GREMLIN Database
DPM3 - Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
PFAM: PF08285 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (90)
Sequences: 589 (456)
Seq/√Len: 48.1
META: 0.367

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_C58_G3.8421.00
70_A73_E3.8101.00
80_E84_D2.8251.00
53_S57_L2.6451.00
3_R7_W2.5031.00
54_L58_G2.4671.00
77_E80_E2.1941.00
47_V51_C1.9860.99
44_W51_C1.8980.99
57_L64_F1.8580.99
53_S56_S1.8410.99
58_G61_V1.8030.99
49_F53_S1.7880.99
44_W48_S1.7080.98
79_K83_A1.6690.98
44_W58_G1.6540.98
67_C70_A1.6270.98
72_K76_K1.6140.98
47_V58_G1.5420.97
73_E77_E1.5230.96
47_V54_L1.4890.96
51_C54_L1.4450.95
78_I82_K1.4250.95
53_S67_C1.4250.95
13_L16_A1.4000.94
78_I81_A1.3810.94
51_C61_V1.3710.94
59_Y63_T1.3610.93
64_F85_L1.3540.93
71_A75_Q1.3500.93
2_T5_Q1.3360.93
72_K75_Q1.3050.92
16_A20_A1.3000.92
49_F57_L1.2320.89
76_K79_K1.2000.88
9_S12_L1.1800.87
4_A7_W1.1790.87
70_A85_L1.1430.86
54_L74_L1.1110.84
70_A84_D1.0680.81
83_A86_R1.0630.81
17_L31_P1.0620.81
67_C71_A1.0350.79
84_D87_K1.0310.79
81_A84_D1.0010.77
60_G90_V0.9720.75
9_S13_L0.9480.73
86_R90_V0.9360.72
16_A83_A0.9300.72
65_N85_L0.9250.71
18_W39_P0.9170.70
84_D88_K0.9140.70
83_A87_K0.8990.69
74_L77_E0.8920.68
2_T7_W0.8590.65
3_R60_G0.8480.64
43_L47_V0.8400.64
66_D73_E0.8320.63
32_K36_E0.8310.63
46_L50_G0.8100.61
34_Q38_I0.7970.60
29_P44_W0.7950.59
3_R6_Q0.7820.58
4_A60_G0.7790.58
57_L60_G0.7770.58
24_G35_R0.7710.57
43_L46_L0.7700.57
52_Y56_S0.7660.57
48_S51_C0.7610.56
8_L15_S0.7610.56
80_E88_K0.7560.56
54_L66_D0.7490.55
27_P39_P0.7430.54
27_P37_I0.7350.53
7_W61_V0.7320.53
49_F89_G0.7290.53
46_L49_F0.7200.52
62_L82_K0.7100.51
44_W54_L0.7070.51
17_L28_L0.7030.50
21_L38_I0.7020.50
11_L21_L0.6870.49
12_L27_P0.6860.49
2_T6_Q0.6820.48
3_R10_L0.6770.48
8_L13_L0.6760.47
6_Q23_L0.6740.47
20_A87_K0.6710.47
3_R14_L0.6660.46
37_I40_V0.6580.46
56_S67_C0.6550.45
19_L34_Q0.6530.45
33_I78_I0.6520.45
64_F67_C0.6440.44
19_L38_I0.6380.44
42_P81_A0.6370.44
50_G89_G0.6310.43
56_S60_G0.6290.43
39_P44_W0.6290.43
75_Q78_I0.6200.42
11_L70_A0.6140.41
4_A8_L0.6110.41
76_K80_E0.6080.41
79_K87_K0.6020.40
60_G70_A0.5990.40
42_P49_F0.5990.40
56_S68_P0.5980.40
28_L35_R0.5940.39
25_L34_Q0.5890.39
22_L39_P0.5870.39
20_A76_K0.5800.38
44_W47_V0.5770.38
21_L62_L0.5760.38
24_G76_K0.5740.38
57_L61_V0.5690.37
2_T73_E0.5690.37
42_P82_K0.5660.37
18_W22_L0.5640.37
60_G64_F0.5380.34
40_V43_L0.5370.34
85_L90_V0.5360.34
56_S61_V0.5320.34
44_W75_Q0.5310.34
57_L67_C0.5290.33
29_P41_L0.5260.33
40_V46_L0.5200.33
55_A62_L0.5160.32
85_L89_G0.5130.32
8_L52_Y0.5120.32
62_L69_E0.5120.32
72_K79_K0.5110.32
70_A77_E0.5030.31
10_L68_P0.5020.31
12_L22_L0.5020.31
12_L46_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3avxA 1 0.4066 63 0.856 Contact Map
4pc3C 1 0.4176 33.1 0.879 Contact Map
2cp9A 1 0.4615 32.8 0.88 Contact Map
1aipC 2 0.4286 29.1 0.883 Contact Map
4qinA 2 1 28.8 0.883 Contact Map
4c7rA 3 0.989 18.9 0.893 Contact Map
1xb2B 1 0.4286 17.7 0.894 Contact Map
4q4gX 1 0 17.5 0.894 Contact Map
3layA 5 0.6374 11.8 0.903 Contact Map
1xjtA 1 0.8571 11.6 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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