SNF2_assoc - PFAM28P - GREMLIN Contacts

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SNF2_assoc - Bacterial SNF2 helicase associated

PFAM:	PF08455	Sequences: RYLLLPPSLLDEFLELLKGKPFTLEEIGGETYEEVEISEEDPPLSFELEKEDDGGYELSLKGLEPIILLESYLYFLYDGKLYRLSKEQIKLLKPLLKLLKEGKGEIVIPKEDLEEFLSKVLPPLKKLGEVEIDEELLEEIVPEPLEAKLYLDEEGDYLTAQLEFSYGDIEINPLDKDIIIRDLEKEQEILQLLESLGFQVDEGGFYLGDEEAIYDFLTDGLPELQELGEVYGSEALKNLKIRTAPKPSVGVSVSSGTDWLELDFDIEGIQEVELAEILKALREKKKYYRLKDGSFLSLEEEWLEKLSELLDDLGLSEKDLKKGKLRLPKYRALYLDELLEENEEELSIERDESFKELIENLKNPEDLDFEVP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	372 (367)
Sequences:	3011 (2557)
Seq/√Len:	133.4
META:	0.662

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
149_L	228_G	6.783	1.00
163_E	170_E	5.156	1.00
148_K	229_E	4.733	1.00
280_A	288_Y	4.546	1.00
181_R	186_E	4.272	1.00
148_K	165_S	4.087	1.00
182_D	185_K	3.872	1.00
147_A	189_I	3.724	1.00
13_F	17_L	3.571	1.00
146_E	229_E	3.518	1.00
166_Y	186_E	3.396	1.00
150_Y	231_Y	3.350	1.00
232_G	236_L	3.328	1.00
148_K	170_E	3.284	1.00
166_Y	181_R	3.252	1.00
47_E	131_E	3.076	1.00
152_D	233_S	3.024	1.00
215_D	219_D	2.940	1.00
108_I	116_F	2.866	1.00
185_K	188_E	2.665	1.00
147_A	164_F	2.577	1.00
164_F	190_L	2.525	1.00
164_F	173_P	2.499	1.00
276_E	279_K	2.435	1.00
258_D	329_K	2.425	1.00
223_E	226_E	2.417	1.00
209_D	212_A	2.383	1.00
41_D	85_S	2.383	1.00
74_Y	83_R	2.329	1.00
149_L	160_A	2.316	1.00
261_E	324_K	2.278	1.00
115_E	119_K	2.218	1.00
48_L	58_L	2.086	1.00
199_Q	202_E	2.079	1.00
359_E	366_D	2.046	1.00
145_L	164_F	1.971	1.00
274_L	278_L	1.967	1.00
269_I	273_E	1.960	1.00
17_L	22_F	1.953	1.00
252_S	351_D	1.940	1.00
356_E	360_N	1.927	1.00
200_V	205_F	1.896	1.00
350_R	354_F	1.878	1.00
361_L	364_P	1.863	1.00
160_A	193_L	1.837	1.00
116_F	120_V	1.801	1.00
45_S	131_E	1.792	1.00
161_Q	172_N	1.779	1.00
196_L	220_G	1.775	1.00
116_F	121_L	1.769	1.00
148_K	231_Y	1.735	1.00
278_L	281_L	1.734	1.00
165_S	170_E	1.734	1.00
351_D	354_F	1.699	1.00
151_L	224_L	1.695	1.00
277_I	296_L	1.685	1.00
195_S	223_E	1.668	1.00
197_G	212_A	1.641	1.00
143_E	167_G	1.640	1.00
39_E	83_R	1.630	1.00
201_D	204_G	1.623	1.00
11_D	14_L	1.609	1.00
266_I	277_I	1.606	1.00
191_Q	194_E	1.606	1.00
57_E	105_E	1.594	1.00
95_L	99_L	1.594	1.00
34_E	37_I	1.586	1.00
146_E	165_S	1.577	1.00
