GREMLIN Database
cwf18 - cwf18 pre-mRNA splicing factor
PFAM: PF08315 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 133 (131)
Sequences: 558 (401)
Seq/√Len: 35.1
META: 0.246

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_A115_E4.4001.00
45_F48_Y3.3481.00
104_W108_R3.0461.00
93_D97_L2.9211.00
104_W109_D2.7921.00
8_D11_A2.7691.00
50_P55_L2.6861.00
100_K103_N2.4731.00
82_A86_E2.2330.99
5_A8_D2.1670.99
1_S8_D2.0670.99
9_R13_L2.0220.98
14_A18_A2.0050.98
116_K120_R1.9270.98
116_K129_I1.8860.97
119_R122_Q1.8850.97
76_L92_L1.8640.97
109_D133_L1.8430.97
35_E38_E1.8390.97
93_D99_P1.8230.97
79_A82_A1.7760.96
45_F50_P1.6870.95
29_E32_E1.6450.94
118_E122_Q1.6330.94
119_R123_N1.6230.94
78_E81_K1.6210.94
103_N107_K1.6050.93
120_R131_E1.5830.93
100_K104_W1.5680.93
85_E88_E1.5280.92
112_K115_E1.4950.91
114_L120_R1.3860.87
64_K79_A1.3800.87
121_T125_I1.3590.86
43_L47_N1.3510.86
116_K119_R1.3460.86
46_R50_P1.3370.85
126_A129_I1.3190.84
7_L115_E1.3130.84
128_L132_R1.2660.82
108_R117_L1.2470.81
7_L11_A1.2390.80
74_A78_E1.2380.80
67_P75_E1.2290.80
7_L15_A1.2010.78
6_A17_R1.1990.78
9_R12_R1.1930.78
24_E27_E1.1770.77
83_E86_E1.1670.76
73_V98_A1.1570.76
29_E42_K1.1430.75
49_D53_R1.1320.74
28_E31_E1.1240.73
113_K117_L1.1170.73
37_E79_A1.1080.72
71_E74_A1.0970.72
39_E42_K1.0940.71
27_E32_E1.0700.70
67_P71_E1.0600.69
28_E32_E1.0570.69
31_E34_E1.0510.68
2_L51_E1.0360.67
98_A122_Q1.0170.66
73_V96_N1.0110.65
78_E82_A1.0100.65
29_E33_E1.0050.65
9_R16_L1.0050.65
47_N106_L1.0010.64
2_L13_L1.0000.64
35_E39_E0.9920.64
107_K132_R0.9870.63
94_L104_W0.9800.63
102_P114_L0.9710.62
113_K128_L0.9680.62
11_A14_A0.9580.61
14_A57_L0.9360.59
77_A81_K0.9240.58
114_L117_L0.9100.57
79_A83_E0.9050.56
45_F51_E0.9040.56
74_A114_L0.8890.55
129_I132_R0.8870.55
50_P53_R0.8660.53
98_A114_L0.8540.52
76_L103_N0.8460.51
18_A111_A0.8440.51
96_N113_K0.8380.51
98_A104_W0.8370.51
99_P108_R0.8360.51
47_N58_G0.8330.50
52_T55_L0.8290.50
11_A15_A0.8250.50
15_A92_L0.8200.49
112_K122_Q0.8160.49
34_E40_L0.8100.48
77_A97_L0.8100.48
34_E39_E0.8070.48
24_E28_E0.7780.46
51_E54_G0.7770.46
24_E29_E0.7720.45
55_L119_R0.7670.45
17_R76_L0.7580.44
101_K113_K0.7580.44
7_L61_A0.7490.43
29_E34_E0.7460.43
36_E40_L0.7420.43
30_E36_E0.7360.42
111_A118_E0.7320.42
33_E36_E0.7310.42
15_A18_A0.7180.41
10_K106_L0.7110.40
6_A97_L0.7100.40
130_R133_L0.7080.40
3_E7_L0.7060.40
53_R90_E0.7050.40
60_E120_R0.7030.39
107_K130_R0.7000.39
7_L91_E0.6980.39
16_L58_G0.6960.39
78_E122_Q0.6910.38
18_A22_K0.6840.38
59_F63_P0.6800.37
37_E131_E0.6760.37
60_E98_A0.6750.37
101_K108_R0.6740.37
32_E37_E0.6690.37
81_K89_D0.6690.37
103_N108_R0.6580.36
58_G63_P0.6580.36
105_D130_R0.6550.36
65_P118_E0.6540.35
73_V76_L0.6450.35
127_E131_E0.6440.35
6_A80_A0.6360.34
32_E38_E0.6350.34
64_K116_K0.6340.34
46_R106_L0.6340.34
117_L130_R0.6290.33
49_D68_T0.6210.33
87_D92_L0.6200.33
36_E118_E0.6190.33
96_N102_P0.6190.33
125_I132_R0.6180.33
27_E30_E0.6120.32
19_L22_K0.6100.32
43_L60_E0.6070.32
61_A120_R0.6040.32
19_L68_T0.6040.32
67_P88_E0.6020.31
102_P110_L0.5970.31
94_L98_A0.5970.31
7_L77_A0.5970.31
20_K102_P0.5960.31
99_P104_W0.5960.31
2_L5_A0.5940.31
18_A37_E0.5930.31
24_E31_E0.5920.31
62_P83_E0.5910.31
32_E36_E0.5840.30
10_K13_L0.5820.30
77_A86_E0.5780.30
81_K126_A0.5710.29
13_L51_E0.5670.29
1_S131_E0.5660.29
46_R108_R0.5650.29
16_L103_N0.5650.29
107_K129_I0.5640.29
106_L113_K0.5630.29
50_P75_E0.5630.29
4_A74_A0.5620.29
80_A133_L0.5620.29
24_E35_E0.5610.28
109_D112_K0.5600.28
66_G118_E0.5560.28
59_F68_T0.5550.28
44_K58_G0.5530.28
8_D54_G0.5490.28
7_L14_A0.5470.28
8_D14_A0.5390.27
49_D69_V0.5320.27
108_R113_K0.5320.27
6_A79_A0.5310.26
83_E87_D0.5280.26
44_K47_N0.5260.26
71_E85_E0.5230.26
69_V76_L0.5220.26
2_L10_K0.5210.26
43_L59_F0.5180.26
20_K56_K0.5180.26
72_Q113_K0.5160.25
30_E120_R0.5150.25
49_D56_K0.5140.25
106_L128_L0.5090.25
107_K112_K0.5030.25
40_L43_L0.5030.25
18_A21_R0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x8kB 1 0.1955 7.1 0.931 Contact Map
4yz6B 1 0.0827 4 0.939 Contact Map
2ay0A 2 0.2707 3.7 0.94 Contact Map
1yybA 1 0.188 3.6 0.94 Contact Map
4i1lA 2 0.1729 3 0.942 Contact Map
2gpeA 2 0.2707 2.4 0.945 Contact Map
2xzeQ 1 0.1353 2.4 0.945 Contact Map
4xo1A 2 0.1654 2.2 0.946 Contact Map
2jnsA 1 0.3609 2.2 0.946 Contact Map
2mdvA 2 0.2556 1.7 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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