GREMLIN Database
7tm_7 - 7tm Chemosensory receptor
PFAM: PF08395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 371 (365)
Sequences: 2572 (2362)
Seq/√Len: 123.6
META: 0.158

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_D183_R7.4001.00
106_D109_L4.2421.00
188_N303_T4.2081.00
303_T306_L3.8381.00
184_F188_N3.7631.00
299_E302_K3.3941.00
28_S32_Y3.1141.00
185_K299_E2.9171.00
238_G339_A2.9131.00
323_L327_S2.8771.00
179_L183_R2.6261.00
223_H227_C2.6191.00
119_R123_R2.3991.00
32_Y35_L2.3911.00
234_N238_G2.3371.00
29_S34_Y2.3091.00
23_G26_S2.2831.00
30_I34_Y2.1501.00
185_K188_N2.1411.00
339_A345_L2.1051.00
29_S32_Y2.1041.00
278_W285_L2.0911.00
30_I33_L2.0731.00
328_L332_H2.0651.00
121_F127_L2.0561.00
172_Q181_K2.0171.00
181_K185_K2.0091.00
124_L128_L1.9931.00
120_R131_L1.9901.00
123_R127_L1.9831.00
282_Y285_L1.9741.00
307_L323_L1.9301.00
31_L34_Y1.8951.00
29_S33_L1.8611.00
294_E347_R1.8071.00
37_L48_L1.8001.00
28_S33_L1.7431.00
120_R123_R1.7311.00
336_K344_D1.7091.00
293_C337_F1.7041.00
119_R126_I1.6931.00
121_F124_L1.6761.00
353_I357_I1.6681.00
96_L100_N1.6501.00
105_L109_L1.6441.00
122_R126_I1.6151.00
32_Y36_L1.6031.00
173_F185_K1.5951.00
23_G27_W1.5931.00
293_C296_V1.5851.00
39_L49_F1.5801.00
31_L35_L1.5701.00
31_L36_L1.5681.00
171_L181_K1.5571.00
30_I35_L1.5541.00
21_S24_R1.5391.00
184_F223_H1.5341.00
136_L139_S1.5331.00
183_R188_N1.5311.00
294_E298_N1.5261.00
41_I44_V1.5191.00
347_R351_L1.5171.00
33_L36_L1.5131.00
120_R127_L1.5121.00
33_L37_L1.5061.00
249_F253_T1.4981.00
280_I285_L1.4951.00
316_D319_L1.4891.00
19_D24_R1.4891.00
128_L132_I1.4831.00
29_S35_L1.4811.00
28_S31_L1.4661.00
129_L132_I1.4591.00
226_L230_V1.4541.00
34_Y42_L1.4541.00
308_H327_S1.4381.00
357_I362_I1.4361.00
291_Y347_R1.4341.00
135_L139_S1.4321.00
217_R322_E1.4281.00
322_E326_F1.4241.00
28_S34_Y1.4191.00
363_I367_F1.4151.00
36_L40_L1.4121.00
156_L162_P1.4041.00
91_N94_K1.3991.00
122_R125_L1.3981.00
29_S36_L1.3951.00
303_T326_F1.3941.00
239_L340_C1.3881.00
201_L204_S1.3861.00
260_L264_L1.3801.00
172_Q237_F1.3781.00
19_D25_F1.3751.00
272_L275_F1.3641.00
125_L129_L1.3561.00
18_I26_S1.3561.00
362_I366_Q1.3551.00
157_L162_P1.3501.00
311_L314_T1.3491.00
183_R190_L1.3491.00
328_L331_L1.3431.00
171_L178_L1.3401.00
345_L349_L1.3341.00
327_S330_L1.3331.00
128_L138_V1.3281.00
188_N299_E1.3141.00
149_Y153_I1.3011.00
249_F356_A1.2981.00
22_T26_S1.2971.00
279_L286_L1.2891.00
31_L47_L1.2891.00
202_L206_L1.2831.00
32_Y40_L1.2821.00
227_C230_V1.2801.00
109_L113_G1.2751.00
98_L233_I1.2741.00
209_R212_S1.2671.00
33_L49_F1.2631.00
95_L98_L1.2581.00
152_S156_L1.2581.00
283_L286_L1.2561.00
336_K346_D1.2481.00
121_F129_L1.2430.99
349_L358_T1.2400.99
18_I23_G1.2400.99
33_L41_I1.2340.99
131_L137_L1.2170.99
131_L135_L1.2170.99
45_L49_F1.2010.99
348_S362_I1.1960.99
29_S37_L1.1950.99
183_R186_L1.1900.99
124_L133_I1.1890.99
