GREMLIN Database
Chitin_synth_1N - Chitin synthase N-terminal
PFAM: PF08407 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (73)
Sequences: 645 (340)
Seq/√Len: 39.7
META: 0.304

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_T57_Y4.2371.00
51_D55_N2.6761.00
51_D54_K2.5471.00
8_L42_Y2.2601.00
18_P64_Y2.2481.00
16_D35_E1.9990.99
19_V23_L1.9290.99
12_N43_T1.8280.98
46_T72_I1.8270.98
52_F59_L1.7450.97
4_K23_L1.6730.96
3_T26_A1.6010.95
11_G14_V1.5830.95
16_D41_R1.5070.94
19_V41_R1.4790.93
20_P48_D1.3530.89
18_P39_H1.3490.89
17_C23_L1.2510.85
7_K74_I1.2440.85
21_S26_A1.2300.84
29_R33_D1.2260.84
25_N51_D1.2130.83
36_E66_R1.1760.81
13_L40_M1.1640.81
68_T72_I1.1520.80
35_E39_H1.1510.80
9_T12_N1.1430.79
23_L28_P1.1410.79
37_F40_M1.1410.79
14_V22_K1.1330.79
48_D69_E1.1220.78
30_R33_D1.1150.78
8_L47_C1.1000.77
47_C63_L1.0710.75
30_R65_G1.0510.73
62_A74_I1.0340.72
19_V48_D1.0260.71
42_Y48_D1.0230.71
30_R70_L1.0220.71
42_Y75_T1.0190.71
2_T15_L1.0160.71
56_G62_A0.9920.69
6_V48_D0.9820.68
2_T23_L0.9710.67
24_L27_L0.9700.67
20_P63_L0.9640.67
27_L39_H0.9480.65
37_F58_T0.9370.64
27_L55_N0.9320.64
56_G64_Y0.9280.64
34_S57_Y0.9170.63
69_E72_I0.8980.61
67_E73_V0.8890.60
29_R34_S0.8640.58
44_A60_R0.8600.58
20_P53_T0.8590.58
28_P37_F0.8120.53
49_P72_I0.8060.53
40_M44_A0.8000.52
45_A48_D0.7960.52
37_F56_G0.7950.52
23_L61_Q0.7950.52
18_P40_M0.7880.51
57_Y61_Q0.7860.51
22_K25_N0.7850.51
12_N57_Y0.7790.50
10_N56_G0.7720.50
37_F73_V0.7590.48
23_L27_L0.7520.48
56_G63_L0.7490.48
30_R34_S0.7370.46
41_R72_I0.7040.43
39_H71_F0.7030.43
61_Q74_I0.6980.43
21_S57_Y0.6930.43
13_L44_A0.6890.42
53_T62_A0.6850.42
60_R66_R0.6810.41
61_Q69_E0.6810.41
16_D40_M0.6790.41
25_N30_R0.6780.41
4_K54_K0.6610.40
58_T63_L0.6470.38
34_S64_Y0.6460.38
17_C37_F0.6440.38
62_A67_E0.6370.38
44_A57_Y0.6210.36
53_T71_F0.6200.36
20_P43_T0.6160.36
54_K61_Q0.5930.34
21_S42_Y0.5860.33
26_A73_V0.5830.33
57_Y74_I0.5820.33
9_T65_G0.5800.33
59_L66_R0.5760.33
26_A45_A0.5740.32
17_C40_M0.5670.32
33_D38_T0.5660.32
36_E49_P0.5660.32
45_A53_T0.5560.31
45_A56_G0.5550.31
7_K63_L0.5550.31
29_R32_T0.5470.30
28_P33_D0.5280.29
39_H43_T0.5220.28
23_L29_R0.5200.28
41_R70_L0.5200.28
12_N18_P0.5050.27
48_D70_L0.5040.27
14_V28_P0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bh1A 4 0.72 11.5 0.915 Contact Map
2hcuA 1 0.8933 5.6 0.926 Contact Map
2j5lA 1 0 5.1 0.927 Contact Map
2axoA 2 0.9067 4.8 0.928 Contact Map
4hn1A 3 0.8267 4.7 0.929 Contact Map
2uvaG 3 0.9067 4.4 0.929 Contact Map
1oi6A 2 0.8533 4.2 0.93 Contact Map
2e29A 1 0.56 4.1 0.931 Contact Map
3sriA 1 0.96 3.9 0.932 Contact Map
4fbnA 1 0.5067 3.6 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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