GREMLIN Database
PIG-X - PIG-X / PBN1
PFAM: PF08320 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 206 (202)
Sequences: 594 (462)
Seq/√Len: 32.5
META: 0.148

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_C125_C11.3581.00
43_Y62_L5.1731.00
99_L175_V4.3831.00
40_V76_V3.9671.00
10_T32_L3.9231.00
34_L38_V3.0581.00
36_S66_E3.0441.00
118_W171_L2.6691.00
102_H177_V2.5961.00
36_S58_G2.5371.00
105_S109_S2.3990.99
96_P176_P2.3750.99
61_D64_A2.3580.99
39_F42_P2.3430.99
58_G62_L2.2070.99
12_V15_G2.1680.99
45_L96_P2.1610.99
41_D62_L2.1040.98
3_G6_R2.0500.98
3_G8_L2.0120.98
38_V116_L1.8640.96
67_Y104_P1.7940.96
134_K152_G1.7340.95
179_D182_H1.7170.94
39_F62_L1.7040.94
102_H155_T1.7040.94
55_A58_G1.6910.94
98_H101_Y1.6110.92
29_H122_F1.6060.92
62_L72_W1.5720.91
133_T154_R1.5300.90
56_V108_E1.5120.90
65_P104_P1.4970.89
21_L181_S1.4950.89
12_V167_G1.4780.88
42_P56_V1.4180.86
36_S60_T1.4010.86
195_L202_L1.3960.85
5_H101_Y1.3900.85
66_E69_S1.3890.85
138_N141_D1.3880.85
62_L65_P1.3570.84
118_W162_P1.3220.82
57_S62_L1.2970.81
83_S86_Q1.2930.81
12_V160_L1.2820.80
5_H8_L1.2820.80
147_Y159_H1.2770.80
44_E96_P1.2550.79
133_T152_G1.2510.78
44_E99_L1.2460.78
29_H69_S1.2380.78
37_G112_A1.2230.77
197_G201_I1.2220.77
37_G69_S1.2190.76
106_S109_S1.2160.76
132_G156_Q1.1890.75
37_G114_V1.1870.75
88_S113_T1.1840.74
6_R194_T1.1800.74
122_F140_F1.1740.74
96_P177_V1.1610.73
38_V46_A1.1590.73
177_V194_T1.1580.73
44_E48_L1.1510.72
9_L197_G1.1400.71
71_Q108_E1.1340.71
56_V163_K1.1340.71
50_R70_K1.1240.70
45_L78_L1.1170.70
5_H98_H1.1130.70
84_D168_E1.1070.69
129_A149_G1.1060.69
31_Y34_L1.0970.68
42_P62_L1.0910.68
113_T174_Q1.0900.68
9_L94_E1.0890.68
10_T41_D1.0870.68
6_R69_S1.0610.66
191_L194_T1.0560.65
9_L92_T1.0490.65
47_S61_D1.0480.65
165_A188_A1.0460.65
26_C35_P1.0380.64
30_A82_P1.0340.64
104_P173_L1.0240.63
134_K137_E1.0180.63
6_R10_T1.0140.62
38_V99_L1.0110.62
44_E72_W1.0070.62
69_S194_T1.0040.61
36_S187_E0.9930.61
44_E61_D0.9860.60
40_V45_L0.9860.60
107_E181_S0.9840.60
6_R74_S0.9820.60
16_S19_E0.9810.60
78_L106_S0.9790.59
108_E180_L0.9680.59
163_K166_S0.9660.58
88_S202_L0.9610.58
32_L57_S0.9600.58
6_R39_F0.9590.58
39_F201_I0.9410.56
68_L174_Q0.9350.56
63_E100_R0.9310.56
140_F157_F0.9280.55
173_L186_V0.9250.55
85_P90_E0.9230.55
73_G124_A0.9230.55
187_E194_T0.9150.54
40_V55_A0.9050.53
128_S160_L0.8950.53
62_L122_F0.8940.53
37_G44_E0.8890.52
104_P192_L0.8780.51
149_G152_G0.8780.51
121_V124_A0.8760.51
17_S20_D0.8750.51
109_S164_P0.8750.51
64_A67_Y0.8720.51
185_L196_L0.8710.51
63_E101_Y0.8650.50
188_A195_L0.8620.50
39_F72_W0.8610.50
47_S50_R0.8600.50
90_E199_L0.8510.49
7_T94_E0.8500.49
114_V144_N0.8300.47
152_G156_Q0.8150.46
108_E196_L0.8120.46
102_H178_G0.8040.45
132_G154_R0.8040.45
6_R178_G0.8030.45
160_L165_A0.8010.45
187_E197_G0.8000.45
123_W194_T0.7990.45
42_P68_L0.7920.44
40_V56_V0.7910.44
50_R102_H0.7890.44
145_L153_P0.7880.44
69_S74_S0.7850.44
31_Y38_V0.7840.44
178_G182_H0.7810.43
74_S77_L0.7810.43
68_L173_L0.7770.43
92_T116_L0.7750.43
95_L198_F0.7720.43
41_D65_P0.7700.42
60_T102_H0.7690.42
86_Q192_L0.7670.42
38_V113_T0.7610.42
61_D65_P0.7610.42
93_V204_A0.7600.42
6_R29_H0.7600.42
137_E142_R0.7580.41
157_F192_L0.7510.41
95_L176_P0.7500.41
8_L64_A0.7490.41
97_L117_P0.7480.41
