GREMLIN Database
FAST_2 - FAST kinase-like protein, subdomain 2
PFAM: PF08368 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (88)
Sequences: 523 (301)
Seq/√Len: 32.1
META: 0.044

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_E81_L3.7521.00
8_N22_R3.3511.00
69_T75_I2.5861.00
38_S74_T2.5611.00
67_V75_I2.2360.99
43_S46_Q2.0960.98
62_Y65_S2.0620.98
12_C22_R2.0530.98
57_L61_N2.0390.98
82_D86_K2.0040.98
6_Q73_Y1.9200.97
20_G23_L1.9080.97
3_K7_L1.8890.97
8_N12_C1.8450.96
60_R83_K1.8110.96
8_N69_T1.7570.95
11_V22_R1.6730.93
4_L78_E1.5150.89
14_E70_P1.4940.89
7_L52_A1.4760.88
14_E77_F1.4750.88
18_Y23_L1.4510.87
16_P71_Y1.3960.85
18_Y21_P1.3610.83
31_S39_L1.3160.81
84_E87_P1.2960.80
69_T73_Y1.2940.80
49_V63_V1.2780.79
63_V82_D1.2780.79
4_L13_L1.2620.79
2_K47_K1.1920.74
13_L71_Y1.1690.73
8_N28_C1.1690.73
56_L63_V1.1150.69
33_L72_G1.1000.68
26_K52_A1.0850.67
29_Q56_L1.0650.66
24_P28_C1.0640.66
13_L83_K1.0400.64
36_L39_L1.0300.63
3_K6_Q1.0190.62
20_G66_S1.0180.62
54_K59_G1.0060.61
48_E87_P1.0050.61
75_I86_K1.0000.61
14_E71_Y0.9800.59
58_G68_L0.9600.58
29_Q37_S0.9320.55
18_Y22_R0.9300.55
45_L49_V0.9290.55
47_K61_N0.9260.55
20_G85_G0.9190.54
15_C58_G0.9060.53
6_Q10_T0.9050.53
2_K43_S0.9050.53
23_L77_F0.9040.53
63_V87_P0.9030.53
6_Q9_A0.9020.53
49_V70_P0.8990.53
31_S35_P0.8940.52
14_E58_G0.8460.48
17_E22_R0.8430.48
21_P75_I0.8360.47
52_A87_P0.8140.46
37_S55_E0.8140.46
4_L31_S0.8120.45
46_Q69_T0.8080.45
54_K61_N0.8070.45
74_T81_L0.8020.45
45_L81_L0.7960.44
45_L48_E0.7850.43
23_L71_Y0.7740.42
38_S78_E0.7710.42
15_C61_N0.7670.42
71_Y77_F0.7600.41
61_N66_S0.7530.41
80_V85_G0.7510.40
64_K80_V0.7320.39
80_V87_P0.7310.39
5_L15_C0.7230.38
9_A17_E0.7150.38
18_Y88_L0.7120.37
67_V78_E0.7100.37
25_P51_E0.6910.36
7_L20_G0.6870.36
10_T13_L0.6800.35
20_G24_P0.6780.35
33_L37_S0.6730.34
10_T14_E0.6720.34
9_A13_L0.6710.34
22_R69_T0.6690.34
34_K55_E0.6650.34
24_P54_K0.6550.33
25_P72_G0.6490.33
64_K70_P0.6390.32
35_P56_L0.6350.32
19_K50_K0.6330.32
21_P57_L0.6290.31
53_L81_L0.6280.31
14_E73_Y0.6210.31
13_L73_Y0.6190.31
53_L82_D0.6190.31
30_K67_V0.6190.31
19_K35_P0.6150.30
54_K60_R0.6140.30
50_K66_S0.6080.30
6_Q66_S0.5990.29
79_V88_L0.5920.29
19_K51_E0.5770.28
31_S44_P0.5770.28
34_K61_N0.5690.27
12_C86_K0.5680.27
31_S54_K0.5670.27
6_Q58_G0.5560.26
49_V72_G0.5510.26
59_G82_D0.5510.26
46_Q71_Y0.5470.26
62_Y68_L0.5420.26
55_E68_L0.5380.25
64_K87_P0.5350.25
9_A73_Y0.5270.25
7_L83_K0.5180.24
49_V79_V0.5140.24
41_K75_I0.5090.23
51_E82_D0.5090.23
73_Y77_F0.5070.23
15_C18_Y0.5050.23
41_K79_V0.5030.23
61_N84_E0.5020.23
63_V79_V0.5010.23
29_Q87_P0.5000.23
46_Q75_I0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3icfA 2 0.7079 21 0.881 Contact Map
3h63A 1 0.7978 19.3 0.883 Contact Map
1iooA 1 0.8652 18.5 0.884 Contact Map
1iqqA 1 0.8876 13.7 0.89 Contact Map
1ucdA 1 0.8764 12.2 0.892 Contact Map
2vldA 2 0.7528 10.5 0.896 Contact Map
1sglA 1 0.8539 9.8 0.897 Contact Map
1jy5A 1 0.8427 9.8 0.897 Contact Map
1vczA 1 0.9551 8.9 0.899 Contact Map
1iybA 2 0.8764 6.7 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0054 seconds.