GREMLIN Database
Prp19 - Prp19/Pso4-like
PFAM: PF08606 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (66)
Sequences: 599 (371)
Seq/√Len: 45.7
META: 0.618

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_L33_T4.3591.00
44_H48_C3.2901.00
58_R61_A2.9561.00
39_H43_Q2.5151.00
22_E27_R2.4361.00
2_A11_T2.3331.00
10_S14_N1.9620.99
8_L11_T1.9570.99
51_I54_L1.9450.99
43_Q48_C1.8730.99
58_R62_R1.7320.98
24_F28_Q1.5330.96
64_A67_N1.4770.95
23_T26_L1.4230.94
63_E67_N1.4100.94
59_D63_E1.3430.92
25_T28_Q1.3080.91
62_R66_A1.2580.89
20_M48_C1.2170.88
8_L12_F1.2160.87
46_A50_V1.2140.87
60_E64_A1.2010.87
4_S13_Q1.1410.84
13_Q27_R1.0900.81
31_E48_C1.0590.79
29_Q56_K1.0290.77
31_E55_I1.0260.77
8_L52_A0.9990.75
19_L25_T0.9910.74
36_E64_A0.9800.73
31_E35_Q0.9720.73
34_R49_R0.9610.72
59_D62_R0.9500.71
43_Q51_I0.9450.71
31_E45_D0.9430.71
3_T66_A0.9400.70
4_S45_D0.9350.70
49_R52_A0.9180.68
17_D21_L0.9070.68
25_T29_Q0.8980.67
14_N36_E0.8880.66
63_E66_A0.8540.63
2_A19_L0.8310.61
39_H48_C0.8250.60
23_T34_R0.8170.59
5_I56_K0.8140.59
21_L45_D0.7970.57
26_L55_I0.7930.57
6_P39_H0.7920.57
12_F30_L0.7870.57
10_S44_H0.7840.56
16_W51_I0.7800.56
17_D20_M0.7780.56
11_T14_N0.7710.55
30_L60_E0.7690.55
3_T7_G0.7670.55
25_T32_T0.7670.55
3_T47_A0.7670.55
48_C55_I0.7410.52
28_Q35_Q0.7390.52
32_T67_N0.7350.51
24_F34_R0.7330.51
12_F16_W0.7300.51
18_A56_K0.7270.51
16_W24_F0.7260.51
5_I12_F0.7220.50
30_L43_Q0.7160.50
20_M27_R0.7080.49
5_I29_Q0.7050.49
5_I9_L0.6810.46
21_L65_L0.6700.45
18_A39_H0.6660.45
4_S42_Y0.6440.43
14_N28_Q0.6250.41
55_I58_R0.6130.40
4_S14_N0.6080.39
10_S63_E0.6080.39
15_E57_E0.5970.38
55_I59_D0.5950.38
54_L57_E0.5850.37
23_T27_R0.5800.37
49_R54_L0.5730.36
5_I17_D0.5710.36
23_T52_A0.5650.35
2_A63_E0.5570.35
9_L65_L0.5540.34
16_W20_M0.5380.33
60_E63_E0.5280.32
19_L23_T0.5270.32
14_N38_S0.5220.31
26_L32_T0.5220.31
25_T57_E0.5170.31
36_E43_Q0.5150.31
33_T40_A0.5110.31
38_S47_A0.5090.30
45_D49_R0.5050.30
46_A53_R0.5050.30
42_Y45_D0.5020.30
40_A59_D0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hnwA 2 1 55.3 0.862 Contact Map
1ciiA 1 1 49.1 0.867 Contact Map
4q4gX 1 0 47 0.868 Contact Map
3vkgA 2 0.8971 40 0.874 Contact Map
4rh7A 1 0.8971 32.9 0.88 Contact Map
1i84S 2 0 30.8 0.881 Contact Map
4cgkA 3 0.6618 30.6 0.881 Contact Map
4l0rA 2 0.9412 26.8 0.885 Contact Map
2lf0A 1 0.7647 25.6 0.886 Contact Map
2lw1A 1 0.9706 25.1 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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