GREMLIN Database
DUF1772 - Domain of unknown function (DUF1772)
PFAM: PF08592 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 137 (129)
Sequences: 13554 (10559)
Seq/√Len: 929.7
META: 0.826

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_V90_N3.4491.00
84_V119_L2.6531.00
17_L21_A2.4881.00
109_A112_L2.4381.00
4_F8_V2.3611.00
25_L29_Q2.0951.00
18_P21_A2.0061.00
88_L115_R1.9631.00
5_A9_V1.9521.00
37_A41_P1.9351.00
36_A39_F1.9121.00
42_L45_G1.9011.00
63_A66_L1.7881.00
7_S121_A1.7631.00
28_F32_Y1.7471.00
105_A109_A1.7361.00
25_L28_F1.7241.00
77_V127_S1.6971.00
36_A40_P1.6691.00
24_L29_Q1.6681.00
43_A46_S1.6641.00
105_A108_E1.6411.00
4_F124_T1.6401.00
108_E112_L1.6091.00
2_A5_A1.5791.00
30_P33_R1.5661.00
80_V85_N1.5631.00
80_V122_V1.5601.00
108_E111_A1.5561.00
131_F135_L1.5481.00
95_A109_A1.5201.00
109_A113_L1.5081.00
115_R118_R1.5061.00
2_A9_V1.5031.00
85_N119_L1.4911.00
29_Q32_Y1.4761.00
42_L46_S1.4751.00
24_L28_F1.4371.00
79_P83_L1.4141.00
26_P30_P1.4131.00
107_A110_R1.3981.00
26_P29_Q1.3681.00
106_A109_A1.3541.00
60_P63_A1.2661.00
110_R113_L1.2421.00
76_G126_L1.2411.00
6_F9_V1.2291.00
82_L86_V1.2291.00
32_Y35_G1.2231.00
10_V14_L1.2091.00
33_R93_A1.1861.00
91_R108_E1.1721.00
110_R114_E1.1631.00
27_Q31_S1.1461.00
5_A10_V1.1441.00
42_L47_L1.1381.00
103_D106_A1.1301.00
46_S50_G1.1251.00
42_L50_G1.1231.00
107_A111_A1.0991.00
37_A40_P1.0911.00
73_L76_G1.0831.00
43_A50_G1.0751.00
132_A136_W1.0711.00
29_Q33_R1.0651.00
19_D110_R1.0551.00
84_V88_L1.0541.00
28_F31_S1.0301.00
36_A41_P1.0011.00
61_G64_W0.9991.00
105_A112_L0.9951.00
92_L95_A0.9931.00
62_A65_L0.9791.00
60_P65_L0.9781.00
24_L27_Q0.9701.00
57_W61_G0.9641.00
47_L50_G0.9621.00
111_A114_E0.9541.00
43_A47_L0.9521.00
46_S49_A0.9471.00
91_R112_L0.9431.00
78_V82_L0.9431.00
105_A110_R0.9291.00
89_N116_W0.9281.00
42_L49_A0.9251.00
42_L48_L0.9231.00
77_V126_L0.9211.00
25_L32_Y0.9121.00
45_G50_G0.9091.00
81_T85_N0.8941.00
117_G121_A0.8851.00
59_G62_A0.8791.00
118_R121_A0.8701.00
47_L75_L0.8641.00
90_N93_A0.8591.00
7_S124_T0.8511.00
106_A110_R0.8501.00
43_A49_A0.8381.00
38_M41_P0.8331.00
33_R36_A0.8331.00
59_G63_A0.8131.00
121_A125_V0.7921.00
12_P16_R0.7911.00
27_Q32_Y0.7891.00
44_L48_L0.7841.00
81_T123_R0.7831.00
77_V80_V0.7811.00
41_P45_G0.7791.00
115_R119_L0.7701.00
105_A113_L0.7701.00
44_L50_G0.7671.00
58_W62_A0.7641.00
57_W60_P0.7631.00
69_A72_L0.7581.00
29_Q35_G0.7561.00
81_T86_V0.7521.00
31_S35_G0.7501.00
126_L130_A0.7441.00
50_G134_L0.7401.00
24_L32_Y0.7351.00
91_R94_A0.7341.00
15_L117_G0.7311.00
112_L115_R0.7261.00
57_W66_L0.7261.00
120_H124_T0.7251.00
80_V126_L0.7211.00
43_A48_L0.7211.00
27_Q30_P0.7211.00
28_F35_G0.7181.00
25_L31_S0.7141.00
11_M15_L0.7111.00
11_M14_L0.7081.00
24_L35_G0.7031.00
80_V119_L0.6951.00
118_R122_V0.6931.00
114_E118_R0.6881.00
80_V84_V0.6851.00
90_N94_A0.6611.00
30_P34_R0.6601.00
38_M42_L0.6571.00
85_N88_L0.6551.00
61_G65_L0.6461.00
12_P15_L0.6391.00
55_L59_G0.6361.00
11_M117_G0.6311.00
103_D109_A0.6311.00
60_P64_W0.6301.00
47_L51_L0.6261.00
40_P43_A0.6201.00
120_H131_F0.6191.00
58_W61_G0.6171.00
20_R26_P0.6151.00
36_A43_A0.6011.00
3_F77_V0.5991.00
9_V12_P0.5961.00
73_L129_A0.5941.00
55_L58_W0.5901.00
40_P46_S0.5901.00
34_R37_A0.5891.00
128_L132_A0.5871.00
69_A133_L0.5851.00
5_A8_V0.5791.00
58_W64_W0.5781.00
19_D107_A0.5771.00
75_L79_P0.5741.00
104_A108_E0.5721.00
14_L31_S0.5681.00
44_L47_L0.5681.00
56_R60_P0.5671.00
71_A75_L0.5561.00
55_L64_W0.5551.00
73_L130_A0.5541.00
58_W66_L0.5501.00
88_L119_L0.5501.00
6_F120_H0.5461.00
127_S131_F0.5451.00
2_A8_V0.5431.00
38_M45_G0.5401.00
39_F42_L0.5381.00
69_A73_L0.5381.00
65_L69_A0.5381.00
57_W62_A0.5381.00
108_E113_L0.5321.00
76_G80_V0.5211.00
129_A133_L0.5191.00
95_A106_A0.5181.00
59_G66_L0.5141.00
45_G49_A0.5121.00
56_R61_G0.5111.00
24_L31_S0.5111.00
74_L130_A0.5071.00
25_L35_G0.5021.00
48_L53_L0.5011.00
6_F10_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqpA 1 0.6569 6.6 0.897 Contact Map
3ne5A 3 0.9124 6.3 0.899 Contact Map
4k0jA 3 0.8248 5.7 0.9 Contact Map
4pd6A 3 0.8905 5.1 0.902 Contact Map
4oh3A 2 0.6715 4.8 0.904 Contact Map
3qnqA 2 0.7007 4.4 0.905 Contact Map
4tphA 2 0.5693 4.3 0.906 Contact Map
4dx5A 3 0.708 4 0.907 Contact Map
3w9iA 3 0.6788 3.3 0.911 Contact Map
3o7qA 1 0.9124 3.3 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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