GREMLIN Database
DUF1722 - Protein of unknown function (DUF1722)
PFAM: PF08349 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 117 (117)
Sequences: 8687 (6011)
Seq/√Len: 555.7
META: 0.878

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_H112_Y2.6931.00
59_M75_L2.4741.00
103_D108_A2.3981.00
8_S11_H2.3391.00
70_E101_K2.2561.00
14_E37_L2.2401.00
11_H41_A2.2041.00
4_L41_A2.0811.00
5_M9_P2.0811.00
22_A30_L1.9911.00
52_T82_R1.9741.00
25_L33_E1.9571.00
56_Q75_L1.9221.00
10_K14_E1.9031.00
21_N24_K1.8901.00
65_Q104_V1.8561.00
9_P13_R1.7871.00
96_R114_N1.7611.00
79_E83_R1.7591.00
99_V108_A1.7431.00
2_L61_Y1.7061.00
11_H37_L1.7031.00
80_D85_L1.6791.00
52_T78_I1.6581.00
11_H40_E1.5891.00
67_S70_E1.5691.00
58_I107_L1.5581.00
11_H14_E1.5561.00
2_L58_I1.5411.00
27_L31_A1.5311.00
98_Y102_Y1.5161.00
4_L38_L1.5051.00
15_L37_L1.4971.00
31_A35_E1.4891.00
68_A72_Q1.4391.00
59_M74_L1.3661.00
36_E40_E1.3551.00
99_V107_L1.3261.00
35_E39_M1.3201.00
29_E33_E1.2951.00
52_T56_Q1.2851.00
25_L30_L1.2761.00
10_K13_R1.2731.00
8_S44_L1.1891.00
3_L111_T1.1781.00
79_E82_R1.1671.00
5_M12_Y1.1581.00
58_I95_L1.1491.00
33_E37_L1.1391.00
33_E36_E1.1381.00
61_Y106_Y1.1291.00
63_K71_K1.1231.00
73_E100_R1.1221.00
65_Q102_Y1.1181.00
9_P50_K1.0981.00
9_P53_N1.0951.00
57_H60_G1.0931.00
25_L29_E1.0911.00
99_V103_D1.0901.00
32_A36_E1.0861.00
74_L78_I1.0711.00
21_N25_L1.0641.00
105_P109_G1.0621.00
74_L98_Y1.0551.00
55_L88_L1.0031.00
47_T50_K1.0011.00
69_D100_R0.9981.00
73_E77_L0.9831.00
98_Y101_K0.9571.00
77_L94_L0.9541.00
51_H88_L0.9441.00
37_L40_E0.9271.00
89_I93_T0.9151.00
26_P29_E0.9141.00
49_K82_R0.9071.00
62_F99_V0.9031.00
69_D103_D0.8971.00
56_Q79_E0.8901.00
13_R17_R0.8791.00
18_L30_L0.8691.00
46_A51_H0.8681.00
2_L5_M0.8671.00
17_R21_N0.8661.00
29_E32_A0.8651.00
76_E80_D0.8611.00
100_R108_A0.8491.00
18_L37_L0.8471.00
37_L41_A0.8191.00
48_R52_T0.8161.00
55_L91_P0.8151.00
67_S101_K0.8041.00
77_L91_P0.8011.00
5_M57_H0.7931.00
16_G20_A0.7901.00
93_T97_H0.7861.00
58_I113_L0.7841.00
53_N57_H0.7811.00
53_N60_G0.7721.00
75_L79_E0.7671.00
6_A51_H0.7621.00
104_V109_G0.7551.00
71_K75_L0.7431.00
48_R84_G0.7361.00
28_E32_A0.7241.00
105_P108_A0.7211.00
56_Q59_M0.7161.00
44_L50_K0.7091.00
72_Q76_E0.7011.00
46_A50_K0.6951.00
69_D101_K0.6931.00
51_H81_Y0.6911.00
94_L97_H0.6821.00
22_A25_L0.6791.00
26_P30_L0.6751.00
14_E17_R0.6711.00
14_E33_E0.6701.00
61_Y104_V0.6691.00
86_V90_V0.6681.00
73_E93_T0.6631.00
7_H46_A0.6601.00
48_R81_Y0.6581.00
62_F95_L0.6561.00
57_H106_Y0.6551.00
73_E97_H0.6521.00
40_E43_A0.6511.00
32_A35_E0.6471.00
4_L34_Y0.6471.00
77_L80_D0.6371.00
12_Y19_V0.6361.00
11_H44_L0.6341.00
73_E94_L0.6341.00
96_R113_L0.6321.00
53_N61_Y0.6191.00
99_V104_V0.6151.00
55_L95_L0.6141.00
27_L30_L0.6091.00
54_V112_Y0.6051.00
69_D72_Q0.6051.00
55_L92_L0.5991.00
35_E38_L0.5961.00
80_D86_V0.5961.00
90_V93_T0.5871.00
86_V89_I0.5861.00
80_D83_R0.5861.00
62_F104_V0.5791.00
35_E80_D0.5700.99
52_T81_Y0.5660.99
77_L86_V0.5650.99
109_G114_N0.5630.99
62_F107_L0.5630.99
93_T96_R0.5630.99
51_H55_L0.5580.99
18_L33_E0.5560.99
16_G60_G0.5550.99
96_R100_R0.5520.99
87_P90_V0.5520.99
19_V22_A0.5450.99
76_E79_E0.5380.99
17_R20_A0.5350.99
6_A54_V0.5310.99
34_Y38_L0.5280.99
54_V58_I0.5240.99
53_N56_Q0.5240.99
40_E44_L0.5210.99
89_I92_L0.5210.99
113_L116_H0.5210.99
49_K52_T0.5170.99
41_A45_P0.5160.99
53_N106_Y0.5110.99
9_P12_Y0.5100.99
56_Q78_I0.5080.99
59_M63_K0.5070.99
58_I112_Y0.5070.99
70_E98_Y0.5050.99
22_A26_P0.5040.99
3_L42_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ykcA 1 0.5812 19 0.895 Contact Map
4fqnA 2 0.6752 18.8 0.896 Contact Map
3nrwA 1 0.7692 14.8 0.9 Contact Map
4a8eA 2 0.7009 13.6 0.902 Contact Map
4cbeA 1 0.9744 13.4 0.902 Contact Map
2czyA 1 0.5897 13.4 0.902 Contact Map
2ld7B 1 0.6154 12.5 0.903 Contact Map
2yqcA 1 0.5726 12.3 0.904 Contact Map
1rzuA 1 0.3675 12.2 0.904 Contact Map
1r1hA 1 0.9658 12.2 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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