GREMLIN Database
DUF1761 - Protein of unknown function (DUF1761)
PFAM: PF08570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (124)
Sequences: 15787 (11767)
Seq/√Len: 1056.7
META: 0.948

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_V87_G2.7661.00
74_L123_A2.5651.00
85_W115_L2.4081.00
29_A105_K2.3501.00
58_A121_M2.3491.00
13_L120_L2.2931.00
97_Y107_F2.2671.00
25_A28_K2.1411.00
29_A103_P2.1381.00
10_A117_G2.1271.00
25_A105_K2.0981.00
7_A55_L2.0341.00
44_A48_G1.9701.00
100_E110_N1.9471.00
13_L116_V1.8671.00
94_L107_F1.8471.00
78_A119_L1.8321.00
82_F119_L1.8281.00
27_M34_E1.7881.00
75_G79_L1.7601.00
64_L84_L1.7471.00
34_E38_K1.6601.00
25_A29_A1.6591.00
93_L111_A1.6521.00
77_G81_G1.6351.00
9_A124_I1.5441.00
7_A51_F1.5211.00
77_G122_G1.4791.00
10_A121_M1.4671.00
53_A94_L1.4631.00
32_L36_D1.4221.00
90_A107_F1.4201.00
33_T36_D1.4201.00
104_W108_L1.4031.00
20_P23_G1.4001.00
63_H67_A1.3371.00
25_A109_I1.3331.00
33_T37_L1.3301.00
57_M118_L1.3221.00
73_T76_H1.2771.00
90_A111_A1.2741.00
11_F15_A1.2681.00
76_H80_L1.2581.00
62_A66_G1.2411.00
12_V15_A1.2361.00
16_L21_L1.2321.00
79_L83_L1.2171.00
107_F111_A1.2041.00
46_I98_L1.1911.00
7_A58_A1.1781.00
29_A106_L1.1721.00
17_W22_F1.1591.00
10_A54_S1.1491.00
36_D39_A1.1241.00
39_A42_N1.1171.00
32_L37_L1.1061.00
50_S99_F1.0971.00
9_A120_L1.0851.00
50_S95_I1.0641.00
76_H79_L1.0611.00
63_H83_L1.0551.00
6_A125_L1.0411.00
24_K28_K1.0381.00
14_G113_Y1.0361.00
96_N114_W1.0351.00
38_K41_G1.0321.00
96_N100_E1.0191.00
35_E38_K1.0171.00
4_L51_F1.0081.00
54_S58_A1.0001.00
49_L98_L0.9931.00
23_G27_M0.9831.00
50_S54_S0.9771.00
13_L113_Y0.9761.00
93_L107_F0.9721.00
53_A91_P0.9711.00
64_L80_L0.9621.00
40_P43_M0.9551.00
118_L122_G0.9501.00
106_L110_N0.9441.00
113_Y117_G0.9421.00
60_V63_H0.9401.00
89_V118_L0.9281.00
78_A123_A0.9271.00
20_P24_K0.9091.00
89_V92_T0.8991.00
94_L97_Y0.8931.00
74_L78_A0.8921.00
117_G121_M0.8861.00
17_W112_G0.8821.00
72_T76_H0.8611.00
62_A125_L0.8491.00
24_K27_M0.8471.00
45_K49_L0.8411.00
85_W90_A0.8341.00
6_A121_M0.8341.00
70_A76_H0.8261.00
59_Y63_H0.8231.00
95_I114_W0.8201.00
64_L68_L0.8161.00
65_L80_L0.8101.00
18_Y110_N0.8041.00
34_E37_L0.7991.00
84_L88_F0.7911.00
85_W111_A0.7861.00
21_L24_K0.7851.00
28_K105_K0.7761.00
63_H66_G0.7651.00
47_F51_F0.7551.00
80_L84_L0.7381.00
45_K48_G0.7371.00
6_A10_A0.7361.00
65_L125_L0.7101.00
87_G91_P0.7091.00
49_L94_L0.7061.00
65_L70_A0.7061.00
93_L96_N0.7051.00
60_V83_L0.7051.00
46_I49_L0.6951.00
97_Y104_W0.6941.00
109_I112_G0.6931.00
63_H79_L0.6901.00
111_A115_L0.6871.00
48_G52_V0.6851.00
95_I99_F0.6841.00
19_S23_G0.6841.00
60_V64_L0.6751.00
9_A13_L0.6641.00
66_G70_A0.6631.00
93_L114_W0.6621.00
93_L97_Y0.6521.00
119_L123_A0.6501.00
79_L82_F0.6431.00
51_F55_L0.6421.00
6_A9_A0.6351.00
13_L117_G0.6321.00
53_A98_L0.6311.00
37_L41_G0.6181.00
115_L119_L0.6151.00
36_D40_P0.6101.00
97_Y100_E0.6091.00
81_G85_W0.6091.00
57_M91_P0.6071.00
2_A5_V0.6071.00
30_A34_E0.5891.00
32_L101_G0.5881.00
58_A125_L0.5861.00
35_E39_A0.5861.00
75_G78_A0.5831.00
97_Y106_L0.5821.00
57_M92_T0.5811.00
7_A11_F0.5791.00
27_M32_L0.5781.00
49_L53_A0.5761.00
4_L7_A0.5731.00
29_A109_I0.5721.00
11_F54_S0.5701.00
82_F115_L0.5681.00
114_W117_G0.5581.00
15_A19_S0.5531.00
6_A124_I0.5521.00
61_L88_F0.5481.00
55_L59_Y0.5471.00
56_V91_P0.5461.00
19_S24_K0.5451.00
74_L77_G0.5431.00
89_V114_W0.5431.00
20_P27_M0.5411.00
67_A70_A0.5401.00
54_S57_M0.5371.00
64_L67_A0.5311.00
94_L104_W0.5221.00
16_L20_P0.5201.00
16_L19_S0.5191.00
37_L40_P0.5161.00
1_L4_L0.5141.00
119_L122_G0.5111.00
12_V16_L0.5081.00
104_W107_F0.5061.00
11_F51_F0.5051.00
56_V87_G0.5021.00
103_P106_L0.5021.00
32_L35_E0.5021.00
59_Y83_L0.5011.00
15_A47_F0.5011.00
92_T114_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.3254 31 0.855 Contact Map
1ldfA 3 0.2063 7.8 0.89 Contact Map
3giaA 1 0.2698 4.9 0.899 Contact Map
3aqpA 1 0.2222 4.2 0.903 Contact Map
3zuxA 1 0.1984 4.2 0.903 Contact Map
4he8N 1 0.5556 4 0.904 Contact Map
4av3A 2 0.8968 3.9 0.905 Contact Map
4wfeA 2 0.9444 3 0.91 Contact Map
1m56C 2 0.9206 3 0.91 Contact Map
4a01A 2 0.9206 2.8 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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