GREMLIN Database
DUF1762 - Protein of unknown function (DUF1762)
PFAM: PF08574 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (73)
Sequences: 584 (472)
Seq/√Len: 55.2
META: 0.296

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_G32_V2.8241.00
62_S70_N2.5731.00
7_Y10_Y2.2941.00
64_A69_R2.2901.00
12_R76_E2.1521.00
7_Y62_S1.9411.00
59_D62_S1.8600.99
8_D13_E1.7790.99
56_D59_D1.7100.99
3_D75_E1.6380.99
71_D76_E1.5690.98
55_E58_D1.5380.98
12_R74_D1.4990.97
26_G31_L1.3990.96
29_G68_Y1.3670.96
8_D57_E1.3510.95
65_E72_Y1.3470.95
65_E73_P1.3470.95
12_R59_D1.3060.94
52_D55_E1.2860.94
60_E69_R1.2760.94
38_E41_W1.2720.94
23_A27_N1.2440.93
37_D40_L1.2170.92
10_Y13_E1.2050.92
60_E67_N1.1990.91
12_R29_G1.1630.90
29_G33_I1.1520.90
19_T22_D1.1480.89
37_D41_W1.1450.89
16_A19_T1.1170.88
18_D24_P1.1040.88
15_D18_D1.0970.87
13_E16_A1.0920.87
41_W45_Y1.0900.87
15_D24_P1.0850.87
21_E24_P1.0850.87
7_Y70_N1.0840.87
57_E68_Y1.0790.86
71_D75_E1.0710.86
23_A26_G1.0650.86
2_D22_D1.0320.84
53_E56_D1.0250.83
8_D34_D1.0130.83
16_A20_S1.0050.82
21_E25_P1.0000.82
19_T25_P0.9760.80
3_D11_Y0.9740.80
55_E64_A0.9520.79
65_E71_D0.9510.78
4_D46_E0.9280.77
20_S25_P0.9130.76
33_I41_W0.9080.75
67_N70_N0.8890.74
17_A20_S0.8830.73
33_I38_E0.8770.73
37_D64_A0.8760.72
33_I36_E0.8670.72
60_E68_Y0.8570.71
64_A72_Y0.8390.69
64_A73_P0.8390.69
46_E51_S0.8270.68
9_V62_S0.8210.68
40_L76_E0.8040.66
46_E50_D0.7940.65
22_D34_D0.7850.64
73_P76_E0.7740.63
72_Y76_E0.7740.63
4_D51_S0.7730.63
64_A68_Y0.7600.61
5_Y9_V0.7570.61
10_Y58_D0.7490.60
43_E46_E0.7440.60
63_N73_P0.7410.60
63_N72_Y0.7410.60
48_D54_E0.7360.59
17_A21_E0.7080.56
65_E70_N0.7020.55
70_N73_P0.6890.54
33_I40_L0.6870.54
27_N31_L0.6870.54
43_E74_D0.6840.54
2_D47_D0.6790.53
10_Y66_N0.6740.52
19_T52_D0.6740.52
18_D23_A0.6610.51
8_D43_E0.6550.50
66_N69_R0.6520.50
44_F48_D0.6510.50
24_P27_N0.6440.49
24_P28_I0.6430.49
13_E58_D0.6400.49
9_V60_E0.6310.48
49_D52_D0.6290.48
25_P39_E0.6160.46
17_A22_D0.6010.45
43_E51_S0.5940.44
4_D49_D0.5860.43
18_D22_D0.5510.39
17_A26_G0.5410.38
51_S54_E0.5400.38
21_E40_L0.5380.38
8_D20_S0.5340.38
20_S23_A0.5340.38
41_W56_D0.5330.38
43_E62_S0.5330.38
36_E46_E0.5300.37
62_S68_Y0.5270.37
6_V9_V0.5110.35
60_E64_A0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kblA 2 0 2.4 0.896 Contact Map
1dq3A 1 0.3684 2.4 0.896 Contact Map
2cw8A 1 0.3684 1.7 0.905 Contact Map
2imzA 2 0.3289 1 0.916 Contact Map
4cayC 1 0.0921 0.8 0.921 Contact Map
3mwyW 2 0.0263 0.7 0.926 Contact Map
4qvrA 1 0 0.5 0.931 Contact Map
3e6uA 1 0.3158 0.5 0.935 Contact Map
2i50A 1 0.3421 0.4 0.936 Contact Map
1am2A 2 0.3553 0.4 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.005 seconds.