GREMLIN Database
DUF1754 - Eukaryotic family of unknown function (DUF1754)
PFAM: PF08555 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 98 (95)
Sequences: 550 (498)
Seq/√Len: 51.1
META: 0.278

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_K89_E3.7391.00
88_F92_R3.3921.00
81_K93_R2.7091.00
83_E87_R2.5031.00
9_K88_F2.2731.00
89_E93_R2.1271.00
81_K96_L2.0451.00
78_D86_R2.0291.00
79_D83_E1.9731.00
90_E93_R1.9701.00
81_K86_R1.9530.99
6_V9_K1.9100.99
9_K91_Q1.8260.99
88_F91_Q1.7930.99
84_A87_R1.7540.99
87_R90_E1.7110.99
83_E86_R1.6810.98
58_E61_E1.6530.98
93_R96_L1.6510.98
2_Y5_V1.6190.98
10_L13_K1.5190.97
15_K18_D1.5130.97
89_E92_R1.4450.96
9_K81_K1.3850.95
24_K27_K1.3650.95
23_K29_K1.3470.94
91_Q95_R1.3130.93
6_V21_G1.2970.93
77_S93_R1.2630.92
63_E68_S1.2290.91
37_E40_A1.2130.90
6_V88_F1.2080.90
5_V9_K1.1940.89
31_K34_K1.1880.89
60_E66_D1.1710.88
92_R96_L1.1240.86
34_K38_E1.1040.85
38_E43_E1.0960.85
64_E72_E1.0860.84
19_V80_H1.0810.84
87_R97_E1.0810.84
86_R92_R1.0780.84
64_E69_G1.0560.83
62_D66_D1.0480.82
19_V97_E1.0460.82
11_K83_E1.0340.81
28_K31_K1.0240.81
48_K51_A1.0000.79
60_E63_E0.9960.79
81_K90_E0.9940.79
29_K32_K0.9880.78
1_E4_N0.9850.78
14_G26_K0.9650.77
45_E52_E0.9620.76
43_E47_E0.9590.76
49_S53_S0.9570.76
79_D86_R0.9570.76
3_D6_V0.9460.75
89_E96_L0.9450.75
59_E65_S0.9430.75
59_E67_E0.9370.74
46_A50_S0.9320.74
9_K15_K0.9260.74
62_D65_S0.9140.73
40_A51_A0.9100.72
7_G15_K0.9020.72
40_A49_S0.9000.71
46_A49_S0.8840.70
33_S45_E0.8730.69
50_S53_S0.8540.67
1_E85_E0.8540.67
50_S76_S0.8390.66
8_G13_K0.8370.66
15_K81_K0.8280.65
63_E66_D0.8190.64
86_R90_E0.7970.62
4_N52_E0.7710.59
25_K95_R0.7680.59
56_E64_E0.7650.59
85_E88_F0.7600.58
35_E38_E0.7590.58
45_E49_S0.7450.57
39_A42_E0.7330.56
44_E50_S0.7200.54
32_K37_E0.7140.54
91_Q97_E0.7120.53
34_K37_E0.7040.53
38_E54_D0.6910.51
38_E41_S0.6860.51
37_E49_S0.6780.50
56_E70_E0.6760.50
33_S36_K0.6700.49
60_E64_E0.6690.49
60_E65_S0.6640.48
3_D16_K0.6610.48
8_G14_G0.6600.48
50_S54_D0.6580.48
64_E67_E0.6520.47
11_K95_R0.6490.47
3_D9_K0.6460.47
70_E73_E0.6430.46
9_K95_R0.6380.46
56_E62_D0.6370.46
11_K22_V0.6240.44
5_V88_F0.6190.44
3_D83_E0.6070.43
54_D65_S0.5990.42
7_G89_E0.5970.42
80_H91_Q0.5940.41
2_Y14_G0.5930.41
79_D93_R0.5920.41
85_E96_L0.5920.41
80_H87_R0.5890.41
49_S62_D0.5840.40
26_K90_E0.5830.40
57_S60_E0.5810.40
17_L83_E0.5810.40
16_K81_K0.5790.40
6_V16_K0.5780.40
83_E93_R0.5750.39
44_E47_E0.5750.39
83_E96_L0.5650.38
44_E48_K0.5650.38
39_A43_E0.5580.38
57_S70_E0.5510.37
1_E5_V0.5500.37
92_R97_E0.5470.37
47_E52_E0.5440.36
25_K85_E0.5380.36
61_E72_E0.5370.36
65_S68_S0.5330.35
51_A54_D0.5320.35
67_E72_E0.5320.35
57_S62_D0.5310.35
37_E42_E0.5280.35
69_G76_S0.5280.35
43_E46_A0.5220.34
6_V81_K0.5150.34
67_E71_E0.5120.33
44_E51_A0.5120.33
59_E62_D0.5120.33
39_A44_E0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zetC 1 0.2449 4.6 0.89 Contact Map
2q8kA 1 0.1735 3.2 0.897 Contact Map
4ipaA 1 0.1327 3 0.899 Contact Map
1914A 1 0.4184 2.8 0.901 Contact Map
1v7mV 1 0.2245 2.7 0.902 Contact Map
2k5kA 1 0.2959 2.4 0.904 Contact Map
4jgxA 2 0.3367 2.3 0.906 Contact Map
4yhuA 1 0 2 0.908 Contact Map
4mqvB 1 0.1837 1.9 0.909 Contact Map
3sgrA 5 0.1837 1.7 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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