GREMLIN Database
SNF2_assoc - Bacterial SNF2 helicase associated
PFAM: PF08455 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 372 (367)
Sequences: 3011 (2557)
Seq/√Len: 133.4
META: 0.662

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_L228_G6.7831.00
163_E170_E5.1561.00
148_K229_E4.7331.00
280_A288_Y4.5461.00
181_R186_E4.2721.00
148_K165_S4.0871.00
182_D185_K3.8721.00
147_A189_I3.7241.00
13_F17_L3.5711.00
146_E229_E3.5181.00
166_Y186_E3.3961.00
150_Y231_Y3.3501.00
232_G236_L3.3281.00
148_K170_E3.2841.00
166_Y181_R3.2521.00
47_E131_E3.0761.00
152_D233_S3.0241.00
215_D219_D2.9401.00
108_I116_F2.8661.00
185_K188_E2.6651.00
147_A164_F2.5771.00
164_F190_L2.5251.00
164_F173_P2.4991.00
276_E279_K2.4351.00
258_D329_K2.4251.00
223_E226_E2.4171.00
209_D212_A2.3831.00
41_D85_S2.3831.00
74_Y83_R2.3291.00
149_L160_A2.3161.00
261_E324_K2.2781.00
115_E119_K2.2181.00
48_L58_L2.0861.00
199_Q202_E2.0791.00
359_E366_D2.0461.00
145_L164_F1.9711.00
274_L278_L1.9671.00
269_I273_E1.9601.00
17_L22_F1.9531.00
252_S351_D1.9401.00
356_E360_N1.9271.00
200_V205_F1.8961.00
350_R354_F1.8781.00
361_L364_P1.8631.00
160_A193_L1.8371.00
116_F120_V1.8011.00
45_S131_E1.7921.00
161_Q172_N1.7791.00
196_L220_G1.7751.00
116_F121_L1.7691.00
148_K231_Y1.7351.00
278_L281_L1.7341.00
165_S170_E1.7341.00
351_D354_F1.6991.00
151_L224_L1.6951.00
277_I296_L1.6851.00
195_S223_E1.6681.00
197_G212_A1.6411.00
143_E167_G1.6401.00
39_E83_R1.6301.00
201_D204_G1.6231.00
11_D14_L1.6091.00
266_I277_I1.6061.00
191_Q194_E1.6061.00
57_E105_E1.5941.00
95_L99_L1.5941.00
34_E37_I1.5861.00
146_E165_S1.5771.00
214_Y295_F1.5751.00
201_D205_F1.5671.00
38_S80_K1.5421.00
192_L227_L1.5401.00
124_L128_G1.5331.00
359_E363_N1.5321.00
36_E80_K1.5111.00
270_Q273_E1.4851.00
167_G186_E1.4771.00
229_E289_R1.4601.00
11_D83_R1.4561.00
160_A198_F1.4551.00
42_P88_Q1.4441.00
46_F128_G1.4401.00
300_E304_E1.4251.00
149_L189_I1.4161.00
163_E172_N1.3881.00
18_K39_E1.3831.00
117_L121_L1.3821.00
51_E54_G1.3781.00
329_K332_A1.3761.00
158_L236_L1.3551.00
149_L162_L1.3541.00
24_L27_I1.3511.00
212_A216_F1.3501.00
276_E291_K1.3431.00
56_Y113_L1.3391.00
15_E18_K1.3371.00
189_I228_G1.3321.00
11_D74_Y1.3021.00
261_E326_R1.2981.00
310_L315_L1.2891.00
299_E302_W1.2811.00
40_E43_P1.2731.00
109_P112_D1.2651.00
339_L348_I1.2651.00
360_N366_D1.2641.00
51_E57_E1.2631.00
165_S168_D1.2571.00
45_S129_E1.2531.00
154_E157_Y1.2501.00
327_L331_R1.2471.00
198_F216_F1.2471.00
307_S311_D1.2451.00
354_F358_I1.2331.00
21_P34_E1.2261.00
145_L185_K1.2221.00
171_I179_I1.2191.00
210_E214_Y1.2161.00
315_L325_L1.2111.00
134_E137_L1.2031.00
202_E205_F1.2021.00
214_Y218_T1.1970.99
153_E239_L1.1930.99
49_E57_E1.1830.99
215_D286_K1.1750.99
316_S319_D1.1720.99
116_F150_Y1.1670.99
330_Y336_D1.1640.99
91_L94_P1.1580.99
212_A215_D1.1580.99
153_E236_L1.1570.99
273_E276_E1.1510.99
356_E359_E1.1500.99
57_E60_L1.1410.99
