7tm_7 - PFAM28P - GREMLIN Contacts

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7tm_7 - 7tm Chemosensory receptor

PFAM:	PF08395	Sequences: LRPLLYLSKLLGLAPFKIDSSTGRFSWSSILYLYLLLILLILLVLLLLFLIVYILIIIFFSSSDLLEIIDILQFVLNYLSVLVILISLWFNRRKLLRLLNKLLELDRKLRRLGSRKNYRRFRRLLILLLVLIILLLLVSLLYYFFLSDYFLSIIFLLLYILPYLILSLIILQFFLLVLLLKQRFKLLNKLLENLLRELNSLLSSRLFLRRLSLLRLRELRELHLRLCDLVELINSIFGLQLLLSFLSNFLFITFNLYYILSSLLGKSSLILLLLFLLWLIIYLLLLLLICYACELVSNEAKKTGTLLHKLLLSTLDKRLKKELELFSLQLLHRPLKFTACGFFDLDRSLLLSIIGAITTYLIILIQFDLSN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	371 (365)
Sequences:	2572 (2362)
Seq/√Len:	123.6
META:	0.158

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
106_D	183_R	7.400	1.00
106_D	109_L	4.242	1.00
188_N	303_T	4.208	1.00
303_T	306_L	3.838	1.00
184_F	188_N	3.763	1.00
299_E	302_K	3.394	1.00
28_S	32_Y	3.114	1.00
185_K	299_E	2.917	1.00
238_G	339_A	2.913	1.00
323_L	327_S	2.877	1.00
179_L	183_R	2.626	1.00
223_H	227_C	2.619	1.00
119_R	123_R	2.399	1.00
32_Y	35_L	2.391	1.00
234_N	238_G	2.337	1.00
29_S	34_Y	2.309	1.00
23_G	26_S	2.283	1.00
30_I	34_Y	2.150	1.00
185_K	188_N	2.141	1.00
339_A	345_L	2.105	1.00
29_S	32_Y	2.104	1.00
278_W	285_L	2.091	1.00
30_I	33_L	2.073	1.00
328_L	332_H	2.065	1.00
121_F	127_L	2.056	1.00
172_Q	181_K	2.017	1.00
181_K	185_K	2.009	1.00
124_L	128_L	1.993	1.00
120_R	131_L	1.990	1.00
123_R	127_L	1.983	1.00
282_Y	285_L	1.974	1.00
307_L	323_L	1.930	1.00
31_L	34_Y	1.895	1.00
29_S	33_L	1.861	1.00
294_E	347_R	1.807	1.00
37_L	48_L	1.800	1.00
28_S	33_L	1.743	1.00
120_R	123_R	1.731	1.00
336_K	344_D	1.709	1.00
293_C	337_F	1.704	1.00
119_R	126_I	1.693	1.00
121_F	124_L	1.676	1.00
353_I	357_I	1.668	1.00
96_L	100_N	1.650	1.00
105_L	109_L	1.644	1.00
122_R	126_I	1.615	1.00
32_Y	36_L	1.603	1.00
173_F	185_K	1.595	1.00
23_G	27_W	1.593	1.00
293_C	296_V	1.585	1.00
39_L	49_F	1.580	1.00
31_L	35_L	1.570	1.00
31_L	36_L	1.568	1.00
171_L	181_K	1.557	1.00
30_I	35_L	1.554	1.00
21_S	24_R	1.539	1.00
184_F	223_H	1.534	1.00
136_L	139_S	1.533	1.00
183_R	188_N	1.531	1.00
294_E	298_N	1.526	1.00
41_I	44_V	1.519	1.00
347_R	351_L	1.517	1.00
33_L	36_L	1.513	1.00
120_R	127_L	1.512	1.00
33_L	37_L	1.506	1.00
249_F	253_T	1.498	1.00
280_I	285_L	1.495	1.00
316_D	319_L	1.489	1.00
19_D	24_R	1.489	1.00
