GREMLIN Database
EcoEI_R_C - EcoEI R protein C-terminal
PFAM: PF08463 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (158)
Sequences: 15540 (9395)
Seq/√Len: 747.4
META: 0.886

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_K13_E3.0771.00
8_R12_R2.8021.00
94_E118_L2.6861.00
32_K36_K2.6591.00
50_T53_Q2.6531.00
90_R94_E2.4691.00
156_E159_E2.3341.00
131_D134_E2.2031.00
53_Q56_E2.1871.00
37_E40_E2.1401.00
153_G156_E1.9961.00
112_E115_E1.9351.00
10_F13_E1.8961.00
22_R26_S1.8781.00
108_A112_E1.8151.00
91_E94_E1.7211.00
138_F141_L1.7131.00
94_E98_K1.7041.00
101_L111_R1.7011.00
116_A141_L1.6981.00
109_E150_L1.6751.00
40_E44_E1.6591.00
2_S5_D1.6371.00
136_P139_T1.6301.00
87_L95_R1.6281.00
111_R115_E1.6191.00
5_D9_K1.5891.00
14_N17_S1.5571.00
130_E133_L1.5381.00
33_A37_E1.5221.00
135_L140_D1.5031.00
36_K39_E1.4891.00
148_V153_G1.4731.00
148_V157_L1.4611.00
99_R103_G1.4481.00
56_E59_G1.4431.00
16_D20_A1.4321.00
146_E149_K1.4321.00
19_D22_R1.4301.00
129_L158_R1.4211.00
55_W58_Y1.4151.00
154_K158_R1.3941.00
147_A157_L1.3901.00
158_R162_E1.3601.00
61_L70_A1.3551.00
90_R122_A1.3501.00
135_L139_T1.3421.00
51_E55_W1.3411.00
97_F115_E1.3361.00
146_E150_L1.3181.00
159_E162_E1.3171.00
20_A23_K1.2991.00
130_E134_E1.2991.00
81_G84_Q1.2761.00
143_G146_E1.2591.00
131_D135_L1.2481.00
159_E163_E1.2391.00
152_G156_E1.2281.00
37_E41_K1.2271.00
31_T34_D1.2251.00
112_E141_L1.2111.00
107_T110_Q1.2001.00
95_R99_R1.1961.00
95_R98_K1.1741.00
119_D122_A1.1631.00
98_K102_F1.1411.00
131_D136_P1.1351.00
112_E116_A1.1281.00
58_Y61_L1.1261.00
115_E119_D1.1181.00
132_L136_P1.1131.00
36_K40_E1.1091.00
51_E127_I1.1001.00
87_L91_E1.1001.00
20_A24_L1.0991.00
120_H124_N1.0981.00
10_F49_F1.0871.00
56_E60_Q1.0871.00
14_N18_I1.0811.00
94_E97_F1.0761.00
40_E43_K1.0651.00
12_R15_F1.0621.00
136_P140_D1.0571.00
109_E112_E1.0551.00
144_L148_V1.0521.00
91_E95_R1.0511.00
41_K44_E1.0391.00
128_E131_D1.0371.00
34_D37_E1.0331.00
120_H123_E1.0191.00
163_E166_E1.0131.00
129_L144_L1.0071.00
142_G145_G1.0011.00
132_L135_L1.0001.00
90_R119_D0.9861.00
145_G148_V0.9851.00
39_E43_K0.9791.00
145_G149_K0.9721.00
102_F105_K0.9691.00
58_Y75_L0.9681.00
155_E159_E0.9641.00
93_A118_L0.9571.00
4_R8_R0.9531.00
49_F53_Q0.9501.00
93_A96_A0.9501.00
30_L34_D0.9471.00
45_P48_G0.9471.00
49_F54_L0.9451.00
9_K12_R0.9311.00
89_R93_A0.9171.00
24_L30_L0.9081.00
92_R96_A0.9081.00
99_R167_A0.9071.00
97_F118_L0.9031.00
160_A164_L0.9021.00
142_G149_K0.8971.00
10_F14_N0.8881.00
38_L76_I0.8861.00
55_W72_L0.8851.00
162_E166_E0.8761.00
108_A111_R0.8741.00
51_E72_L0.8551.00
101_L106_F0.8361.00
74_D92_R0.8281.00
15_F18_I0.8281.00
