FIST - PFAM28P - GREMLIN Contacts

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FIST - FIST N domain

PFAM:	PF08495	Sequences: DLVLVFASPHADDLEALLAALREALPGAPLIGCSTAGEIGGDGVELEDGVVALALTFDDAGEELAEALPKLALVLADGLSVNGEELLAGLNEALGAPGVPVVGGLAGDGGLRFKTYVFLNGEVLSDGAVGVLLYGDKLPVGTGVSQGWRPIGPPRVVTKAEGNVVYELDGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	171 (168)
Sequences:	21146 (16876)
Seq/√Len:	1302.0
META:	0.89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
159_K	167_E	4.929	1.00
159_K	166_Y	4.691	1.00
157_V	160_A	3.350	1.00
29_P	120_N	2.987	1.00
31_I	131_V	2.711	1.00
161_E	166_Y	2.592	1.00
167_E	170_G	2.538	1.00
33_C	106_A	2.488	1.00
155_R	168_L	2.286	1.00
7_A	14_L	2.199	1.00
5_V	21_L	2.145	1.00
155_R	169_D	2.113	1.00
32_G	118_F	2.069	1.00
3_V	54_A	2.012	1.00
35_T	38_E	1.968	1.00
119_L	122_E	1.950	1.00
20_A	24_A	1.933	1.00
22_R	121_G	1.923	1.00
124_L	127_G	1.910	1.00
20_A	23_E	1.841	1.00
22_R	120_N	1.831	1.00
38_E	49_G	1.830	1.00
94_L	97_P	1.823	1.00
62_E	66_E	1.807	1.00
61_G	65_A	1.782	1.00
16_A	19_A	1.731	1.00
15_E	19_A	1.727	1.00
85_E	88_A	1.697	1.00
102_V	142_T	1.673	1.00
19_A	23_E	1.670	1.00
13_D	16_A	1.637	1.00
2_L	131_V	1.603	1.00
3_V	25_L	1.601	1.00
108_D	113_F	1.555	1.00
60_A	65_A	1.547	1.00
72_A	132_L	1.538	1.00
83_G	105_L	1.532	1.00
8_S	38_E	1.452	1.00
116_Y	119_L	1.421	1.00
71_L	100_P	1.401	1.00
3_V	28_A	1.368	1.00
50_V	53_L	1.349	1.00
51_V	54_A	1.346	1.00
71_L	140_V	1.343	1.00
72_A	130_G	1.316	1.00
165_V	168_L	1.306	1.00
60_A	64_L	1.302	1.00
62_E	92_E	1.301	1.00
63_E	66_E	1.292	1.00
73_L	102_V	1.271	1.00
16_A	20_A	1.258	1.00
52_A	55_L	1.250	1.00
4_L	31_I	1.250	1.00
115_T	118_F	1.244	1.00
158_T	167_E	1.229	1.00
5_V	32_G	1.215	1.00
6_F	75_L	1.214	1.00
80_S	126_D	1.195	1.00
14_L	118_F	1.184	1.00
89_G	93_A	1.183	1.00
160_A	166_Y	1.168	1.00
4_L	73_L	1.155	1.00
46_L	50_V	1.151	1.00
82_N	85_E	1.150	1.00
69_P	134_Y	1.145	1.00
46_L	49_G	1.138	1.00
74_V	86_L	1.131	1.00
109_G	112_R	1.128	1.00
61_G	64_L	1.126	1.00
114_K	125_S	1.121	1.00
31_I	129_V	1.110	1.00
73_L	133_L	1.108	1.00
135_G	138_L	1.105	1.00
69_P	132_L	1.093	1.00
7_A	17_L	1.077	1.00
60_A	63_E	1.073	1.00
119_L	129_V	1.072	1.00
90_L	101_V	1.061	1.00
5_V	52_A	1.052	1.00
116_Y	125_S	1.050	1.00
25_L	28_A	1.034	1.00
33_C	75_L	1.015	1.00
63_E	67_A	1.014	1.00
156_V	169_D	1.002	1.00
70_K	136_D	0.999	1.00
87_L	101_V	0.999	1.00
117_V	129_V	0.997	1.00
2_L	55_L	0.981	1.00
91_N	101_V	0.978	1.00
77_D	80_S	0.968	1.00
78_G	105_L	0.961	1.00
3_V	30_L	0.959	1.00
72_A	99_V	0.955	1.00
85_E	162_G	0.953	1.00
17_L	50_V	0.934	1.00
52_A	56_T	0.933	1.00
5_V	118_F	0.924	1.00
70_K	134_Y	0.924	1.00
11_A	14_L	0.921	1.00
88_A	91_N	0.911	1.00
76_A	105_L	0.911	1.00
17_L	20_A	0.908	1.00
50_V	55_L	0.907	1.00
51_V	55_L	0.903	1.00
9_P	13_D	0.897	1.00
161_E	164_V	0.897	1.00
62_E	93_A	0.895	1.00
22_R	27_G	0.895	1.00
85_E	89_G	0.893	1.00
81_V	86_L	0.892	1.00
41_G	44_V	0.886	1.00
38_E	51_V	0.885	1.00
18_L	118_F	0.877	1.00
36_A	107_G	0.874	1.00
61_G	89_G	0.872	1.00
62_E	65_A	0.869	1.00
76_A	86_L	0.867	1.00
48_D	51_V	0.866	1.00
34_S	116_Y	0.853	1.00
71_L	133_L	0.840	1.00
9_P	12_D	0.840	1.00
89_G	92_E	0.831	1.00
19_A	121_G	0.829	1.00
86_L	128_A	0.826	1.00
43_G	48_D	0.820	1.00
74_V	130_G	0.819	1.00
115_T	119_L	0.814	1.00