128_L	132_I	1.483	1.00
29_S	35_L	1.481	1.00
28_S	31_L	1.466	1.00
129_L	132_I	1.459	1.00
226_L	230_V	1.454	1.00
34_Y	42_L	1.454	1.00
308_H	327_S	1.438	1.00
357_I	362_I	1.436	1.00
291_Y	347_R	1.434	1.00
135_L	139_S	1.432	1.00
217_R	322_E	1.428	1.00
322_E	326_F	1.424	1.00
28_S	34_Y	1.419	1.00
363_I	367_F	1.415	1.00
36_L	40_L	1.412	1.00
156_L	162_P	1.404	1.00
91_N	94_K	1.399	1.00
122_R	125_L	1.398	1.00
29_S	36_L	1.395	1.00
303_T	326_F	1.394	1.00
239_L	340_C	1.388	1.00
201_L	204_S	1.386	1.00
260_L	264_L	1.380	1.00
172_Q	237_F	1.378	1.00
19_D	25_F	1.375	1.00
272_L	275_F	1.364	1.00
125_L	129_L	1.356	1.00
18_I	26_S	1.356	1.00
362_I	366_Q	1.355	1.00
157_L	162_P	1.350	1.00
311_L	314_T	1.349	1.00
183_R	190_L	1.349	1.00
328_L	331_L	1.343	1.00
171_L	178_L	1.340	1.00
345_L	349_L	1.334	1.00
327_S	330_L	1.333	1.00
128_L	138_V	1.328	1.00
188_N	299_E	1.314	1.00
149_Y	153_I	1.301	1.00
249_F	356_A	1.298	1.00
22_T	26_S	1.297	1.00
279_L	286_L	1.289	1.00
31_L	47_L	1.289	1.00
202_L	206_L	1.283	1.00
32_Y	40_L	1.282	1.00
227_C	230_V	1.280	1.00
109_L	113_G	1.275	1.00
98_L	233_I	1.274	1.00
209_R	212_S	1.267	1.00
33_L	49_F	1.263	1.00
95_L	98_L	1.258	1.00
152_S	156_L	1.258	1.00
283_L	286_L	1.256	1.00
336_K	346_D	1.248	1.00
121_F	129_L	1.243	0.99
349_L	358_T	1.240	0.99
18_I	23_G	1.240	0.99
33_L	41_I	1.234	0.99
131_L	137_L	1.217	0.99
131_L	135_L	1.217	0.99
45_L	49_F	1.201	0.99
348_S	362_I	1.196	0.99
29_S	37_L	1.195	0.99
183_R	186_L	1.190	0.99
124_L	133_I	1.189	0.99
3_P	11_L	1.188	0.99
123_R	128_L	1.188	0.99
122_R	132_I	1.182	0.99
33_L	46_L	1.179	0.99
212_S	215_R	1.178	0.99
147_S	157_L	1.176	0.99
18_I	21_S	1.172	0.99
124_L	127_L	1.170	0.99
44_V	48_L	1.166	0.99
125_L	137_L	1.161	0.99
6_Y	9_K	1.159	0.99
26_S	29_S	1.158	0.99
20_S	24_R	1.156	0.99
33_L	40_L	1.156	0.99
126_I	130_V	1.151	0.99
183_R	187_L	1.148	0.99
37_L	41_I	1.141	0.99
183_R	189_K	1.135	0.99
5_L	9_K	1.133	0.99
12_G	16_F	1.131	0.99
33_L	44_V	1.127	0.99
332_H	337_F	1.123	0.99
148_D	151_L	1.122	0.99
130_V	136_L	1.115	0.99
201_L	205_R	1.113	0.99
34_Y	45_L	1.113	0.99
158_L	164_L	1.111	0.99
349_L	359_T	1.109	0.99
126_I	133_I	1.109	0.99
359_T	363_I	1.109	0.99
185_K	198_L	1.107	0.99
346_D	358_T	1.104	0.99
35_L	38_I	1.104	0.99
36_L	39_L	1.102	0.99
296_V	337_F	1.085	0.99
32_Y	48_L	1.063	0.98