187_Q191_Q1.1380.99
251_V354_F1.1350.99
194_E199_Q1.1350.99
112_D115_E1.1280.99
151_L236_L1.1230.99
216_F224_L1.1210.99
259_W326_R1.1080.99
164_F186_E1.1030.99
76_L81_L1.1020.99
211_E287_Y1.1010.99
234_E237_K1.1010.99
148_K163_E1.0910.99
38_S41_D1.0910.99
182_D186_E1.0900.99
343_E346_L1.0830.99
48_L130_V1.0730.99
210_E287_Y1.0650.99
144_P185_K1.0640.99
319_D322_K1.0630.99
336_D350_R1.0550.99
264_F270_Q1.0470.99
233_S288_Y1.0470.99
72_Y76_L1.0460.99
123_P127_L1.0390.99
306_L309_L1.0380.99
169_I179_I1.0370.99
213_I233_S1.0330.99
160_A228_G1.0300.98
14_L37_I1.0240.98
218_T297_S1.0170.98
50_K110_K1.0150.98
198_F207_L0.9940.98
86_K90_K0.9910.98
6_P9_L0.9850.98
88_Q91_L0.9850.98
133_D136_L0.9850.98
149_L230_V0.9810.98
193_L228_G0.9800.98
152_D235_A0.9790.98
225_Q230_V0.9740.98
196_L222_P0.9700.98
237_K294_S0.9640.98
355_K359_E0.9640.98
351_D357_L0.9610.98
53_D58_L0.9580.98
7_P10_L0.9570.98
166_Y293_G0.9540.97
355_K366_D0.9490.97
353_S357_L0.9480.97
162_L173_P0.9460.97
261_E264_F0.9440.97
58_L62_G0.9370.97
41_D88_Q0.9370.97
152_D159_T0.9260.97
59_S105_E0.9240.97
312_D316_S0.9230.97
320_L324_K0.9210.97
152_D335_L0.9210.97
130_V238_N0.9200.97
253_V329_K0.9130.97
145_L149_L0.9130.97
49_E59_S0.9070.97
225_Q228_G0.9000.96
28_G32_Y0.8990.96
269_I277_I0.8940.96
43_P82_Y0.8920.96
33_E37_I0.8920.96
164_F189_I0.8920.96
55_G107_V0.8870.96
93_K97_K0.8790.96
215_D218_T0.8790.96
41_D46_F0.8690.96
125_K142_P0.8640.95
363_N366_D0.8620.95
351_D364_P0.8620.95
43_P88_Q0.8580.95
94_P99_L0.8560.95
46_F60_L0.8540.95
85_S88_Q0.8510.95
125_K130_V0.8510.95
199_Q203_G0.8510.95
289_R295_F0.8510.95
151_L160_A0.8500.95
278_L284_K0.8480.95
34_E38_S0.8480.95
352_E356_E0.8460.95
259_W262_L0.8430.95
10_L14_L0.8390.95
222_P225_Q0.8380.95
250_G281_L0.8380.95
11_D73_L0.8350.95
253_V262_L0.8330.95
147_A162_L0.8320.94
235_A277_I0.8310.94
173_P181_R0.8310.94
9_L12_E0.8300.94
161_Q204_G0.8280.94
38_S43_P0.8280.94
354_F357_L0.8250.94
264_F298_L0.8240.94
233_S236_L0.8220.94
27_I32_Y0.8220.94
152_D273_E0.8180.94
117_L140_I0.8160.94
359_E367_L0.8140.94
200_V203_G0.8140.94
283_E287_Y0.8130.94
211_E285_K0.8130.94
260_L296_L0.8120.94
273_E277_I0.8120.94
192_L196_L0.8110.94
335_L348_I0.8070.94
242_R292_D0.8020.93
13_F339_L0.8020.93
151_L228_G0.8020.93
192_L223_E0.7970.93
313_L316_S0.7910.93
303_L336_D0.7910.93
92_L127_L0.7900.93
27_I30_E0.7900.93
36_E40_E0.7890.93
273_E288_Y0.7890.93
342_N346_L0.7890.93
193_L197_G0.7850.93
231_Y287_Y0.7840.93
196_L224_L0.7830.92
203_G206_Y0.7820.92
144_P182_D0.7820.92
13_F16_L0.7820.92
235_A285_K0.7800.92
211_E216_F0.7790.92
41_D44_L0.7780.92
231_Y289_R0.7760.92
49_E133_D0.7720.92
88_Q128_G0.7710.92
263_D324_K0.7700.92
56_Y136_L0.7690.92
216_F219_D0.7690.92
61_K66_I0.7680.92
151_L255_S0.7670.92
50_K139_E0.7660.92
336_D362_K0.7640.92
174_L205_F0.7630.92
199_Q204_G0.7620.91
232_G240_K0.7600.91
187_Q190_L0.7600.91
72_Y83_R0.7590.91
173_P190_L0.7590.91
