GREMLIN Database
SYF2 - SYF2 splicing factor
PFAM: PF08231 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 154 (151)
Sequences: 509 (355)
Seq/√Len: 28.9
META: 0.287

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_E143_D5.3611.00
98_L102_L4.0451.00
62_Y66_K3.4601.00
137_K140_R2.7351.00
130_R140_R2.4660.99
101_D105_Q2.3830.99
102_L148_E2.2940.99
107_E111_K2.2520.98
94_A97_R2.2200.98
148_E152_N2.2110.98
129_E132_K2.1520.98
147_A151_Q2.0320.97
90_P94_A2.0320.97
47_A51_Q1.8790.95
37_F40_Y1.8470.95
130_R138_L1.8410.95
91_S95_V1.8020.94
134_F137_K1.8020.94
143_D150_R1.7570.93
58_D62_Y1.7270.93
19_A23_D1.7260.93
98_L101_D1.7170.92
64_K68_A1.6680.91
14_W22_W1.6370.90
96_D99_V1.6130.90
58_D61_A1.5910.89
20_E141_F1.5820.89
47_A50_R1.5780.89
11_A14_W1.5670.88
15_T18_E1.4930.86
105_Q108_K1.4860.85
64_K67_E1.4570.84
77_Y82_S1.4550.84
37_F142_Y1.4430.84
131_N135_N1.4370.83
21_R24_K1.4320.83
91_S94_A1.3960.82
139_E150_R1.3780.81
113_S116_R1.3720.80
95_V99_V1.3470.79
54_N104_K1.3350.79
63_E67_E1.3300.78
45_Y49_K1.3270.78
14_W18_E1.3130.77
9_K12_L1.2770.75
40_Y142_Y1.2740.75
27_K129_E1.2620.74
62_Y76_F1.2440.73
21_R64_K1.2410.73
63_E66_K1.2310.73
51_Q101_D1.2270.72
134_F140_R1.2130.71
39_D42_Q1.2110.71
66_K71_E1.2000.71
60_E64_K1.1930.70
99_V102_L1.1890.70
17_E25_K1.1770.69
34_D38_S1.1610.68
19_A29_K1.1500.67
146_T149_I1.1180.65
78_R82_S1.1160.65
18_E22_W1.1110.65
6_F9_K1.1060.64
95_V98_L1.1000.64
76_F82_S1.0980.64
10_K18_E1.0970.64
138_L142_Y1.0940.63
54_N68_A1.0930.63
113_S130_R1.0870.63
48_Y127_I1.0860.63
10_K19_A1.0770.62
96_D103_E1.0760.62
36_G152_N1.0750.62
102_L124_V1.0710.62
146_T150_R1.0690.62
143_D146_T1.0670.61
16_A19_A1.0340.59
148_E151_Q1.0220.58
44_A134_F1.0150.57
30_A82_S0.9840.55
40_Y43_A0.9710.54
13_D151_Q0.9680.54
43_A50_R0.9670.54
44_A47_A0.9650.54
67_E100_A0.9440.52
124_V129_E0.9430.52
48_Y90_P0.9370.51
103_E106_E0.9310.51
38_S42_Q0.9270.51
83_L138_L0.9160.50
112_F115_R0.8990.48
75_A83_L0.8950.48
95_V102_L0.8880.48
105_Q109_R0.8800.47
118_F132_K0.8780.47
45_Y152_N0.8770.47
34_D37_F0.8730.46
77_Y86_G0.8660.46
64_K102_L0.8610.46
65_Q69_A0.8580.45
129_E140_R0.8540.45
14_W17_E0.8490.45
28_K49_K0.8480.45
24_K28_K0.8470.44
103_E151_Q0.8360.44
37_F48_Y0.8320.43
146_T154_E0.8290.43
2_A7_E0.8250.43
15_T22_W0.8240.43
149_I154_E0.8210.42
32_R46_R0.8180.42
130_R133_Q0.8150.42
19_A22_W0.8100.42
136_K140_R0.8030.41
39_D50_R0.8020.41
11_A16_A0.7960.41
57_P62_Y0.7900.40
125_T140_R0.7850.40
10_K29_K0.7810.39
126_Y132_K0.7740.39