3_P11_L1.1880.99
123_R128_L1.1880.99
122_R132_I1.1820.99
33_L46_L1.1790.99
212_S215_R1.1780.99
147_S157_L1.1760.99
18_I21_S1.1720.99
124_L127_L1.1700.99
44_V48_L1.1660.99
125_L137_L1.1610.99
6_Y9_K1.1590.99
26_S29_S1.1580.99
20_S24_R1.1560.99
33_L40_L1.1560.99
126_I130_V1.1510.99
183_R187_L1.1480.99
37_L41_I1.1410.99
183_R189_K1.1350.99
5_L9_K1.1330.99
12_G16_F1.1310.99
33_L44_V1.1270.99
332_H337_F1.1230.99
148_D151_L1.1220.99
130_V136_L1.1150.99
201_L205_R1.1130.99
34_Y45_L1.1130.99
158_L164_L1.1110.99
349_L359_T1.1090.99
126_I133_I1.1090.99
359_T363_I1.1090.99
185_K198_L1.1070.99
346_D358_T1.1040.99
35_L38_I1.1040.99
36_L39_L1.1020.99
296_V337_F1.0850.99
32_Y48_L1.0630.98
281_I285_L1.0620.98
312_L315_L1.0610.98
153_I156_L1.0530.98
122_R136_L1.0530.98
22_T29_S1.0530.98
130_V133_I1.0510.98
35_L42_L1.0510.98
92_R102_L1.0480.98
326_F329_Q1.0450.98
88_L92_R1.0410.98
178_L185_K1.0370.98
43_L50_L1.0360.98
38_I42_L1.0350.98
119_R133_I1.0350.98
147_S152_S1.0320.98
121_F125_L1.0290.98
274_L285_L1.0270.98
343_F351_L1.0120.98
327_S331_L1.0110.98
209_R214_L1.0100.98
146_L149_Y1.0100.98
125_L128_L1.0090.98
174_F179_L1.0070.98
352_S355_G1.0060.98
278_W286_L1.0050.98
124_L135_L1.0000.98
175_L179_L0.9990.98
124_L136_L0.9950.98
332_H343_F0.9950.98
5_L16_F0.9950.98
350_L353_I0.9940.98
28_S35_L0.9930.97
123_R129_L0.9910.97
122_R129_L0.9910.97
20_S27_W0.9870.97
315_L319_L0.9840.97
287_L291_Y0.9760.97
123_R126_I0.9720.97
144_F153_I0.9700.97
120_R124_L0.9690.97
51_I54_I0.9650.97
361_L367_F0.9650.97
19_D26_S0.9640.97
134_L137_L0.9630.97
338_T344_D0.9590.97
178_L181_K0.9570.97
253_T257_Y0.9500.97
279_L283_L0.9500.97
203_S206_L0.9470.97
42_L45_L0.9470.97
73_Q76_L0.9460.97
356_A360_Y0.9440.97
21_S25_F0.9440.97
40_L44_V0.9430.97
125_L131_L0.9410.97
136_L140_L0.9390.96
131_L134_L0.9220.96
210_R214_L0.9210.96
125_L132_I0.9200.96
355_G359_T0.9200.96
348_S352_S0.9180.96
186_L189_K0.9160.96
314_T319_L0.9150.96
14_A237_F0.9150.96
358_T361_L0.9090.96
234_N340_C0.9070.96
6_Y14_A0.9060.96
326_F331_L0.8990.96
30_I45_L0.8980.95
88_L240_Q0.8950.95
227_C347_R0.8940.95
20_S23_G0.8930.95
127_L130_V0.8920.95
73_Q77_N0.8880.95
324_E328_L0.8870.95
332_H349_L0.8860.95
278_W281_I0.8840.95
31_L46_L0.8790.95
39_L45_L0.8780.95
314_T317_K0.8750.95
18_I25_F0.8740.95
122_R141_L0.8740.95
290_C293_C0.8740.95
291_Y296_V0.8740.95
282_Y286_L0.8720.95
253_T293_C0.8700.95
38_I45_L0.8660.95
338_T341_G0.8650.94
120_R133_I0.8640.94
282_Y287_L0.8610.94
35_L50_L0.8600.94
126_I140_L0.8580.94
17_K25_F0.8580.94
182_Q185_K0.8570.94
128_L131_L0.8570.94
124_L140_L0.8560.94
127_L135_L0.8480.94
101_K232_L0.8450.94
243_L257_Y0.8440.94
127_L133_I0.8430.94
211_L214_L0.8410.94
342_F345_L0.8380.93
275_F278_W0.8370.93
147_S150_F0.8350.93
337_F359_T0.8340.93
126_I129_L0.8320.93
31_L45_L0.8310.93
347_R363_I0.8300.93
324_E353_I0.8270.93
106_D113_G0.8260.93
360_Y363_I0.8250.93
