GREMLIN Database
FIST - FIST N domain
PFAM: PF08495 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (168)
Sequences: 21146 (16876)
Seq/√Len: 1302.0
META: 0.89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_K167_E4.9291.00
159_K166_Y4.6911.00
157_V160_A3.3501.00
29_P120_N2.9871.00
31_I131_V2.7111.00
161_E166_Y2.5921.00
167_E170_G2.5381.00
33_C106_A2.4881.00
155_R168_L2.2861.00
7_A14_L2.1991.00
5_V21_L2.1451.00
155_R169_D2.1131.00
32_G118_F2.0691.00
3_V54_A2.0121.00
35_T38_E1.9681.00
119_L122_E1.9501.00
20_A24_A1.9331.00
22_R121_G1.9231.00
124_L127_G1.9101.00
20_A23_E1.8411.00
22_R120_N1.8311.00
38_E49_G1.8301.00
94_L97_P1.8231.00
62_E66_E1.8071.00
61_G65_A1.7821.00
16_A19_A1.7311.00
15_E19_A1.7271.00
85_E88_A1.6971.00
102_V142_T1.6731.00
19_A23_E1.6701.00
13_D16_A1.6371.00
2_L131_V1.6031.00
3_V25_L1.6011.00
108_D113_F1.5551.00
60_A65_A1.5471.00
72_A132_L1.5381.00
83_G105_L1.5321.00
8_S38_E1.4521.00
116_Y119_L1.4211.00
71_L100_P1.4011.00
3_V28_A1.3681.00
50_V53_L1.3491.00
51_V54_A1.3461.00
71_L140_V1.3431.00
72_A130_G1.3161.00
165_V168_L1.3061.00
60_A64_L1.3021.00
62_E92_E1.3011.00
63_E66_E1.2921.00
73_L102_V1.2711.00
16_A20_A1.2581.00
52_A55_L1.2501.00
4_L31_I1.2501.00
115_T118_F1.2441.00
158_T167_E1.2291.00
5_V32_G1.2151.00
6_F75_L1.2141.00
80_S126_D1.1951.00
14_L118_F1.1841.00
89_G93_A1.1831.00
160_A166_Y1.1681.00
4_L73_L1.1551.00
46_L50_V1.1511.00
82_N85_E1.1501.00
69_P134_Y1.1451.00
46_L49_G1.1381.00
74_V86_L1.1311.00
109_G112_R1.1281.00
61_G64_L1.1261.00
114_K125_S1.1211.00
31_I129_V1.1101.00
73_L133_L1.1081.00
135_G138_L1.1051.00
69_P132_L1.0931.00
7_A17_L1.0771.00
60_A63_E1.0731.00
119_L129_V1.0721.00
90_L101_V1.0611.00
5_V52_A1.0521.00
116_Y125_S1.0501.00
25_L28_A1.0341.00
33_C75_L1.0151.00
63_E67_A1.0141.00
156_V169_D1.0021.00
70_K136_D0.9991.00
87_L101_V0.9991.00
117_V129_V0.9971.00
2_L55_L0.9811.00
91_N101_V0.9781.00
77_D80_S0.9681.00
78_G105_L0.9611.00
3_V30_L0.9591.00
72_A99_V0.9551.00
85_E162_G0.9531.00
17_L50_V0.9341.00
52_A56_T0.9331.00
5_V118_F0.9241.00
70_K134_Y0.9241.00
11_A14_L0.9211.00
88_A91_N0.9111.00
76_A105_L0.9111.00
17_L20_A0.9081.00
50_V55_L0.9071.00
51_V55_L0.9031.00
9_P13_D0.8971.00
161_E164_V0.8971.00
62_E93_A0.8951.00
22_R27_G0.8951.00
85_E89_G0.8931.00
81_V86_L0.8921.00
41_G44_V0.8861.00
38_E51_V0.8851.00
18_L118_F0.8771.00
36_A107_G0.8741.00
61_G89_G0.8721.00
62_E65_A0.8691.00
76_A86_L0.8671.00
48_D51_V0.8661.00
34_S116_Y0.8531.00
71_L133_L0.8401.00
9_P12_D0.8401.00
89_G92_E0.8311.00
19_A121_G0.8291.00
86_L128_A0.8261.00
43_G48_D0.8201.00
74_V130_G0.8191.00
115_T119_L0.8141.00
5_V18_L0.8141.00
135_G139_P0.8081.00
95_G98_G0.8051.00
65_A68_L0.8001.00
108_D112_R0.7861.00
40_G46_L0.7861.00
64_L68_L0.7851.00