18_K22_F0.7540.91
181_R328_P0.7540.91
258_D290_L0.7480.91
146_E175_D0.7480.91
332_A354_F0.7460.91
201_D206_Y0.7450.91
258_D261_E0.7390.90
32_Y35_V0.7390.90
362_K365_E0.7380.90
60_L106_I0.7360.90
43_P48_L0.7350.90
57_E107_V0.7340.90
58_L61_K0.7330.90
278_L282_R0.7330.90
337_E341_E0.7300.90
362_K369_F0.7280.90
33_E36_E0.7270.89
212_A217_L0.7250.89
236_L334_Y0.7230.89
233_S238_N0.7220.89
213_I216_F0.7210.89
152_D236_L0.7200.89
276_E288_Y0.7180.89
268_G271_E0.7170.89
151_L230_V0.7170.89
28_G31_T0.7140.89
337_E340_E0.7140.89
14_L24_L0.7130.89
269_I274_L0.7120.88
214_Y297_S0.7110.88
108_I115_E0.7100.88
191_Q195_S0.7040.88
100_K108_I0.7030.88
345_E360_N0.7030.88
12_E52_D0.7020.88
84_L89_I0.7020.88
37_I203_G0.7000.88
167_G181_R0.6970.87
5_L17_L0.6950.87
89_I93_K0.6950.87
252_S263_D0.6920.87
69_L81_L0.6910.87
336_D340_E0.6850.86
364_P367_L0.6840.86
347_S354_F0.6840.86
304_E307_S0.6830.86
190_L205_F0.6830.86
242_R294_S0.6830.86
282_R311_D0.6810.86
17_L24_L0.6800.86
210_E289_R0.6800.86
332_A358_I0.6790.86
355_K358_I0.6780.86
30_E47_E0.6760.86
23_T30_E0.6760.86
47_E61_K0.6750.86
111_E371_V0.6730.86
366_D370_E0.6730.86
219_D223_E0.6680.85
284_K304_E0.6660.85
314_G317_E0.6650.85
16_L24_L0.6640.85
40_E58_L0.6620.85
154_E159_T0.6620.85
323_G332_A0.6610.84
361_L365_E0.6610.84
250_G259_W0.6600.84
151_L232_G0.6580.84
279_K317_E0.6570.84
54_G57_E0.6560.84
350_R353_S0.6560.84
23_T33_E0.6550.84
91_L127_L0.6530.84
54_G107_V0.6530.84
54_G110_K0.6520.84
348_I351_D0.6520.84
214_Y331_R0.6490.83
145_L171_I0.6480.83
89_I95_L0.6480.83
346_L349_E0.6480.83
12_E15_E0.6450.83
158_L271_E0.6440.83
309_L313_L0.6420.83
210_E295_F0.6420.83
350_R357_L0.6420.83
12_E16_L0.6400.83
281_L295_F0.6370.82
260_L273_E0.6360.82
265_D271_E0.6350.82
172_N175_D0.6320.82
158_L216_F0.6320.82
273_E278_L0.6320.82
264_F268_G0.6290.81
151_L181_R0.6280.81
183_L187_Q0.6280.81
189_I222_P0.6270.81
292_D314_G0.6260.81
178_I217_L0.6260.81
47_E59_S0.6240.81
38_S82_Y0.6240.81
351_D358_I0.6220.81
60_L103_K0.6220.81
28_G35_V0.6220.81
75_F84_L0.6210.81
5_L37_I0.6200.81
347_S356_E0.6200.81
73_L84_L0.6180.80
62_G124_L0.6180.80
276_E325_L0.6180.80
89_I277_I0.6170.80
130_V285_K0.6170.80
39_E85_S0.6170.80
32_Y36_E0.6140.80
121_L125_K0.6120.80
251_V303_L0.6120.80
363_N367_L0.6110.80
50_K53_D0.6100.79
37_I83_R0.6100.79
315_L320_L0.6090.79
23_T370_E0.6090.79
29_G32_Y0.6080.79
216_F287_Y0.6070.79
319_D331_R0.6060.79
213_I296_L0.6050.79
312_D315_L0.6050.79
65_P68_L0.6040.79
84_L88_Q0.6040.79
40_E46_F0.6030.79
286_K299_E0.6010.78
348_I371_V0.6010.78
199_Q206_Y0.6000.78
93_K211_E0.5990.78
362_K370_E0.5990.78
150_Y297_S0.5980.78
11_D292_D0.5980.78
90_K93_K0.5970.78
337_E342_N0.5950.78
58_L190_L0.5950.78
306_L310_L0.5950.78
117_L120_V0.5940.78
19_G22_F0.5940.78
171_I181_R0.5930.78
27_I34_E0.5930.78
13_F281_L0.5900.77
234_E288_Y0.5900.77
144_P188_E0.5900.77
96_L311_D0.5900.77
