GREMLIN Database
DUF1736 - Domain of unknown function (DUF1736)
PFAM: PF08409 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (66)
Sequences: 3089 (2409)
Seq/√Len: 296.6
META: 0.871

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_R36_W4.0301.00
31_L71_Y2.6931.00
33_R37_L2.6821.00
64_A67_S2.5771.00
29_Y33_R2.4621.00
17_A55_L1.7231.00
56_V64_A1.7081.00
14_L22_T1.7011.00
35_L70_L1.6991.00
25_L59_L1.6711.00
29_Y56_V1.6611.00
19_F22_T1.6381.00
51_N54_P1.6191.00
23_R27_A1.5551.00
45_S52_Q1.5261.00
17_A22_T1.3481.00
60_S63_R1.2771.00
59_L64_A1.2651.00
24_L28_L1.2601.00
37_L48_Y1.2581.00
65_L69_A1.2241.00
29_Y63_R1.2181.00
22_T26_T1.1891.00
32_G67_S1.1671.00
46_A49_S1.1491.00
28_L64_A1.1331.00
36_W40_W1.0751.00
25_L28_L1.0441.00
14_L23_R1.0031.00
31_L46_A0.9961.00
51_N55_L0.9881.00
14_L17_A0.9761.00
30_V49_S0.9691.00
49_S52_Q0.9671.00
10_V46_A0.9531.00
14_L27_A0.9481.00
13_P55_L0.9461.00
18_P22_T0.9411.00
17_A57_T0.9311.00
11_D47_D0.9301.00
11_D52_Q0.9281.00
28_L71_Y0.9261.00
13_P18_P0.9041.00
25_L64_A0.8991.00
14_L55_L0.8921.00
22_T55_L0.8891.00
18_P21_T0.8811.00
38_L52_Q0.8701.00
24_L27_A0.8501.00
28_L67_S0.8301.00
17_A26_T0.8201.00
41_P44_L0.8141.00
38_L43_P0.8131.00
25_L29_Y0.8091.00
28_L32_G0.8071.00
13_P52_Q0.8031.00
35_L67_S0.8031.00
32_G70_L0.7710.99
13_P54_P0.7700.99
26_T31_L0.7670.99
20_W24_L0.7670.99
36_W43_P0.7610.99
35_L39_L0.7290.99
64_A68_L0.7180.99
26_T47_D0.7110.99
31_L35_L0.7030.99
65_L68_L0.6930.99
15_A27_A0.6860.98
61_D64_A0.6830.98
9_F16_G0.6740.98
32_G36_W0.6570.98
42_A73_A0.6560.98
11_D50_Y0.6470.98
27_A30_V0.6390.98
27_A34_Y0.6370.98
57_T63_R0.6340.97
56_V63_R0.6340.97
60_S65_L0.6270.97
62_P66_L0.6240.97
11_D34_Y0.6110.97
34_Y46_A0.5970.96
30_V34_Y0.5960.96
33_R53_I0.5800.96
67_S71_Y0.5760.96
62_P69_A0.5760.96
31_L70_L0.5750.96
29_Y64_A0.5680.95
46_A52_Q0.5660.95
13_P30_V0.5620.95
16_G46_A0.5600.95
11_D49_S0.5590.95
20_W68_L0.5580.95
27_A31_L0.5500.94
66_L69_A0.5470.94
13_P19_F0.5350.94
32_G71_Y0.5280.93
44_L53_I0.5220.93
60_S73_A0.5100.92
11_D16_G0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lf3A 1 0.36 6.7 0.891 Contact Map
1zzpA 1 0.3333 1.2 0.927 Contact Map
4ub6R 1 0.2 1.2 0.927 Contact Map
2bruC 1 0.48 1.1 0.927 Contact Map
4um9B 2 0 1.1 0.928 Contact Map
4pj0R 1 0.2 1 0.93 Contact Map
2mmuA 1 0.5333 0.9 0.931 Contact Map
2ohdA 5 0.2667 0.9 0.931 Contact Map
4i6mD 1 0 0.8 0.933 Contact Map
4httA 1 0.2533 0.8 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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