GREMLIN Database
HrpB_C - ATP-dependent helicase C-terminal
PFAM: PF08482 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 133 (133)
Sequences: 14917 (8029)
Seq/√Len: 696.2
META: 0.886

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_P32_Q3.3261.00
45_T51_R2.6511.00
63_V90_H2.6371.00
25_R33_R2.5591.00
66_V71_L2.3441.00
19_D22_A2.2941.00
76_E106_A2.2551.00
99_V120_L2.2111.00
43_H51_R2.0961.00
35_R38_R2.0411.00
107_G111_G2.0111.00
65_A90_H1.9811.00
76_E79_R1.9401.00
71_L74_L1.9351.00
35_R39_L1.9201.00
39_L82_G1.9201.00
71_L89_L1.8971.00
21_L25_R1.8911.00
115_E118_K1.7881.00
111_G114_P1.7771.00
106_A110_R1.7621.00
117_R121_R1.6851.00
54_I62_P1.6601.00
77_T106_A1.6531.00
68_L113_Y1.6531.00
18_L23_A1.6471.00
47_P74_L1.5691.00
88_L103_R1.5661.00
117_R131_E1.5511.00
38_R82_G1.5241.00
46_V52_I1.5131.00
25_R37_D1.5081.00
46_V66_V1.5061.00
79_R86_P1.5001.00
67_R96_G1.4801.00
115_E119_E1.4691.00
75_A110_R1.4451.00
54_I64_L1.4161.00
9_V14_D1.4151.00
100_Q112_S1.3891.00
54_I87_L1.3801.00
64_L89_L1.3571.00
34_R38_R1.3471.00
61_P103_R1.3281.00
67_R128_P1.3201.00
5_Y26_A1.3131.00
81_A85_V1.3131.00
107_G112_S1.3031.00
22_A25_R1.2931.00
90_H101_V1.2851.00
10_R14_D1.2741.00
30_W34_R1.2711.00
57_E60_G1.2591.00
32_Q35_R1.2521.00
11_S14_D1.2461.00
52_I64_L1.2321.00
33_R37_D1.2241.00
9_V18_L1.2181.00
58_A61_P1.2141.00
55_D63_V1.2071.00
104_D107_G1.1171.00
116_V119_E1.1031.00
31_E34_R1.0991.00
50_S70_E1.0921.00
48_S70_E1.0841.00
72_F128_P1.0761.00
29_P33_R1.0591.00
66_V70_E1.0521.00
35_R82_G1.0481.00
31_E35_R1.0271.00
44_L54_I1.0261.00
121_R131_E1.0251.00
43_H53_R1.0161.00
114_P118_K1.0071.00
68_L99_V1.0061.00
75_A106_A1.0061.00
71_L91_L0.9921.00
20_L23_A0.9581.00
112_S116_V0.9471.00
13_A17_R0.9341.00
15_L18_L0.9311.00
14_D17_R0.9221.00
44_L87_L0.9191.00
114_P117_R0.9071.00
12_L15_L0.9051.00
22_A26_A0.9041.00
12_L16_K0.8961.00
40_A85_V0.8881.00
5_Y23_A0.8821.00
77_T89_L0.8801.00
30_W33_R0.8741.00
2_L6_L0.8461.00
40_A81_A0.8461.00
86_P103_R0.8461.00
34_R37_D0.8411.00
63_V88_L0.8401.00
55_D90_H0.8341.00
57_E63_V0.8331.00
88_L101_V0.8281.00
55_D65_A0.8271.00
79_R83_G0.8221.00
68_L72_F0.8141.00
112_S115_E0.8011.00
28_L33_R0.8001.00
55_D58_A0.7941.00
110_R114_P0.7811.00
46_V50_S0.7741.00
119_E122_G0.7601.00
118_K122_G0.7591.00
9_V15_L0.7511.00
119_E123_R0.7451.00
48_S74_L0.7351.00
42_E53_R0.7291.00
44_L74_L0.7291.00
96_G99_V0.7291.00
128_P132_D0.7201.00
60_G103_R0.7201.00
93_S99_V0.7171.00
90_H98_P0.7151.00
13_A16_K0.7151.00
16_K19_D0.7121.00
6_L9_V0.7101.00
65_A96_G0.7001.00
65_A92_L0.6981.00
28_L32_Q0.6831.00
9_V12_L0.6811.00
93_S97_R0.6801.00
40_A80_I0.6611.00
28_L36_L0.6591.00
80_I87_L0.6571.00
99_V116_V0.6541.00
52_I66_V0.6471.00
48_S52_I0.6451.00
111_G115_E0.6391.00
23_A27_L0.6371.00
96_G122_G0.6361.00
50_S96_G0.6321.00
5_Y9_V0.6311.00
68_L71_L0.6281.00
130_P133_P0.6231.00
57_E61_P0.6191.00
74_L89_L0.6191.00
93_S120_L0.6141.00
93_S124_Y0.6131.00
36_L40_A0.6111.00
122_G128_P0.6011.00
54_I63_V0.5991.00
77_T86_P0.5991.00
26_A33_R0.5961.00
19_D25_R0.5911.00
121_R125_P0.5891.00
20_L27_L0.5871.00
120_L125_P0.5861.00
31_E38_R0.5851.00
67_R70_E0.5841.00
46_V64_L0.5841.00
18_L22_A0.5841.00
42_E51_R0.5821.00
98_P101_V0.5791.00
20_L24_L0.5791.00
37_D42_E0.5771.00
12_L20_L0.5761.00
60_G63_V0.5751.00
50_S67_R0.5731.00
60_G88_L0.5721.00
39_L81_A0.5671.00
12_L18_L0.5631.00
5_Y18_L0.5611.00
99_V112_S0.5611.00
69_Q72_F0.5611.00
78_P89_L0.5601.00
3_A7_A0.5601.00
112_S120_L0.5571.00
107_G110_R0.5551.00
114_P119_E0.5541.00
55_D59_D0.5501.00
9_V17_R0.5491.00
21_L42_E0.5471.00
46_V70_E0.5461.00
11_S16_K0.5451.00
116_V121_R0.5441.00
4_P27_L0.5441.00
64_L87_L0.5431.00
23_A26_A0.5391.00
68_L91_L0.5341.00
6_L15_L0.5311.00
82_G85_V0.5301.00
115_E123_R0.5301.00
80_I85_V0.5291.00
61_P88_L0.5271.00
105_L109_W0.5271.00
112_S122_G0.5181.00
26_A30_W0.5110.99
100_Q119_E0.5050.99
12_L17_R0.5050.99
22_A27_L0.5040.99
70_E92_L0.5020.99
70_E128_P0.5010.99
48_S66_V0.5010.99
96_G128_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0yA 1 0.8496 59.1 0.925 Contact Map
4v194 1 0.3383 21.4 0.942 Contact Map
5afrA 2 0.7444 16.7 0.945 Contact Map
1dwmA 1 0.5038 14.1 0.946 Contact Map
1mitA 1 0.5038 13.1 0.947 Contact Map
1vbwA 1 0.4962 12.2 0.948 Contact Map
4aeeA 1 0.4812 11.4 0.949 Contact Map
3cr8A 4 0.797 11.4 0.949 Contact Map
1v47A 2 0.8421 9.6 0.95 Contact Map
4bhxA 2 0.4211 9.3 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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