GREMLIN Database
AntA - AntA/AntB antirepressor
PFAM: PF08346 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (68)
Sequences: 4011 (3282)
Seq/√Len: 398.0
META: 0.818

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_D18_D3.8771.00
16_F52_Y2.6671.00
14_T22_D2.6631.00
29_F58_M2.3931.00
26_E67_R2.3751.00
30_V33_E2.0021.00
3_A16_F1.8271.00
2_S5_E1.7821.00
23_R66_E1.6891.00
27_Y65_V1.6881.00
20_I24_I1.6231.00
39_L43_S1.6151.00
3_A54_L1.5591.00
39_L42_N1.5221.00
14_T18_D1.4031.00
44_G47_R1.3791.00
44_G48_P1.3701.00
27_Y61_E1.3501.00
27_Y58_M1.3241.00
36_I53_A1.3231.00
58_M62_L1.2871.00
2_S53_A1.1681.00
54_L58_M1.1651.00
42_N46_G1.1351.00
3_A52_Y1.1331.00
15_D21_K1.1221.00
9_F63_A1.0871.00
41_K44_G1.0841.00
23_R26_E1.0791.00
20_I52_Y1.0741.00
43_S46_G1.0521.00
43_S48_P1.0521.00
40_K43_S1.0241.00
42_N45_G1.0221.00
17_S21_K1.0091.00
37_S50_K1.0041.00
2_S51_D0.9931.00
37_S42_N0.9931.00
5_E9_F0.9721.00
17_S22_D0.9631.00
37_S47_R0.9631.00
24_I58_M0.9501.00
32_N36_I0.9311.00
54_L62_L0.9291.00
43_S47_R0.9251.00
57_D61_E0.9181.00
18_D22_D0.9031.00
7_H12_V0.8861.00
46_G49_S0.8581.00
20_I54_L0.8551.00
61_E65_V0.8381.00
42_N47_R0.8311.00
57_D60_K0.8291.00
40_K44_G0.8251.00
45_G49_S0.8211.00
14_T17_S0.7961.00
41_K48_P0.7901.00
12_V66_E0.7771.00
4_R16_F0.7611.00
6_L54_L0.7581.00
41_K45_G0.7501.00
12_V15_D0.7491.00
56_L60_K0.7451.00
38_F47_R0.7321.00
6_L63_A0.7271.00
39_L44_G0.7221.00
37_S45_G0.7061.00
59_A63_A0.6991.00
22_D25_E0.6820.99
53_A63_A0.6820.99
40_K45_G0.6790.99
38_F53_A0.6690.99
5_E8_E0.6670.99
24_I27_Y0.6580.99
23_R62_L0.6360.99
37_S48_P0.6340.99
53_A56_L0.6310.99
38_F41_K0.6310.99
37_S44_G0.6250.99
4_R51_D0.6160.99
23_R27_Y0.6070.99
18_D21_K0.6060.99
41_K47_R0.6030.99
20_I25_E0.6020.99
15_D22_D0.6000.99
24_I29_F0.5970.99
38_F42_N0.5920.99
62_L65_V0.5910.99
17_S50_K0.5910.99
65_V68_N0.5890.98
55_T58_M0.5740.98
39_L46_G0.5700.98
28_G61_E0.5590.98
31_E37_S0.5540.98
18_D40_K0.5480.98
6_L10_L0.5320.97
18_D39_L0.5240.97
3_A20_I0.5140.96
5_E56_L0.5100.96
37_S40_K0.5030.96
33_E36_I0.5010.96
60_K64_M0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bbnI 1 0.9559 23.3 0.853 Contact Map
5aj3I 1 0.9412 14.7 0.865 Contact Map
4tp8I 1 0.9412 14.6 0.866 Contact Map
2qlzA 2 0.8676 13.6 0.868 Contact Map
4rb5I 1 0.9412 12.3 0.87 Contact Map
2btoA 4 0.6765 9.5 0.876 Contact Map
3zeyK 1 0.8824 7.3 0.883 Contact Map
4w23Q 1 0.8676 7 0.884 Contact Map
4bpeI 1 0.8676 6.8 0.884 Contact Map
3hrzD 1 0.4412 6.6 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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