GREMLIN Database
PDR_assoc - Plant PDR ABC transporter associated
PFAM: PF08370 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (64)
Sequences: 1005 (669)
Seq/√Len: 83.6
META: 0.089

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_F43_F3.3921.00
23_F28_W2.9801.00
35_A42_L2.1091.00
49_L53_Y1.9681.00
22_L63_V1.8841.00
44_N58_G1.8091.00
27_Y31_I1.8031.00
41_L45_I1.7551.00
22_L46_L1.7211.00
10_E14_V1.7031.00
31_I35_A1.6731.00
4_V33_V1.6571.00
21_G26_A1.6551.00
28_W32_G1.5421.00
14_V18_K1.5341.00
48_T52_T1.5170.99
29_Y44_N1.4920.99
28_W31_I1.4650.99
6_P20_R1.4600.99
22_L62_A1.4400.99
26_A40_T1.4320.99
32_G37_L1.3470.99
10_E18_K1.3280.99
42_L50_A1.3120.99
14_V24_T1.2840.98
35_A39_F1.2640.98
28_W41_L1.2580.98
7_N15_A1.1660.97
35_A44_N1.1550.97
36_L40_T1.0840.95
37_L41_L1.0660.95
39_F50_A1.0600.95
50_A53_Y1.0440.94
15_A46_L1.0090.93
46_L56_P0.9890.92
34_G47_F0.9880.92
14_V25_E0.9690.91
27_Y33_V0.9600.91
12_L38_G0.9500.91
17_L24_T0.9440.90
11_T14_V0.9340.90
17_L22_L0.9340.90
4_V63_V0.9290.90
44_N54_L0.9220.89
49_L52_T0.8850.87
2_S37_L0.8690.86
22_L53_Y0.8490.85
24_T57_L0.8410.84
12_L40_T0.8360.84
5_L8_S0.8170.83
29_Y54_L0.7940.81
46_L55_N0.7840.80
16_V32_G0.7690.79
14_V23_F0.7530.77
27_Y46_L0.7410.76
16_V49_L0.7320.75
9_N18_K0.6870.70
35_A47_F0.6820.70
6_P21_G0.6790.70
6_P60_S0.6780.69
17_L36_L0.6750.69
32_G47_F0.6710.69
5_L10_E0.6710.69
13_G17_L0.6690.68
3_K11_T0.6670.68
16_V22_L0.6430.65
42_L62_A0.6340.64
38_G50_A0.6300.64
12_L31_I0.6230.63
31_I42_L0.6210.63
45_I49_L0.6170.62
6_P37_L0.6130.62
52_T60_S0.5870.58
19_S41_L0.5830.58
20_R23_F0.5830.58
32_G63_V0.5740.57
33_V45_I0.5680.56
48_T53_Y0.5580.55
21_G30_W0.5560.54
58_G61_Q0.5560.54
24_T53_Y0.5520.54
6_P11_T0.5490.53
31_I44_N0.5450.53
23_F35_A0.5440.53
2_S36_L0.5400.52
8_S17_L0.5300.51
23_F38_G0.5290.51
5_L15_A0.5280.51
4_V64_I0.5270.51
2_S16_V0.5260.50
55_N58_G0.5250.50
8_S33_V0.5140.49
2_S11_T0.5070.48
42_L46_L0.5010.47
8_S42_L0.5000.47
17_L46_L0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qi1A 3 0.6562 23.3 0.868 Contact Map
1xioA 2 0.5938 19.2 0.873 Contact Map
3qapA 1 0.5938 15 0.879 Contact Map
3wt9A 1 0.7031 11 0.886 Contact Map
1m0kA 3 0.5156 8.8 0.891 Contact Map
4l35A 3 0.6406 8.4 0.892 Contact Map
4fbzA 3 0.6875 7.8 0.894 Contact Map
3ddlA 2 0.7344 4.9 0.903 Contact Map
3ayfA 2 0.625 3.7 0.909 Contact Map
3am6A 3 0.6406 3.5 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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