GREMLIN Database
LGFP - LGFP repeat
PFAM: PF08310 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (53)
Sequences: 20385 (15659)
Seq/√Len: 2150.9
META: 0.831

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_A17_R3.6381.00
46_A50_G2.7401.00
44_K48_L2.6371.00
20_H25_S2.3681.00
25_S42_R2.0321.00
8_E17_R1.8471.00
9_T18_Y1.8001.00
40_A43_D1.7961.00
3_Y22_Q1.6531.00
44_K47_A1.6441.00
29_S32_T1.6391.00
8_E19_Q1.5971.00
6_T9_T1.5111.00
42_R46_A1.4631.00
27_Y37_V1.4201.00
28_W34_A1.4201.00
3_Y19_Q1.3311.00
6_T20_H1.3141.00
7_D19_Q1.2281.00
25_S46_A1.2191.00
43_D47_A1.0991.00
18_Y27_Y1.0901.00
6_T19_Q1.0841.00
5_T22_Q1.0651.00
9_T20_H1.0181.00
45_W51_E1.0141.00
39_G43_D1.0141.00
1_L24_G0.9851.00
37_V42_R0.9781.00
11_T18_Y0.9571.00
26_I36_E0.9431.00
49_G52_R0.9011.00
5_T20_H0.8901.00
41_I44_K0.8881.00
32_T35_H0.8791.00
17_R28_W0.8241.00
13_D52_R0.8141.00
8_E28_W0.7981.00
18_Y25_S0.7961.00
28_W33_G0.7911.00
26_I34_A0.7771.00
42_R50_G0.7741.00
21_F26_I0.7651.00
4_P19_Q0.7561.00
20_H50_G0.7551.00
27_Y45_W0.7461.00
15_G31_A0.7351.00
48_L53_G0.7341.00
3_Y7_D0.7301.00
10_A14_G0.7271.00
39_G42_R0.6941.00
20_H46_A0.6941.00
11_T15_G0.6751.00
29_S33_G0.6691.00
29_S35_H0.6581.00
4_P7_D0.6431.00
25_S50_G0.6321.00
15_G29_S0.6131.00
37_V45_W0.6131.00
43_D46_A0.6001.00
13_D51_E0.5951.00
38_H41_I0.5871.00
11_T14_G0.5801.00
12_P15_G0.5701.00
30_P33_G0.5691.00
20_H42_R0.5661.00
3_Y21_F0.5651.00
15_G30_P0.5611.00
23_G40_A0.5531.00
41_I45_W0.5481.00
39_G44_K0.5341.00
31_A35_H0.5311.00
27_Y50_G0.5301.00
38_H42_R0.5251.00
8_E21_F0.5191.00
1_L26_I0.5181.00
35_H38_H0.5171.00
11_T16_G0.5161.00
24_G36_E0.5021.00
2_G22_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i6sA 2 0.8868 5.3 0.836 Contact Map
4pwoA 1 0.9057 4.9 0.839 Contact Map
4ml1A 4 0.9811 4.3 0.843 Contact Map
1t3bA 2 0.9811 3.6 0.849 Contact Map
1tdjA 2 0.3396 3.6 0.849 Contact Map
1v58A 2 0.9623 3.3 0.851 Contact Map
4npbA 2 0.9811 3.2 0.853 Contact Map
1eejA 2 0.9811 2.8 0.858 Contact Map
4csu9 1 0.6226 2.2 0.865 Contact Map
1ztdA 2 0.9245 2.2 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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