5_V	18_L	0.814	1.00
135_G	139_P	0.808	1.00
95_G	98_G	0.805	1.00
65_A	68_L	0.800	1.00
108_D	112_R	0.786	1.00
40_G	46_L	0.786	1.00
64_L	68_L	0.785	1.00
119_L	124_L	0.780	1.00
29_P	119_L	0.780	1.00
18_L	22_R	0.776	1.00
51_V	56_T	0.776	1.00
7_A	34_S	0.773	1.00
47_E	50_V	0.773	1.00
3_V	27_G	0.769	1.00
21_L	52_A	0.764	1.00
109_G	113_F	0.764	1.00
19_A	22_R	0.761	1.00
66_E	93_A	0.760	1.00
10_H	48_D	0.743	1.00
14_L	18_L	0.743	1.00
106_A	117_V	0.733	1.00
40_G	44_V	0.731	1.00
15_E	122_E	0.729	1.00
84_E	88_A	0.721	1.00
61_G	67_A	0.721	1.00
157_V	168_L	0.720	1.00
90_L	130_G	0.717	1.00
15_E	123_V	0.711	1.00
7_A	118_F	0.705	1.00
72_A	101_V	0.703	1.00
38_E	48_D	0.702	1.00
46_L	51_V	0.701	1.00
77_D	115_T	0.698	1.00
18_L	123_V	0.693	1.00
100_P	142_T	0.692	1.00
59_D	63_E	0.685	1.00
14_L	123_V	0.685	1.00
142_T	145_S	0.685	1.00
51_V	58_D	0.685	1.00
136_D	139_P	0.682	1.00
148_W	152_G	0.680	1.00
73_L	76_A	0.676	1.00
33_C	36_A	0.672	1.00
40_G	51_V	0.664	1.00
23_E	26_P	0.662	1.00
50_V	56_T	0.659	1.00
158_T	170_G	0.654	1.00
15_E	18_L	0.646	1.00
53_L	56_T	0.642	1.00
99_V	132_L	0.638	1.00
60_A	68_L	0.631	1.00
4_L	55_L	0.628	1.00
43_G	46_L	0.625	1.00
72_A	90_L	0.617	1.00
72_A	94_L	0.617	1.00
10_H	109_G	0.616	1.00
153_P	169_D	0.615	1.00
75_L	129_V	0.615	1.00
74_V	90_L	0.613	1.00
64_L	67_A	0.613	1.00
144_V	147_G	0.612	1.00
10_H	13_D	0.611	1.00
50_V	54_A	0.610	1.00
86_L	90_L	0.602	1.00
151_I	154_P	0.601	1.00
34_S	106_A	0.597	1.00
44_V	49_G	0.593	1.00
157_V	165_V	0.590	1.00
3_V	21_L	0.590	1.00
121_G	124_L	0.588	1.00
8_S	48_D	0.581	1.00
47_E	51_V	0.580	1.00
21_L	24_A	0.576	1.00
22_R	30_L	0.574	1.00
143_G	146_Q	0.570	1.00
32_G	127_G	0.570	1.00
20_A	25_L	0.565	1.00
10_H	14_L	0.564	1.00
70_K	132_L	0.564	1.00
145_S	148_W	0.561	1.00
54_A	58_D	0.560	1.00
29_P	131_V	0.559	1.00
63_E	68_L	0.559	1.00
72_A	76_A	0.556	1.00
34_S	108_D	0.554	1.00
75_L	133_L	0.554	1.00
70_K	98_G	0.553	1.00
46_L	53_L	0.549	1.00
70_K	135_G	0.549	1.00
118_F	123_V	0.544	1.00
22_R	25_L	0.543	1.00
77_D	81_V	0.543	1.00
77_D	126_D	0.542	1.00
9_P	112_R	0.542	1.00
26_P	29_P	0.540	1.00
102_V	140_V	0.538	1.00
4_L	53_L	0.537	1.00
107_G	115_T	0.535	1.00
3_V	57_F	0.535	1.00
65_A	93_A	0.534	1.00
148_W	151_I	0.532	1.00
6_F	33_C	0.532	1.00
44_V	47_E	0.531	1.00
96_A	99_V	0.531	1.00
53_L	57_F	0.530	1.00
31_I	119_L	0.529	1.00
42_D	45_E	0.528	1.00
38_E	107_G	0.527	1.00
10_H	112_R	0.527	1.00
163_N	166_Y	0.525	1.00
108_D	115_T	0.525	1.00
91_N	95_G	0.523	1.00
36_A	109_G	0.522	1.00
21_L	25_L	0.521	1.00
59_D	68_L	0.519	1.00
96_A	100_P	0.518	1.00
2_L	31_I	0.517	1.00
18_L	30_L	0.514	1.00
44_V	48_D	0.514	1.00
147_G	151_I	0.513	1.00
94_L	98_G	0.506	1.00
46_L	52_A	0.506	1.00
145_S	150_P	0.503	1.00
38_E	46_L	0.501	1.00
9_P	109_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1mgpA	1	0.3158	11.9	0.919	Contact Map
1pzxA	1	0.3392	10.2	0.921	Contact Map
3hzhA	1	0.5205	7.8	0.925	Contact Map
3eulA	2	0.538	7.5	0.926	Contact Map
3pl5A	1	0.3333	7.3	0.926	Contact Map
3fwzA	2	0.3977	6.6	0.928	Contact Map
3eeiA	2	0.5205	5.8	0.93	Contact Map
3bl6A	2	0.5205	5.6	0.93	Contact Map
3eodA	1	0.4854	5.5	0.93	Contact Map
1srrA	2	0.5322	5.5	0.93	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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