GREMLIN Database
PRP3 - pre-mRNA processing factor 3 (PRP3)
PFAM: PF08572 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 214 (210)
Sequences: 516 (348)
Seq/√Len: 24.0
META: 0.221

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_R196_Q4.3041.00
206_E210_A3.8481.00
92_Y95_I3.7451.00
5_D8_L3.4681.00
23_N28_Y3.3241.00
150_L153_K2.9461.00
156_K159_L2.7140.99
174_L178_L2.6640.99
199_E203_A2.5400.99
201_Q205_E2.5290.99
32_A36_R2.4710.98
135_K138_Q2.4350.98
203_A207_A2.3960.98
151_K159_L2.2200.97
140_K143_R2.2190.97
31_Q35_L2.1820.97
151_K154_Q2.1110.96
142_R146_R2.0930.96
148_E151_K2.0660.95
209_E212_K1.9750.94
179_G182_A1.9100.93
43_E47_R1.9090.93
156_K162_E1.9000.93
170_K184_Q1.8760.92
15_R18_R1.7260.88
122_E126_P1.7050.88
80_E83_D1.6910.87
94_D97_D1.6630.86
205_E209_E1.6590.86
169_V177_V1.6490.86
4_F8_L1.6450.86
89_G94_D1.6060.84
169_V174_L1.5930.84
50_E54_K1.5730.83
145_R149_E1.5540.82
115_V119_P1.5280.81
189_V193_V1.5250.81
17_R20_L1.5220.81
166_P196_Q1.5170.81
155_E171_L1.5120.80
28_Y32_A1.5020.80
170_K180_S1.4940.80
174_L179_G1.4790.79
197_M201_Q1.4790.79
16_K19_Q1.4620.78
86_L112_Q1.4320.77
41_L48_I1.4130.76
154_Q158_R1.4020.75
204_H211_R1.3780.74
140_K144_Q1.3780.74
120_P126_P1.3630.73
23_N27_K1.3570.73
157_I165_P1.3490.72
24_E179_G1.3470.72
94_D98_E1.3410.72
61_L65_E1.3360.71
202_Q205_E1.3300.71
45_K51_A1.3110.70
175_M183_V1.3100.70
153_K162_E1.3020.69
193_V196_Q1.3010.69
145_R148_E1.2690.67
203_A206_E1.2370.65
171_L197_M1.2280.65
60_D66_K1.2140.64
34_A61_L1.2120.64
177_V187_T1.2040.63
6_P9_G1.2030.63
60_D64_A1.1990.63
168_K172_S1.1760.61
51_A54_K1.1710.61
11_K33_E1.1690.61
119_P122_E1.1560.60
59_E69_K1.1510.60
190_E204_H1.1510.60
32_A187_T1.1440.59
200_R204_H1.1300.58
183_V192_R1.1270.58
167_P190_E1.1220.58
180_S183_V1.1150.57
147_M154_Q1.1110.57
92_Y97_D1.1070.57
140_K145_R1.1040.56
45_K55_A1.0980.56
60_D68_P1.0940.56
30_Q131_L1.0860.55
155_E166_P1.0770.54
39_A191_A1.0750.54
176_R188_K1.0740.54
191_A195_R1.0710.54
50_E53_R1.0640.54
156_K163_P1.0620.53
185_D188_K1.0580.53
28_Y31_Q1.0570.53
52_A55_A1.0550.53
175_M187_T1.0520.53
202_Q210_A1.0500.53
178_L193_V1.0500.53
25_K183_V1.0490.53
111_V145_R1.0470.52
48_I55_A1.0460.52
138_Q187_T1.0320.51
154_Q165_P1.0310.51
181_E205_E1.0280.51
143_R159_L1.0250.51
202_Q206_E1.0250.51
141_L158_R1.0240.51
50_E166_P1.0200.50
107_I181_E1.0180.50
48_I54_K1.0160.50
200_R208_N1.0050.49
20_L192_R0.9990.49
166_P181_E0.9990.49
146_R173_N0.9980.49
118_E123_K0.9960.49
19_Q111_V0.9910.48
20_L155_E0.9890.48
36_R187_T0.9840.48
68_P179_G0.9830.48
131_L143_R0.9740.47
42_E54_K0.9720.47
178_L192_R0.9630.46
157_I176_R0.9490.45
163_P166_P0.9470.45
61_L66_K0.9460.45
113_H135_K0.9410.45
13_K16_K0.9380.45
155_E192_R0.9320.44
44_L48_I0.9240.44
134_T190_E0.9100.43
60_D144_Q0.9070.42
123_K131_L0.9060.42
128_P131_L0.9040.42
145_R162_E0.8920.41
29_I111_V0.8860.41
41_L54_K0.8820.41
63_L172_S0.8790.41
38_K68_P0.8790.41
150_L154_Q0.8770.40
44_L111_V0.8730.40
27_K130_P0.8700.40
204_H208_N0.8690.40
34_A45_K0.8650.40
51_A150_L0.8630.39
44_L55_A0.8570.39
162_E165_P0.8540.39
36_R81_W0.8520.39
149_E172_S0.8510.39
182_A212_K0.8490.39
132_Y143_R0.8490.39
130_P188_K0.8410.38
90_K111_V0.8400.38
198_A202_Q0.8340.38
18_R22_F0.8330.37
37_R40_Q0.8320.37
59_E68_P0.8270.37
186_P208_N0.8260.37
165_P185_D0.8200.37
164_P213_L0.8170.36
91_T95_I0.8140.36
46_K50_E0.8090.36
26_G81_W0.8060.36
119_P210_A0.8030.35