281_I	285_L	1.062	0.98
312_L	315_L	1.061	0.98
153_I	156_L	1.053	0.98
122_R	136_L	1.053	0.98
22_T	29_S	1.053	0.98
130_V	133_I	1.051	0.98
35_L	42_L	1.051	0.98
92_R	102_L	1.048	0.98
326_F	329_Q	1.045	0.98
88_L	92_R	1.041	0.98
178_L	185_K	1.037	0.98
43_L	50_L	1.036	0.98
38_I	42_L	1.035	0.98
119_R	133_I	1.035	0.98
147_S	152_S	1.032	0.98
121_F	125_L	1.029	0.98
274_L	285_L	1.027	0.98
343_F	351_L	1.012	0.98
327_S	331_L	1.011	0.98
209_R	214_L	1.010	0.98
146_L	149_Y	1.010	0.98
125_L	128_L	1.009	0.98
174_F	179_L	1.007	0.98
352_S	355_G	1.006	0.98
278_W	286_L	1.005	0.98
124_L	135_L	1.000	0.98
175_L	179_L	0.999	0.98
124_L	136_L	0.995	0.98
332_H	343_F	0.995	0.98
5_L	16_F	0.995	0.98
350_L	353_I	0.994	0.98
28_S	35_L	0.993	0.97
123_R	129_L	0.991	0.97
122_R	129_L	0.991	0.97
20_S	27_W	0.987	0.97
315_L	319_L	0.984	0.97
287_L	291_Y	0.976	0.97
123_R	126_I	0.972	0.97
144_F	153_I	0.970	0.97
120_R	124_L	0.969	0.97
51_I	54_I	0.965	0.97
361_L	367_F	0.965	0.97
19_D	26_S	0.964	0.97
134_L	137_L	0.963	0.97
338_T	344_D	0.959	0.97
178_L	181_K	0.957	0.97
253_T	257_Y	0.950	0.97
279_L	283_L	0.950	0.97
203_S	206_L	0.947	0.97
42_L	45_L	0.947	0.97
73_Q	76_L	0.946	0.97
356_A	360_Y	0.944	0.97
21_S	25_F	0.944	0.97
40_L	44_V	0.943	0.97
125_L	131_L	0.941	0.97
136_L	140_L	0.939	0.96
131_L	134_L	0.922	0.96
210_R	214_L	0.921	0.96
125_L	132_I	0.920	0.96
355_G	359_T	0.920	0.96
348_S	352_S	0.918	0.96
186_L	189_K	0.916	0.96
314_T	319_L	0.915	0.96
14_A	237_F	0.915	0.96
358_T	361_L	0.909	0.96
234_N	340_C	0.907	0.96
6_Y	14_A	0.906	0.96
326_F	331_L	0.899	0.96
30_I	45_L	0.898	0.95
88_L	240_Q	0.895	0.95
227_C	347_R	0.894	0.95
20_S	23_G	0.893	0.95
127_L	130_V	0.892	0.95
73_Q	77_N	0.888	0.95
324_E	328_L	0.887	0.95
332_H	349_L	0.886	0.95
278_W	281_I	0.884	0.95
31_L	46_L	0.879	0.95
39_L	45_L	0.878	0.95
314_T	317_K	0.875	0.95
18_I	25_F	0.874	0.95
122_R	141_L	0.874	0.95
290_C	293_C	0.874	0.95
291_Y	296_V	0.874	0.95
282_Y	286_L	0.872	0.95
253_T	293_C	0.870	0.95
38_I	45_L	0.866	0.95
338_T	341_G	0.865	0.94
120_R	133_I	0.864	0.94
282_Y	287_L	0.861	0.94
35_L	50_L	0.860	0.94
126_I	140_L	0.858	0.94
17_K	25_F	0.858	0.94
182_Q	185_K	0.857	0.94
128_L	131_L	0.857	0.94
124_L	140_L	0.856	0.94
127_L	135_L	0.848	0.94
101_K	232_L	0.845	0.94
243_L	257_Y	0.844	0.94
127_L	133_I	0.843	0.94
