GREMLIN Database
DEAD_assoc - DEAD/H associated
PFAM: PF08494 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 191 (189)
Sequences: 17267 (8843)
Seq/√Len: 643.2
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_E166_R3.9281.00
171_R176_E3.7461.00
3_T6_T3.2391.00
6_T178_R2.9871.00
6_T180_V2.9141.00
83_P173_E2.8761.00
107_N151_T2.8091.00
167_E171_R2.5621.00
153_R157_E2.5421.00
164_R167_E2.4911.00
31_V164_R2.4491.00
25_S32_N2.3581.00
23_V60_I2.2381.00
83_P170_R2.0281.00
170_R174_S2.0191.00
167_E170_R2.0011.00
161_D164_R1.9811.00
39_L60_I1.9651.00
166_R170_R1.9271.00
87_E91_E1.9181.00
11_R181_A1.8901.00
41_K45_R1.8801.00
42_R89_L1.8471.00
85_E88_D1.8151.00
91_E152_Y1.7781.00
101_K133_D1.7711.00
7_L23_V1.7711.00
86_L165_L1.7011.00
56_T59_G1.6681.00
163_P166_R1.6631.00
111_A147_L1.6491.00
82_D173_E1.6441.00
34_A165_L1.5881.00
82_D85_E1.5861.00
184_T188_S1.5671.00
103_R159_A1.5511.00
113_L147_L1.5211.00
118_R121_K1.4961.00
110_R154_E1.4801.00
27_F168_L1.4761.00
171_R177_I1.4751.00
157_E163_P1.4601.00
36_G53_A1.4311.00
15_E18_G1.4151.00
12_F22_V1.4131.00
95_L140_R1.3931.00
44_C93_A1.3911.00
168_L177_I1.3851.00
137_A140_R1.3781.00
9_V23_V1.3631.00
88_D92_Q1.3621.00
27_F31_V1.3571.00
103_R154_E1.3281.00
86_L166_R1.3221.00
45_R92_Q1.3071.00
31_V165_L1.2851.00
76_D80_L1.2841.00
148_L152_Y1.2831.00
172_I179_V1.2791.00
31_V168_L1.2651.00
41_K92_Q1.2371.00
180_V184_T1.2361.00
32_N60_I1.2211.00
85_E89_L1.2191.00
144_D149_R1.2191.00
117_R122_R1.2081.00
88_D91_E1.2081.00
149_R153_R1.1861.00
65_P70_F1.1811.00
130_M133_D1.1791.00
170_R173_E1.1751.00
46_R76_D1.1471.00
40_A53_A1.1261.00
29_R57_D1.1181.00
151_T155_C1.1001.00
7_L27_F1.0971.00
150_E153_R1.0971.00
117_R121_K1.0861.00
11_R183_D1.0841.00
9_V21_L1.0821.00
12_F184_T1.0821.00
41_K93_A1.0791.00
24_H32_N1.0741.00
21_L64_L1.0701.00
38_A89_L1.0691.00
95_L152_Y1.0641.00
103_R158_D1.0601.00
75_E79_R1.0491.00
36_G60_I1.0341.00
109_A128_Q1.0281.00
54_A61_V1.0241.00
134_D137_A1.0241.00
34_A90_L1.0231.00
13_R19_W1.0191.00
108_A114_L1.0121.00
8_V24_H1.0011.00
34_A160_L1.0001.00
42_R85_E0.9891.00
68_H71_P0.9881.00
44_C50_E0.9831.00
35_L165_L0.9791.00
135_L139_V0.9771.00
76_D79_R0.9641.00
11_R21_L0.9631.00
115_P118_R0.9571.00
42_R81_L0.9561.00
84_D173_E0.9561.00
107_N147_L0.9561.00
124_P127_Q0.9531.00
171_R174_S0.9531.00
138_V142_Y0.9381.00
39_L79_R0.9331.00
150_E154_E0.9311.00
71_P75_E0.9231.00
5_R176_E0.9161.00
5_R171_R0.9131.00
38_A90_L0.9131.00
27_F32_N0.9111.00
33_R55_A0.9031.00
11_R19_W0.9021.00
42_R46_R0.9001.00
37_L97_S0.9001.00
99_L155_C0.8971.00
38_A86_L0.8931.00
108_A147_L0.8881.00
109_A116_R0.8831.00
162_L166_R0.8791.00
100_F151_T0.8791.00
27_F171_R0.8721.00
118_R131_S0.8711.00
65_P69_S0.8701.00
123_K131_S0.8651.00
20_Q61_V0.8571.00
53_A62_L0.8571.00
123_K127_Q0.8571.00
172_I177_I0.8511.00
35_L169_L0.8361.00
168_L171_R0.8351.00
40_A93_A0.8331.00
13_R17_G0.8171.00
39_L62_L0.8161.00
4_D27_F0.8121.00
66_E69_S0.8101.00
181_A184_T0.8101.00
83_P166_R0.8031.00
172_I175_G0.8021.00
6_T176_E0.8021.00
29_R55_A0.7971.00
87_E157_E0.7961.00
79_R82_D0.7931.00