214_Y	295_F	1.575	1.00
201_D	205_F	1.567	1.00
38_S	80_K	1.542	1.00
192_L	227_L	1.540	1.00
124_L	128_G	1.533	1.00
359_E	363_N	1.532	1.00
36_E	80_K	1.511	1.00
270_Q	273_E	1.485	1.00
167_G	186_E	1.477	1.00
229_E	289_R	1.460	1.00
11_D	83_R	1.456	1.00
160_A	198_F	1.455	1.00
42_P	88_Q	1.444	1.00
46_F	128_G	1.440	1.00
300_E	304_E	1.425	1.00
149_L	189_I	1.416	1.00
163_E	172_N	1.388	1.00
18_K	39_E	1.383	1.00
117_L	121_L	1.382	1.00
51_E	54_G	1.378	1.00
329_K	332_A	1.376	1.00
158_L	236_L	1.355	1.00
149_L	162_L	1.354	1.00
24_L	27_I	1.351	1.00
212_A	216_F	1.350	1.00
276_E	291_K	1.343	1.00
56_Y	113_L	1.339	1.00
15_E	18_K	1.337	1.00
189_I	228_G	1.332	1.00
11_D	74_Y	1.302	1.00
261_E	326_R	1.298	1.00
310_L	315_L	1.289	1.00
299_E	302_W	1.281	1.00
40_E	43_P	1.273	1.00
109_P	112_D	1.265	1.00
339_L	348_I	1.265	1.00
360_N	366_D	1.264	1.00
51_E	57_E	1.263	1.00
165_S	168_D	1.257	1.00
45_S	129_E	1.253	1.00
154_E	157_Y	1.250	1.00
327_L	331_R	1.247	1.00
198_F	216_F	1.247	1.00
307_S	311_D	1.245	1.00
354_F	358_I	1.233	1.00
21_P	34_E	1.226	1.00
145_L	185_K	1.222	1.00
171_I	179_I	1.219	1.00
210_E	214_Y	1.216	1.00
315_L	325_L	1.211	1.00
134_E	137_L	1.203	1.00
202_E	205_F	1.202	1.00
214_Y	218_T	1.197	0.99
153_E	239_L	1.193	0.99
49_E	57_E	1.183	0.99
215_D	286_K	1.175	0.99
316_S	319_D	1.172	0.99
116_F	150_Y	1.167	0.99
330_Y	336_D	1.164	0.99
91_L	94_P	1.158	0.99
212_A	215_D	1.158	0.99
153_E	236_L	1.157	0.99
273_E	276_E	1.151	0.99
356_E	359_E	1.150	0.99
57_E	60_L	1.141	0.99
187_Q	191_Q	1.138	0.99
251_V	354_F	1.135	0.99
194_E	199_Q	1.135	0.99
112_D	115_E	1.128	0.99
151_L	236_L	1.123	0.99
216_F	224_L	1.121	0.99
259_W	326_R	1.108	0.99
164_F	186_E	1.103	0.99
76_L	81_L	1.102	0.99
211_E	287_Y	1.101	0.99
234_E	237_K	1.101	0.99
148_K	163_E	1.091	0.99
38_S	41_D	1.091	0.99
182_D	186_E	1.090	0.99
343_E	346_L	1.083	0.99
48_L	130_V	1.073	0.99
210_E	287_Y	1.065	0.99
144_P	185_K	1.064	0.99
319_D	322_K	1.063	0.99
336_D	350_R	1.055	0.99
264_F	270_Q	1.047	0.99
233_S	288_Y	1.047	0.99
72_Y	76_L	1.046	0.99
123_P	127_L	1.039	0.99
306_L	309_L	1.038	0.99
169_I	179_I	1.037	0.99
213_I	233_S	1.033	0.99
160_A	228_G	1.030	0.98
14_L	37_I	1.024	0.98
218_T	297_S	1.017	0.98
50_K	110_K	1.015	0.98
198_F	207_L	0.994	0.98
86_K	90_K	0.991	0.98
6_P	9_L	0.985	0.98
88_Q	91_L	0.985	0.98
133_D	136_L	0.985	0.98
