GREMLIN Database
COPI_assoc - COPI associated protein
PFAM: PF08507 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 129 (114)
Sequences: 905 (782)
Seq/√Len: 73.2
META: 0.529

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_G98_G4.1781.00
85_L89_I3.3941.00
74_I98_G3.1791.00
78_L81_L3.0621.00
19_G43_G2.4021.00
91_G95_L2.3831.00
88_I92_I2.1871.00
42_F75_F2.1831.00
12_G43_G2.1701.00
13_V17_L2.0981.00
77_G95_L2.0941.00
62_F72_F2.0241.00
46_L73_Y2.0031.00
16_I43_G1.9981.00
17_L21_L1.9421.00
42_F72_F1.8641.00
69_R94_L1.8141.00
62_F68_G1.7861.00
14_L90_A1.7601.00
113_P116_M1.7241.00
38_Y75_F1.6170.99
12_G19_G1.6080.99
50_E69_R1.5950.99
70_G102_I1.5320.99
79_L82_G1.5150.99
15_L19_G1.4570.99
8_N73_Y1.4400.99
92_I96_A1.3870.98
61_G65_S1.3350.98
12_G46_L1.3210.98
45_L60_F1.2810.97
111_E115_N1.2730.97
78_L82_G1.2570.97
67_L105_G1.2320.97
112_P116_M1.2290.96
38_Y42_F1.2280.96
50_E73_Y1.2150.96
11_V97_V1.1840.96
57_R64_F1.1750.95
109_S113_P1.1730.95
69_R73_Y1.1660.95
77_G91_G1.1560.95
80_L83_G1.1460.95
86_L90_A1.1400.95
109_S115_N1.1360.95
21_L24_I1.1340.95
35_L38_Y1.1230.94
43_G50_E1.1170.94
20_I24_I1.1050.94
38_Y63_L1.0870.93
46_L76_V1.0820.93
111_E114_R1.0810.93
7_L11_V1.0540.92
43_G62_F1.0460.92
101_Y105_G1.0410.92
67_L102_I1.0290.91
22_Q36_G1.0220.91
12_G47_V0.9940.90
73_Y77_G0.9790.89
110_I116_M0.9730.89
48_L51_F0.9650.88
14_L18_G0.9650.88
16_I20_I0.9630.88
5_R52_R0.9620.88
74_I102_I0.9510.87
109_S116_M0.9440.87
16_I23_F0.9230.86
3_I7_L0.9220.86
77_G98_G0.9190.86
61_G64_F0.9130.85
4_F12_G0.9080.85
47_V104_L0.9070.85
51_F57_R0.8990.84
58_R100_L0.8810.83
109_S114_R0.8800.83
27_F33_I0.8670.82
10_V13_V0.8540.81
65_S68_G0.8450.80
37_I41_L0.8450.80
8_N65_S0.8440.80
49_L63_L0.8360.80
54_P76_V0.8230.79
45_L53_I0.8110.78
84_G88_I0.8050.77
23_F34_I0.8050.77
105_G108_P0.8040.77
108_P112_P0.8010.77
91_G94_L0.7910.76
18_G90_A0.7640.73
26_L92_I0.7640.73
110_I113_P0.7550.72
104_L107_I0.7550.72
106_F113_P0.7530.72
59_Y72_F0.7520.72
16_I76_V0.7510.72
10_V89_I0.7470.72
53_I65_S0.7450.71
106_F111_E0.7430.71
109_S112_P0.7360.70
49_L69_R0.7270.70
110_I114_R0.7260.69
72_F76_V0.7250.69
18_G49_L0.7230.69
60_F73_Y0.7220.69
112_P115_N0.7190.69
17_L20_I0.7160.68
89_I92_I0.7160.68
85_L92_I0.7110.68
19_G42_F0.7090.68
15_L39_V0.7040.67
84_G102_I0.6960.66
48_L54_P0.6900.66
107_I110_I0.6850.65
57_R61_G0.6780.64
108_P116_M0.6760.64
73_Y97_V0.6750.64
30_F33_I0.6670.63
46_L80_L0.6660.63
74_I77_G0.6620.62
63_L72_F0.6600.62
43_G68_G0.6540.61
48_L106_F0.6490.61
9_L13_V0.6460.60
31_F61_G0.6290.58
60_F69_R0.6220.58
4_F7_L0.6200.57
31_F37_I0.6170.57
77_G94_L0.6130.56
48_L67_L0.6090.56
16_I47_V0.6060.56
40_I92_I0.6050.55
10_V41_L0.6050.55
13_V33_I0.6040.55
13_V86_L0.5930.54
33_I37_I0.5850.53
45_L103_V0.5820.53
79_L101_Y0.5710.51
46_L63_L0.5700.51
10_V21_L0.5700.51
17_L24_I0.5670.51
70_G92_I0.5620.50
34_I51_F0.5550.49
99_L103_V0.5540.49
14_L74_I0.5520.49
35_L91_G0.5520.49
27_F103_V0.5510.49
63_L68_G0.5510.49
58_R90_A0.5490.49
19_G22_Q0.5470.48
6_I37_I0.5410.48
83_G86_L0.5390.47
24_I100_L0.5390.47
40_I43_G0.5350.47
4_F98_G0.5330.47
53_I86_L0.5320.46
27_F90_A0.5320.46
53_I56_I0.5300.46
70_G105_G0.5270.46
38_Y50_E0.5260.46
32_S94_L0.5250.46
9_L14_L0.5230.45
85_L88_I0.5150.44
44_L97_V0.5120.44
16_I37_I0.5110.44
32_S103_V0.5080.43
28_S71_L0.5050.43
77_G90_A0.5050.43
70_G77_G0.5050.43
64_F110_I0.5010.43
36_G66_F0.5000.43
78_L91_G0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6yA 2 0.8295 40.4 0.868 Contact Map
4pypA 1 0.8372 26.4 0.88 Contact Map
4ev6A 3 0.4574 18.8 0.888 Contact Map
3l1lA 2 0.8372 16.5 0.891 Contact Map
4i0uA 4 0.4496 15.5 0.892 Contact Map
4bgnA 3 0.845 13.5 0.895 Contact Map
3rvyA 3 0.7907 12.9 0.896 Contact Map
2jlnA 1 0.876 9.7 0.902 Contact Map
4zw9A 1 0.938 8.5 0.904 Contact Map
2xq2A 2 0.969 8.1 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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