GREMLIN Database
DUF1738 - Domain of unknown function (DUF1738)
PFAM: PF08401 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 129 (120)
Sequences: 11229 (7752)
Seq/√Len: 707.7
META: 0.907

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_G127_T5.1451.00
66_L71_A4.4751.00
4_Q8_D3.1231.00
68_F72_Q2.8951.00
68_F77_Q2.4491.00
23_K27_A2.2581.00
37_A66_L2.1211.00
92_R121_P2.0961.00
65_W85_T2.0511.00
12_A16_A1.9921.00
34_P48_V1.9911.00
79_R82_E1.9711.00
54_A85_T1.8671.00
54_A58_R1.8541.00
69_K72_Q1.8531.00
13_A16_A1.8511.00
35_R64_R1.7321.00
71_A76_G1.7041.00
72_Q77_Q1.6221.00
48_V52_W1.6171.00
8_D12_A1.5761.00
86_P127_T1.5411.00
93_L120_I1.5371.00
2_V5_E1.5301.00
86_P125_Y1.5291.00
41_K44_R1.4931.00
55_A65_W1.4901.00
38_V73_E1.4571.00
69_K73_E1.4291.00
71_A78_V1.4221.00
36_N41_K1.3721.00
38_V74_L1.3561.00
5_E9_R1.3491.00
9_R57_E1.3331.00
91_K122_F1.3121.00
37_A41_K1.2881.00
66_L70_Q1.2461.00
14_L19_A1.2341.00
12_A15_E1.2281.00
17_G20_P1.2221.00
36_N39_T1.2211.00
95_K120_I1.2101.00
93_L122_F1.2071.00
78_V82_E1.1961.00
94_E118_K1.1951.00
35_R40_G1.1901.00
37_A64_R1.1831.00
9_R54_A1.1791.00
90_W121_P1.1681.00
9_R13_A1.1681.00
97_E100_D1.1631.00
54_A65_W1.1411.00
19_A22_R1.1351.00
46_I50_L1.1311.00
87_V128_V1.1111.00
46_I88_V1.0831.00
5_E8_D1.0811.00
3_Y88_V1.0811.00
9_R12_A1.0551.00
33_L48_V1.0401.00
99_D102_G1.0261.00
94_E116_E1.0211.00
5_E86_P1.0151.00
60_Y65_W1.0061.00
35_R42_P0.9901.00
68_F78_V0.9741.00
87_V126_Y0.9731.00
70_Q73_E0.9651.00
5_E125_Y0.9631.00
11_I15_E0.9421.00
33_L52_W0.9261.00
12_A57_E0.9131.00
13_A53_A0.9121.00
92_R118_K0.9081.00
34_P65_W0.9071.00
104_E112_G0.8701.00
118_K121_P0.8491.00
88_V123_L0.8471.00
60_Y82_E0.8451.00
35_R63_P0.8281.00
34_P52_W0.8271.00
33_L42_P0.8251.00
23_K26_S0.8141.00
2_V88_V0.8081.00
82_E85_T0.8081.00
95_K117_R0.8001.00
13_A20_P0.7991.00
68_F84_G0.7991.00
66_L76_G0.7961.00
95_K98_E0.7851.00
50_L54_A0.7751.00
50_L86_P0.7731.00
99_D103_G0.7691.00
13_A18_V0.7651.00
34_P51_L0.7601.00
36_N70_Q0.7601.00
49_L52_W0.7561.00
3_Y7_T0.7531.00
97_E117_R0.7491.00
89_F122_F0.7471.00
39_T70_Q0.7451.00
6_V50_L0.7361.00
96_E116_E0.7341.00
38_V66_L0.7321.00
7_T10_I0.7291.00
68_F80_K0.7261.00
92_R95_K0.7251.00
36_N66_L0.7181.00
7_T11_I0.7131.00
35_R41_K0.7111.00
40_G64_R0.7031.00
10_I14_L0.6951.00
68_F129_F0.6911.00
95_K99_D0.6911.00
89_F92_R0.6881.00
37_A71_A0.6851.00
14_L23_K0.6841.00
90_W123_L0.6771.00
67_T126_Y0.6731.00
21_W24_P0.6631.00
84_G129_F0.6581.00
99_D115_E0.6551.00
50_L85_T0.6521.00
113_E116_E0.6511.00
54_A60_Y0.6491.00
37_A74_L0.6441.00
98_E102_G0.6411.00
112_G115_E0.6361.00
96_E99_D0.6331.00
96_E114_E0.6291.00
60_Y85_T0.6251.00
102_G112_G0.6151.00
4_Q7_T0.6121.00
81_G129_F0.6111.00
53_A56_M0.6051.00
44_R90_W0.6041.00
14_L17_G0.6031.00
78_V129_F0.5981.00
112_G116_E0.5891.00
115_E118_K0.5851.00
9_R85_T0.5841.00
95_K100_D0.5801.00
68_F81_G0.5771.00
100_D104_E0.5681.00
20_P71_A0.5681.00
13_A19_A0.5661.00
78_V81_G0.5651.00
10_I13_A0.5601.00
96_E100_D0.5601.00
92_R122_F0.5601.00
50_L53_A0.5581.00
91_K124_R0.5541.00
98_E101_D0.5521.00
58_R82_E0.5511.00
35_R38_V0.5501.00
28_A32_G0.5501.00
3_Y6_V0.5441.00
70_Q74_L0.5421.00
114_E117_R0.5391.00
89_F126_Y0.5371.00
2_V125_Y0.5371.00
66_L74_L0.5361.00
27_A31_L0.5341.00
14_L18_V0.5281.00
32_G63_P0.5251.00
101_D113_E0.5231.00
67_T90_W0.5201.00
53_A57_E0.5191.00
80_K129_F0.5161.00
36_N45_G0.5151.00
97_E101_D0.5141.00
13_A22_R0.5131.00
29_G32_G0.5110.99
51_L87_V0.5090.99
103_G112_G0.5080.99
99_D112_G0.5050.99
68_F71_A0.5040.99
80_K83_K0.5030.99
55_A58_R0.5000.99
122_F126_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5aj3G 1 0.3333 6.6 0.923 Contact Map
1lvmA 2 0.3411 4.6 0.929 Contact Map
4hw4A 2 0.3023 2.8 0.936 Contact Map
3p0jA 1 0.3256 2.6 0.937 Contact Map
3l32A 2 0.3023 2.6 0.937 Contact Map
3sp7A 1 0.2791 2.6 0.937 Contact Map
3hm6X 1 0.2868 2 0.941 Contact Map
4k5aA 1 0.2946 1.9 0.942 Contact Map
4kiyG 1 0.2946 1.8 0.942 Contact Map
3hgtA 2 0.3023 1.8 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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