152_D285_K0.5880.77
286_K290_L0.5870.77
252_S255_S0.5870.77
153_E233_S0.5870.77
60_L63_L0.5860.77
122_P151_L0.5850.77
99_L102_G0.5850.77
215_D223_E0.5840.76
4_L7_P0.5820.76
25_E32_Y0.5810.76
237_K288_Y0.5800.76
143_E179_I0.5790.76
87_E126_K0.5780.76
352_E355_K0.5760.75
56_Y211_E0.5760.75
132_I136_L0.5740.75
336_D358_I0.5730.75
19_G30_E0.5720.75
320_L323_G0.5710.75
27_I31_T0.5710.75
88_Q92_L0.5710.75
254_S257_T0.5690.75
20_K28_G0.5680.74
136_L279_K0.5680.74
124_L272_V0.5670.74
147_A185_K0.5670.74
347_S363_N0.5670.74
198_F287_Y0.5670.74
218_T241_I0.5660.74
76_L79_G0.5640.74
224_L228_G0.5630.74
291_K303_L0.5630.74
145_L260_L0.5630.74
217_L239_L0.5620.74
254_S326_R0.5620.74
319_D369_F0.5620.74
337_E357_L0.5620.74
176_K341_E0.5600.73
30_E33_E0.5600.73
69_L167_G0.5590.73
194_E200_V0.5580.73
207_L216_F0.5580.73
276_E343_E0.5580.73
5_L9_L0.5560.73
24_L29_G0.5560.73
37_I46_F0.5560.73
3_L56_Y0.5560.73
20_K24_L0.5560.73
57_E61_K0.5550.73
350_R355_K0.5550.73
241_I274_L0.5540.73
185_K189_I0.5530.73
122_P125_K0.5520.72
193_L207_L0.5520.72
152_D287_Y0.5520.72
353_S368_D0.5520.72
356_E368_D0.5500.72
89_I280_A0.5490.72
128_G132_I0.5490.72
153_E232_G0.5480.72
199_Q205_F0.5480.72
335_L339_L0.5480.72
336_D354_F0.5450.71
253_V307_S0.5450.71
249_V339_L0.5450.71
257_T351_D0.5450.71
200_V206_Y0.5450.71
151_L351_D0.5440.71
32_Y268_G0.5430.71
350_R364_P0.5430.71
29_G33_E0.5420.71
6_P274_L0.5420.71
15_E20_K0.5410.71
179_I298_L0.5410.71
84_L292_D0.5400.71
60_L68_L0.5400.71
125_K348_I0.5380.70
230_V301_E0.5360.70
135_E139_E0.5350.70
250_G265_D0.5340.70
359_E368_D0.5330.70
196_L221_L0.5330.70
353_S356_E0.5320.70
64_E75_F0.5300.69
310_L362_K0.5280.69
277_I280_A0.5270.69
147_A153_E0.5270.69
38_S44_L0.5270.69
219_D299_E0.5260.69
92_L96_L0.5250.69
42_P46_F0.5240.68
162_L193_L0.5240.68
206_Y360_N0.5230.68
49_E52_D0.5220.68
274_L315_L0.5220.68
307_S314_G0.5220.68
5_L308_E0.5220.68
122_P126_K0.5200.68
64_E69_L0.5200.68
230_V268_G0.5180.68
301_E304_E0.5170.67
186_E293_G0.5160.67
234_E240_K0.5160.67
313_L334_Y0.5120.67
359_E364_P0.5120.67
164_F281_L0.5110.67
66_I229_E0.5100.66
309_L327_L0.5080.66
172_N194_E0.5070.66
216_F222_P0.5070.66
62_G65_P0.5070.66
327_L332_A0.5060.66
80_K110_K0.5060.66
276_E333_L0.5060.66
150_Y287_Y0.5050.66
208_G213_I0.5040.66
162_L189_I0.5030.65
99_L104_G0.5030.65
213_I232_G0.5020.65
263_D274_L0.5020.65
230_V290_L0.5000.65
31_T34_E0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w7jB 1 0.1532 3.1 0.966 Contact Map
3tutA 1 0.1613 2.9 0.967 Contact Map
2y9jY 3 0.2876 2.9 0.967 Contact Map
2m7lA 1 0.1989 2.8 0.967 Contact Map
3hs2A 3 0.1505 2.8 0.967 Contact Map
1q1oA 1 0.2204 2.5 0.968 Contact Map
1c07A 1 0.2177 2.5 0.968 Contact Map
1hsjA 2 0.2366 2.4 0.968 Contact Map
1lfdA 1 0.2151 2.3 0.968 Contact Map
3lqvP 1 0.0565 2.3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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