166_P199_E0.8010.35
47_R148_E0.7970.35
79_V124_N0.7950.35
38_K69_K0.7890.35
138_Q196_Q0.7880.35
27_K154_Q0.7870.34
22_F26_G0.7850.34
171_L194_R0.7760.34
57_I61_L0.7730.34
184_Q207_A0.7690.33
75_V192_R0.7660.33
20_L27_K0.7660.33
14_R25_K0.7660.33
79_V90_K0.7660.33
36_R56_G0.7630.33
129_K189_V0.7580.33
116_P141_L0.7530.32
16_K153_K0.7530.32
174_L184_Q0.7520.32
118_E179_G0.7510.32
45_K48_I0.7510.32
102_S111_V0.7510.32
86_L141_L0.7490.32
140_K187_T0.7470.32
33_E37_R0.7430.32
164_P212_K0.7420.32
18_R23_N0.7390.31
106_K156_K0.7370.31
167_P175_M0.7300.31
64_A158_R0.7290.31
118_E121_Q0.7290.31
66_K69_K0.7260.31
69_K74_E0.7230.30
79_V87_L0.7230.30
48_I56_G0.7220.30
65_E147_M0.7200.30
40_Q141_L0.7100.30
115_V123_K0.7090.30
23_N192_R0.7060.29
144_Q176_R0.7050.29
17_R99_K0.7040.29
61_L64_A0.7040.29
163_P177_V0.6980.29
186_P200_R0.6970.29
108_T159_L0.6950.29
4_F10_A0.6950.29
115_V145_R0.6930.29
184_Q197_M0.6930.29
9_G111_V0.6910.29
44_L56_G0.6860.28
63_L157_I0.6840.28
130_P147_M0.6780.28
30_Q162_E0.6760.28
47_R195_R0.6710.27
14_R18_R0.6710.27
8_L13_K0.6690.27
174_L181_E0.6650.27
17_R202_Q0.6630.27
15_R41_L0.6620.27
87_L181_E0.6600.27
49_A189_V0.6590.27
167_P196_Q0.6580.27
127_P202_Q0.6570.27
20_L104_D0.6550.27
188_K197_M0.6550.27
130_P145_R0.6550.27
45_K63_L0.6540.26
68_P188_K0.6520.26
115_V125_K0.6520.26
106_K110_Y0.6500.26
154_Q189_V0.6480.26
153_K174_L0.6450.26
91_T94_D0.6420.26
57_I60_D0.6390.26
142_R177_V0.6380.26
131_L155_E0.6360.25
31_Q59_E0.6350.25
184_Q187_T0.6320.25
135_K169_V0.6310.25
110_Y188_K0.6310.25
33_E52_A0.6300.25
107_I187_T0.6290.25
146_R177_V0.6270.25
140_K149_E0.6240.25
126_P154_Q0.6230.25
76_P80_E0.6200.25
51_A55_A0.6130.24
188_K209_E0.6130.24
111_V124_N0.6120.24
31_Q181_E0.6110.24
17_R136_K0.6060.24
14_R97_D0.6030.24
182_A189_V0.6020.24
39_A52_A0.5950.23
145_R159_L0.5950.23
55_A110_Y0.5940.23
169_V176_R0.5910.23
123_K150_L0.5900.23
45_K54_K0.5870.23
60_D136_K0.5840.23
143_R183_V0.5840.23
44_L52_A0.5830.23
31_Q41_L0.5810.23
55_A64_A0.5810.23
41_L49_A0.5790.23
20_L171_L0.5770.22
88_P103_K0.5740.22
78_D153_K0.5740.22
79_V95_I0.5730.22
43_E96_D0.5730.22
70_V106_K0.5690.22
153_K193_V0.5660.22
125_K206_E0.5660.22
185_D213_L0.5620.22
52_A157_I0.5600.22
48_I53_R0.5590.22
90_K126_P0.5550.21
208_N211_R0.5520.21
135_K178_L0.5510.21
181_E195_R0.5510.21
153_K168_K0.5490.21
81_W130_P0.5480.21
173_N190_E0.5440.21
143_R156_K0.5440.21
51_A166_P0.5420.21
45_K60_D0.5390.21
17_R27_K0.5360.20
170_K175_M0.5360.20
32_A120_P0.5350.20
43_E46_K0.5330.20
14_R171_L0.5310.20
179_G196_Q0.5290.20
150_L203_A0.5230.20
79_V84_E0.5230.20
208_N213_L0.5220.20
45_K72_E0.5190.20
107_I179_G0.5180.20
59_E65_E0.5160.20
134_T167_P0.5150.20
16_K37_R0.5140.19
151_K181_E0.5130.19
140_K175_M0.5130.19
56_G63_L0.5090.19
37_R44_L0.5070.19
59_E70_V0.5070.19
143_R211_R0.5070.19
115_V171_L0.5050.19
25_K154_Q0.5050.19
135_K154_Q0.5040.19
32_A40_Q0.5030.19
63_L66_K0.5030.19
10_A24_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zs9C 1 0.1449 6.1 0.966 Contact Map
3r3tA 3 0.1869 5 0.968 Contact Map
4ql0A 2 0.3879 5 0.968 Contact Map
2rmgA 1 0.1776 4.2 0.969 Contact Map
2jxcB 1 0.1215 3.7 0.97 Contact Map
3sjdD 1 0.1215 3.7 0.97 Contact Map
2rmhA 1 0.1776 3.4 0.97 Contact Map
4o9bA 3 0.1822 3.4 0.97 Contact Map
2b9sB 1 0.1355 3.2 0.971 Contact Map
4g9jC 1 0.0607 2.9 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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