149_L	230_V	0.981	0.98
193_L	228_G	0.980	0.98
152_D	235_A	0.979	0.98
225_Q	230_V	0.974	0.98
196_L	222_P	0.970	0.98
237_K	294_S	0.964	0.98
355_K	359_E	0.964	0.98
351_D	357_L	0.961	0.98
53_D	58_L	0.958	0.98
7_P	10_L	0.957	0.98
166_Y	293_G	0.954	0.97
355_K	366_D	0.949	0.97
353_S	357_L	0.948	0.97
162_L	173_P	0.946	0.97
261_E	264_F	0.944	0.97
58_L	62_G	0.937	0.97
41_D	88_Q	0.937	0.97
152_D	159_T	0.926	0.97
59_S	105_E	0.924	0.97
312_D	316_S	0.923	0.97
320_L	324_K	0.921	0.97
152_D	335_L	0.921	0.97
130_V	238_N	0.920	0.97
253_V	329_K	0.913	0.97
145_L	149_L	0.913	0.97
49_E	59_S	0.907	0.97
225_Q	228_G	0.900	0.96
28_G	32_Y	0.899	0.96
269_I	277_I	0.894	0.96
43_P	82_Y	0.892	0.96
33_E	37_I	0.892	0.96
164_F	189_I	0.892	0.96
55_G	107_V	0.887	0.96
93_K	97_K	0.879	0.96
215_D	218_T	0.879	0.96
41_D	46_F	0.869	0.96
125_K	142_P	0.864	0.95
363_N	366_D	0.862	0.95
351_D	364_P	0.862	0.95
43_P	88_Q	0.858	0.95
94_P	99_L	0.856	0.95
46_F	60_L	0.854	0.95
85_S	88_Q	0.851	0.95
125_K	130_V	0.851	0.95
199_Q	203_G	0.851	0.95
289_R	295_F	0.851	0.95
151_L	160_A	0.850	0.95
278_L	284_K	0.848	0.95
34_E	38_S	0.848	0.95
352_E	356_E	0.846	0.95
259_W	262_L	0.843	0.95
10_L	14_L	0.839	0.95
222_P	225_Q	0.838	0.95
250_G	281_L	0.838	0.95
11_D	73_L	0.835	0.95
253_V	262_L	0.833	0.95
147_A	162_L	0.832	0.94
235_A	277_I	0.831	0.94
173_P	181_R	0.831	0.94
9_L	12_E	0.830	0.94
161_Q	204_G	0.828	0.94
38_S	43_P	0.828	0.94
354_F	357_L	0.825	0.94
264_F	298_L	0.824	0.94
233_S	236_L	0.822	0.94
27_I	32_Y	0.822	0.94
152_D	273_E	0.818	0.94
117_L	140_I	0.816	0.94
359_E	367_L	0.814	0.94
200_V	203_G	0.814	0.94
283_E	287_Y	0.813	0.94
211_E	285_K	0.813	0.94
260_L	296_L	0.812	0.94
273_E	277_I	0.812	0.94
192_L	196_L	0.811	0.94
335_L	348_I	0.807	0.94
242_R	292_D	0.802	0.93
13_F	339_L	0.802	0.93
151_L	228_G	0.802	0.93
192_L	223_E	0.797	0.93
313_L	316_S	0.791	0.93
303_L	336_D	0.791	0.93
92_L	127_L	0.790	0.93
27_I	30_E	0.790	0.93
36_E	40_E	0.789	0.93
273_E	288_Y	0.789	0.93
342_N	346_L	0.789	0.93
193_L	197_G	0.785	0.93
231_Y	287_Y	0.784	0.93
196_L	224_L	0.783	0.92
203_G	206_Y	0.782	0.92
144_P	182_D	0.782	0.92
13_F	16_L	0.782	0.92
235_A	285_K	0.780	0.92
211_E	216_F	0.779	0.92
41_D	44_L	0.778	0.92
231_Y	289_R	0.776	0.92
49_E	133_D	0.772	0.92
88_Q	128_G	0.771	0.92
263_D	324_K	0.770	0.92
