GREMLIN Database
DUF1732 - Domain of unknown function (DUF1732)
PFAM: PF08340 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (85)
Sequences: 28625 (13565)
Seq/√Len: 1471.4
META: 0.946

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_A70_L3.8611.00
55_G67_V3.2811.00
25_Q28_E2.4231.00
6_L10_S2.2141.00
19_L47_M2.2081.00
44_L77_I2.1171.00
13_T17_V2.0171.00
73_E76_K1.9081.00
39_K69_E1.8891.00
61_A65_R1.7801.00
23_L27_R1.7461.00
26_F47_M1.6901.00
66_L69_E1.6041.00
11_D76_K1.5231.00
29_L39_K1.4811.00
21_S25_Q1.4741.00
26_F44_L1.4501.00
52_N56_S1.4471.00
24_A28_E1.3871.00
41_D82_Q1.3861.00
25_Q39_K1.3781.00
29_L43_L1.3731.00
58_A63_I1.3331.00
62_E65_R1.3311.00
26_F40_L1.3311.00
51_A74_I1.3051.00
16_L20_R1.3031.00
20_R24_A1.2801.00
65_R69_E1.2581.00
27_R31_A1.2521.00
25_Q65_R1.2411.00
33_G36_V1.2331.00
52_N71_K1.2021.00
41_D72_A1.1781.00
7_A10_S1.1771.00
47_M51_A1.1731.00
21_S61_A1.1711.00
28_E32_S1.1701.00
47_M74_I1.1631.00
32_S36_V1.1361.00
32_S39_K1.0761.00
69_E72_A1.0541.00
12_I54_I1.0501.00
19_L23_L0.9931.00
29_L40_L0.9871.00
16_L54_I0.9691.00
26_F77_I0.9651.00
1_Q5_L0.9641.00
5_L8_D0.9611.00
66_L70_L0.9501.00
24_A27_R0.9501.00
48_N56_S0.9471.00
40_L81_V0.9411.00
10_S59_N0.9391.00
62_E66_L0.9311.00
25_Q43_L0.9261.00
39_K72_A0.9161.00
13_T76_K0.9011.00
29_L32_S0.8921.00
4_A8_D0.8761.00
64_T68_V0.8731.00
12_I63_I0.8701.00
61_A64_T0.8671.00
23_L47_M0.8631.00
54_I67_V0.8621.00
58_A64_T0.8581.00
19_L54_I0.8471.00
65_R68_V0.8331.00
1_Q4_A0.8301.00
17_V21_S0.8281.00
28_E31_A0.8261.00
16_L41_D0.7831.00
44_L48_N0.7761.00
21_S24_A0.7731.00
17_V20_R0.7731.00
69_E73_E0.7681.00
28_E65_R0.7481.00
26_F30_L0.7451.00
3_V7_A0.7401.00
63_I66_L0.7291.00
29_L36_V0.7251.00
55_G68_V0.7181.00
25_Q29_L0.7121.00
72_A76_K0.7021.00
38_R41_D0.6961.00
20_R27_R0.6961.00
12_I58_A0.6861.00
38_R75_E0.6751.00
44_L81_V0.6661.00
70_L74_I0.6541.00
1_Q6_L0.6461.00
30_L36_V0.6431.00
41_D48_N0.6331.00
48_N74_I0.6331.00
75_E78_R0.6251.00
78_R82_Q0.6241.00
17_V73_E0.6211.00
68_V72_A0.6201.00
29_L72_A0.6081.00
18_R22_H0.6041.00
13_T73_E0.6041.00
44_L47_M0.6031.00
55_G71_K0.6011.00
60_D63_I0.5981.00
24_A31_A0.5881.00
12_I16_L0.5841.00
4_A7_A0.5811.00
8_D72_A0.5801.00
67_V71_K0.5791.00
43_L68_V0.5761.00
48_N78_R0.5721.00
34_E39_K0.5621.00
25_Q41_D0.5611.00
61_A68_V0.5591.00
41_D81_V0.5561.00
19_L51_A0.5481.00
51_A67_V0.5471.00
37_G42_F0.5471.00
51_A54_I0.5461.00
21_S43_L0.5341.00
42_F52_N0.5281.00
74_I80_Q0.5261.00
32_S35_P0.5231.00
48_N71_K0.5211.00
60_D65_R0.5211.00
20_R23_L0.5121.00
19_L70_L0.5031.00
43_L61_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ll8A 1 0.4706 27 0.892 Contact Map
2e7sA 2 0.9882 11 0.91 Contact Map
4y66B 1 0.9176 9.5 0.912 Contact Map
2ocyA 4 1 9.2 0.913 Contact Map
1gaxA 1 0.7529 6.6 0.918 Contact Map
1m1jB 2 0.9882 6.5 0.918 Contact Map
3ojaB 1 1 6.2 0.919 Contact Map
4cbcA 3 0 6.2 0.919 Contact Map
1sesA 2 0.9176 6.2 0.919 Contact Map
2lz1A 1 0.5176 6.1 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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