119_L124_L0.7801.00
29_P119_L0.7801.00
18_L22_R0.7761.00
51_V56_T0.7761.00
7_A34_S0.7731.00
47_E50_V0.7731.00
3_V27_G0.7691.00
21_L52_A0.7641.00
109_G113_F0.7641.00
19_A22_R0.7611.00
66_E93_A0.7601.00
10_H48_D0.7431.00
14_L18_L0.7431.00
106_A117_V0.7331.00
40_G44_V0.7311.00
15_E122_E0.7291.00
84_E88_A0.7211.00
61_G67_A0.7211.00
157_V168_L0.7201.00
90_L130_G0.7171.00
15_E123_V0.7111.00
7_A118_F0.7051.00
72_A101_V0.7031.00
38_E48_D0.7021.00
46_L51_V0.7011.00
77_D115_T0.6981.00
18_L123_V0.6931.00
100_P142_T0.6921.00
59_D63_E0.6851.00
14_L123_V0.6851.00
142_T145_S0.6851.00
51_V58_D0.6851.00
136_D139_P0.6821.00
148_W152_G0.6801.00
73_L76_A0.6761.00
33_C36_A0.6721.00
40_G51_V0.6641.00
23_E26_P0.6621.00
50_V56_T0.6591.00
158_T170_G0.6541.00
15_E18_L0.6461.00
53_L56_T0.6421.00
99_V132_L0.6381.00
60_A68_L0.6311.00
4_L55_L0.6281.00
43_G46_L0.6251.00
72_A90_L0.6171.00
72_A94_L0.6171.00
10_H109_G0.6161.00
153_P169_D0.6151.00
75_L129_V0.6151.00
74_V90_L0.6131.00
64_L67_A0.6131.00
144_V147_G0.6121.00
10_H13_D0.6111.00
50_V54_A0.6101.00
86_L90_L0.6021.00
151_I154_P0.6011.00
34_S106_A0.5971.00
44_V49_G0.5931.00
157_V165_V0.5901.00
3_V21_L0.5901.00
121_G124_L0.5881.00
8_S48_D0.5811.00
47_E51_V0.5801.00
21_L24_A0.5761.00
22_R30_L0.5741.00
143_G146_Q0.5701.00
32_G127_G0.5701.00
20_A25_L0.5651.00
10_H14_L0.5641.00
70_K132_L0.5641.00
145_S148_W0.5611.00
54_A58_D0.5601.00
29_P131_V0.5591.00
63_E68_L0.5591.00
72_A76_A0.5561.00
34_S108_D0.5541.00
75_L133_L0.5541.00
70_K98_G0.5531.00
46_L53_L0.5491.00
70_K135_G0.5491.00
118_F123_V0.5441.00
22_R25_L0.5431.00
77_D81_V0.5431.00
77_D126_D0.5421.00
9_P112_R0.5421.00
26_P29_P0.5401.00
102_V140_V0.5381.00
4_L53_L0.5371.00
107_G115_T0.5351.00
3_V57_F0.5351.00
65_A93_A0.5341.00
148_W151_I0.5321.00
6_F33_C0.5321.00
44_V47_E0.5311.00
96_A99_V0.5311.00
53_L57_F0.5301.00
31_I119_L0.5291.00
42_D45_E0.5281.00
38_E107_G0.5271.00
10_H112_R0.5271.00
163_N166_Y0.5251.00
108_D115_T0.5251.00
91_N95_G0.5231.00
36_A109_G0.5221.00
21_L25_L0.5211.00
59_D68_L0.5191.00
96_A100_P0.5181.00
2_L31_I0.5171.00
18_L30_L0.5141.00
44_V48_D0.5141.00
147_G151_I0.5131.00
94_L98_G0.5061.00
46_L52_A0.5061.00
145_S150_P0.5031.00
38_E46_L0.5011.00
9_P109_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mgpA 1 0.3158 11.9 0.919 Contact Map
1pzxA 1 0.3392 10.2 0.921 Contact Map
3hzhA 1 0.5205 7.8 0.925 Contact Map
3eulA 2 0.538 7.5 0.926 Contact Map
3pl5A 1 0.3333 7.3 0.926 Contact Map
3fwzA 2 0.3977 6.6 0.928 Contact Map
3eeiA 2 0.5205 5.8 0.93 Contact Map
3bl6A 2 0.5205 5.6 0.93 Contact Map
3eodA 1 0.4854 5.5 0.93 Contact Map
1srrA 2 0.5322 5.5 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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