GREMLIN Database
DUF1724 - Domain of unknown function (DUF1724)
PFAM: PF08350 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 62 (59)
Sequences: 2226 (1550)
Seq/√Len: 201.8
META: 0.855

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_L49_G3.4911.00
40_S45_A3.2691.00
23_S37_D3.1081.00
54_E58_K2.1831.00
8_E59_R2.0861.00
4_Y57_K1.9391.00
7_D61_E1.9031.00
22_L45_A1.7001.00
21_F41_F1.6691.00
17_V49_G1.6081.00
25_G33_Y1.5621.00
55_Y59_R1.5531.00
25_G37_D1.4931.00
46_L50_K1.4921.00
53_F57_K1.4861.00
6_Y10_I1.3951.00
47_K51_E1.3791.00
21_F39_I1.2481.00
9_D12_K1.2461.00
48_W52_L1.2301.00
33_Y45_A1.2291.00
43_P47_K1.1931.00
44_S50_K1.1061.00
6_Y60_S1.0601.00
28_N32_K1.0481.00
14_A18_T0.9811.00
33_Y37_D0.9781.00
35_Y51_E0.9731.00
45_A49_G0.9711.00
20_K29_K0.9700.99
14_A25_G0.9680.99
29_K59_R0.9560.99
36_K44_S0.9380.99
17_V46_L0.9360.99
16_T23_S0.9240.99
25_G28_N0.9170.99
20_K46_L0.9080.99
14_A27_F0.9050.99
50_K54_E0.8900.99
14_A33_Y0.8680.99
7_D12_K0.8550.99
39_I49_G0.8390.99
4_Y13_L0.8200.98
14_A23_S0.8110.98
57_K60_S0.8090.98
2_K6_Y0.8070.98
34_D38_L0.8030.98
2_K5_V0.7800.98
27_F33_Y0.7670.97
48_W55_Y0.7480.97
40_S46_L0.7390.97
27_F49_G0.7340.97
16_T53_F0.7270.96
29_K61_E0.7150.96
56_Y59_R0.6910.95
54_E57_K0.6820.95
34_D39_I0.6660.94
39_I58_K0.6660.94
16_T49_G0.6630.94
16_T25_G0.6580.94
6_Y9_D0.6570.94
4_Y53_F0.6560.94
15_L20_K0.6420.93
47_K50_K0.6290.92
4_Y51_E0.6240.92
13_L34_D0.6220.92
4_Y60_S0.6190.92
36_K40_S0.6180.92
4_Y8_E0.6140.91
7_D54_E0.6130.91
15_L33_Y0.6020.91
16_T37_D0.6010.90
20_K41_F0.6000.90
32_K56_Y0.5910.90
14_A49_G0.5900.90
46_L49_G0.5690.88
31_G58_K0.5630.87
13_L16_T0.5590.87
22_L42_D0.5480.86
14_A17_V0.5440.86
27_F38_L0.5370.85
47_K58_K0.5360.85
2_K8_E0.5360.85
3_L8_E0.5330.84
6_Y12_K0.5280.84
43_P58_K0.5240.83
44_S58_K0.5100.82
19_D46_L0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qphA 2 0.9032 71 0.768 Contact Map
1byrA 2 0.9677 27.6 0.823 Contact Map
4ggjA 2 0.9839 24.5 0.828 Contact Map
4gelA 2 0.9677 8.9 0.859 Contact Map
1di1A 1 0.9516 8.7 0.86 Contact Map
3hsiA 2 1 8 0.862 Contact Map
4kwdA 2 0.9677 8 0.862 Contact Map
1z7lA 1 0.4194 7.1 0.865 Contact Map
3qweA 2 0.6774 6.8 0.867 Contact Map
1v0wA 1 0.9839 4.8 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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