31_L39_L0.8230.93
18_I24_R0.8210.93
17_K22_T0.8190.93
123_R138_V0.8180.93
30_I43_L0.8180.93
40_L48_L0.8170.93
29_S49_F0.8150.93
25_F28_S0.8150.93
24_R27_W0.8150.93
297_S300_A0.8130.92
354_I357_I0.8100.92
119_R129_L0.8080.92
223_H332_H0.8080.92
184_F227_C0.8070.92
18_I27_W0.8060.92
326_F330_L0.8050.92
119_R122_R0.8040.92
304_G327_S0.8010.92
34_Y46_L0.8000.92
210_R213_L0.7940.92
122_R140_L0.7930.91
46_L50_L0.7910.91
270_I274_L0.7900.91
79_L90_F0.7890.91
76_L84_I0.7880.91
347_R350_L0.7880.91
79_L84_I0.7810.91
18_I22_T0.7800.91
331_L348_S0.7790.91
22_T25_F0.7770.91
39_L47_L0.7740.90
220_R224_L0.7710.90
89_W92_R0.7660.90
20_S26_S0.7640.90
122_R128_L0.7620.90
108_K112_L0.7610.90
17_K20_S0.7610.90
35_L44_V0.7600.90
17_K26_S0.7590.90
150_F156_L0.7590.90
124_L131_L0.7570.89
65_L69_I0.7560.89
91_N95_L0.7560.89
152_S157_L0.7550.89
31_L42_L0.7510.89
127_L132_I0.7500.89
31_L37_L0.7500.89
249_F361_L0.7420.89
208_L211_L0.7410.88
120_R135_L0.7410.88
249_F353_I0.7390.88
119_R135_L0.7360.88
167_S173_F0.7360.88
278_W283_L0.7330.88
32_Y37_L0.7290.88
134_L138_V0.7290.88
166_L169_I0.7280.88
41_I51_I0.7280.88
184_F226_L0.7260.87
120_R128_L0.7250.87
151_L155_F0.7220.87
19_D22_T0.7220.87
122_R130_V0.7210.87
173_F183_R0.7200.87
36_L47_L0.7190.87
180_L184_F0.7180.87
256_L260_L0.7170.87
327_S333_R0.7160.87
34_Y47_L0.7150.87
150_F153_I0.7150.87
220_R227_C0.7140.87
208_L212_S0.7140.87
275_F279_L0.7130.86
132_I140_L0.7120.86
84_I88_L0.7110.86
320_K334_P0.7110.86
315_L318_R0.7100.86
159_Y162_P0.7080.86
171_L174_F0.7060.86
340_C351_L0.7060.86
30_I41_I0.7050.86
170_I173_F0.7040.86
66_L69_I0.7040.86
119_R128_L0.7030.86
234_N341_G0.7020.86
216_L256_L0.7000.85
179_L185_K0.6970.85
29_S38_I0.6950.85
3_P7_L0.6930.85
19_D27_W0.6910.85
187_L190_L0.6900.85
174_F181_K0.6890.85
194_L199_N0.6850.84
76_L80_S0.6850.84
36_L43_L0.6830.84
37_L44_V0.6820.84
31_L38_I0.6800.84
98_L236_I0.6800.84
157_L160_I0.6800.84
170_I174_F0.6790.84
166_L171_L0.6730.83
177_V181_K0.6730.83
322_E349_L0.6700.83
172_Q175_L0.6700.83
20_S43_L0.6700.83
19_D45_L0.6680.83
306_L309_K0.6660.83
311_L316_D0.6640.82
354_I363_I0.6640.82
317_K321_K0.6600.82
29_S47_L0.6590.82
341_G366_Q0.6590.82
174_F178_L0.6580.82
72_L77_N0.6570.82
156_L161_L0.6560.82
42_L52_V0.6560.82
28_S43_L0.6520.81
280_I283_L0.6500.81
121_F139_S0.6490.81
353_I363_I0.6490.81
167_S178_L0.6460.81
186_L194_L0.6450.81
77_N81_V0.6430.80
240_Q253_T0.6400.80
30_I36_L0.6400.80
150_F157_L0.6370.80
30_I40_L0.6360.80
272_L284_L0.6350.79
355_G360_Y0.6330.79
220_R290_C0.6320.79
20_S25_F0.6300.79
148_D153_I0.6300.79
152_S162_P0.6290.79
39_L48_L0.6280.79
44_V50_L0.6250.78
97_R232_L0.6250.78
132_I136_L0.6230.78
300_A306_L0.6220.78
355_G364_L0.6220.78
63_S66_L0.6160.77
146_L151_L0.6150.77
339_A360_Y0.6130.77
100_N133_I0.6110.77
127_L131_L0.6110.77
24_R36_L0.6110.77
257_Y336_K0.6100.77
106_D118_Y0.6090.77