211_L	214_L	0.841	0.94
342_F	345_L	0.838	0.93
275_F	278_W	0.837	0.93
147_S	150_F	0.835	0.93
337_F	359_T	0.834	0.93
126_I	129_L	0.832	0.93
31_L	45_L	0.831	0.93
347_R	363_I	0.830	0.93
324_E	353_I	0.827	0.93
106_D	113_G	0.826	0.93
360_Y	363_I	0.825	0.93
31_L	39_L	0.823	0.93
18_I	24_R	0.821	0.93
17_K	22_T	0.819	0.93
123_R	138_V	0.818	0.93
30_I	43_L	0.818	0.93
40_L	48_L	0.817	0.93
29_S	49_F	0.815	0.93
25_F	28_S	0.815	0.93
24_R	27_W	0.815	0.93
297_S	300_A	0.813	0.92
354_I	357_I	0.810	0.92
119_R	129_L	0.808	0.92
223_H	332_H	0.808	0.92
184_F	227_C	0.807	0.92
18_I	27_W	0.806	0.92
326_F	330_L	0.805	0.92
119_R	122_R	0.804	0.92
304_G	327_S	0.801	0.92
34_Y	46_L	0.800	0.92
210_R	213_L	0.794	0.92
122_R	140_L	0.793	0.91
46_L	50_L	0.791	0.91
270_I	274_L	0.790	0.91
79_L	90_F	0.789	0.91
76_L	84_I	0.788	0.91
347_R	350_L	0.788	0.91
79_L	84_I	0.781	0.91
18_I	22_T	0.780	0.91
331_L	348_S	0.779	0.91
22_T	25_F	0.777	0.91
39_L	47_L	0.774	0.90
220_R	224_L	0.771	0.90
89_W	92_R	0.766	0.90
20_S	26_S	0.764	0.90
122_R	128_L	0.762	0.90
108_K	112_L	0.761	0.90
17_K	20_S	0.761	0.90
35_L	44_V	0.760	0.90
17_K	26_S	0.759	0.90
150_F	156_L	0.759	0.90
124_L	131_L	0.757	0.89
65_L	69_I	0.756	0.89
91_N	95_L	0.756	0.89
152_S	157_L	0.755	0.89
31_L	42_L	0.751	0.89
127_L	132_I	0.750	0.89
31_L	37_L	0.750	0.89
249_F	361_L	0.742	0.89
208_L	211_L	0.741	0.88
120_R	135_L	0.741	0.88
249_F	353_I	0.739	0.88
119_R	135_L	0.736	0.88
167_S	173_F	0.736	0.88
278_W	283_L	0.733	0.88
32_Y	37_L	0.729	0.88
134_L	138_V	0.729	0.88
166_L	169_I	0.728	0.88
41_I	51_I	0.728	0.88
184_F	226_L	0.726	0.87
120_R	128_L	0.725	0.87
151_L	155_F	0.722	0.87
19_D	22_T	0.722	0.87
122_R	130_V	0.721	0.87
173_F	183_R	0.720	0.87
36_L	47_L	0.719	0.87
180_L	184_F	0.718	0.87
256_L	260_L	0.717	0.87
327_S	333_R	0.716	0.87
34_Y	47_L	0.715	0.87
150_F	153_I	0.715	0.87
220_R	227_C	0.714	0.87
208_L	212_S	0.714	0.87
275_F	279_L	0.713	0.86
132_I	140_L	0.712	0.86
84_I	88_L	0.711	0.86
320_K	334_P	0.711	0.86
315_L	318_R	0.710	0.86
159_Y	162_P	0.708	0.86
171_L	174_F	0.706	0.86
340_C	351_L	0.706	0.86
30_I	41_I	0.705	0.86
170_I	173_F	0.704	0.86
66_L	69_I	0.704	0.86
119_R	128_L	0.703	0.86
234_N	341_G	0.702	0.86
216_L	256_L	0.700	0.85
179_L	185_K	0.697	0.85
29_S	38_I	0.695	0.85
3_P	7_L	0.693	0.85
19_D	27_W	0.691	0.85