44_A138_L0.7730.39
81_D89_K0.7710.39
39_D51_Q0.7680.38
150_R154_E0.7670.38
105_Q130_R0.7630.38
108_K152_N0.7630.38
59_L63_E0.7620.38
132_K136_K0.7580.38
79_T148_E0.7570.38
12_L15_T0.7560.38
110_K120_D0.7560.38
122_A150_R0.7480.37
46_R116_R0.7440.37
41_E44_A0.7440.37
48_Y55_L0.7350.36
40_Y51_Q0.7300.36
2_A6_F0.7290.36
103_E107_E0.7280.36
148_E154_E0.7280.36
16_A22_W0.7040.34
134_F146_T0.7020.34
39_D44_A0.7020.34
149_I153_L0.7000.34
69_A82_S0.7000.34
35_F42_Q0.6960.33
119_D134_F0.6930.33
145_Y154_E0.6920.33
83_L86_G0.6910.33
138_L141_F0.6900.33
64_K106_E0.6890.33
11_A18_E0.6890.33
59_L99_V0.6890.33
131_N134_F0.6820.32
48_Y57_P0.6820.32
13_D82_S0.6790.32
95_V142_Y0.6750.32
35_F38_S0.6730.32
121_D136_K0.6680.31
144_K147_A0.6650.31
92_K100_A0.6600.31
47_A129_E0.6590.31
47_A124_V0.6580.31
111_K120_D0.6560.31
29_K58_D0.6530.30
27_K30_A0.6530.30
19_A26_K0.6510.30
17_E145_Y0.6490.30
11_A15_T0.6480.30
14_W23_D0.6460.30
94_A121_D0.6330.29
69_A78_R0.6280.29
43_A126_Y0.6270.29
94_A114_R0.6260.29
50_R54_N0.6230.28
58_D96_D0.6140.28
10_K14_W0.6110.28
43_A47_A0.6090.28
100_A103_E0.6060.27
142_Y145_Y0.6040.27
132_K141_F0.6030.27
47_A106_E0.6020.27
61_A150_R0.6010.27
7_E41_E0.5990.27
44_A48_Y0.5980.27
24_K49_K0.5970.27
70_G76_F0.5950.27
41_E90_P0.5910.26
145_Y149_I0.5870.26
33_A46_R0.5850.26
133_Q138_L0.5840.26
24_K60_E0.5820.26
120_D148_E0.5800.26
8_R12_L0.5780.26
63_E77_Y0.5750.26
104_K132_K0.5740.25
16_A96_D0.5690.25
17_E119_D0.5670.25
130_R136_K0.5530.24
66_K79_T0.5510.24
18_E25_K0.5500.24
14_W153_L0.5500.24
47_A133_Q0.5480.24
64_K148_E0.5430.24
15_T20_E0.5390.23
11_A98_L0.5380.23
15_T29_K0.5350.23
133_Q136_K0.5350.23
56_K80_A0.5290.23
127_I149_I0.5270.23
12_L125_T0.5270.23
79_T100_A0.5260.23
93_E116_R0.5260.23
36_G115_R0.5250.23
36_G140_R0.5250.23
131_N138_L0.5220.23
2_A35_F0.5170.22
39_D134_F0.5160.22
30_A49_K0.5150.22
11_A19_A0.5150.22
48_Y142_Y0.5110.22
36_G39_D0.5100.22
115_R139_E0.5100.22
135_N140_R0.5100.22
61_A91_S0.5090.22
13_D60_E0.5070.22
34_D126_Y0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xs1A 1 0.8896 2.8 0.954 Contact Map
3tj1A 2 0.1039 1.9 0.958 Contact Map
4zriC 1 0.0974 1.8 0.958 Contact Map
1rzuA 1 0.3442 1.6 0.96 Contact Map
2mjgA 2 0.2987 1.4 0.961 Contact Map
3nuhB 1 0.2078 1.3 0.961 Contact Map
4zrkE 1 0.1169 1.3 0.962 Contact Map
2p58B 1 0 1.2 0.963 Contact Map
3basA 2 0.474 1.1 0.963 Contact Map
2v6eA 2 0.4091 1.1 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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