56_Y	136_L	0.769	0.92
216_F	219_D	0.769	0.92
61_K	66_I	0.768	0.92
151_L	255_S	0.767	0.92
50_K	139_E	0.766	0.92
336_D	362_K	0.764	0.92
174_L	205_F	0.763	0.92
199_Q	204_G	0.762	0.91
232_G	240_K	0.760	0.91
187_Q	190_L	0.760	0.91
72_Y	83_R	0.759	0.91
173_P	190_L	0.759	0.91
18_K	22_F	0.754	0.91
181_R	328_P	0.754	0.91
258_D	290_L	0.748	0.91
146_E	175_D	0.748	0.91
332_A	354_F	0.746	0.91
201_D	206_Y	0.745	0.91
258_D	261_E	0.739	0.90
32_Y	35_V	0.739	0.90
362_K	365_E	0.738	0.90
60_L	106_I	0.736	0.90
43_P	48_L	0.735	0.90
57_E	107_V	0.734	0.90
58_L	61_K	0.733	0.90
278_L	282_R	0.733	0.90
337_E	341_E	0.730	0.90
362_K	369_F	0.728	0.90
33_E	36_E	0.727	0.89
212_A	217_L	0.725	0.89
236_L	334_Y	0.723	0.89
233_S	238_N	0.722	0.89
213_I	216_F	0.721	0.89
152_D	236_L	0.720	0.89
276_E	288_Y	0.718	0.89
268_G	271_E	0.717	0.89
151_L	230_V	0.717	0.89
28_G	31_T	0.714	0.89
337_E	340_E	0.714	0.89
14_L	24_L	0.713	0.89
269_I	274_L	0.712	0.88
214_Y	297_S	0.711	0.88
108_I	115_E	0.710	0.88
191_Q	195_S	0.704	0.88
100_K	108_I	0.703	0.88
345_E	360_N	0.703	0.88
12_E	52_D	0.702	0.88
84_L	89_I	0.702	0.88
37_I	203_G	0.700	0.88
167_G	181_R	0.697	0.87
5_L	17_L	0.695	0.87
89_I	93_K	0.695	0.87
252_S	263_D	0.692	0.87
69_L	81_L	0.691	0.87
336_D	340_E	0.685	0.86
364_P	367_L	0.684	0.86
347_S	354_F	0.684	0.86
304_E	307_S	0.683	0.86
190_L	205_F	0.683	0.86
242_R	294_S	0.683	0.86
282_R	311_D	0.681	0.86
17_L	24_L	0.680	0.86
210_E	289_R	0.680	0.86
332_A	358_I	0.679	0.86
355_K	358_I	0.678	0.86
30_E	47_E	0.676	0.86
23_T	30_E	0.676	0.86
47_E	61_K	0.675	0.86
111_E	371_V	0.673	0.86
366_D	370_E	0.673	0.86
219_D	223_E	0.668	0.85
284_K	304_E	0.666	0.85
314_G	317_E	0.665	0.85
16_L	24_L	0.664	0.85
40_E	58_L	0.662	0.85
154_E	159_T	0.662	0.85
323_G	332_A	0.661	0.84
361_L	365_E	0.661	0.84
250_G	259_W	0.660	0.84
151_L	232_G	0.658	0.84
279_K	317_E	0.657	0.84
54_G	57_E	0.656	0.84
350_R	353_S	0.656	0.84
23_T	33_E	0.655	0.84
91_L	127_L	0.653	0.84
54_G	107_V	0.653	0.84
54_G	110_K	0.652	0.84
348_I	351_D	0.652	0.84
214_Y	331_R	0.649	0.83
145_L	171_I	0.648	0.83
89_I	95_L	0.648	0.83
346_L	349_E	0.648	0.83
12_E	15_E	0.645	0.83
158_L	271_E	0.644	0.83
309_L	313_L	0.642	0.83
210_E	295_F	0.642	0.83
350_R	357_L	0.642	0.83
12_E	16_L	0.640	0.83
281_L	295_F	0.637	0.82
260_L	273_E	0.636	0.82
265_D	271_E	0.635	0.82