91_E149_R0.7911.00
13_R16_L0.7901.00
137_A141_R0.7901.00
20_Q63_S0.7871.00
41_K89_L0.7771.00
45_R89_L0.7731.00
7_L168_L0.7691.00
7_L25_S0.7671.00
36_G55_A0.7671.00
100_F148_L0.7641.00
90_L162_L0.7581.00
75_E181_A0.7551.00
92_Q95_L0.7531.00
16_L19_W0.7511.00
44_C51_L0.7511.00
163_P167_E0.7421.00
14_D18_G0.7421.00
171_R175_G0.7411.00
52_Q63_S0.7351.00
12_F187_P0.7341.00
101_K137_A0.7341.00
153_R158_D0.7311.00
140_R152_Y0.7231.00
33_R37_L0.7231.00
155_C159_A0.7191.00
114_L132_A0.7181.00
42_R45_R0.7151.00
46_R80_L0.7141.00
74_L78_L0.7131.00
94_L152_Y0.7101.00
25_S168_L0.7101.00
5_R178_R0.7081.00
84_D170_R0.7061.00
136_L139_V0.7031.00
14_D17_G0.7001.00
40_A50_E0.6991.00
117_R123_K0.6971.00
87_E162_L0.6951.00
65_P68_H0.6941.00
179_V182_V0.6901.00
22_V61_V0.6881.00
99_L159_A0.6801.00
86_L162_L0.6791.00
118_R123_K0.6791.00
103_R107_N0.6791.00
136_L140_R0.6781.00
13_R18_G0.6781.00
175_G178_R0.6761.00
67_Q138_V0.6751.00
110_R150_E0.6751.00
38_A169_L0.6751.00
132_A136_L0.6741.00
51_L62_L0.6731.00
105_R132_A0.6721.00
74_L77_V0.6681.00
109_A123_K0.6671.00
42_R80_L0.6651.00
104_F136_L0.6601.00
67_Q70_F0.6571.00
96_A140_R0.6551.00
115_P119_P0.6431.00
37_L93_A0.6421.00
113_L139_V0.6391.00
78_L81_L0.6381.00
94_L155_C0.6361.00
109_A114_L0.6311.00
26_P58_D0.6301.00
35_L38_A0.6281.00
133_D136_L0.6201.00
139_V142_Y0.6151.00
43_L51_L0.6131.00
101_K131_S0.6111.00
66_E71_P0.6091.00
14_D20_Q0.6081.00
104_F113_L0.6011.00
40_A62_L0.5991.00
27_F177_I0.5981.00
14_D63_S0.5951.00
7_L35_L0.5941.00
168_L172_I0.5901.00
94_L160_L0.5901.00
7_L177_I0.5891.00
33_R36_G0.5871.00
103_R106_E0.5801.00
12_F20_Q0.5791.00
48_G69_S0.5761.00
100_F136_L0.5741.00
71_P74_L0.5731.00
93_A96_A0.5721.00
90_L93_A0.5721.00
98_P102_R0.5721.00
81_L89_L0.5711.00
169_L173_E0.5711.00
99_L160_L0.5701.00
24_H59_G0.5691.00
70_F74_L0.5681.00
23_V39_L0.5621.00
104_F108_A0.5601.00
86_L169_L0.5591.00
33_R159_A0.5581.00
26_P56_T0.5571.00
187_P191_A0.5461.00
94_L107_N0.5441.00
19_W64_L0.5401.00
107_N110_R0.5391.00
71_P76_D0.5391.00
24_H191_A0.5340.99
91_E156_L0.5310.99
49_F65_P0.5300.99
95_L98_P0.5280.99
43_L80_L0.5270.99
44_C96_A0.5260.99
41_K96_A0.5260.99
52_Q130_M0.5240.99
40_A44_C0.5230.99
81_L169_L0.5210.99
40_A51_L0.5210.99
87_E163_P0.5210.99
78_L179_V0.5210.99
101_K117_R0.5200.99
108_A135_L0.5190.99
49_F64_L0.5190.99
146_P149_R0.5170.99
102_R106_E0.5150.99
121_K127_Q0.5150.99
184_T187_P0.5110.99
127_Q131_S0.5100.99
43_L64_L0.5080.99
117_R120_G0.5080.99
121_K124_P0.5070.99
7_L172_I0.5070.99
16_L20_Q0.5040.99
37_L53_A0.5000.99
83_P87_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v4gA 5 0.3874 15.5 0.941 Contact Map
2y26A 8 0.3246 13.8 0.943 Contact Map
3crvA 1 0.3874 11.4 0.945 Contact Map
1xxaA 4 0.3717 9.1 0.947 Contact Map
3lapA 6 0.3717 9.1 0.947 Contact Map
1jyoA 2 0.4921 8.1 0.948 Contact Map
2f9fA 1 0.4607 8.1 0.948 Contact Map
3kl4A 1 0.3089 7.8 0.949 Contact Map
1b4aA 5 0.3822 7.6 0.949 Contact Map
2p5mA 4 0.3665 7.1 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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