GREMLIN Database
TRAM1 - TRAM1-like protein
PFAM: PF08390 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 63 (61)
Sequences: 979 (664)
Seq/√Len: 85.0
META: 0.309

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_Y24_G6.7551.00
3_K26_K3.8491.00
26_K29_A2.8631.00
45_I49_V2.4841.00
9_Y22_G2.1211.00
45_I50_L1.7261.00
43_A46_M1.6511.00
32_F35_I1.6291.00
10_P19_G1.6241.00
8_S30_F1.6191.00
30_F34_Y1.3560.99
39_T46_M1.2770.98
53_L57_L1.2700.98
46_M51_R1.2610.98
40_F44_F1.2590.98
39_T43_A1.2590.98
7_L21_Y1.2500.98
44_F48_Y1.2290.98
3_K29_A1.2220.98
13_D17_E1.1840.97
59_I62_R1.1510.97
28_L32_F1.1330.96
4_F32_F1.1180.96
51_R55_R1.1150.96
23_K43_A1.0960.96
13_D16_P1.0600.95
2_S9_Y1.0370.94
31_V51_R1.0330.94
14_Y17_E0.9750.92
4_F48_Y0.9680.92
14_Y19_G0.9620.91
23_K40_F0.9240.90
43_A48_Y0.9000.89
14_Y18_T0.8910.88
42_R52_P0.8880.88
52_P58_G0.8760.87
31_V38_F0.8730.87
23_K28_L0.8710.87
23_K38_F0.8630.86
57_L60_S0.8620.86
23_K29_A0.8470.85
15_P18_T0.8330.84
39_T45_I0.8260.84
32_F36_V0.8260.84
31_V54_A0.8130.83
50_L53_L0.8070.82
43_A47_E0.8070.82
5_I41_L0.7800.80
57_L62_R0.7680.79
7_L37_V0.7540.78
34_Y37_V0.7480.77
17_E25_P0.7460.77
6_F34_Y0.7300.76
15_P41_L0.7250.75
21_Y41_L0.7100.74
5_I37_V0.7080.73
16_P19_G0.7010.73
30_F42_R0.6960.72
46_M52_P0.6900.71
44_F51_R0.6870.71
39_T42_R0.6810.70
44_F62_R0.6790.70
38_F41_L0.6720.69
31_V57_L0.6640.69
2_S6_F0.6420.66
2_S35_I0.6370.65
3_K10_P0.6270.64
11_V22_G0.6170.63
42_R54_A0.5970.60
8_S29_A0.5960.60
25_P28_L0.5900.59
12_P19_G0.5830.59
5_I33_F0.5690.57
10_P16_P0.5680.57
4_F55_R0.5670.56
46_M50_L0.5640.56
18_T22_G0.5570.55
4_F29_A0.5550.55
38_F54_A0.5500.54
19_G25_P0.5480.54
7_L53_L0.5460.54
48_Y55_R0.5400.53
25_P36_V0.5360.52
53_L56_R0.5350.52
12_P16_P0.5300.52
4_F26_K0.5190.50
30_F41_L0.5170.50
28_L31_V0.5130.49
42_R46_M0.5070.48
36_V39_T0.5060.48
30_F52_P0.5030.48
51_R60_S0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l9dA 1 0.0159 5.4 0.888 Contact Map
2vpzA 1 1 3.2 0.9 Contact Map
2e7zA 1 0.9683 2.8 0.903 Contact Map
2iv2X 1 1 2.7 0.904 Contact Map
2lf8A 1 0.5238 2.7 0.904 Contact Map
3l15A 1 0.6667 2.6 0.905 Contact Map
1awcA 1 0.4603 2.5 0.905 Contact Map
4ojdH 3 0.1429 2.4 0.907 Contact Map
2ed2A 1 0.4762 2.2 0.908 Contact Map
2napA 1 1 2.1 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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