187_L	190_L	0.690	0.85
174_F	181_K	0.689	0.85
194_L	199_N	0.685	0.84
76_L	80_S	0.685	0.84
36_L	43_L	0.683	0.84
37_L	44_V	0.682	0.84
31_L	38_I	0.680	0.84
98_L	236_I	0.680	0.84
157_L	160_I	0.680	0.84
170_I	174_F	0.679	0.84
166_L	171_L	0.673	0.83
177_V	181_K	0.673	0.83
322_E	349_L	0.670	0.83
172_Q	175_L	0.670	0.83
20_S	43_L	0.670	0.83
19_D	45_L	0.668	0.83
306_L	309_K	0.666	0.83
311_L	316_D	0.664	0.82
354_I	363_I	0.664	0.82
317_K	321_K	0.660	0.82
29_S	47_L	0.659	0.82
341_G	366_Q	0.659	0.82
174_F	178_L	0.658	0.82
72_L	77_N	0.657	0.82
156_L	161_L	0.656	0.82
42_L	52_V	0.656	0.82
28_S	43_L	0.652	0.81
280_I	283_L	0.650	0.81
121_F	139_S	0.649	0.81
353_I	363_I	0.649	0.81
167_S	178_L	0.646	0.81
186_L	194_L	0.645	0.81
77_N	81_V	0.643	0.80
240_Q	253_T	0.640	0.80
30_I	36_L	0.640	0.80
150_F	157_L	0.637	0.80
30_I	40_L	0.636	0.80
272_L	284_L	0.635	0.79
355_G	360_Y	0.633	0.79
220_R	290_C	0.632	0.79
20_S	25_F	0.630	0.79
148_D	153_I	0.630	0.79
152_S	162_P	0.629	0.79
39_L	48_L	0.628	0.79
44_V	50_L	0.625	0.78
97_R	232_L	0.625	0.78
132_I	136_L	0.623	0.78
300_A	306_L	0.622	0.78
355_G	364_L	0.622	0.78
63_S	66_L	0.616	0.77
146_L	151_L	0.615	0.77
339_A	360_Y	0.613	0.77
100_N	133_I	0.611	0.77
127_L	131_L	0.611	0.77
24_R	36_L	0.611	0.77
257_Y	336_K	0.610	0.77
106_D	118_Y	0.609	0.77
190_L	194_L	0.609	0.77
21_S	28_S	0.608	0.76
17_K	24_R	0.608	0.76
275_F	282_Y	0.608	0.76
77_N	89_W	0.607	0.76
342_F	359_T	0.606	0.76
178_L	183_R	0.604	0.76
120_R	125_L	0.604	0.76
37_L	43_L	0.603	0.76
85_L	89_W	0.602	0.76
173_F	184_F	0.602	0.76
173_F	177_V	0.602	0.76
26_S	31_L	0.601	0.76
322_E	342_F	0.600	0.76
307_L	330_L	0.599	0.75
70_D	73_Q	0.599	0.75
220_R	329_Q	0.598	0.75
317_K	320_K	0.594	0.75
119_R	132_I	0.594	0.75
70_D	75_V	0.592	0.75
167_S	172_Q	0.590	0.74
101_K	225_R	0.590	0.74
133_I	136_L	0.588	0.74
73_Q	78_Y	0.587	0.74
143_Y	154_I	0.585	0.74
42_L	47_L	0.581	0.73
311_L	315_L	0.580	0.73
175_L	181_K	0.580	0.73
185_K	199_N	0.580	0.73
92_R	95_L	0.579	0.73
339_A	361_L	0.577	0.73
17_K	21_S	0.577	0.73
171_L	180_L	0.577	0.73
170_I	181_K	0.574	0.72
234_N	338_T	0.572	0.72
177_V	296_V	0.565	0.71
220_R	322_E	0.565	0.71
151_L	163_Y	0.564	0.71
88_L	99_L	0.563	0.71
147_S	153_I	0.562	0.71
168_L	172_Q	0.561	0.71
361_L	365_I	0.560	0.70
103_L	106_D	0.560	0.70