172_N	175_D	0.632	0.82
158_L	216_F	0.632	0.82
273_E	278_L	0.632	0.82
264_F	268_G	0.629	0.81
151_L	181_R	0.628	0.81
183_L	187_Q	0.628	0.81
189_I	222_P	0.627	0.81
292_D	314_G	0.626	0.81
178_I	217_L	0.626	0.81
47_E	59_S	0.624	0.81
38_S	82_Y	0.624	0.81
351_D	358_I	0.622	0.81
60_L	103_K	0.622	0.81
28_G	35_V	0.622	0.81
75_F	84_L	0.621	0.81
5_L	37_I	0.620	0.81
347_S	356_E	0.620	0.81
73_L	84_L	0.618	0.80
62_G	124_L	0.618	0.80
276_E	325_L	0.618	0.80
89_I	277_I	0.617	0.80
130_V	285_K	0.617	0.80
39_E	85_S	0.617	0.80
32_Y	36_E	0.614	0.80
121_L	125_K	0.612	0.80
251_V	303_L	0.612	0.80
363_N	367_L	0.611	0.80
50_K	53_D	0.610	0.79
37_I	83_R	0.610	0.79
315_L	320_L	0.609	0.79
23_T	370_E	0.609	0.79
29_G	32_Y	0.608	0.79
216_F	287_Y	0.607	0.79
319_D	331_R	0.606	0.79
213_I	296_L	0.605	0.79
312_D	315_L	0.605	0.79
65_P	68_L	0.604	0.79
84_L	88_Q	0.604	0.79
40_E	46_F	0.603	0.79
286_K	299_E	0.601	0.78
348_I	371_V	0.601	0.78
199_Q	206_Y	0.600	0.78
93_K	211_E	0.599	0.78
362_K	370_E	0.599	0.78
150_Y	297_S	0.598	0.78
11_D	292_D	0.598	0.78
90_K	93_K	0.597	0.78
337_E	342_N	0.595	0.78
58_L	190_L	0.595	0.78
306_L	310_L	0.595	0.78
117_L	120_V	0.594	0.78
19_G	22_F	0.594	0.78
171_I	181_R	0.593	0.78
27_I	34_E	0.593	0.78
13_F	281_L	0.590	0.77
234_E	288_Y	0.590	0.77
144_P	188_E	0.590	0.77
96_L	311_D	0.590	0.77
152_D	285_K	0.588	0.77
286_K	290_L	0.587	0.77
252_S	255_S	0.587	0.77
153_E	233_S	0.587	0.77
60_L	63_L	0.586	0.77
122_P	151_L	0.585	0.77
99_L	102_G	0.585	0.77
215_D	223_E	0.584	0.76
4_L	7_P	0.582	0.76
25_E	32_Y	0.581	0.76
237_K	288_Y	0.580	0.76
143_E	179_I	0.579	0.76
87_E	126_K	0.578	0.76
352_E	355_K	0.576	0.75
56_Y	211_E	0.576	0.75
132_I	136_L	0.574	0.75
336_D	358_I	0.573	0.75
19_G	30_E	0.572	0.75
320_L	323_G	0.571	0.75
27_I	31_T	0.571	0.75
88_Q	92_L	0.571	0.75
254_S	257_T	0.569	0.75
20_K	28_G	0.568	0.74
136_L	279_K	0.568	0.74
124_L	272_V	0.567	0.74
147_A	185_K	0.567	0.74
347_S	363_N	0.567	0.74
198_F	287_Y	0.567	0.74
218_T	241_I	0.566	0.74
76_L	79_G	0.564	0.74
224_L	228_G	0.563	0.74
291_K	303_L	0.563	0.74
145_L	260_L	0.563	0.74
217_L	239_L	0.562	0.74
254_S	326_R	0.562	0.74
319_D	369_F	0.562	0.74
337_E	357_L	0.562	0.74
176_K	341_E	0.560	0.73
30_E	33_E	0.560	0.73
69_L	167_G	0.559	0.73
194_E	200_V	0.558	0.73
207_L	216_F	0.558	0.73
276_E	343_E	0.558	0.73
5_L	9_L	0.556	0.73
