GREMLIN Database
Yos1 - Yos1-like
PFAM: PF08571 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (75)
Sequences: 557 (419)
Seq/√Len: 48.3
META: 0.368

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_L67_V3.1961.00
70_Y74_L3.0081.00
20_E53_R2.7591.00
15_I49_I2.7371.00
2_G6_E2.2361.00
18_L23_F2.1131.00
16_A60_L1.9240.99
69_V73_L1.8560.99
47_N55_L1.7200.98
45_I50_S1.6380.98
62_A65_I1.6020.97
3_T6_E1.6010.97
66_L70_Y1.5850.97
6_E71_E1.4700.96
16_A57_R1.4390.95
2_G70_Y1.3810.94
8_A36_G1.3560.93
50_S55_L1.3410.93
2_G55_L1.3410.93
11_L14_A1.3400.93
57_R63_L1.2890.92
14_A42_K1.2690.91
11_L15_I1.2080.89
53_R72_L1.2080.89
58_I61_I1.1970.88
49_I56_M1.1960.88
29_W42_K1.1750.87
39_P44_Q1.1720.87
52_V65_I1.1660.87
28_G31_S1.1650.87
14_A20_E1.1500.86
63_L67_V1.1380.85
20_E29_W1.1370.85
6_E74_L1.1300.85
29_W45_I1.0600.81
15_I46_I1.0500.80
31_S55_L1.0430.80
29_W46_I1.0400.80
16_A52_V1.0140.78
6_E26_K1.0040.77
11_L73_L0.9900.76
30_S50_S0.9740.75
37_D40_S0.9720.75
12_L56_M0.9700.75
46_I49_I0.9490.73
35_Q65_I0.9430.73
23_F46_I0.9410.73
65_I69_V0.9400.73
17_I21_D0.9240.71
41_V56_M0.9090.70
59_P64_N0.9080.70
21_D30_S0.8820.68
27_I30_S0.8550.65
65_I71_E0.8510.65
33_F36_G0.8500.65
7_A10_L0.8470.64
14_A25_A0.8350.63
3_T8_A0.8340.63
11_L69_V0.8310.63
16_A46_I0.8290.63
6_E70_Y0.7930.59
49_I57_R0.7750.58
21_D29_W0.7720.57
32_G36_G0.7710.57
31_S41_V0.7580.56
26_K44_Q0.7560.56
46_I51_A0.7500.55
10_L61_I0.7450.55
1_L4_L0.7370.54
51_A62_A0.7340.54
46_I71_E0.7270.53
41_V47_N0.7250.53
8_A12_L0.7230.52
3_T7_A0.7200.52
12_L16_A0.7080.51
8_A14_A0.7000.50
67_V73_L0.6950.50
17_I33_F0.6920.49
12_L52_V0.6900.49
51_A54_T0.6890.49
47_N51_A0.6800.48
37_D66_L0.6780.48
3_T9_L0.6770.48
72_L75_G0.6740.47
52_V72_L0.6690.47
8_A37_D0.6610.46
63_L73_L0.6460.45
5_L66_L0.6420.44
41_V45_I0.6390.44
8_A25_A0.6240.42
14_A32_G0.6090.41
51_A55_L0.5980.40
9_L51_A0.5960.40
15_I61_I0.5900.39
32_G53_R0.5830.39
14_A65_I0.5800.38
20_E48_L0.5760.38
30_S34_G0.5760.38
10_L14_A0.5740.38
20_E60_L0.5640.37
30_S46_I0.5630.37
28_G42_K0.5560.36
40_S56_M0.5530.36
10_L13_N0.5440.35
14_A64_N0.5420.35
38_E65_I0.5410.35
36_G43_A0.5360.34
38_E43_A0.5330.34
44_Q50_S0.5330.34
1_L5_L0.5110.32
16_A20_E0.5010.31
35_Q38_E0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mv6A 1 0.4 25.2 0.884 Contact Map
2q7rA 3 0.48 4.2 0.919 Contact Map
4g80S 1 0.4533 3.4 0.923 Contact Map
2jo1A 1 0.7067 3.2 0.924 Contact Map
4akgA 2 0.9333 2.9 0.925 Contact Map
4z7fA 2 0.4 2.7 0.926 Contact Map
2mkvA 1 0.52 2.4 0.928 Contact Map
3m66A 1 0.56 2.1 0.93 Contact Map
3tixB 1 0.3867 2 0.931 Contact Map
3dtgA 2 0.84 1.8 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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