53
20_G85_S0.6770.52
62_E73_K0.6750.52
33_L103_L0.6740.52
55_P58_P0.6740.52
86_V94_E0.6730.52
68_R77_T0.6700.52
43_I48_D0.6680.51
30_V71_A0.6680.51
57_P106_P0.6530.50
66_R79_I0.6520.50
26_L41_S0.6490.49
6_A11_K0.6490.49
48_D61_E0.6380.48
65_E69_K0.6350.48
22_I102_M0.6270.47
63_E91_N0.6260.47
19_G24_R0.6230.47
26_L34_T0.6210.46
15_Q21_T0.6200.46
10_A17_L0.6080.45
48_D67_T0.6070.45
4_R68_R0.6040.45
65_E68_R0.6040.45
20_G87_V0.5980.44
16_Q19_G0.5920.43
20_G89_R0.5900.43
36_E86_V0.5870.43
33_L50_L0.5810.42
20_G99_V0.5810.42
12_Q77_T0.5810.42
7_L85_S0.5760.42
87_V94_E0.5700.41
92_A95_G0.5610.40
60_T64_K0.5560.40
4_R16_Q0.5560.40
27_R105_N0.5510.39
72_R100_F0.5500.39
66_R76_L0.5470.39
78_L101_D0.5440.38
80_P97_R0.5410.38
12_Q20_G0.5410.38
59_R81_D0.5290.37
74_L98_R0.5270.37
64_K76_L0.5210.36
62_E69_K0.5170.36
5_R12_Q0.5130.35
72_R76_L0.5100.35
13_V51_W0.5070.35
22_I71_A0.5030.34
41_S77_T0.5010.34
43_I70_E0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j6bA 2 0.5794 14.5 0.894 Contact Map
4ww0A 4 0.3645 10.5 0.901 Contact Map
4npsA 1 0.4019 8 0.906 Contact Map
1jzpA 1 0.1869 6 0.911 Contact Map
3ag7A 1 0.8598 6 0.911 Contact Map
2zu6B 1 0.785 5.8 0.912 Contact Map
2ekgA 2 0.9626 5.5 0.913 Contact Map
2ixnA 1 0.9252 4.9 0.915 Contact Map
3q1xA 3 0.9346 4.3 0.917 Contact Map
2xxaA 1 0.8037 4.2 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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