24_L	29_G	0.556	0.73
37_I	46_F	0.556	0.73
3_L	56_Y	0.556	0.73
20_K	24_L	0.556	0.73
57_E	61_K	0.555	0.73
350_R	355_K	0.555	0.73
241_I	274_L	0.554	0.73
185_K	189_I	0.553	0.73
122_P	125_K	0.552	0.72
193_L	207_L	0.552	0.72
152_D	287_Y	0.552	0.72
353_S	368_D	0.552	0.72
356_E	368_D	0.550	0.72
89_I	280_A	0.549	0.72
128_G	132_I	0.549	0.72
153_E	232_G	0.548	0.72
199_Q	205_F	0.548	0.72
335_L	339_L	0.548	0.72
336_D	354_F	0.545	0.71
253_V	307_S	0.545	0.71
249_V	339_L	0.545	0.71
257_T	351_D	0.545	0.71
200_V	206_Y	0.545	0.71
151_L	351_D	0.544	0.71
32_Y	268_G	0.543	0.71
350_R	364_P	0.543	0.71
29_G	33_E	0.542	0.71
6_P	274_L	0.542	0.71
15_E	20_K	0.541	0.71
179_I	298_L	0.541	0.71
84_L	292_D	0.540	0.71
60_L	68_L	0.540	0.71
125_K	348_I	0.538	0.70
230_V	301_E	0.536	0.70
135_E	139_E	0.535	0.70
250_G	265_D	0.534	0.70
359_E	368_D	0.533	0.70
196_L	221_L	0.533	0.70
353_S	356_E	0.532	0.70
64_E	75_F	0.530	0.69
310_L	362_K	0.528	0.69
277_I	280_A	0.527	0.69
147_A	153_E	0.527	0.69
38_S	44_L	0.527	0.69
219_D	299_E	0.526	0.69
92_L	96_L	0.525	0.69
42_P	46_F	0.524	0.68
162_L	193_L	0.524	0.68
206_Y	360_N	0.523	0.68
49_E	52_D	0.522	0.68
274_L	315_L	0.522	0.68
307_S	314_G	0.522	0.68
5_L	308_E	0.522	0.68
122_P	126_K	0.520	0.68
64_E	69_L	0.520	0.68
230_V	268_G	0.518	0.68
301_E	304_E	0.517	0.67
186_E	293_G	0.516	0.67
234_E	240_K	0.516	0.67
313_L	334_Y	0.512	0.67
359_E	364_P	0.512	0.67
164_F	281_L	0.511	0.67
66_I	229_E	0.510	0.66
309_L	327_L	0.508	0.66
172_N	194_E	0.507	0.66
216_F	222_P	0.507	0.66
62_G	65_P	0.507	0.66
327_L	332_A	0.506	0.66
80_K	110_K	0.506	0.66
276_E	333_L	0.506	0.66
150_Y	287_Y	0.505	0.66
208_G	213_I	0.504	0.66
162_L	189_I	0.503	0.65
99_L	104_G	0.503	0.65
213_I	232_G	0.502	0.65
263_D	274_L	0.502	0.65
230_V	290_L	0.500	0.65
31_T	34_E	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1w7jB	1	0.1532	3.1	0.966	Contact Map
3tutA	1	0.1613	2.9	0.967	Contact Map
2y9jY	3	0.2876	2.9	0.967	Contact Map
2m7lA	1	0.1989	2.8	0.967	Contact Map
3hs2A	3	0.1505	2.8	0.967	Contact Map
1q1oA	1	0.2204	2.5	0.968	Contact Map
1c07A	1	0.2177	2.5	0.968	Contact Map
1hsjA	2	0.2366	2.4	0.968	Contact Map
1lfdA	1	0.2151	2.3	0.968	Contact Map
3lqvP	1	0.0565	2.3	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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