25_W80_A0.8191.00
100_W103_G0.8181.00
53_Q57_A0.8171.00
14_N41_K0.8171.00
52_E55_W0.8091.00
161_L165_N0.8061.00
162_E165_N0.8031.00
117_I127_I0.8001.00
8_R79_V0.8001.00
119_D123_E0.7841.00
6_Y10_F0.7771.00
101_L105_K0.7741.00
144_L147_A0.7711.00
41_K45_P0.7701.00
110_Q160_A0.7701.00
17_S20_A0.7691.00
142_G146_E0.7641.00
27_N30_L0.7641.00
133_L148_V0.7601.00
6_Y9_K0.7551.00
155_E158_R0.7531.00
12_R16_D0.7481.00
39_E51_E0.7451.00
94_E122_A0.7431.00
33_A36_K0.7421.00
96_A99_R0.7421.00
106_F114_L0.7341.00
141_L144_L0.7261.00
54_L79_V0.7251.00
5_D8_R0.7041.00
6_Y49_F0.7021.00
120_H138_F0.6951.00
163_E167_A0.6911.00
89_R125_G0.6881.00
5_D12_R0.6861.00
94_E115_E0.6851.00
141_L147_A0.6831.00
114_L160_A0.6831.00
54_L58_Y0.6831.00
110_Q156_E0.6671.00
76_I79_V0.6631.00
100_W106_F0.6601.00
8_R81_G0.6571.00
15_F25_W0.6501.00
89_R92_R0.6461.00
2_S9_K0.6401.00
18_I41_K0.6381.00
83_D92_R0.6351.00
78_H82_L0.6331.00
147_A150_L0.6311.00
19_D23_K0.6291.00
87_L92_R0.6251.00
93_A122_A0.6221.00
147_A161_L0.6191.00
157_L163_E0.6191.00
3_Y7_F0.6171.00
100_W104_K0.6111.00
59_G63_A0.6061.00
44_E48_G0.6061.00
4_R7_F0.6051.00
133_L136_P0.6041.00
118_L122_A0.6001.00
121_Y126_V0.5991.00
71_D74_D0.5961.00
2_S6_Y0.5941.00
116_A119_D0.5911.00
99_R102_F0.5891.00
24_L34_D0.5881.00
127_I131_D0.5831.00
75_L79_V0.5811.00
157_L161_L0.5771.00
109_E146_E0.5761.00
148_V154_K0.5751.00
52_E56_E0.5741.00
133_L144_L0.5731.00
97_F101_L0.5721.00
104_K163_E0.5721.00
96_A167_A0.5721.00
107_T111_R0.5711.00
108_A115_E0.5701.00
7_F10_F0.5691.00
27_N166_E0.5691.00
24_L27_N0.5621.00
3_Y53_Q0.5621.00
100_W105_K0.5611.00
143_G147_A0.5611.00
74_D93_A0.5591.00
43_K54_L0.5581.00
88_T91_E0.5521.00
28_P31_T0.5511.00
157_L160_A0.5471.00
16_D25_W0.5471.00
134_E139_T0.5431.00
102_F106_F0.5421.00
120_H131_D0.5391.00
11_L80_A0.5371.00
14_N24_L0.5351.00
142_G147_A0.5341.00
38_L41_K0.5321.00
73_F77_R0.5291.00
101_L107_T0.5281.00
18_I37_E0.5271.00
39_E71_D0.5271.00
49_F57_A0.5201.00
158_R163_E0.5171.00
130_E135_L0.5161.00
70_A75_L0.5131.00
15_F22_R0.5101.00
116_A138_F0.5041.00
10_F41_K0.5031.00
156_E163_E0.5001.00
18_I22_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wzkA 1 0.8698 47.6 0.893 Contact Map
4a64A 4 0.8047 21.6 0.911 Contact Map
4eozB 1 0.5385 14.7 0.917 Contact Map
1hsjA 2 0.6805 12.1 0.92 Contact Map
3nw0A 1 0.3254 10.9 0.922 Contact Map
4ka7A 1 0.9053 8.2 0.926 Contact Map
2lw4A 1 0.3314 7.5 0.927 Contact Map
4il1A 1 0.432 7.3 0.928 Contact Map
2hyeC 1 0.8817 7.1 0.928 Contact Map
3c18A 2 0.8462 7.1 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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