GREMLIN Database
DUF1737 - Domain of unknown function (DUF1737)
PFAM: PF08410 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (50)
Sequences: 3904 (2185)
Seq/√Len: 309.0
META: 0.912

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_R22_A2.9041.00
23_L29_L2.4161.00
5_R16_C2.1281.00
33_P49_A1.9021.00
6_L16_C1.7431.00
21_E25_E1.7241.00
13_A17_H1.6851.00
7_L22_A1.6491.00
30_Y33_P1.5601.00
34_A47_A1.5231.00
6_L47_A1.5031.00
22_A25_E1.4881.00
3_L52_K1.4451.00
35_V47_A1.3941.00
20_S24_A1.3761.00
35_V46_C1.3381.00
10_P43_R1.3291.00
18_R21_E1.3231.00
3_L20_S1.2971.00
9_G18_R1.2451.00
38_D43_R1.2391.00
32_S49_A1.2361.00
37_F40_E1.2351.00
5_R50_V1.1261.00
3_L24_A1.1211.00
3_L27_W1.1101.00
6_L33_P1.0811.00
19_V50_V1.0071.00
7_L50_V0.9921.00
9_G12_D0.9381.00
39_G43_R0.9331.00
12_D16_C0.9221.00
9_G14_A0.9081.00
7_L15_F0.9071.00
29_L51_V0.8391.00
9_G15_F0.8301.00
17_H21_E0.8191.00
36_T44_V0.8181.00
16_C20_S0.8151.00
36_T47_A0.8121.00
40_E43_R0.7961.00
35_V44_V0.7790.99
35_V45_I0.7550.99
11_D14_A0.7540.99
7_L19_V0.7510.99
6_L46_C0.7500.99
28_E51_V0.7460.99
30_Y51_V0.7430.99
8_T47_A0.7360.99
38_D41_T0.7310.99
14_A18_R0.6970.99
33_P46_C0.6650.98
10_P45_I0.6580.98
30_Y49_A0.6570.98
17_H25_E0.6570.98
15_F50_V0.6430.98
20_S23_L0.6380.98
22_A50_V0.6290.98
29_L32_S0.6260.98
20_S52_K0.6130.97
14_A17_H0.6030.97
27_W51_V0.5980.97
27_W50_V0.5930.97
13_A21_E0.5810.96
8_T12_D0.5740.96
12_D46_C0.5720.96
11_D17_H0.5630.96
8_T46_C0.5590.95
37_F43_R0.5460.95
36_T42_G0.5430.95
11_D15_F0.5370.94
3_L21_E0.5220.93
8_T45_I0.5220.93
20_S27_W0.5050.92
4_Y7_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uw1A 2 1 27 0.813 Contact Map
3s5jB 2 0.9057 25.4 0.815 Contact Map
4fbdA 2 0.9434 23.5 0.818 Contact Map
3dahA 5 0.9245 23 0.819 Contact Map
3tx2A 1 1 21.7 0.821 Contact Map
2pd0A 2 0.9811 21.3 0.822 Contact Map
3icoA 1 0.9623 17.9 0.828 Contact Map
4tm7A 1 0.9811 16.9 0.83 Contact Map
2ji4A 5 0.9057 16.8 0.83 Contact Map
3bvxA 1 0.9245 15.9 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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