349_L	355_G	0.559	0.70
197_E	201_L	0.559	0.70
195_L	199_N	0.559	0.70
127_L	134_L	0.557	0.70
121_F	126_I	0.557	0.70
35_L	39_L	0.550	0.69
127_L	136_L	0.549	0.69
359_T	362_I	0.548	0.69
34_Y	37_L	0.547	0.69
290_C	350_L	0.547	0.69
235_S	341_G	0.546	0.69
314_T	321_K	0.544	0.68
129_L	136_L	0.544	0.68
94_K	232_L	0.544	0.68
99_L	102_L	0.543	0.68
330_L	357_I	0.542	0.68
170_I	179_L	0.542	0.68
347_R	352_S	0.542	0.68
95_L	114_S	0.539	0.68
327_S	355_G	0.539	0.68
222_L	226_L	0.538	0.67
64_D	67_E	0.537	0.67
250_L	255_N	0.537	0.67
181_K	188_N	0.535	0.67
179_L	182_Q	0.532	0.67
30_I	42_L	0.532	0.67
222_L	253_T	0.532	0.67
8_S	14_A	0.531	0.66
327_S	349_L	0.531	0.66
19_D	23_G	0.530	0.66
127_L	138_V	0.530	0.66
150_F	162_P	0.530	0.66
126_I	134_L	0.529	0.66
132_I	141_L	0.529	0.66
245_F	349_L	0.529	0.66
173_F	181_K	0.529	0.66
121_F	131_L	0.528	0.66
33_L	47_L	0.527	0.66
32_Y	43_L	0.525	0.66
8_S	234_N	0.523	0.65
269_L	274_L	0.523	0.65
153_I	157_L	0.523	0.65
320_K	324_E	0.522	0.65
274_L	279_L	0.521	0.65
172_Q	183_R	0.520	0.65
313_S	319_L	0.520	0.65
329_Q	332_H	0.519	0.65
69_I	72_L	0.518	0.65
243_L	259_I	0.518	0.65
170_I	285_L	0.517	0.64
44_V	47_L	0.516	0.64
94_K	235_S	0.515	0.64
36_L	49_F	0.515	0.64
42_L	48_L	0.514	0.64
271_L	275_F	0.513	0.64
148_D	162_P	0.511	0.64
363_I	366_Q	0.511	0.64
187_L	219_L	0.510	0.63
223_H	304_G	0.509	0.63
128_L	139_S	0.509	0.63
304_G	347_R	0.509	0.63
21_S	34_Y	0.509	0.63
226_L	248_N	0.508	0.63
121_F	132_I	0.507	0.63
77_N	84_I	0.507	0.63
126_I	138_V	0.507	0.63
154_I	164_L	0.507	0.63
151_L	159_Y	0.506	0.63
346_D	351_L	0.506	0.63
33_L	45_L	0.506	0.63
119_R	125_L	0.505	0.63
125_L	133_I	0.504	0.62
330_L	333_R	0.504	0.62
114_S	118_Y	0.502	0.62
15_P	25_F	0.501	0.62
150_F	155_F	0.501	0.62
25_F	34_Y	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ksdA	1	0.1968	9.7	0.945	Contact Map
3vw7A	1	0.2561	2.6	0.958	Contact Map
4mqsA	1	0.2642	2.4	0.959	Contact Map
2kluA	1	0.1833	2.3	0.959	Contact Map
3pblA	1	0.2749	1.9	0.961	Contact Map
4gycB	2	0.1402	1.8	0.962	Contact Map
2lnlA	1	0.2857	1.7	0.962	Contact Map
4s0vA	1	0.2776	1.7	0.962	Contact Map
4bvnA	1	0.2534	1.4	0.964	Contact Map
4ib4A	1	0.2911	1.4	0.964	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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