cwf18 - PFAM28P - GREMLIN Contacts

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cwf18 - cwf18 pre-mRNA splicing factor

PFAM:	PF08315	Sequences: SLEAAALDRKARLAALRALKRKQEESEEEEEEEEEEEEELPKLKFRNYDPETRGLKLGFEAPPKPGPTVEEQVAELAEAAKAEAEEDEDEELDLFNLAPKKPNWDLKRDLAKKLEKLERRTQNAIAELIRERL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	133 (131)
Sequences:	558 (401)
Seq/√Len:	35.1
META:	0.246

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
111_A	115_E	4.400	1.00
45_F	48_Y	3.348	1.00
104_W	108_R	3.046	1.00
93_D	97_L	2.921	1.00
104_W	109_D	2.792	1.00
8_D	11_A	2.769	1.00
50_P	55_L	2.686	1.00
100_K	103_N	2.473	1.00
82_A	86_E	2.233	0.99
5_A	8_D	2.167	0.99
1_S	8_D	2.067	0.99
9_R	13_L	2.022	0.98
14_A	18_A	2.005	0.98
116_K	120_R	1.927	0.98
116_K	129_I	1.886	0.97
119_R	122_Q	1.885	0.97
76_L	92_L	1.864	0.97
109_D	133_L	1.843	0.97
35_E	38_E	1.839	0.97
93_D	99_P	1.823	0.97
79_A	82_A	1.776	0.96
45_F	50_P	1.687	0.95
29_E	32_E	1.645	0.94
118_E	122_Q	1.633	0.94
119_R	123_N	1.623	0.94
78_E	81_K	1.621	0.94
103_N	107_K	1.605	0.93
120_R	131_E	1.583	0.93
100_K	104_W	1.568	0.93
85_E	88_E	1.528	0.92
112_K	115_E	1.495	0.91
114_L	120_R	1.386	0.87
64_K	79_A	1.380	0.87
121_T	125_I	1.359	0.86
43_L	47_N	1.351	0.86
116_K	119_R	1.346	0.86
46_R	50_P	1.337	0.85
126_A	129_I	1.319	0.84
7_L	115_E	1.313	0.84
128_L	132_R	1.266	0.82
108_R	117_L	1.247	0.81
7_L	11_A	1.239	0.80
74_A	78_E	1.238	0.80
67_P	75_E	1.229	0.80
7_L	15_A	1.201	0.78
6_A	17_R	1.199	0.78
9_R	12_R	1.193	0.78
24_E	27_E	1.177	0.77
83_E	86_E	1.167	0.76
73_V	98_A	1.157	0.76
29_E	42_K	1.143	0.75
49_D	53_R	1.132	0.74
28_E	31_E	1.124	0.73
113_K	117_L	1.117	0.73
37_E	79_A	1.108	0.72
71_E	74_A	1.097	0.72
39_E	42_K	1.094	0.71
27_E	32_E	1.070	0.70
67_P	71_E	1.060	0.69
28_E	32_E	1.057	0.69
31_E	34_E	1.051	0.68
2_L	51_E	1.036	0.67
98_A	122_Q	1.017	0.66
73_V	96_N	1.011	0.65
78_E	82_A	1.010	0.65
29_E	33_E	1.005	0.65
9_R	16_L	1.005	0.65
47_N	106_L	1.001	0.64
2_L	13_L	1.000	0.64
35_E	39_E	0.992	0.64
107_K	132_R	0.987	0.63
94_L	104_W	0.980	0.63
102_P	114_L	0.971	0.62
113_K	128_L	0.968	0.62
11_A	14_A	0.958	0.61
14_A	57_L	0.936	0.59
77_A	81_K	0.924	0.58
114_L	117_L	0.910	0.57
79_A	83_E	0.905	0.56
45_F	51_E	0.904	0.56
74_A	114_L	0.889	0.55
129_I	132_R	0.887	0.55
50_P	53_R	0.866	0.53
98_A	114_L	0.854	0.52
76_L	103_N	0.846	0.51
18_A	111_A	0.844	0.51
96_N	113_K	0.838	0.51
98_A	104_W	0.837	0.51
99_P	108_R	0.836	0.51
47_N	58_G	0.833	0.50
52_T	55_L	0.829	0.50
11_A	15_A	0.825	0.50
15_A	92_L	0.820	0.49
112_K	122_Q	0.816	0.49
34_E	40_L	0.810	0.48
77_A	97_L	0.810	0.48
34_E	39_E	0.807	0.48
24_E	28_E	0.778	0.46
51_E	54_G	0.777	0.46