137_E141_D0.7470.41
138_N181_S0.7450.40
4_F96_P0.7450.40
85_P168_E0.7440.40
58_G93_V0.7420.40
124_A155_T0.7410.40
9_L44_E0.7380.40
41_D77_L0.7380.40
3_G122_F0.7360.40
62_L157_F0.7350.40
11_S185_L0.7340.40
55_A121_V0.7310.39
195_L199_L0.7300.39
172_T193_V0.7290.39
12_V84_D0.7290.39
43_Y123_W0.7280.39
112_A175_V0.7270.39
69_S178_G0.7230.39
21_L160_L0.7220.39
166_S169_L0.7200.38
109_S179_D0.7190.38
117_P121_V0.7160.38
142_R145_L0.7150.38
80_L109_S0.7130.38
182_H185_L0.7090.38
117_P123_W0.7090.38
12_V166_S0.7080.37
26_C200_W0.7080.37
101_Y176_P0.7080.37
3_G42_P0.7050.37
35_P187_E0.7040.37
112_A180_L0.6990.37
140_F155_T0.6960.37
29_H32_L0.6950.36
120_D143_V0.6950.36
165_A168_E0.6930.36
142_R197_G0.6930.36
99_L117_P0.6930.36
48_L52_A0.6860.36
30_A44_E0.6860.36
96_P125_C0.6850.36
36_S171_L0.6840.36
128_S180_L0.6810.35
6_R32_L0.6790.35
85_P169_L0.6740.35
40_V172_T0.6720.35
29_H201_I0.6710.35
200_W204_A0.6700.35
138_N155_T0.6690.35
2_T6_R0.6680.34
18_I114_V0.6660.34
144_N152_G0.6660.34
63_E98_H0.6620.34
21_L134_K0.6540.33
3_G139_P0.6520.33
89_S112_A0.6510.33
54_V108_E0.6500.33
110_G117_P0.6500.33
187_E191_L0.6480.33
38_V62_L0.6470.33
44_E119_P0.6460.33
2_T178_G0.6450.33
168_E195_L0.6400.32
84_D192_L0.6380.32
157_F162_P0.6330.32
96_P198_F0.6300.32
6_R72_W0.6280.32
173_L187_E0.6230.31
58_G99_L0.6190.31
79_E157_F0.6170.31
54_V203_W0.6160.31
5_H176_P0.6150.31
55_A77_L0.6140.31
151_F157_F0.6100.30
86_Q168_E0.6050.30
89_S115_E0.6010.30
59_E71_Q0.6010.30
63_E176_P0.5990.29
2_T107_E0.5990.29
73_G139_P0.5990.29
38_V97_L0.5980.29
122_F151_F0.5970.29
172_T180_L0.5950.29
128_S137_E0.5950.29
44_E79_E0.5940.29
39_F76_V0.5890.29
43_Y74_S0.5890.29
78_L169_L0.5860.29
84_D87_C0.5840.28
6_R140_F0.5820.28
28_L199_L0.5790.28
94_E102_H0.5790.28
43_Y89_S0.5770.28
61_D67_Y0.5770.28
6_R26_C0.5750.28
149_G154_R0.5740.28
39_F69_S0.5660.27
62_L69_S0.5650.27
43_Y77_L0.5620.27
12_V111_Y0.5600.27
11_S97_L0.5600.27
105_S186_V0.5600.27
85_P172_T0.5590.27
140_F146_G0.5590.27
64_A68_L0.5560.27
147_Y151_F0.5520.26
84_D169_L0.5490.26
96_P196_L0.5480.26
161_P172_T0.5480.26
60_T66_E0.5460.26
135_F171_L0.5450.26
84_D89_S0.5440.26
132_G152_G0.5440.26
32_L66_E0.5430.26
11_S189_G0.5420.26
70_K201_I0.5420.26
5_H100_R0.5410.26
138_N157_F0.5400.26
24_S189_G0.5350.25
144_N149_G0.5320.25
39_F65_P0.5320.25
95_L174_Q0.5300.25
75_E78_L0.5290.25
24_S165_A0.5290.25
85_P130_E0.5280.25
112_A172_T0.5270.25
38_V114_V0.5270.25
73_G123_W0.5260.25
8_L173_L0.5250.25
15_G23_P0.5240.25
56_V191_L0.5230.25
175_V200_W0.5190.24
135_F140_F0.5190.24
81_A175_V0.5160.24
123_W158_Y0.5140.24
164_P189_G0.5120.24
83_S87_C0.5120.24
121_V146_G0.5110.24
39_F194_T0.5080.24
8_L87_C0.5030.23
29_H44_E0.5010.23
31_Y137_E0.5010.23
62_L104_P0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qleD 1 0.199 7.8 0.946 Contact Map
2micA 2 0.1553 7.7 0.946 Contact Map
1m56D 1 0.1942 6.3 0.948 Contact Map
1edyA 2 0.5728 3.9 0.953 Contact Map
1ayoA 2 0.5534 3.7 0.954 Contact Map
4gwpB 1 0.2476 3.2 0.955 Contact Map
2m59A 2 0.1214 2.6 0.957 Contact Map
4h62Q 1 0.2718 2.5 0.958 Contact Map
2zxxC 1 0.2864 2.5 0.958 Contact Map
2k9pA 1 0.1796 2.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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