190_L194_L0.6090.77
21_S28_S0.6080.76
17_K24_R0.6080.76
275_F282_Y0.6080.76
77_N89_W0.6070.76
342_F359_T0.6060.76
178_L183_R0.6040.76
120_R125_L0.6040.76
37_L43_L0.6030.76
85_L89_W0.6020.76
173_F184_F0.6020.76
173_F177_V0.6020.76
26_S31_L0.6010.76
322_E342_F0.6000.76
307_L330_L0.5990.75
70_D73_Q0.5990.75
220_R329_Q0.5980.75
317_K320_K0.5940.75
119_R132_I0.5940.75
70_D75_V0.5920.75
167_S172_Q0.5900.74
101_K225_R0.5900.74
133_I136_L0.5880.74
73_Q78_Y0.5870.74
143_Y154_I0.5850.74
42_L47_L0.5810.73
311_L315_L0.5800.73
175_L181_K0.5800.73
185_K199_N0.5800.73
92_R95_L0.5790.73
339_A361_L0.5770.73
17_K21_S0.5770.73
171_L180_L0.5770.73
170_I181_K0.5740.72
234_N338_T0.5720.72
177_V296_V0.5650.71
220_R322_E0.5650.71
151_L163_Y0.5640.71
88_L99_L0.5630.71
147_S153_I0.5620.71
168_L172_Q0.5610.71
361_L365_I0.5600.70
103_L106_D0.5600.70
349_L355_G0.5590.70
197_E201_L0.5590.70
195_L199_N0.5590.70
127_L134_L0.5570.70
121_F126_I0.5570.70
35_L39_L0.5500.69
127_L136_L0.5490.69
359_T362_I0.5480.69
34_Y37_L0.5470.69
290_C350_L0.5470.69
235_S341_G0.5460.69
314_T321_K0.5440.68
129_L136_L0.5440.68
94_K232_L0.5440.68
99_L102_L0.5430.68
330_L357_I0.5420.68
170_I179_L0.5420.68
347_R352_S0.5420.68
95_L114_S0.5390.68
327_S355_G0.5390.68
222_L226_L0.5380.67
64_D67_E0.5370.67
250_L255_N0.5370.67
181_K188_N0.5350.67
179_L182_Q0.5320.67
30_I42_L0.5320.67
222_L253_T0.5320.67
8_S14_A0.5310.66
327_S349_L0.5310.66
19_D23_G0.5300.66
127_L138_V0.5300.66
150_F162_P0.5300.66
126_I134_L0.5290.66
132_I141_L0.5290.66
245_F349_L0.5290.66
173_F181_K0.5290.66
121_F131_L0.5280.66
33_L47_L0.5270.66
32_Y43_L0.5250.66
8_S234_N0.5230.65
269_L274_L0.5230.65
153_I157_L0.5230.65
320_K324_E0.5220.65
274_L279_L0.5210.65
172_Q183_R0.5200.65
313_S319_L0.5200.65
329_Q332_H0.5190.65
69_I72_L0.5180.65
243_L259_I0.5180.65
170_I285_L0.5170.64
44_V47_L0.5160.64
94_K235_S0.5150.64
36_L49_F0.5150.64
42_L48_L0.5140.64
271_L275_F0.5130.64
148_D162_P0.5110.64
363_I366_Q0.5110.64
187_L219_L0.5100.63
223_H304_G0.5090.63
128_L139_S0.5090.63
304_G347_R0.5090.63
21_S34_Y0.5090.63
226_L248_N0.5080.63
121_F132_I0.5070.63
77_N84_I0.5070.63
126_I138_V0.5070.63
154_I164_L0.5070.63
151_L159_Y0.5060.63
346_D351_L0.5060.63
33_L45_L0.5060.63
119_R125_L0.5050.63
125_L133_I0.5040.62
330_L333_R0.5040.62
114_S118_Y0.5020.62
15_P25_F0.5010.62
150_F155_F0.5010.62
25_F34_Y0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ksdA 1 0.1968 9.7 0.945 Contact Map
3vw7A 1 0.2561 2.6 0.958 Contact Map
4mqsA 1 0.2642 2.4 0.959 Contact Map
2kluA 1 0.1833 2.3 0.959 Contact Map
3pblA 1 0.2749 1.9 0.961 Contact Map
4gycB 2 0.1402 1.8 0.962 Contact Map
2lnlA 1 0.2857 1.7 0.962 Contact Map
4s0vA 1 0.2776 1.7 0.962 Contact Map
4bvnA 1 0.2534 1.4 0.964 Contact Map
4ib4A 1 0.2911 1.4 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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