24_E	29_E	0.772	0.45
55_L	119_R	0.767	0.45
17_R	76_L	0.758	0.44
101_K	113_K	0.758	0.44
7_L	61_A	0.749	0.43
29_E	34_E	0.746	0.43
36_E	40_L	0.742	0.43
30_E	36_E	0.736	0.42
111_A	118_E	0.732	0.42
33_E	36_E	0.731	0.42
15_A	18_A	0.718	0.41
10_K	106_L	0.711	0.40
6_A	97_L	0.710	0.40
130_R	133_L	0.708	0.40
3_E	7_L	0.706	0.40
53_R	90_E	0.705	0.40
60_E	120_R	0.703	0.39
107_K	130_R	0.700	0.39
7_L	91_E	0.698	0.39
16_L	58_G	0.696	0.39
78_E	122_Q	0.691	0.38
18_A	22_K	0.684	0.38
59_F	63_P	0.680	0.37
37_E	131_E	0.676	0.37
60_E	98_A	0.675	0.37
101_K	108_R	0.674	0.37
32_E	37_E	0.669	0.37
81_K	89_D	0.669	0.37
103_N	108_R	0.658	0.36
58_G	63_P	0.658	0.36
105_D	130_R	0.655	0.36
65_P	118_E	0.654	0.35
73_V	76_L	0.645	0.35
127_E	131_E	0.644	0.35
6_A	80_A	0.636	0.34
32_E	38_E	0.635	0.34
64_K	116_K	0.634	0.34
46_R	106_L	0.634	0.34
117_L	130_R	0.629	0.33
49_D	68_T	0.621	0.33
87_D	92_L	0.620	0.33
36_E	118_E	0.619	0.33
96_N	102_P	0.619	0.33
125_I	132_R	0.618	0.33
27_E	30_E	0.612	0.32
19_L	22_K	0.610	0.32
43_L	60_E	0.607	0.32
61_A	120_R	0.604	0.32
19_L	68_T	0.604	0.32
67_P	88_E	0.602	0.31
102_P	110_L	0.597	0.31
94_L	98_A	0.597	0.31
7_L	77_A	0.597	0.31
20_K	102_P	0.596	0.31
99_P	104_W	0.596	0.31
2_L	5_A	0.594	0.31
18_A	37_E	0.593	0.31
24_E	31_E	0.592	0.31
62_P	83_E	0.591	0.31
32_E	36_E	0.584	0.30
10_K	13_L	0.582	0.30
77_A	86_E	0.578	0.30
81_K	126_A	0.571	0.29
13_L	51_E	0.567	0.29
1_S	131_E	0.566	0.29
46_R	108_R	0.565	0.29
16_L	103_N	0.565	0.29
107_K	129_I	0.564	0.29
106_L	113_K	0.563	0.29
50_P	75_E	0.563	0.29
4_A	74_A	0.562	0.29
80_A	133_L	0.562	0.29
24_E	35_E	0.561	0.28
109_D	112_K	0.560	0.28
66_G	118_E	0.556	0.28
59_F	68_T	0.555	0.28
44_K	58_G	0.553	0.28
8_D	54_G	0.549	0.28
7_L	14_A	0.547	0.28
8_D	14_A	0.539	0.27
49_D	69_V	0.532	0.27
108_R	113_K	0.532	0.27
6_A	79_A	0.531	0.26
83_E	87_D	0.528	0.26
44_K	47_N	0.526	0.26
71_E	85_E	0.523	0.26
69_V	76_L	0.522	0.26
2_L	10_K	0.521	0.26
43_L	59_F	0.518	0.26
20_K	56_K	0.518	0.26
72_Q	113_K	0.516	0.25
30_E	120_R	0.515	0.25
49_D	56_K	0.514	0.25
106_L	128_L	0.509	0.25
107_K	112_K	0.503	0.25
40_L	43_L	0.503	0.25
18_A	21_R	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4x8kB	1	0.1955	7.1	0.931	Contact Map
4yz6B	1	0.0827	4	0.939	Contact Map
2ay0A	2	0.2707	3.7	0.94	Contact Map
1yybA	1	0.188	3.6	0.94	Contact Map
4i1lA	2	0.1729	3	0.942	Contact Map
2gpeA	2	0.2707	2.4	0.945	Contact Map
2xzeQ	1	0.1353	2.4	0.945	Contact Map
4xo1A	2	0.1654	2.2	0.946	Contact Map
2jnsA	1	0.3609	2.2	0.946	Contact Map
2mdvA	2	0.2556	1.7	0.95	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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